Filed Pursuant to Rule 424(b)(5)
Registration No. 333-276658
PROSPECTUS SUPPLEMENT
(To Prospectus Dated January 30, 2024)
763,638 Shares of Common Stock
We are offering 763,638 shares of our common stock,
$0.0001 par value per share, pursuant to this prospectus supplement and the accompanying prospectus to several institutional investors.
The purchase price of each share of common stock to the purchasers identified in the securities purchase agreement dated July 18, 2024,
by and among us and the purchasers listed on the signature pages thereto (the “SPA”) is $2.75 share.
In a concurrent private placement (the “Private
Placement”), we are also selling to the purchasers common stock warrants (the “Unregistered Warrants”) to purchase up
to 763,638 shares (the “Unregistered Warrant Shares”) of our common stock. The Unregistered Warrants and Unregistered Warrant
Shares (collectively, the “Unregistered Securities”) are not being registered under the Securities Act of 1933, as amended
(the “Securities Act”), and are not offered pursuant to this prospectus supplement and the accompanying prospectus. The Unregistered
Securities are being offered pursuant to an exemption from the registration requirements of the Securities Act provided in Section
4(a)(2) of the Securities Act and Regulation D promulgated thereunder. The Unregistered Warrants are exercisable for five years from
the date of issuance and have an exercise price of $2.75 per Unregistered Warrant Share.
Our common stock is traded on The Nasdaq Capital Market under the
symbol “SILO.” On July 18, 2024, the last sale price of our common stock as reported on The Nasdaq Capital Market was
$3.47 per share.
As of July 18, 2024, the aggregate market
value of our outstanding common stock held by non-affiliates was approximately $12,267,789 based on 3,720,818 outstanding shares of common
stock, of which approximately 3,535,386 shares are held by non-affiliates, and a per share price of $3.47 based upon the closing sale
price of our common stock on The Nasdaq Capital Market on July 18, 2024. We have sold approximately
$1,965,284 of securities pursuant to General Instruction I.B.6 of Form S-3 during the prior 12-calendar month period that ends on and
includes the date of this prospectus supplement (excluding this offering). Accordingly, based on the foregoing, we are currently eligible
under General Instruction I.B.6 of Form S-3 to offer and sell shares of our Common Stock having an aggregate offering price of up to approximately
$2,123,979. Pursuant to General Instruction I.B.6 of Form S-3, in no event will we sell securities registered on the registration statement,
of which this prospectus supplement is a part, in a public primary offering with a value exceeding more than one-third of our public float
in any 12 month period so long as our public float remains below $75.0 million.
We have retained H.C. Wainwright & Co.,
LLC to act as our exclusive placement agent (the “Placement Agent”) in connection with this offering. The Placement Agent
is not purchasing or selling any of the securities offered pursuant to this prospectus supplement and the accompanying prospectus and
the Placement Agent is not required to arrange the purchase or sale of any specific number of securities or dollar amount and has agreed
to use its reasonable best efforts to sell the securities offered by this prospectus supplement and the accompanying prospectus.
We have agreed to pay the Placement Agent certain cash fees set forth in the table below, which assumes that we sell all of the securities
we are offering pursuant to this prospectus supplement and the accompanying prospectus. See “Plan of Distribution” beginning
on page S-17 of this prospectus supplement for additional information with respect to the
compensation we will pay the Placement Agent.
Investing in our securities involves a high
degree of risk. You should read the “Risk Factors” section beginning on page S-10 of this prospectus supplement and
page 10 of the accompanying prospectus and in the documents incorporated by reference in this prospectus supplement for a discussion of
factors to consider before deciding to invest in our common stock.
| |
Per Share | | |
Total | |
Offering price | |
$ | 2.75000 | | |
$ | 2,100,004 | |
Placement Agent fees (1) | |
$ | 0.20625 | | |
$ | 157,500 | |
Proceeds, before expenses, to us (2) | |
$ | 2.54375 | | |
$ | 1,942,504 | |
(1) |
Consists of a cash fee
of 7.5% of the aggregate gross proceeds in this offering. In addition, we have agreed to pay a management fee of 1.0% of the aggregate
gross proceeds raised in this offering, pay $25,000 for non-accountable expenses, $50,000 for expenses of legal counsel and other out-of-pocket
expenses and $15,950 for clearing fees. In addition, we have agreed to issue the Placement Agent warrants (the “Placement Agent
Warrants”) to purchase shares of our common stock equal to 7.5% of the aggregate number of the shares sold in this offering. See
“Plan of Distribution” beginning on page S-17 of this prospectus supplement for additional information with respect to the
compensation we will pay the Placement Agent. |
(2) |
The amount of the offering
proceeds to us presented in this table does not take into account the proceeds from the exercise of any of the Placement Agent
Warrants. |
Neither the Securities and Exchange Commission
nor any state securities commission has approved or disapproved of these securities or determined if this prospectus supplement or the
accompanying prospectus is truthful or complete. Any representation to the contrary is a criminal offense.
Delivery of the securities offered hereby is expected
to be made on or about July 22, 2024, subject to satisfaction of certain customary closing conditions.
H.C. Wainwright & Co.
The date of this prospectus supplement is July
18, 2024
TABLE OF CONTENTS
PROSPECTUS SUPPLEMENT
PROSPECTUS
ABOUT THIS PROSPECTUS SUPPLEMENT
This prospectus supplement and the accompanying
prospectus are part of a registration statement that we filed with the U.S. Securities and Exchange Commission utilizing a “shelf”
registration process. This document is in two parts. The first part is this prospectus supplement, which describes the specific terms
of this offering and also adds to and updates information contained in the accompanying prospectus and the documents incorporated by reference
herein. The second part, the accompanying prospectus, provides more general information. Generally, when we refer to this prospectus,
we are referring to both parts of this document combined. To the extent there is a conflict between the information contained in this
prospectus supplement and the information contained in the accompanying prospectus or any document incorporated by reference therein filed
prior to the date of this prospectus supplement, you should rely on the information in this prospectus supplement; provided that if any
statement in one of these documents is inconsistent with a statement in another document having a later date—for example, a document
incorporated by reference in the accompanying prospectus—the statement in the document having the later date modifies or supersedes
the earlier statement.
