Bruker Introduces Vutara™ VXL Best-in-Class Super-Resolution Microscope and Spatial Biology Analysis Capabilities
October 21 2020 - 7:00AM
Business Wire
Accessible 3D Single-Molecule Localization
Microscopy for Studying Subcellular Organelles and Spatial
Multiomics
Bruker Corporation (Nasdaq: BRKR) today announced the release of
the Vutara VXL Super-Resolution Fluorescence Microscope for
nanoscale biological imaging. The new system opens an affordable
and easy-to-use path for both core facilities and individual
investigators to enter the world of super-resolution imaging by
incorporating Bruker’s industry-leading single-molecule
localization (SML) technology in a streamlined system with compact
footprint.
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Bruker's Vutara VXL Super-Resolution
Fluorescence Microscope (Photo: Business Wire)
Vutara VXL serves as a biological microscopy workstation
for research on DNA, RNA and proteins, from macromolecular
complexes and super-structures, to chromatin structure and
chromosomal substructures, to studying functional relationships in
genomes and in various subcellular organelles. This novel system
also supports advanced spatial biology research in extracellular
matrix structures, extracellular vesicles (EV), virology,
neuroscience, and live-cell imaging. When combined with Bruker’s
unique microscope fluidics unit, Vutara VXL enables
multiplexed imaging for targeted, sub-micrometer multiomics in
genomics, transcriptomics, and proteomics research. The Vutara
VXL software already supports leading-edge methods, such as
OligoSTORM, Optical Reconstruction of Chromatin Architecture
(ORCA), and DNA PAINT labeling methodologies.
“I am thrilled about the release of Vutara VXL, as this
instrument is fundamental in making SML microscopy more accessible
to the scientific community, and to the spatial 3D genomics
research community in particular,” said Jennifer E.
Phillips-Cremins, Ph.D., Associate Professor of Biotechnology and
Genetics at the University of Pennsylvania. “Witnessing first-hand
Bruker’s software and hardware development to enhance the spatial
genomics capabilities that are required for my research bears
testament to both their dedication and the functionality and
versatility of the Vutara platform.”
“We believe that enabling 3D single-molecule localization
microscopy in the hands of more researchers will further advance a
better understanding of cellular biology at the nano level,
particularly in the emerging field of spatial omics imaging,” added
Xiaomei Li, Ph.D., Vice President and General Manager of Bruker’s
Fluorescence Microscopy business. “Combined with its large field of
view and ability to perform optical nanoscopy, Vutara VXL
delivers multimodal capabilities and high-throughput data
acquisition to enable a wider range of studies for spatially
resolved genomics and transcriptomics.”
About Vutara VXL
Based on the Vutara super-resolution platform’s proprietary
biplane technology, proven industry-leading capabilities with fully
integrated fluidics with unlimited multiplexing potential, and
powerful analytical software, the new Vutara VXL facilitates
scientific research from experiment initiation and data collection
through analysis to publication. The system enables researchers to
obtain intrinsic 3D super-resolution data and achieve 20 nm
localization precision in XY, 50 nm in Z for organic dyes, and even
finer with DNA PAINT probes. A proprietary emission path allows the
system to achieve low background fluorescence, even in thick
samples, routinely imaging large Z volumes in tissue slices up to
30 µm in thickness at arbitrary distances from the coverslip. With
the SRX software package and its Quantitative Localization
Microscopy analysis suite, Vutara VXL facilitates the entire
imaging process from acquisition and localization, and provides
in-depth visual and quantitative information from biological
samples in a single, seamless workflow. Utilizing real-time
localization analysis and data visualization, multi-location
recording capabilities, and scripting functions for automated data
analysis, completion of an entire workflow cycle can be
accomplished in a matter of minutes, providing a significant
enhancement to work throughput. As a multi-modality workstation for
single-molecule localization microscopy as well as conventional
diffraction-limited widefield imaging, Vutara VXL is an
ideal platform for bioinformatics, such as looking at the spatial
distribution of the transcriptome in conjunction with
high-resolution genomic or proteomic imaging.
About Bruker Corporation (Nasdaq: BRKR)
Bruker is enabling scientists to make breakthrough discoveries
and develop new applications that improve the quality of human
life. Bruker’s high-performance scientific instruments and
high-value analytical and diagnostic solutions enable scientists to
explore life and materials at molecular, cellular, and microscopic
levels. In close cooperation with our customers, Bruker is enabling
innovation, improved productivity and customer success in life
science molecular research, in applied and pharma applications, in
microscopy and nanoanalysis, and in industrial applications, as
well as in cell biology, preclinical imaging, clinical phenomics
and proteomics research and clinical microbiology. For more
information, please visit: www.bruker.com.
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Investors: Miroslava Minkova Director, Investor Relations
& Corporate Development Bruker Corporation T: +1 (978) 663-3660
x1479 E: Investor.Relations@bruker.com Media: Stephen
Hopkins Content Marketing Manager Bruker Nano Surfaces and
Metrology Division T: +1 (520) 741-1044 x1022 E:
steve.hopkins@bruker.com
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