Halozyme Therapeutics Incorporated (HALO) Quote

I get emails from refinitive which gives me updates. Don’t have a link.

I get emails from refinitive which gives me updates. Don’t have a link.

Where did you see that? Link?

Benchmark upped to 75 price target from 60.

From Artisan:

"Halozyme Therapeutics surged higher after it reported better-than-expected Q2 results and reconfirmed its current-year guidance. Cash flow growth during the quarter was driven by a 12% increase in royalty revenues, although we note that some of these revenues were pulled forward from Q3 to Q2. Based on talks management is having with other biotech companies, we think the company will secure more new deals this year to license its ENHANZE® drug delivery platform. We value Halozyme’s high cash flows, which it has used to support share buybacks."

HALO near a 52 week high

I see a proper return and a short squeeze next week. Hold onto those shares

"The company recently reported that it has 10.04 million shares sold short, which is 10.74% of all regular shares that are available for trading. Based on its trading volume, it would take traders 7.75 days to cover their short positions on average"

I see the market doesn't agree that it's a 'gimmee'.

Not to the dedicated few. Neither milestone payments could be included in year end financials nor near term income.

Neither of these approvals is much of a surprise.

Volume seems pretty lite for a news day.

Volume seems pretty lite for a news day.

The cadence with halo at least for 2024 has been to run up ahead (weeks to months) of anticipated catalysts, then take a haircut (5-10%) a week (or two) before the news release and then resume a sustained run up.

FDA approves atezolizumab and hyaluronidase-tqjs for subcutaneous injection

On September 12, 2024, the Food and Drug Administration approved atezolizumab and hyaluronidase-tqjs (Tecentriq Hybreza, Genentech, Inc.) for subcutaneous injection for all the adult indications as the intravenous formulation of atezolizumab (Tecentriq, Genentech, Inc.), including non-small cell lung cancer (NSCLC), small cell lung cancer (SCLC), hepatocellular carcinoma (HCC), melanoma, and alveolar soft part sarcoma (ASPS). See the prescribing information for the specific indications.


Source: usfda@public.govdelivery.com

-- OJ

I've been in since $1.88 and I'll be half out at $80. Then let it ride

I think Helen has a better understanding of the new partnerships in the pipeline.

I feel ya though, I'm tired of hearing "In final talks", regarding partnerships. Time to sign, my dear

Another nibble @ 58.98.
I'm thinking a 10% jump (if it's an up market day), Followed by a pullback to 5-8% gain, the following day.
Based on drug valuation, historical reactions, 52 week high and mostly the markets emotional response.

I hope the longs had a chance to load up more :)

Atezolizumab SC approval on slide 5.
September 15, 2024.

This is a Sunday. Does the FDA announce things on a Sunday?

I would hope that CDMO is picking up the difference since their large expansion. Still don't know why they don't buy CDMO and have everything in house.

Something interesting :https://finance.yahoo.com/news/q1-2025-avid-bioservices-inc-105934221.html. link from yahoo.
Avid Bioservices and Catalent are Halozymes fill and finish resources for the enzyme. Quote below is from Avid latest call ins the Q and A. Couple this question with the article below where the plants at Catalent are being sold to someone Halozyme is not that thrilled with and you wonder where is the excess product we are going to need in the future is going to come from.

"I wanted to ask about Halozyme, which obviously a key customer was over half your revenue in fiscal '23, but that was down to about a third and fiscal 2024.
Can you just give us an update around what exactly happened in fiscal 2023, how Halozyme revenues trended so far are trended so far in the first quarter and kind of what you're baking in for Halozyme revenue here in fiscal 2025 and just your overall level of visibility into revenue this year from this key customer?"

Couple this question with the article: https://finance.yahoo.com/news/novo-catalent-deal-affects-halozyme-081711085.html? When you read this you have to wonder what is Halozyme doing for production as the need for more product is going up every year.

Page 5 of Halo’s most recent Halozyme slide deck (see link below)

Upcoming Potential
Approvals

• Ocrelizumab SC (U.S.),
September 13, 2024
• Atezolizumab SC (U.S.),
September 15, 2024
• Nivolumab SC (U.S.)
December 29, 2024

But I’m not seeing Atezolizumab SC (U.S.) on FDA’s PDUFA date calendar!?

Does anyone else see it?

https://s28.q4cdn.com/284259014/files/doc_financials/2024/q2/HALO-2Q24-Earnings-Deck-FINAL-FINAL-004.pdf

Thank you, Mr. Market for giving us a chance to load up with a 10% discount (from recent all time high) ahead of the two blockbuster ENHANZE/halozyme PDUFA dates next week

Good that they have money to count. And yes Merck is late to the party. They should have SC keytruda on the market by now.

Ok great, I am convinced, a company with a billion dollar product has no competition, no other company has any interest now and never will, cool. And Merck are fools for wasting time and money on a worthless product, idiots.

Go HALOoooooooo up please.......with no competition in the future, it is clear sailing up.

P.S. Nice Housnlab pipeline chart Howeeme, wish that the no competition company HALO would have a helpful informative pipeline an investor could quickly look to determine what is it they are working on. Guess they are to busy counting their money and not looking behind for the non-existing competition.

https://huonslab.com/layout/eng/home.php?go=pipeline. They are a long way away from anything.

Merck is late to the game. Years away from any approval. If anything they will lose share to opdivo.

Sorry, some of the comments are a bit confusing, not sure what some are trying state.

In any case, I see them as competition and will continue following the progress being made.

Patent filings by both Alteogen and Merck, along with clinical trials, shows Merck is making progress on Hybrozyme (ALT-B4, MK-5180). Merck is actually carrying the heavy load, while Alteogen reaps benefits.