We further note that the representations, warranties
and covenants made by us in any agreement that is filed as an exhibit to any document that is incorporated by reference herein were made
solely for the benefit of the parties to such agreement, including, in some cases, for the purpose of allocating risk among the parties
to such agreements, and should not be deemed to be a representation, warranty or covenant to you. Moreover, such representations, warranties
or covenants were accurate only as of the date when made. Accordingly, such representations, warranties and covenants should not be relied
on as accurately representing the current state of our affairs.
You should rely only on the information contained
in this prospectus supplement or the accompanying prospectus, or incorporated by reference herein. We have not authorized, and the Placement
Agent not authorized, anyone to provide you with information that is different. The information contained in this prospectus supplement
or the accompanying prospectus, or incorporated by reference herein or therein is accurate only as of the respective dates thereof, regardless
of the time of delivery of this prospectus supplement and the accompanying prospectus or of any sale of our securities. It is important
for you to read and consider all information contained in this prospectus supplement and the accompanying prospectus, including the documents
incorporated by reference herein and therein, in making your investment decision. You should also read and consider the information in
the documents to which we have referred you in the sections entitled “Where You Can Find More Information” and “Incorporation
of Documents By Reference” in this prospectus supplement and in the accompanying prospectus, respectively.
We are offering to sell, and seeking offers to
buy, the securities offered by this prospectus supplement only in jurisdictions where offers and sales are permitted. The distribution
of this prospectus supplement and the accompanying prospectus and the offering of the securities offered by this prospectus supplement
in certain jurisdictions may be restricted by law. Persons outside the United States who come into possession of this prospectus supplement
and the accompanying prospectus must inform themselves about, and observe any restrictions relating to, the offering of the securities
and the distribution of this prospectus supplement and the accompanying prospectus outside the United States. This prospectus supplement
and the accompanying prospectus do not constitute, and may not be used in connection with, an offer to sell, or a solicitation of an offer
to buy, any securities offered by this prospectus supplement and the accompanying prospectus by any person in any jurisdiction in which
it is unlawful for such person to make such an offer or solicitation.
All references in this prospectus supplement and
the accompanying prospectus to “Silo,” the “Company,” “we,” “us,” “our,” or
similar terms refer to Silo Pharma, Inc. and its subsidiary taken as a whole, except where the context otherwise requires or as otherwise
indicated.
PROSPECTUS
SUPPLEMENT SUMMARY
This summary highlights
selected information about us, this offering and information appearing elsewhere in this prospectus supplement, in the accompanying prospectus
and in the documents incorporated by reference herein and therein. This summary is not complete and does not contain all the information
you should consider before investing in our securities pursuant to this prospectus supplement and the accompanying prospectus. Before
making an investment decision, to fully understand this offering and its consequences to you, you should carefully read this entire prospectus
supplement and the accompanying prospectus, including “Risk Factors,” the financial statements, and related notes, and the
other information incorporated by reference herein and therein.
Overview
We are a developmental stage biopharmaceutical
company developing novel therapeutics that address underserved conditions including PTSD, stress-induced anxiety disorders, fibromyalgia,
and central nervous system (CNS) diseases. We are focused on developing novel therapies that include conventional drugs and psychedelic
formulations. The Company’s lead program, SPC-15, is an intranasal drug targeting PTSD and stress-induced anxiety disorders. SP-26
is a time-release ketamine-based loaded implant for fibromyalgia and chronic pain relief. Silo’s two preclinical programs are SPC-14,
an intranasal compound for the treatment of Alzheimer’s disease, and SPU-16, a CNS-homing peptide targeting the central nervous
system with initial research indication in multiple sclerosis (MS).
Rare Disease Therapeutics
We seek to acquire and/or develop intellectual
property or technology rights from leading universities and researchers to treat rare diseases, including the use of psychedelic drugs,
such as psilocybin, ketamine, and the potential benefits they may have in certain cases involving depression, mental health issues and
neurological disorders. We are focused on developing traditional therapeutics and psychedelic medicine. The company concentrates on the
development and commercialization of therapies for unmet needs from indications such as depression, post-traumatic stress disorder (“PTSD”),
, and other rare neurological disorders. Our mission is to identify assets to license and fund the research which we believe will be transformative
to the well-being of patients and the health care industry.
Psilocybin is considered a serotonergic hallucinogen
and is an active ingredient in some species of mushrooms. Recent industry studies using psychedelics, such as psilocybin, have been promising,
and we believe there is a large unmet need with many people suffering from depression, mental health issues and neurological disorders.
While classified as a Schedule I substance under the Controlled Substances Act (“CSA”), there is an accumulating body of evidence
that psilocybin may have beneficial effects on depression and other mental health conditions. Therefore, the U.S. Food and Drug Administration
(“FDA”) and U.S. Drug Enforcement Agency (“DEA”) have permitted the use of psilocybin in clinical studies for
the treatment of a range of psychiatric conditions.
The potential of psilocybin therapy in mental
health conditions has been demonstrated in a number of academic-sponsored studies over the last decade. In these early studies, it was
observed that psilocybin therapy provided rapid reductions in depression symptoms after a single high dose, with antidepressant effects
lasting for up to at least six months for a number of patients. These studies assessed symptoms related to depression and anxiety through
a number of widely used and validated scales. The data generated by these studies suggest that psilocybin is generally well-tolerated
and may have the potential to treat depression when administered with psychological support.
We have engaged in discussions with a number of
world-renowned educational institutions and advisors regarding potential opportunities and have formed a scientific advisory board that
is intended to help advise management regarding potential acquisition and development of products.
In addition, as more fully described below, we
have entered into a license agreement with the University of Maryland, Baltimore, and are developing a Ketamine polymer implant. In addition,
we have recently entered into a sponsored research agreement with Columbia University pursuant to which we have been granted an option
to license certain patents and inventions relating to the treatment of Alzheimer’s disease and stress-induced affective disorders
using Ketamine in combination with certain other compounds.
