**This CUSIP applies
to the American Depositary Shares, each representing one Ordinary Share
CUSIP
No. 023111206
1
|
NAMES OF REPORTING PERSONS
Baker Bros. Advisors LP
|
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
|
(a) ¨
|
(b) ¨
|
3
|
SEC USE ONLY
|
4
|
CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
|
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY
EACH
REPORTING
PERSON
WITH
|
5
|
SOLE VOTING POWER
21,169,805
|
6
|
SHARED VOTING POWER
-0-
|
7
|
SOLE DISPOSITIVE POWER
21,169,805
|
8
|
SHARED DISPOSITIVE POWER
-0-
|
9
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
21,169,805
|
10
|
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
CERTAIN SHARES (See Instructions)
|
¨
|
11
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
5.3% (1)
|
12
|
TYPE OF REPORTING PERSON (See Instructions)
IA, PN
|
|
(1)
|
Based on 395,825,887 Ordinary Shares of Amarin Corporation plc (the “Issuer”), including 395,629,060 Ordinary Shares represented
by American Depositary Shares (“ADS”) outstanding as of October 29, 2021, as reported in the Issuer’s Form 10-Q filed
with the Securities and Exchange Commission (“SEC”) on November 3, 2021. Each ADS represents 1 Ordinary Share of the Issuer.
|
CUSIP
No. 023111206
1
|
NAMES OF REPORTING PERSONS
Baker Bros. Advisors (GP) LLC
|
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
|
(a) ¨
|
(b) ¨
|
3
|
SEC USE ONLY
|
4
|
CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
|
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY
EACH
REPORTING
PERSON
WITH
|
5
|
SOLE VOTING POWER
21,169,805
|
6
|
SHARED VOTING POWER
-0-
|
7
|
SOLE DISPOSITIVE POWER
21,169,805
|
8
|
SHARED DISPOSITIVE POWER
-0-
|
9
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
21,169,805
|
10
|
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See Instructions)
|
¨
|
11
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
5.3% (1)
|
12
|
TYPE OF REPORTING PERSON (See Instructions)
HC, OO
|
|
(1)
|
Based on 395,825,887 Ordinary Shares of the Issuer, including 395,629,060 Ordinary Shares represented by ADS outstanding as of October
29, 2021, as reported in the Issuer’s Form 10-Q filed with the SEC on November 3, 2021. Each ADS represents 1 Ordinary Share of
the Issuer.
|
CUSIP
No. 023111206
1
|
NAMES OF REPORTING PERSONS
Felix J. Baker
|
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
|
(a) ¨
|
(b) ¨
|
3
|
SEC USE ONLY
|
4
|
CITIZENSHIP OR PLACE OF ORGANIZATION
United States
|
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY
EACH
REPORTING
PERSON
WITH
|
5
|
SOLE VOTING POWER
21,293,177
|
6
|
SHARED VOTING POWER
-0-
|
7
|
SOLE DISPOSITIVE POWER
21,293,177
|
8
|
SHARED DISPOSITIVE POWER
-0-
|
9
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
21,293,177
|
10
|
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See Instructions)
|
¨
|
11
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
5.4% (1)
|
12
|
TYPE OF REPORTING PERSON (See Instructions)
IN, HC
|
|
(1)
|
Based on 395,825,887 Ordinary Shares of the Issuer, including 395,629,060 Ordinary Shares represented by ADS outstanding as of October
29, 2021, as reported in the Issuer’s Form 10-Q filed with the SEC on November 3, 2021. Each ADS represents 1 Ordinary Share of
the Issuer.
|
CUSIP
No. 023111206
1
|
NAMES OF REPORTING PERSONS
Julian C. Baker
|
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
|
(a) ¨
|
(b)
¨
|
3
|
SEC USE ONLY
|
4
|
CITIZENSHIP OR PLACE OF ORGANIZATION
United States
|
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY
EACH
REPORTING
PERSON
WITH
|
5
|
SOLE VOTING POWER
21,293,177
|
6
|
SHARED VOTING POWER
-0-
|
7
|
SOLE DISPOSITIVE POWER
21,293,177
|
8
|
SHARED DISPOSITIVE POWER
-0-
|
9
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
21,293,177
|
10
|
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See Instructions)
|
¨
|
11
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
5.4% (1)
|
12
|
TYPE OF REPORTING PERSON (See Instructions)
IN, HC
|
|
(1)
|
Based on 395,825,887 Ordinary Shares of the Issuer, including 395,629,060 Ordinary Shares represented by ADS outstanding as of October
29, 2021, as reported in the Issuer’s Form 10-Q filed with the SEC on November 3, 2021. Each ADS represents 1 Ordinary Share of
the Issuer.
|
Amendment No. 6 to Schedule 13G
This Amendment No. 6 to Schedule 13G amends and restates the previously
filed Schedule 13G filed by Baker Bros. Advisors LP (the “Adviser”), Baker Bros. Advisors (GP) LLC (the “Adviser GP”),
Julian C. Baker and Felix J. Baker (collectively, the “Reporting Persons”). Except as supplemented herein, such statements,
as heretofore amended and supplemented, remain in full force and effect.
|
Item 1(a)
|
Name of Issuer:
|
Amarin Corporation plc (the
“Issuer”)
|
Item 1(b)
|
Address of Issuer’s Principal Executive Offices:
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77 Sir John Rogerson’s Quay, Block C
Grand Canal Docklands, Dublin 2, Ireland
|
Item 2(a)
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Name of Person Filing:
|
This Amendment No. 6 is being filed jointly by the Reporting
Persons.
|
Item 2(b)
|
Address of Principal Business Office or, if None, Residence:
|
The business address of each of the Reporting
Persons is:
c/o Baker Bros. Advisors LP
860 Washington Street, 3rd
Floor
New York, NY 10014
(212) 339-5690
The Adviser is a limited partnership organized under the laws
of the State of Delaware. The Adviser GP is a limited liability company organized under the laws of the State of Delaware. The citizenship
of each of Julian C. Baker and Felix J. Baker is the United States of America.
