CUSIP No.
023111206
1
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NAMES OF REPORTING PERSONS
Baker Bros. Advisors LP
|
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
(a)
¨
(b)
¨
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3
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SEC USE ONLY
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4
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CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
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NUMBER OF
SHARES
BENEFICIALLY
OWNED BY
EACH
REPORTING
PERSON
WITH
|
5
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SOLE VOTING POWER
42,592,824
|
6
|
SHARED VOTING POWER
-0-
|
7
|
SOLE DISPOSITIVE POWER
42,592,824
|
8
|
SHARED DISPOSITIVE POWER
-0-
|
9
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
42,592,824
|
10
|
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES
¨
(See Instructions)
|
11
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
13.2% (1)
|
12
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TYPE OF REPORTING PERSON (See Instructions)
IA, PN
|
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(1)
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Based on 322,916,876 shares of Amarin Corporation plc (the “Issuer”) outstanding as of November 29, 2018, including
both shares held as ADS and shares held as Ordinary Shares of the Issuer, as reported in the Issuer’s Prospectus filed with
the Securities and Exchange Commission (“SEC”) on November 28, 2018.
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CUSIP No.
023111206
1
|
NAMES OF REPORTING PERSONS
Baker Bros. Advisors (GP) LLC
|
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
(a)
¨
(b)
¨
|
3
|
SEC USE ONLY
|
4
|
CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
|
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY
EACH
REPORTING
PERSON
WITH
|
5
|
SOLE VOTING POWER
42,592,824
|
6
|
SHARED VOTING POWER
-0-
|
7
|
SOLE DISPOSITIVE POWER
42,592,824
|
8
|
SHARED DISPOSITIVE POWER
-0-
|
9
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
42,592,824
|
10
|
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES
¨
(See Instructions)
|
11
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
13.2% (1)
|
12
|
TYPE OF REPORTING PERSON (See Instructions)
HC, OO
|
|
(1)
|
Based on 322,916,876 shares of the Issuer outstanding as of November 29, 2018, including both shares held as ADS and shares
held as Ordinary Shares of the Issuer, as reported in the Issuer’s Prospectus filed with the SEC on November 28, 2018.
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CUSIP No.
023111206
1
|
NAMES OF REPORTING PERSONS
Felix J. Baker
|
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
(a)
¨
(b)
¨
|
3
|
SEC USE ONLY
|
4
|
CITIZENSHIP OR PLACE OF ORGANIZATION
United States
|
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY
EACH
REPORTING
PERSON
WITH
|
5
|
SOLE VOTING POWER
42,592,824
|
6
|
SHARED VOTING POWER
-0-
|
7
|
SOLE DISPOSITIVE POWER
42,592,824
|
8
|
SHARED DISPOSITIVE POWER
-0-
|
9
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
42,592,824
|
10
|
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES
¨
(See Instructions)
|
11
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
13.2% (1)
|
12
|
TYPE OF REPORTING PERSON (See Instructions)
IN, HC
|
|
(1)
|
Based on 322,916,876 shares of the Issuer outstanding as of November 29, 2018, including both shares held as ADS and shares
held as Ordinary Shares of the Issuer, as reported in the Issuer’s Prospectus filed with the SEC on November 28, 2018.
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CUSIP No.
023111206
1
|
NAMES OF REPORTING PERSONS
Julian C. Baker
|
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
(a)
¨
(b)
¨
|
3
|
SEC USE ONLY
|
4
|
CITIZENSHIP OR PLACE OF ORGANIZATION
United States
|
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY
EACH
REPORTING
PERSON
WITH
|
5
|
SOLE VOTING POWER
42,592,824
|
6
|
SHARED VOTING POWER
-0-
|
7
|
SOLE DISPOSITIVE POWER
42,592,824
|
8
|
SHARED DISPOSITIVE POWER
-0-
|
9
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
42,592,824
|
10
|
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES
¨
(See Instructions)
|
11
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
13.2% (1)
|
12
|
TYPE OF REPORTING PERSON (See Instructions)
IN, HC
|
|
(1)
|
Based on 322,916,876 shares of the Issuer outstanding as of November 29, 2018, including both shares held as ADS and shares
held as Ordinary Shares of the Issuer, as reported in the Issuer’s Prospectus filed with the SEC on November 28, 2018.
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Amendment No. 3 to Schedule 13G
This Amendment No. 3 to Schedule 13G amends the previously filed
Schedule 13G filed by Baker Bros. Advisors LP (the “Adviser”), Baker Bros. Advisors (GP) LLC (the “Adviser GP”),
Julian C. Baker and Felix J. Baker (collectively, the “Reporting Persons”). Except as supplemented herein, such statements,
as heretofore amended and supplemented, remain in full force and effect.
Item 1(a)
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Name of Issuer:
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Amarin Corporation plc (the “Issuer”)
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Item 1(b)
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Address of Issuer’s Principal Executive Offices:
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2 Pembroke House, Upper Pembroke Street 28-32
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Dublin 2, Ireland
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Item 2(a)
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Name of Person Filing:
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This Amendment No. 3 is being filed jointly by the Reporting Persons.
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Item 2(b)
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Address of Principal Business Office or, if None, Residence:
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The business address of each of the Reporting Persons is:
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c/o Baker Bros. Advisors LP
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860 Washington Street, 3
rd
Floor
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New York, NY 10014
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(212) 339-5690
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Item 2(c)
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Citizenship:
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The Adviser is a limited partnership organized under the laws of the State of Delaware. The Adviser GP is a limited liability company organized under the laws of the State of Delaware. The citizenship of each of Julian C. Baker and Felix J. Baker is the United States of America.