We plan to actively pursue the acquisition and/or
development of intellectual property or technology rights to treat rare diseases, and to ultimately expand our business to focus on this
new line of business.
Product Candidates
We are currently focusing on four product candidates:
(i) SPC-15 for treatment of depression disorders; (ii) SP-26 for treatments of chronic pain; (iii)SPC-14 for the treatment of Alzheimer’s
disease and (iv) SPU-16 for the treatment of CNS disorders with an initial indication for multiple sclerosis.
SPC-15
On October 1, 2021, the Company entered into a
sponsored research agreement with Columbia University pursuant to which the Company has been granted an option to license certain assets
currently under development, including assets related to SPC-15 for the treatment of depression disorders. On September 22, 2022, we entered
into a First Amendment to Sponsored Research Agreement with Columbia to extend the term of the Columbia Agreement to conduct further research
studies, which extension runs through March 31, 2024. On April 11, 2023 the assets under development for which we have the option to license
as described above were issued a patent from the U.S. Patent & Trademark Office (USPTO) for “Biomarkers for Efficacy of Prophylactic
Treatments Against Stress-Induced Affective Disorders” (US 11,622,948, B2). We exercised our option for an exclusive license agreement
for SPC-15, a prophylactic treatment for stress-induced affective disorders including anxiety and PTSD pursuant to which we were granted
an exclusive license to further develop, manufacture, and commercialize SPC-15 worldwide pursuant to an exclusive license agreement entered
into on July 1, 2024. See “----License Agreements between the Company and Vendor—Exclusive License Agreement with Columbia
University.”
SPC-15 is a targeted prophylactic therapeutic
composition for the treatment and prevention for stress-induced affective disorders including PTSD. The treatment predicts levels of severity
or progression of such disorders and their metabolomic biomarkers’ response to pharmacological treatments. We intend to develop
SPC-15 under the Section 505(b)(2) regulatory pathway of the FDA rules. Section 505(b)(2) of the Federal Food, Drug, and Cosmetic Act
(“FDCA”) was enacted to enable sponsors to seek New Drug Application (“NDA”) approval for novel repurposed drugs
without the need for such sponsors to undertake time consuming and expensive pre-clinical safety studies and Phase 1 safety studies. Proceeding
under this regulatory pathway, we will be able to rely upon publicly available data with respect to our active ingredient in our NDA submission
to the FDA for marketing approval.
On November 15, 2023, the Company entered an exclusive
license agreement with Medspray Pharma BV for its proprietary patented soft mist nasal spray technology, as the delivery mechanism for
SPC-15, which agreement has an effective date of October 31, 2023. Preclinical and formulation studies are expected to be completed in
the first quarter of 2024 and the Company submitted a pre-IND meeting request to FDA in June 2024.
SP-26
In March 2023, the Company filed a provisional
patent application with the USPTO to use SP-26 for treatment of chronic pain, including fibromyalgia Fibromyalgia is a chronic condition
causing pain to the connective tissues through the body including muscles, ligaments, and tendons. Musculoskeletal pain is often accompanied
by sleep difficulties, fatigue, mood disorders, and problems with memory and concentration. Fibromyalgia affects about 4 million American
adults, or about 2% of the adult population.
We intend to develop SP-26 following the Section
505(b)(2) regulatory pathway of the FDA rules. Section 505(b)(2) of the FDCA was enacted to enable sponsors to seek NDA approval for novel
repurposed drugs without the need for such sponsors to undertake time consuming and expensive pre-clinical safety studies and Phase 1
safety studies. Proceeding under this regulatory pathway, we will be able to rely upon publicly available data with respect to our active
ingredient in our NDA submission to the FDA for marketing approval.
SPC-14
On October 1, 2021, the Company entered into a
sponsored research agreement with Columbia University (“Columbia”) pursuant to which Columbia shall conduct two different
studies related to the use of SPC-14 for the treatment of Alzheimer’s. See “Investigator-Sponsored Study Agreements between
the Company and Vendors---Sponsored Research Agreement with Columbia University for the Study of Ketamine in Combination with Other Drugs
for Treatment of Alzheimer’s and Depression Disorders.” for additional details. In addition, Company has been granted an option
to license certain assets currently under development, including SPC-14 for the treatment of Alzheimer’s disease. We exercised our
option for an exclusive license agreement for SPC-15, a prophylactic treatment for stress-induced affective disorders including anxiety
and PTSD pursuant to which were granted an exclusive license to further develop, manufacture, and commercialize SPC-15 worldwide pursuant
to an exclusive license agreement entered into on July 1, 2024. See “----License Agreements between the Company and Vendor—Exclusive
License Agreement with Columbia University.” We expect to have the complete license agreement with Columbia completed in the first
half of 2024.
SPC-14 is a novel drug combining two approved
therapeutics, so we intend to develop SPC-14 following the Section 505(b)(2) regulatory pathway of the FDA rules. Section 505(b)(2) of
the FDCA was enacted to enable sponsors to seek NDA approval for novel repurposed drugs without the need for such sponsors to undertake
time consuming and expensive pre-clinical safety studies and Phase 1 safety studies. Proceeding under this regulatory pathway, we will
be able to rely upon publicly available data with respect to our active ingredient in our NDA submission to the FDA for marketing approval.
On October 13, 2022, the Company extended the
term of the sponsored research agreement with Columbia to conduct further research studies into the mechanism of action of SPC-14 in the
treatment of Alzheimer’s disease. We expect the results from further preclinical studies in 2024.
SPU-16
On February 12, 2021, we entered into a Master
License Agreement (the “UMB License Agreement”) with the University of Maryland, Baltimore (“UMB”) pursuant to
which UMB granted us an exclusive, worldwide, sublicensable, royalty-bearing license to certain intellectual property (i) to make, have
made, use, sell, offer to sell, and import certain licensed products and (ii) to use the invention titled “Central nervous system-homing
peptides in vivo and their use for the investigation and treatment of multiple sclerosis and other neuroinflammatory pathology,”
or SPU-16. See “License Agreements between the Company and Vendors--Vendor License Agreement with the University of Maryland, Baltimore
for CNS Homing Peptide” for additional details. On April 11, 2023 certain intellectual property under the UMB License Agreement
described above were issued a patent from the U.S. Patent & Trademark Office (USPTO) for “Peptide-Targeted Liposomal Delivery
For Treatment, Diagnosis, and Imaging of Diseases and Disorders” (US 11,766,403, B2).