Item 2(d)
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Title of Class of Securities
|
Ordinary Shares, 50 pence par value per share (“Ordinary
Shares”)
023111206
|
Item 3.
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If this statement is filed pursuant to §§240.13d-1(b) or (c), check whether the person filing is a:
|
(a) ¨
Broker or dealer registered under Section 15 of the Exchange Act.
(b) ¨
Bank as defined in section 3(a)(6) of the Exchange Act.
(c) ¨
Insurance company as defined in section 3(a)(19) of the Exchange Act.
(d) ¨
Investment company registered under section 8 of the Investment Company Act of 1940.
(e) x
An investment adviser in accordance with Rule 13d-1(b)(1)(ii)(E).
(f) ¨
An employee benefit plan or endowment fund in accordance with Rule 13d-1(b)(1)(ii)(F).
(g) x
A parent holding company or control person in accordance with Rule 13d-1(b)(1)(ii)(G).
(h) ¨
A savings association as defined in Section 3(b) of the Federal Deposit Insurance Act.
(i) ¨
A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company
Act of 1940.
(j) ¨
Group, in accordance with Rule 13d-1(b)(1)(ii)(J).
Items 5 through 9 and 11 of each of the cover pages to this Amendment
No. 6 are incorporated herein by reference. Set forth below is the aggregate number of American Depositary Shares (“ADS”)
directly held by each of Baker Brothers Life Sciences, L.P. (“Life Sciences”) and 667, L.P. (“667”, and together
with Life Sciences, the “Funds”) which may be deemed to be indirectly beneficially owned by the Reporting Persons. Each ADS
represents 1 Ordinary Share of the Issuer.
The information set forth below is based on 395,825,887 Ordinary Shares,
including 395,629,060 Ordinary Shares of the Issuer represented by ADS outstanding as of October 29, 2021, as reported in the Issuer’s
Form 10-Q filed with the SEC on November 3, 2021. Such percentage figures are calculated in accordance with Rule 13d-3 under the Securities
Exchange Act of 1934, as amended.
Name
|
|
Number of Ordinary Shares we own or have the right to acquire within 60 days
|
|
|
Percent of Class Outstanding
|
|
667, L.P.
|
|
|
1,784,805
|
|
|
|
0.4
|
%
|
Baker Brothers Life Sciences, L.P.
|
|
|
19,385,000
|
|
|
|
4.9
|
%
|
Total
|
|
|
21,169,805
|
|
|
|
5.3
|
%
|
Each of Julian C. Baker and Felix J. Baker own 123,372 ADS. Were
Julian C. Baker and Felix J. Baker to form a group with the Funds, such group would in aggregate own 21,416,549 ADS.
The Adviser GP, Felix J. Baker and Julian C. Baker as managing members
of the Adviser GP, and the Adviser may be deemed to be beneficial owners of securities of the Issuer directly held by the Funds.
The Adviser GP is the sole general partner of the Adviser. Pursuant
to the management agreements, as amended, among the Adviser, Life Sciences and 667 and their respective general partners, the Funds’
respective general partners relinquished to the Adviser all discretion and authority with respect to the investment and voting power of
the securities held by the Funds, and thus the Adviser has complete and unlimited discretion and authority with respect to the Funds’
investments and voting power over investments.
Item 5.
|
Ownership of Five Percent or Less of a Class.
|
If this statement is being filed
to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of
the class of securities, check the following ¨. N/A
Item 6.
|
Ownership of More than Five Percent on Behalf of Another Person.
|
N/A
|
Item 7.
|
Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company
or Control Person.
|
The information in Item 4 is
incorporated herein by reference.
|
Item 8.
|
Identification and Classification of Members of the Group.
|
N/A
|
Item 9.
|
Notice of Dissolution of Group.
|
N/A
By signing below I certify that, to the best of
my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not
acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities
and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.
SIGNATURE
After reasonable inquiry and to the best of my knowledge and belief,
I certify that the information set forth in this statement is true, complete and correct.
February 14, 2022
|
BAKER BROS. ADVISORS LP
|
|
|
By: Baker Bros. Advisors (GP) LLC, its general partner
|
|
|
By:
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/s/ Scott L. Lessing
|
|
|
Name: Scott L. Lessing
|
|
|
Title: President
|
|
BAKER BROS. ADVISORS (GP) LLC
|
|
|
By:
|
/s/ Scott L. Lessing
|
|
|
Name: Scott L. Lessing
|
|
|
Title: President
|
|
|
/s/ Julian C. Baker
|
|
|
Julian C. Baker
|
|
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/s/ Felix J. Baker
|
|
|
Felix J. Baker
|