RNS Number:2215O
Protherics PLC
31 July 2003

Protherics Plc ("the Company")

NOTIFICATION OF MAJOR INTERESTS IN SHARES

The Company received a notification from M & G Investment Management Limited on
behalf of Prudential plc and certain of its subsidiary companies, informing it
that they have an interest in 12,238,577 ordinary shares, representing 5.91% of
the issued share capital of the Company.

31 July, 2003


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