In this free webinar, learn about various DNA-encoded library platforms and how they can be strategically used in the drug discovery process to identify hits more efficiently. Gain insights into different selection strategies for DNA-encoded library technology, including cell/membrane prep and protein-based selections. Attendees will be introduced to a detailed case study from BioAge on the discovery of novel inhibitors using DNA-encoded library technology. The featured speakers will discuss how to determine biophysical and biochemical activities, physicochemical properties and overall drug-likeness of molecules identified through DNA-encoded library screening.

TORONTO, July 11, 2024 /PRNewswire-PRWeb/ -- Discover an informative webinar focusing on the transformative potential of DNA-encoded library technology in early-stage, small-molecule drug discovery, particularly for targeting G protein-coupled receptors (GPCRs).

DNA-encoded libraries have seen remarkable advancements in recent years and have made a significant impact in successfully identifying a variety of hit compounds that have progressed to various stages of drug development. Proteins are the major targets used in DNA-encoded library selection as they can be either extracted from biological samples or, more often, expressed in the recombinant form, which allows for different designs of protein constructs. DNA-encoded library technology presents a disruptive hit identification platform that can vastly expedite the course of early-stage small-molecule drug discovery.

In this webinar, the expert speakers will provide an introduction to DNA-encoded library selection on different target types ranging from enzymes to receptors and highlight the unique advantages or features for the application of DNA-encoded libraries on these targets. They will also describe various DNA-encoded library platforms that have been developed and how they can be utilized to achieve success in the drug discovery process.

Furthermore, as a case study, BioAge will share their experience in using DNA-encoded library technology for their study entitled "The discovery of novel and potent indazole NLRP3 inhibitors enabled by DNA-encoded library screening", which was published in Bioorganic & Medicinal Chemistry Letters. In this work, the researchers have demonstrated a selection strategy for drug discovery using DNA-encoded library technology, directly identified small molecule structures, biophysical and biochemical activities, physicochemical properties and other factors.

Register for this webinar today to understand how DNA-encoded library technology can revolutionize small-molecule drug discovery.

Join Alex Shaginian, PhD, Vice President of Business Development and Chemical Sciences, HitGen, Rusty Montgomery, PhD, SVP-Research, BioAge Labs; and David Israel, PhD, Vice President of Lead Discovery Sciences, HitGen, for the live webinar on Wednesday, July 17, 2024, at 2pm EDT (11am PDT).

For more information, or to register for this event, visit Evolving DNA-Encoded Library Technology and Its Application for Innovative Drug Discovery.

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