SPU-16 is a novel peptide homing specifically
to inflamed CNS areas. It may be used to diagnose neuroinflammation in patients, and targeted delivery of drugs into the spinal cord.
The initial indication is for multiple sclerosis (MS). The peptides have been tested in the EAE mouse model of human MS, where they show
homing specifically to inflamed CNS areas.
Product Development Pipeline
The following table summarizes our product development
pipeline.
License Agreements between the Company and
Vendor
Vendor License Agreement with the University
of Maryland, Baltimore for CNS Homing Peptide
On February 12, 2021, we entered into a Master
License Agreement (the “UMB License Agreement”) with the University of Maryland, Baltimore (“UMB”) pursuant to
which UMB granted us an exclusive, worldwide, sublicensable, royalty-bearing license to certain intellectual property (i) to make, have
made, use, sell, offer to sell, and import certain licensed products and (ii) to use the invention titled, “Central nervous system-homing
peptides in vivo and their use for the investigation and treatment of multiple sclerosis and other neuroinflammatory pathology”
(the “Invention”) and UMB’s confidential information to develop and perform certain licensed processes for the therapeutic
treatment of neuroinflammatory disease. The term of the License Agreement shall commence on the UMB Effective Date and shall continue
until the latest of (i) ten years from the date of First Commercial Sale (as defined in the Sublicense Agreement) of the Licensed Product
in such country and (ii) the date of expiration of the last to expire claim of the Patent Rights (as defined in the UMB License Agreement)
covering such Licensed Product in such country, or (iii) the expiration of data protection, new chemical entity, orphan drug exclusivity,
regulatory exclusivity, or other legally enforceable market exclusivity, if applicable, unless terminated earlier pursuant to the terms
of the agreement. Pursuant to the UMB License Agreement, we agreed to pay UMB (i) a license fee of $75,000, (ii) certain event-based milestone
payments, (iii) royalty payments, depending on net revenues, (iv) minimum royalty payments, and (v) a tiered percentage of sublicense
income. The UMB License Agreement will remain in effect until the later of: (a) the last patent covered under the UMB License Agreement
expires, (b) the expiration of data protection, new chemical entity, orphan drug exclusivity, regulatory exclusivity, or other legally
enforceable market exclusivity, if applicable, or (c) ten years after the first commercial sale of a licensed product in that country,
unless earlier terminated in accordance with the provisions of the UMB License Agreement. The term of the UMB License Agreement shall
expire 15 years after the effective date in which (a) there were never any patent rights, (b) there was never any data protection, new
chemical entity, orphan drug exclusivity, regulatory exclusivity, or other legally enforceable market exclusivity or (c) there was never
a first commercial sale of a licensed product.
As described below, the Company has entered into
an investigator sponsored research agreement with UMB related to a clinical study to examine a novel peptide-guided drug delivery approach
for the treatment of Multiple Sclerosis.
Commercial Evaluation License and Option Agreement
with UMB for Joint Homing Peptide
Effective as of February 26, 2021, the Company,
through its wholly-subsidiary, Silo Pharma, Inc., and University of Maryland, Baltimore (“UMB”), entered into a commercial
evaluation license and option agreement (“License Agreement”), which granted the Company an exclusive, non-sublicensable,
non-transferable license to with respect to the exploration of the potential use of joint-homing peptides for use in the investigation
and treatment of arthritogenic processes. The License Agreement also granted the Company an exclusive option to negotiate and obtain an
exclusive, sublicensable, royalty-bearing license (“Exclusive Option”) to with respect to the subject technology. The License
Agreement had a term of six months from the effective date. Both parties could have terminated the License Agreement within thirty days
by giving a written notice.
On July 6, 2021, the Company entered into a First
Amendment Agreement (“Amended License Agreement”) with UMB to extend the term of the original License Agreement by an additional
six months such that the Amended License Agreement was effective until February 25, 2022 however, if the Company exercises the Exclusive
Option, the License Agreement shall expire at the end of the negotiation period (as defined in the License Agreement) or upon execution
of a master license agreement, whichever occurs first. The Company paid a license fee of $10,000 to UMB in March 2021 pursuant to the
License Agreement, which was expensed, since the Company could not conclude that such costs would be recoverable for this early-stage
venture.
On January 28, 2022, the Company and University
of Maryland, Baltimore entered into a second amendment to the License Agreement dated February 26, 2021 (“Second Amendment”).
The Second Amendment extended the term of the License Agreement until December 31, 2022. However, if the Company exercises the Exclusive
Option, the License Agreement shall expire at the end of the negotiation period (as defined in the License Agreement) or upon execution
of a master license agreement, whichever occurs first.
On June 22, 2022, the Company and UMB entered
into a third amendment to the License Agreement dated February 26, 2021 under which UMB agreed, to expand the scope of the license granted
in the CELA to add additional Patent Rights with respect to an invention generally known as “Peptide-Targeted Liposomal Delivery
for Treatment Diagnosis, and Imaging of Diseases and Disorders.” On December 16, 2022, the Company and UMB entered into a fourth
amendment to License Agreement (the “Fourth Amendment”) dated February 26, 2021 to extend the term of the License Agreement
until March 31, 2023. In addition, the parties agreed in the Fourth Amendment to allow the Company to extend the term of the License Agreement
to June 30, 2023 by paying UMB a fee of $1,000 on or before February 28, 2023. This fee was paid and thus the term of the License Agreement
was extended to June 30, 2023. We let this license expire by its terms on December 31, 2023.