IMO, Merck is pushing thru with the MK-5180 because in the long run it will be significantly cheaper then dealing with HALO. They will also have control of the product and will be cheaply expanding it into other products, making their products more competitive.

https://www.oncologypipeline.com/apexonco/mercks-subq-keytruda-headscratcher

Coded MK-3475A, co-formulation with Alteogen's MK-5180 (rh hyaluronidase)

https://www.freepatentsonline.com/y2024/0150467.html

COMPOSITIONS AND METHODS FOR TREATING CANCER WITH SUBCUTANEOUS ADMINISTRATION OF ANTI-PD1 ANTIBODIES

https://www.freepatentsonline.com/WO2024091417A1.html

HUMAN HYALURONIDASE 1 MUTANTS

https://clinicaltrials.gov/study/NCT06504394

A Study to Evaluate the Safety and Efficacy of Pembrolizumab (MK-3475) Coformulated With Hyaluronidase (MK-3475A) in Participants With Relapsed or Refractory Classical Hodgkin Lymphoma (rrcHL) or Relapsed or Refractory Primary Mediastinal Large B-cell Lymphoma (rrPMBCL)(MK-3475A-F65)

Huonslab's Hydiffuze is same sequence with halo's
after few years, Huonslab is not competitor

Okay, thanks.

Okay, thanks.

Okay, thanks. I forgot about that and I guess Tecentriq is PD- L1 so they were allowed to use it.

It's very easy to buy both stocks!
nowadays, many Koreans buy a US stocks instead of Korean stocks.

well, i think it just 'TIME' view
Until just a few years ago, SC injection did not get noticed in the market.
Merck needed a means to defend the patent expiration, They realized that the IV to SC change was the answer.
But, Halo was already under contract with BMS(PD-1 exclusive), so they found alteogen

In Korea, there lots of reports of this.
Alteogen has found a way to evade ENHAZE's patents, which it has been granted registration permission by the PCT and U.S. Patent and Trademark Office, and they are bolstering the patent chain to prevent the entry of competitors other than Halo and Alteogen.

I think that they were trying to sell Merck on the idea by testing on their own many years ago. Merck never bit on this. Big mistake!!!

Merck could not use Enhanze for Keytruda because BMS had signed an exclusive contract for PD-1’s.

Is it easy for Korean investors to buy US stocks? I have read that it is almost impossible for American investors to invest in Korean stocks.

Do you have any idea why Merck chose Alteogen instead of Halo? Have you read any analyst reports that comment on this?

I hear you but she really doesn’t seem to give them much credit at all. My take is that they feel very confident about being top dog for a long time. I’ve been listening to her since she came on board and these conversations are at a different level than before. Hearing way more confidence in these meetings than ever before. We’ll get deals just hard to say when these big companies pull the trigger. She’s added billions to the market cap so I don’t have doubts like many people that post here. Plus I’m a big fan of all the financial maneuvers that they’ve done also.

She carefully worded reply, stating no one else "is" approved for SC injections at this time....(~16:00 minutes into talk)......As pointed out earlier, there are two competitors knocking on the door.....

Houslab "HyDiffuze," and Alteogen, "Hybrozyme." Both are progressing along on several fronts, and Merck has already bitten the apple and chewing on it....in time both will be SC competitors............

She needs to be more truthful......and as for the new deal.....lets go.....there should be several by now....especially the HVAI which she has been pushing for years now and there is a whole group working on HVAIs............appears market is not happy with her.....

Great interview today. Halo running on all cylinders. Helen basically says there is no competition and seems to have very little concern. Lots to look forward to. As long as she’s CEO I’m not going anywhere.

Micro glassification suspensions...sounds like freeze dried to me.
testing? Phase 1 ? Phase 2? Where is Lindy Biosciences, anyway? Chime in experts?

Catalysts from today’s WF conference with Helen:

IRB part B assessment on theraputics with 2 active ingredients is expected any day now. If part B follows part D went, more pharma will look at Enhanze and partership with Halozyme to delay CMS price negotatiations by additional 5 or more years.

Regarding check point inhibitors (Opdivo, Tecentriq), Helen said that pharma will likely expedite conversion to SC with Enhanze ASAP. This is because experience with Herceptin years ago showed that once patients convert to SC, they never go to IV biosimilars. So BMS and Roche will be eager to get their patients converted to Opdivo SC and Tecentriq SC on accelerated pace.

At least one new partnership before year end.

2 PDUFA dates this month and one is September.

A juicy 7% haircut since the recent all-time-high for reasons that have nothing to do with halozyme. Enjoy the bargain shopping.

Great story.
Congratulations.

Yes, I remember HTI. I first got involved shortly after HALO went public at $4/sh. Apparently, some of the seed money investors wanted management to pump the stock so they could make lots of money. Management refused. So they dumped their stock and I bought my first shares at $1.59.

Memory isn't what it used to be

HTI traded on the Amex exchange. I bought when the mkt cap was 50 million and 5k shares traded per day. Found the stock looking for Randall Kirk 13d filings. Sounded like a good idea at the time. Something like 18 years ago.

HTI traded on the Amex exchange. I bought when the mkt cap was 50 million and 5k shares traded per day. Found the stock looking for Randall Kirk 13d filings. Sounded like a good idea at the time. Something like 18 years ago.

It was HTI to be exact. Yes, I'm one of them. Do you remember Rod? I often wonder what happened to him.

How many of us were here when this was HTIC on OTC? Just curious

Agree, the reason for posting it with the deal, so your point is?