Tenet Healthcare Corp.'s (THC) $1.73 billion agreement to acquire Vanguard Health Systems Inc. (VHS) will forge a far-larger hospital operator as the industry is poised for major changes tied to the health-care overhaul.

Dallas-based Tenet said it will expand to 79 hospitals from 49, and significantly increase its geographic reach, adding markets such as Detroit and Chicago and particularly deepening its presence in Texas. Tenet also said the acquisition marks what it hopes will be a stepped-up effort to acquire other hospitals, where its deal pace has been relatively slow.

The hospital sector could see significant benefits from the health overhaul, but there are also some potential downsides. More people are expected to gain health coverage, and thus be able to pay for their care. This could be a particular boon in some of Vanguard and Tenet's hospitals in regions with many uninsured people, said Sheryl Skolnick, an analyst with CRT Capital Group LLC. Still, hospitals face some cutbacks in government payments, some of which are set to ramp up in future years.

Hospitals also continue to face a slowdown in patient traffic that has been seen as tied--at least partly--to the recession and its aftermath. Tenet cautioned that inpatient volumes remain weak in the current quarter.

Tenet Chief Executive Trevor Fetter said in an interview that "there's a very compelling strategic rationale that would occur without health reform," including annual synergies that Tenet projects at $100 million to $200 million.

He said the projected savings included overhead reductions and better management of supplies. Tenet's Conifer unit, which handles billing and other revenue matters, could also improve certain results at Vanguard hospitals, he suggested.

Tenet plans to pay $21 in cash for each Vanguard share, a 70% premium to Friday's closing price. Including the assumption of $2.5 billion in Vanguard debt, Tenet said the deal is worth $4.3 billion.

Mr. Fetter also said the transaction focused on the combined companies' strong Texas footprint because of the state's overall growth, as well as the effects of the health overhaul there as some uninsured people gain coverage through the law's new insurance marketplaces.

Though the state's government has so far declined to accept the health law's expansion of Medicaid coverage, leaving one new source of hospital revenue likely unavailable, Mr. Fetter said he has "confidence" the expansion of the health-benefit program for low-income people will eventually take place in Texas.

Tenet said it expected to close the deal by the end of 2013. Analysts said the lack of meaningful overlap between the two companies' markets meant there were likely to be few antitrust objections.

Vanguard shares surged 67% Monday to $20.70, near the offer price, while Tenet shares rose 4.5% to $43.73.

The deal for Vanguard may brighten the spotlight on another hospital company, Health Management Associates Inc. (HMA), which recently said it had hired advisers partly to help with "ongoing consideration of strategic alternatives and opportunities available" after Health Management's largest shareholder indicated it might push for changes, including new board members, at the company. A.J. Rice, an analyst at UBS, said the fact that Tenet's shares also saw a runup may "be encouraging to a would-be bidder" for Health Management.

A Health Management spokeswoman declined to comment.

Write to Anna Wilde Mathews at anna.mathews@wsj.com and Jon Kamp at jon.kamp@dowjones.com

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