Joint Venture Agreement with Zylö Therapeutics,
Inc. for Z-pod™ Technology
On April 22, 2021, the Company entered into a
Joint Venture Agreement with Zylö Therapeutics, Inc. (“ZTI”) pursuant to which the parties agreed to form a joint venture
entity, to be named Ketamine Joint Venture, LLC, to, among other things, focus on the clinical development of ketamine using ZTI’s
Z-pod™ technology. Pursuant to the Joint Venture Agreement, the Company shall act as the manager of the Joint Venture. The Venture
shall terminate if the development program does not meet certain specifications and milestones as set forth in the Joint Venture Agreement
within 30 days of the date set forth in the Joint Venture Agreement. Notwithstanding the foregoing, the Manager may, in its sole discretion,
terminate the Venture at any time.
Pursuant to the terms of the Joint Venture Agreement, (A)
the Company shall contribute (1) $225,000 and (2) its expertise and the expertise of its science advisory board and (B) ZTI shall contribute
(1) certain rights to certain of its patented technology as set forth in the JV Agreement, (2) a license to the know-how and trade secrets
with respect to its Z-pod™ technology for the loading and release of ketamine, (3) ketamine to be used for clinical purposes, (4)
reasonable use of its facilities and permits and (5) its expertise and know-how. Pursuant to the Joint Venture Agreement, 51% of the interest
in the Joint Venture shall initially be owned by the Company and 49% of the interest in the Joint Venture shall initially be owned by
ZTI, subject to adjustment in the event of additional contributions by either party. Notwithstanding the foregoing, in no event shall
either party own more than 60% of the interest in the Joint Venture. As of the date of this prospectus supplement, the joint venture entity
has not been formed yet.
Furthermore, pursuant to the terms of the JV Agreement,
ZTI shall grant the Joint Venture a sublicense pursuant to its license agreement (the “License Agreement”) with Albert Einstein
College of Medicine dated November 27, 2017, in the event that the Company or a third party makes a request indicating that the patented
technology (the “Patented Technology”) licensed to ZTI pursuant to the License Agreement is needed to advance the development
of the Joint Venture or it is contemplated or determined that the Patented Technology will be sold. Furthermore, pursuant to the JV Agreement,
ZTI granted the Company an exclusive option to enter into a separate joint venture for the clinical development of psilocybin using ZTI’s
Z-pod™ technology on the same terms and conditions set forth in the JV Agreement, which option shall expire 24 months after the
JV Effective Date. We do not intend to continue with Zylo and have entered into an agreement to develop a polymer implant for dosage and
time release of Ketamine for chronic pain and Fibromyalgia.
Exclusive License Agreement between Medspray
Pharma BV and the Company
On November 15, 2023, we entered into an Exclusive
License Agreement (the “Medspray License Agreement”) with Medspray Pharma BV (“Medspray”) pursuant to which Medspray
granted us an exclusive, non-revocable, worldwide royalty bearing license for Medspray’s proprietary patented soft mist nasal spray
technology for marketing, promotion, sale and distribution of the products licensed by Medspray to us under the Medspray License Agreement.
The Medspray License Agreement has an effective date of October 31, 2023 and expires on the earlier of (i) termination of the Medspray
License Agreement or expiry of all Medspray license rights in the United States, Germany, United Kingdom, Spain, Italy and France. In
consideration of the exclusive rights granted by Medspray to us, we agreed to pay Medspray a royalty on a quarterly basis equal to 5%
of net sales. The term of the agreement commences on the effective date and continues until the earlier of (i) expiration of the last
to expire of Medspray’s patent rights or (ii) December 31, 2023 (the “Initial Term”) at which time, the Medspray License
Agreement will automatically renew for a successive period of three (3) years, unless terminated by either party upon one year prior written
notice prior to the end of any term; provided, however, the Medspray may terminate the Medspray License Agreement immediately if fail
to have any licensed product under the Medspray License Agreement registered with the FDA or EMA by July 1, 2028 or has filed to reach
the point of first sale of any licensed product under the Medspray License Agreement by July 1, 2028.
Exclusive License Agreement with Columbia University
On July 1, 2024, we entered into an exclusive
license agreement (the “Columbia License Agreement”) with Columbia University (“Columbia”) effective as of June
28, 2024 (the “Effective Date”) and pursuant to which we have been granted exclusive rights to certain patents and technical
information to develop, manufacture and commercialize Products related to our SPC-15 (as defined in the Columbia License Agreement), including
therapies for stress-induced affective disorders and other conditions.
The term of the Columbia License Agreement shall
commence on the Effective Date and shall continue on a country-by-country and product-by-product basis until the latest of: (a) the date
of expiration of the last to expire of the issued Patents (as defined in the Columbia License Agreement), (b) twenty (20) years after
the first bona fide commercial sale of the Product in the country in question, or (c) expiration of any market exclusivity period granted
by a regulatory agency for a Product in the country in question. Pursuant to the Columbia License Agreement, we agreed to pay Columbia
(i) initial and annual license fees ranging from the low five figures to mid five figures that are creditable to earned royalties and
milestone payments due to Columbia in the same calendar year, (ii) certain development-based and other milestone payments, (iii) royalty
payments, depending on net revenues, (iv) minimum royalty payments, and (v) certain non-royalty sublicense income. Royalties on each particular
Product are payable on a country-by-country and product-by-product basis until the later of (i) twenty (20) years after the first bona
fide commercial sale of such particular Technology Product in each country and (ii) expiration of any market exclusivity period granted
by a regulatory agency of such particular Product in such country.
