SCHEDULE 10                                  
                                                                               
                   NOTIFICATION OF MAJOR INTERESTS IN SHARES                   

1. Name of company

Acambis plc                                                                    

2. Name of shareholder having a major interest

Barclays PLC                                                                   

3. Please state whether notification indicates that it is in respect of holding
of the shareholder named in 2 above or in respect of a non-beneficial interest
or in the case of an individual holder if it is a holding of that person's
spouse or children under the age of 18

As above                                                                       

4. Name of the registered holder(s) and, if more than one holder, the number of
shares held by each of them

The legal entities holding these shares are as follows:                        
                                                                               
Barclays Private Bank and Trust Ltd 1,403 shares                               
                                                                               
Barclays Nikko Global Investors Ltd 388 shares                                 
                                                                               
Barclays Life Assurance Co Ltd 276,369 shares                                  
                                                                               
Barclays Global Investors Japan Trust & Banking 4,852 shares                   
                                                                               
Barclays Global Investors Australia Ltd 73,097 shares                          
                                                                               
Barclays Global Investors, N.A. 1,937,154 shares                               
                                                                               
Barclays Global Investors Ltd 4,004,171 shares                                 

5. Number of shares / amount of stock acquired

71,390                                                                         

6. Percentage of issued class

0.07%                                                                          

7. Number of shares / amount of stock disposed

N/A                                                                            

8. Percentage of issued class

N/A                                                                            

9. Class of security

Ordinary shares of 10p each                                                    

10. Date of transaction

11 September 2003                                                              

11. Date company informed

17 September 2003                                                              

12. Total holding following this notification

6,297,434                                                                      

13. Total percentage holding of issued class following this notification

6.01%                                                                          

14. Any additional information

N/A                                                                            

15. Name of contact and telephone number for queries

Elizabeth Brown tel: 01223 275300                                              

16. Name and signature of authorised company official responsible for making
this notification

Elizabeth Brown, Company Secretary                                             

Date of notification

18 September 2003                                                              

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END