RNS Number:3095O
CeNeS Pharmaceuticals PLC
04 August 2003



                   CeNeS Pharmaceuticals plc ("the Company")


                            Directors' Shareholding



The Company today announces that, on 1 August 2003, awards of options over
ordinary shares of 10p in the Company ("Ordinary Shares") were made to the
following Directors under a long term incentive plan, the CeNeS Pharmaceuticals
Executive Share Incentive plan:

Director:                                                           Neil Clark
Number of Ordinary Shares over which options granted:                1,647,500
Exercise price in pence:                                              Nil Cost
Date of grant:                                                         1.08.03
Period of exercise:                                                    3 years
Total number of Ordinary Shares over which options held following this
notification: 3,140,346

Director :                                                        Alan Goodman
Number of Ordinary Shares over which options granted:                1,299,375
Exercise price in pence:                                              Nil Cost
Date of grant:                                                         1.08.03
Period of exercise:                                                    3 years


Total number of Ordinary Shares over which options held following this
notification: 4,378,287


The option awards announced today are subject to performance targets related to
the Ordinary Share price performance over three years. These targets must be met
or exceeded before the Executive Options may be exercised.


4 August 2003





For further information:

Neil Clark, CeNeS Pharmaceuticals plc - 01223 266466






                      This information is provided by RNS
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