Investigator-Sponsored Study Agreements between
the Company and Vendors
Sponsored Research Agreement with Columbia
University for the Study of Ketamine in Combination with Other Drugs for Treatment of Alzheimer’s and Depression Disorders
On October 1, 2021, the Company entered into a
sponsored research agreement with Columbia University (“Columbia”) pursuant to which Columbia shall conduct two different
studies related to all uses of Ketamine or its metabolites in combination with Prucalopride, one of which is related to Alzheimer’s
and the other of which is related to Depression, PTSD and Stress Projects. In addition, Company has been granted an option to license
certain assets currently under development, including Alzheimer’s disease. The term of the option will commence on the effective
date of this agreement and will expire upon the earlier of (i) 90 days after the date of the Company’s receipt of a final research
report for each specific research proposal as defined in the agreement or (ii) termination of the research. If the Company elects to exercise
the option, both parties will commence negotiation of a license agreement and will execute a license agreement no later than 3 months
after the dated of the exercise of the option. We exercised our option for an exclusive license agreement for SPC-15, a prophylactic treatment
for stress-induced affective disorders including anxiety and PTSD pursuant to which we were granted an exclusive license to further develop,
manufacture, and commercialize SPC-15 worldwide. See “---License Agreements between the Company and Vendor—Exclusive License
Agreement with Columbia University.” Columbia University and the Company will work towards developing a therapeutic treatment for
patients suffering from Alzheimer’s disease to posttraumatic stress disorder. During a one-year period from the date of this agreement,
the Company shall pay a total of $1,436,082 to Columbia University for the support of the research according to the payment schedule as
follows: (i) 30% at signing, (ii) 30% at four and half months after the start of the project, (iii) 30% at nine months after the start
of the project and, (iv)10% at completion of the project. On October 13, 2022, the Company entered into an amendment of the sponsored
research agreement pursuant to which the parties agreed to extend the payment schedule until March 31, 2024. The Company paid the first
payment of $430,825 in November 2021 and the second payment of $430,825 in July 2022.
Sponsored Research Agreement with University
of Maryland, Baltimore for the Study of Targeted liposomal drug delivery for rheumatoid arthritis
On July 6, 2021, we entered into a sponsored research
agreement (the “July 2021 Sponsored Research Agreement”) with UMB pursuant to which UMB shall evaluate the pharmacokinetics
of dexamethasone delivered to arthritic rats via liposome. The research pursuant to the July 2021 Sponsored Research Agreement commenced
on September 1, 2021 and will continue until the substantial completion thereof, subject to renewal upon written consent of the parties
with a project timeline of twelve months. The July 2021 Sponsored Research Agreement may be terminated by either party upon 30 days’
prior written notice to the other party. In addition, if either party commits any material breach of or defaults with respect to any terms
or conditions of the July 2021 Sponsored Research Agreement and fails to remedy such default or breach within 10 business days after written
notice from the other party, the party giving notice may terminate the July 2021 Sponsored Research Agreement as of the date of receipt
of such notice by the other party. If the Company terminates the July 2021 Sponsored Research Agreement for any reason other than an uncured
material breach by UMB, we shall relinquish any and all rights it may have in the Results (as defined in the July 2021 Sponsored Research
Agreement) to UMB. In addition, if the July 2021 Sponsored Research Agreement is terminated early, we, among other things, will pay all
costs incurred and accrued by UMB as of the date of termination. Pursuant to the terms of the July 2021 Sponsored Research Agreement,
UMB granted us an option (the “Option”) to negotiate and obtain an exclusive license to any UMB Arising IP (as defined in
the July 2021 Sponsored Research Agreement) and UMB’s rights in any Joint Arising IP (as defined in the July 2021 Sponsored Research
Agreement) (collectively, the “UMB IP”). We may exercise the Option by giving UMB written notice within 60 days after it receives
notice from UMB of the UMB IP. We shall pay total fees of $276,285 as set forth in the July 2021 Sponsored Research Agreement. The Company
paid the first payment of $92,095 on September 1, 2021 and on August 31, 2022, the Company paid the second payment of $92,095.
Sponsored Research Agreement with The
Regents of the University of California for the Effect of Psilocybin on Inflammation in the Blood
On June 1, 2021, the Company entered into a sponsored
research agreement (“Sponsored Research Agreement”) with The Regents of the University of California, on behalf of its San
Francisco Campus (“UCSF”) pursuant to which UCSF shall conduct a study to examine psilocybin’s effect on inflammatory
activity in humans to accelerate its implementation as a potential treatment for Parkinson’s Disease, chronic pain, and bipolar
disorder. The purpose of this is to show what effect psilocybin has on inflammation in the blood. The Company believe that this study
will help support the UMB homing peptide study. Pursuant to the Agreement, we shall pay UCSF a total fee of $342,850 to conduct the research
over the two-year period. The Agreement shall be effective for a period of two years from the effective date, subject to renewal or earlier
termination as set forth in the Sponsored Research Agreement. During the years ended December 31, 2022 and 2021, pursuant to the Sponsored
Research Agreement, the Company paid to UCSF $181,710 and $100,570, respectively. We have notified UCSF we do not plan to continue this
study.
Investigator-Sponsored Study Agreement with
UMB for CNS Homing Peptide
On January 5, 2021, we entered into an investigator-sponsored
study agreement with UMB. The research project is a clinical study to examine a novel peptide-guided drug delivery approach for the treatment
of Multiple Sclerosis (“MS”). More specifically, the study is designed to evaluate (1) whether MS-1-displaying liposomes can
effectively deliver dexamethasone to the central nervous system and (2) whether MS-1-displaying liposomes are superior to plain liposomes,
also known as free drug, in inhibiting the relapses and progression of Experimental Autoimmune Encephalomyelitis. Pursuant to the agreement,
the research commenced on March 1, 2021 and will continue until substantial completion, subject to renewal upon mutual written consent
of the parties. The total cost under the investigator-sponsored study agreement shall not exceed $81,474. which is payable in two
equal installments of $40,737 upon execution of the Sponsored Study Agreement and $40,737 upon completion of the project with an estimated
project timeline of nine months. The Company paid $40,737 on January 13, 2021. This project is postponed until further notice and the
second payment is not due.
Recent Developments
Exclusive License Agreement with Columbia University
On July 1, 2024, we entered into an Exclusive
License Agreement with Columbia University under which we were granted an exclusive license to further develop, manufacture, and commercialize
SPC-15 worldwide. See “----License Agreements between the Company and Vendor—Exclusive License Agreement with Columbia University.”
Pre-IND Submission
On June 4, 2024, we submitted a pre-Investigational
New Drug (pre-IND) briefing package and meeting request to the U.S. Food and Drug Administration (FDA) for SPC-15, Silo’s intranasal
prophylactic treatment for post-traumatic stress disorder (PTSD) and stress-induced anxiety disorder.