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Item 2(d)
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Title of Class of Securities
|
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American Depositary Shares (“ADS”), each representing one Ordinary Share, 50 pence par value per share
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Item 2(e)
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CUSIP Number
|
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023111206
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Item 3.
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If this statement is filed pursuant to §§240.13d-1(b) or (c), check whether the person filing is a:
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(a)
¨
Broker or dealer registered under Section 15 of the Exchange Act.
(b)
¨
Bank as defined in section 3(a)(6) of the Exchange Act.
(c)
¨
Insurance company as defined in section 3(a)(19) of the Exchange Act.
(d)
¨
Investment company registered under section 8 of the Investment Company Act of 1940.
(e)
x
An investment adviser in accordance with Rule 13d-1(b)(1)(ii)(E).
(f)
¨
An employee benefit plan or endowment fund in accordance with Rule 13d-1(b)(1)(ii)(F).
(g)
x
A parent holding company or control person in accordance with Rule 13d-1(b)(1)(ii)(G).
(h)
¨
A savings association as defined in Section 3(b) of the Federal Deposit Insurance Act.
(i)
¨
A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act
of 1940.
(j)
¨
Group, in accordance with Rule 13d-1(b)(1)(ii)(J).
Items 5 through 9 and 11 of each of the cover pages to this
Amendment No. 3 are incorporated herein reference. Set forth below is the aggregate number of ADS as well as ADS that may be acquired
upon the conversion of the Series A Preference Shares (“Series A Preferred”), directly held by each of Baker Brothers
Life Sciences, L.P. (“Life Sciences”) and 667, L.P. (“667”, and together with Life Sciences, the “Funds”),
subject to the limitation on conversion described below. The Series A Preferred are convertible into ADS on a 10 for 1 basis and
have no voting rights. The information set forth below is based upon 322,916,876 shares of the Issuer outstanding as of November
29, 2018, including both shares held as ADS and shares held as Ordinary Shares of the Issuer, as reported in the Issuer’s
Prospectus filed with the SEC on November 28, 2018. Such percentage figures are calculated in accordance with Rule 13d-3 under
the Securities Exchange Act of 1934, as amended.
Name
|
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Number of ADS we own or
have the right to acquire
within 60 days
|
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Percent of Class
Outstanding
|
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667, L.P.
|
|
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5,474,310
|
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1.7
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%
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Baker Brothers Life Sciences, L.P.
|
|
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37,118,514
|
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11.5
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%
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Total
|
|
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42,592,824
|
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13.2
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%
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The Series A Preferred are only convertible to the extent that
the holders thereof together with their affiliates would beneficially own, for purposes of Section 13(d) of the Securities Exchange
Act of 1934, as amended, no more than 4.99% of the outstanding Ordinary Shares or ADS of the Issuer after conversion (“Series
A Beneficial Ownership Limitation”). As a result of this restriction, the number of shares that may be issued upon conversion
of the Series A Preferred by the above holders may change depending upon changes in the outstanding shares. By written notice to
the Issuer, the Funds may from time to time increase or decrease the Series A Beneficial Ownership Limitation applicable to that
Fund to any other percentage not in excess of 19.9%. Any such increase will not be effective until the 61st day after such
notice is delivered to the Issuer.
Pursuant to the management agreements, as amended, among the
Adviser, the Funds and their respective general partners, the Funds’ respective general partners relinquished to the Adviser
all discretion and authority with respect to the investment and voting power of the securities held by the Funds, and thus the
Adviser has complete and unlimited discretion and authority with respect to the Funds’ investments and voting power over
investments.
The Adviser GP, Felix J. Baker and Julian C. Baker as managing
members of the Adviser GP, and the Adviser may be deemed to be beneficial owners of securities of the Issuer directly held by the
Funds, and may be deemed to have the power to vote or direct the vote of and the power to dispose or direct the disposition of
such securities.
The Reporting Persons disclaim beneficial ownership of the securities
held by each of the Funds, and this Amendment No. 3 shall not be deemed an admission that the Reporting Persons are the beneficial
owners of such securities for purposes of Section 13(d) or for any other purpose.
Item 5.
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Ownership of Five Percent or Less of a Class.
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If this statement
is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more
than five percent of the class of securities, check the following
¨
. N/A
Item 6.
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Ownership of More than Five Percent on Behalf of Another Person.
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The information in Item 4 is incorporated herein by reference.
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Item 7.
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Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
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The information in Item
4 is incorporated herein by reference.
Item 8.
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Identification and Classification of Members of the Group.
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N/A
Item 9.
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Notice of Dissolution of Group.
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N/A
By signing below I certify that, to the best
of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and
were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of
the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose
or effect.
SIGNATURE
After reasonable inquiry and to the best of my knowledge and
belief, I certify that the information set forth in this statement is true, complete and correct.
February 13, 2019
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BAKER BROS. ADVISORS LP
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By: Baker Bros. Advisors (GP) LLC, its general partner
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By:
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/s/ Scott L. Lessing
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Name: Scott L. Lessing
Title: President
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BAKER BROS. ADVISORS (GP) LLC
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By:
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/s/ Scott L. Lessing
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Name: Scott L. Lessing
Title: President
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/s/ Julian C. Baker
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Julian C. Baker
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/s/ Felix J. Baker
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Felix J. Baker
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