Statement of Changes in Beneficial Ownership (4)

FORM 4 [ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person ^* Casteel Marty	2. Issuer Name and Ticker or Trading Symbol SIMMONS FIRST NATIONAL CORP [ SFNC ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __X__ Director _____ 10% Owner _____ Officer (give title below) _____ Other (specify below)
(Last) (First) (Middle) SIMMONS FIRST NATIONAL CORP, 501 MAIN STREET	3. Date of Earliest Transaction (MM/DD/YYYY) 2/2/2021
(Street) PINE BLUFF, AR 71601 (City) (State) (Zip)	4. If Amendment, Date Original Filed (MM/DD/YYYY)	6. Individual or Joint/Group Filing (Check Applicable Line) _X _ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	3. Trans. Code (Instr. 8)		4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	Code	V	Amount	(A) or (D)	Price		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
Common Stock	2/2/2021		M		8680	A	$20.29	172612	D
Common Stock	2/2/2021		M		15270	A	$22.20	187882	D
Common Stock	2/2/2021		M		42410	A	$22.75	230292	D
Common Stock	2/2/2021		M		9810	A	$23.51	240102	D
Common Stock	2/2/2021		S		76170	D	$25.32 ⁽⁷⁾	163932	D

*Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)*
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	4. Trans. Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	8. Price of Derivative Security (Instr. 5)			11. Nature of Indirect Beneficial Ownership (Instr. 4)
Non-Qualified Stock Option	$20.29 ⁽¹⁾	2/2/2021		M			8680 ⁽²⁾	12/31/2015	3/31/2021 ⁽³⁾	Common	8680 ⁽²⁾	$0.00	0	D
Non-Qualified Stock Option	$22.20 ⁽¹⁾	2/2/2021		M			15270 ⁽²⁾	⁽⁴⁾	3/31/2021 ⁽³⁾	Common	15270 ⁽²⁾	$0.00	0	D
Non-Qualified Stock Option	$22.75 ⁽¹⁾	2/2/2021		M			42410 ⁽²⁾	⁽⁵⁾	3/31/2021 ⁽³⁾	Common	42410 ⁽²⁾	$0.00	0	D
Non-Qualified Stock Option	$23.51 ⁽¹⁾	2/2/2021		M			9810 ⁽²⁾	⁽⁶⁾	3/31/2021 ⁽³⁾	Common	9810 ⁽²⁾	$0.00	0	D

Explanation of Responses:
(1)	On February 8, 2018, the Company effected a 2-for-1 stock split. The exercise price reported in this Form 4 has been adjusted to reflect the stock split.
(2)	On February 8, 2018, the Company effected a 2-for-1 stock split. The options and number of shares reported in this Form 4 have been adjusted to reflect the stock split.
(3)	Upon Mr. Casteel's retirement, which was effective March 31, 2020, the expiration date was accelerated to March 31, 2021.
(4)	5,090 options became exercisable on March 25, 2016; 5,090 options became exercisable on March 25, 2017; and 5,090 options became exercisable on March 25, 2018.
(5)	10,730 options became exercisable on December 31, 2015; 21,460 options became exercisable on December 31, 2016; and 10,220 options became exercisable on December 31, 2017.
(6)	3,270 options became exercisable on January 19, 2017; 3,270 options became exercisable on January 19, 2018; and 3,270 options became exercisable on January 19, 2019.
(7)	The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $24.95 to $25.49, inclusive. The reporting person undertakes to provide Simmons First National Corporation ("Simmons"), any security holder of Simmons, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Reporting Owners
Reporting Owner Name / Address	Relationships
Reporting Owner Name / Address	Director	10% Owner	Officer	Other
Casteel Marty SIMMONS FIRST NATIONAL CORP 501 MAIN STREET PINE BLUFF, AR 71601	X