June 2024 Registered Direct Offering and Concurrent
Private Placement
On June 4, 2024, we entered into a securities
purchase agreement (the “June 2024 Purchase Agreement”) with certain institutional investors, pursuant to which we agreed
to sell to such investors 883,395 shares (the “Shares”) of Common Stock, pre-funded warrants (the “Pre-Funded Warrants”)
to purchase up to 34,037 shares of Common Stock (the “Pre-Funded Warrant Shares”), having an exercise price of $0.0001 per
share, at a purchase price of $2.18 per share of Common Stock and a purchase price of $2.1799 per Pre-Funded Warrant (the “June
2024 Offering”). The shares of Common Stock and Pre-Funded Warrants (and shares of common stock underlying the Pre-Funded Warrants)
were offered by us pursuant to its shelf registration statement on Form S-3 (File No. 333-276658), which was declared effective by the
Securities and Exchange Commission on January 30, 2024.
Concurrently with the sale of Common Stock and/or
the Pre-Funded Warrants, pursuant to the June 2024 Purchase Agreement in a private placement, for each share of Common Stock and/or Pre-Funded
Warrant purchased by the investors, such investors received an unregistered warrant (the “June 2024 Common Warrant”) to purchase
one share of Common Stock (the “June 2024 Common Warrant Shares”). The warrants have an exercise price of $2.06 per share,
and are exercisable immediately upon issuance for a five-year period.
The closing of the sales of these securities under
the June 2024 Purchase Agreement took place on June 6, 2024. The gross proceeds from the offering were approximately $2 million, prior
to deducting placement agent’s fees and other offering expenses payable by the Company. We intend to use the net proceeds from the
offering for working capital and other general corporate purposes.
On April 23, 2024, we entered into an engagement
agreement with H.C. Wainwright & Co., LLC, as exclusive placement agent (the “Placement Agent”), pursuant to which the
Placement Agent agreed to act as placement agent on a reasonable “best efforts” basis in connection with the Offering. We
agreed to pay the Placement Agent an aggregate cash fee equal to 7.5% of the gross proceeds from the sale of securities in the Offering
and a management fee equal to 1.0% of the gross proceeds raised in the Offering. We also agreed to issue the Placement Agent (or its designees)
a warrant (the “June 2024 Placement Agent Warrant”) to purchase up to 7.5% of the aggregate number of shares of Common Stock
and/or Pre-Funded Warrants sold in the offering, or warrants to purchase up to 68,807 shares of Common Stock, at an exercise price equal
to 125.0% of the offering price per share of Common Stock, or $2.725 per share. The June 2024 Placement Agent Warrants are exercisable
immediately upon issuance for a period of five years following the commencement of the sales pursuant to the Offering. In addition, we
agreed to pay the Placement Agent $25,000 for non-accountable expenses, $50,000 for legal expenses and other out-of-pocket expenses and
$15,950 for clearing fees.
Our Corporate Information
We were incorporated
as in the State of New York on July 13, 2010. On January 24, 2013, the Company changed its state of incorporation from New York to Delaware.
On December 19, 2023, the Company changed its state of incorporation from Delaware to Nevada. Our principal executive offices are located
at 677 N Washington Blvd Sarasota Fl 34236 and our telephone number is (718) 400-9031.
THE OFFERING
Common Stock Offered by Us |
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763,638 shares. |
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Offering Price |
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$2.75 per share.
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Common Stock to be Outstanding Immediately After this Offering (1) |
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4,484,456 shares (excluding shares of common stock issuable upon the Unregistered Warrants and the Placement Agent Warrants). |
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Use of Proceeds |
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The net proceeds from our sale of securities in this offering will
be approximately $1.76 million, after deducting Placement Agent fees and other estimated offering expenses payable by us. We intend
to use the net proceeds to us from this offering for general corporate and working capital purposes. See “Use of Proceeds.” |
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Concurrent Private Placement |
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In a concurrent Private Placement, we are also selling to the purchasers Unregistered Warrants to purchase up to 763,638 Unregistered Warrant Shares. The Unregistered Securities are not being registered under the Securities Act and are not offered pursuant to this prospectus supplement and the accompanying prospectus and are being offered pursuant to an exemption from the registration requirements of the Securities Act provided in Section 4(a)(2) of the Securities Act and Regulation D promulgated thereunder. The Unregistered Warrants are exercisable for five years from the date of issuance and have an exercise price of $2.75 per Unregistered Warrant Share. See “Concurrent Private Placement.” |
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Risk Factors |
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Investing in our securities involves a high degree of risk. You should read the “Risk Factors” section beginning on page S-10 of this prospectus supplement and page 10 of the accompanying prospectus and in the documents incorporated by reference in this prospectus supplement for a discussion of factors to consider before deciding to invest in our securities. |
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Nasdaq Capital Market symbol |
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“SILO”. |
(1) |
The number of shares of common stock to be outstanding immediately after this offering is based on 3,720,818 shares of our common stock outstanding as of July 18, 2024, and excludes, as of such date: |
| ● | 22,850
shares of Common Stock issuable upon exercise of options outstanding under the Silo Pharma, Inc. Amended and Restated 2020 Omnibus (the
“2020 Plan”) with a weighted-average exercise price of $9.19 per share; |
| ● | 4,000
shares of Common Stock issuable upon exercise of non-plan options outstanding with a weighted-average exercise price of $0.005 per share; |
| ● | 447,150
shares of Common Stock reserved for future issuance under the 2020 Plan; |
| ● | 347,080 shares of Common Stock issuable upon the exercise
of warrants outstanding at an exercise price of $15.34 per share; |
| ● | 57,500
shares of Common Stock issuable upon the exercise of warrants outstanding at an exercise price of $6.25 per share; |
| ● | 917,432
shares of common stock issuable upon exercise of June 2024 Warrants outstanding at an exercise price of $2.06 per share; |
| ● | 68,807 shares of common stock issuable upon exercise of June
2024 Placement Agent Warrants issued as compensation to the Placement Agent in connection with this June 2024 Offering at an exercise
price of $2.725 per share; |
| ● | 763,638
shares of common stock issuable upon exercise of Unregistered Warrants outstanding issued in the concurrent Private Placement at an exercise
price of $2.75 per share; and |
| ● | 57,273
shares of common stock issuable upon exercise of Placement Agent Warrants to be issued as compensation to the Placement Agent in connection
with this offering at an exercise price of $3.4375 per share. |
Unless otherwise indicated, all information in
this prospectus supplement assumes no exercise of options or warrants described above and no exercise of the Unregistered Warrants issued
to the purchasers in the concurrent Private Placement or the Placement Agent Warrants to be issued as compensation to the Placement Agent
for this offering.
