UPLC Systems Help Support Agency's Science-Based Efforts to Protect Consumers and Ensure Food is Safe for Consumption MILFORD, Mass., Oct. 20 /PRNewswire-FirstCall/ -- Waters Corporation (NYSE:WAT) announced today that the U.S. Food and Drug Administration's Center for Food Safety and Applied Nutrition (CFSAN), College Park, MD recently purchased nine Waters® ACQUITY UltraPerformance LC® (UPLC®) Systems to support its priority to protect the U.S. food supply by monitoring domestically-produced and imported food sold in interstate commerce. The new instruments will be placed within CFSAN's Office of Regulatory Science for developing and validating robust and reproducible methods for testing food additives, pesticide residues, dietary supplements, mycotoxins, vitamins, seafood toxins, industrial chemicals, and regulated food and cosmetic products. FDA scientists chose the Waters ACQUITY UPLC Systems based on the need for liquid chromatography instrumentation with the required resolution, sensitivity, and speed to meet the ever-increasing challenges of modern multi-residue analysis. The agency's College Park laboratories are currently equipped with three ACQUITY UPLC Systems along with two nanoACQUITY UPLC® Systems, several of which are paired with mass spectrometers for analyte quantification and identity confirmation. The additional UPLC systems will add to the capacity of the FDA's laboratories to develop additional methods and give a larger number of investigators access to the state-of-the-art technology. The FDA's Office of Regulatory Science develops liquid chromatography (LC) and liquid chromatography/mass spectrometry (LC/MS) based methods of analyzing foods and sharing their expertise with other FDA field laboratories. The methods are essential for carrying out many agency duties including pre-market approval of new food additives, risk assessment and setting of priorities, coordinated enforcement and compliance with pesticide tolerances set by the Environmental Protection Agency (EPA), surveillance, and outbreak response. The Food and Drug Administration is responsible for the safety of 80% of the food consumed in the United States excluding meat, poultry, and processed egg products which are regulated by the USDA's Food Safety and Inspection Service. CFSAN's mission is to protect public health by making sure the nation's food supply is safe, secure, sanitary, wholesome, and properly labeled. Liquid chromatography (LC) is a vital tool for separating out the constituents of test samples whether they are foods and beverages, blood or plasma, drinking water, and drug formulations making it possible to measure their concentrations and confirm their identity. When introduced in 2004, Waters award-winning ACQUITY UPLC System was the first commercially available liquid chromatograph designed from the ground up around new-generation analytical columns packed with new 1.7 micron particles. In addition to offering greater resolution, more sensitivity and faster run times, UPLC systems consume up to 95% less solvent than many legacy HPLC methods making UPLC methods a "greener" alternative for the analytical laboratory. When coupled with a mass spectrometer, Waters ACQUITY UPLC Systems promote increased source efficiencies and dramatic improvements in MS sensitivity and spectral quality as the result of increased peak concentrations and reduced chromatographic dispersion. Five years after its introduction and thousands of installations later, the ACQUITY UPLC System is still unrivalled and is proving its strategic value for laboratory-dependent organizations both large and small ways as measured by increased efficiency, productivity, capacity utilization, time-to-market, and cost savings. For more information about Waters ACQUITY UltraPerformance LC products, visit http://www.waters.com/uplc . To see a video about how one commercial testing laboratory successfully uses UPLC for food safety testing, visit: http://www.waters.com/webassets/other/corp/ba/index.html?xcid=pr200910_mitchel l3&locale=en_US#FoodSafety/MartinMitchell/Intro or click here. About Waters Corporation (http://www.waters.com/) Waters Corporation creates business advantages for laboratory-dependent organizations by delivering practical and sustainable innovation to enable significant advancements in such areas as healthcare delivery, environmental management, food safety and water quality worldwide. Pioneering a connected portfolio of separations science, laboratory information management, mass spectrometry and thermal analysis, Waters technology breakthroughs and laboratory solutions provide an enduring platform for customer success. With revenue of $1.58 billion in 2008 and 5,000 employees, Waters is driving scientific discovery and operational excellence for customers worldwide. Waters, ACQUITY, nanoACQUITY UPLC, ACQUITY UPLC, ACQUITY UltraPerformance LC, and UPLC are trademarks of Waters Corporation. DATASOURCE: Waters Corporation CONTACT: Brian J. Murphy of Waters Corporation, +1-508-482-2614, Web Site: http://www.waters.com/

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