RISK FACTORS
An investment in our securities involves a
high degree of risk. Before deciding whether to invest in our securities, you should consider carefully the risks described below, together
with other information in this prospectus supplement, the accompanying prospectus and the information and documents incorporated by reference.
You should also consider the risks, uncertainties and assumptions discussed under the heading “Risk Factors” included in our
most recent Annual Report on Form 10-K and the subsequent reports that we file with the SEC which are on file with the SEC and are incorporated
herein by reference, and which may be amended, supplemented or superseded from time to time by other reports we file with the SEC in the
future. If any of these risks actually occur, our business, financial condition, results of operations or cash flow could be adversely
effected. This could cause the trading price of our common stock to decline, resulting in a loss of all or part of your investment. The
risks and uncertainties described below are not the only ones facing us. Additional risks and uncertainties not presently known to us,
or that we currently see as immaterial, may also harm our business. Please also read carefully the section below entitled “Special
Note Regarding Forward-Looking Statements.”
Risks Related to This Offering and Our Common Stock
Our management team may invest or spend
the proceeds raised in this offering in ways with which you may not agree or which may not yield a significant return.
Our management will have broad discretion over
the use of proceeds from this offering and could spend the proceeds in ways that do not improve our results of operations or enhance
the value of our common stock. The failure by management to apply these funds effectively could result in financial losses that could
have a material adverse effect on our business, cause the price of our common stock to decline, and delay the development of our product
candidates.
You will experience substantial dilution.
Based on an offering price of $2.75 per share,
and a pro forma net tangible book value of $8.65 million, or approximately $1.93 per share of common stock, as of March 31, 2024, if you
purchase securities in this offering, you will experience dilution of approximately $0.82 per share in the net tangible book value of
the common stock you purchase representing the difference between our as adjusted pro forma net tangible book value per share after giving
effect to this offering and the offering price per share of common stock. The exercise of outstanding stock options and warrants, including
those sold in this offering, will result in further dilution of your investment.
If you purchase securities in this offering,
you may also experience future dilution as a result of future equity offerings.
We expect that significant additional capital
will be needed in the future to continue our planned operations, including research and development, increased marketing, hiring new personnel,
commercializing our products, and continuing activities as an operating public company. To the extent we raise additional capital by issuing
equity securities, our shareholders may experience substantial dilution. We may sell common stock, convertible securities or other equity
securities in one or more transactions at prices and in a manner we determine from time to time. If we sell common stock, convertible
securities or other equity securities in more than one transaction, investors may be materially diluted by subsequent sales. Such sales
may also result in material dilution to our existing shareholders, and new investors could gain rights superior to our existing shareholders.
We do not intend to pay cash dividends on
our shares of common stock so any returns will be limited to the value of our shares.
We have never paid or
declared any cash dividends on our common stock, and we do not anticipate paying any cash dividends on our common stock in the foreseeable
future. We currently anticipate that we will retain future earnings for the development, operation and expansion of our business. Any
future determination to pay dividends will be at the discretion of our board of directors and will depend upon a number of factors, including
our results of operations, financial condition, future prospects, contractual restrictions, restrictions imposed by applicable law and
other factors that our board of directors deems relevant. Therefore, any return to shareholders will be limited to the increase, if any,
of our share price.
We are currently
listed on The Nasdaq Capital Market. If we are unable to maintain listing of our securities on Nasdaq or any stock exchange, our stock
price could be adversely affected and the liquidity of our stock and our ability to obtain financing could be impaired and it may be more
difficult for our shareholders to sell their securities.
Although our common stock
is currently listed on The Nasdaq Capital Market, we may not be able to continue to meet the exchange’s minimum listing requirements
or those of any other national exchange. The Listing Rules of Nasdaq require listing issuers to comply with certain standards in order
to remain listed on its exchange. If, for any reason, we should fail to maintain compliance with these listing standards and Nasdaq should
delist our securities from trading on its exchange and we are unable to obtain listing on another national securities exchange, a reduction
in some or all of the following may occur, each of which could have a material adverse effect on our shareholders:
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the liquidity of our common stock; |
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the market price of our common stock; |
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our ability to obtain financing for the continuation of our operations; |
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the number of investors that will consider investing in our common stock; |
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the number of market makers in our common stock; |
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the availability of information concerning the trading prices and volume of our common stock; and |
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the number of broker-dealers willing to execute trades in shares of our common stock. |
SPECIAL NOTE REGARDING
FORWARD-LOOKING STATEMENTS
This prospectus supplement and the documents incorporated
by reference herein contain forward-looking statements that are based on current management expectations. Statements other than statements
of historical fact included in this prospectus supplement, including statements about us and the future growth and anticipated operating
results and cash expenditures, are forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 (“Securities
Act”), as amended, and Section 21E of the Securities Exchange Act of 1934, as amended (“Exchange Act”). When used in
this prospectus supplement the words “anticipate,” “objective,” “may,” “might,” “should,”
“could,” “can,” “intend,” “expect,” “believe,” “estimate,” “predict,”
“potential,” “plan” or the negative of these and similar expressions identify forward-looking statements. These
statements reflect our current views with respect to uncertain future events and are based on imprecise estimates and assumptions and
subject to risk and uncertainties. Given these uncertainties, you should not place undue reliance on these forward-looking statements.
While we believe our plans, intentions and expectations reflected in those forward-looking statements are reasonable, these plans, intentions
or expectations may not be achieved. Our actual results, performance or achievements could differ materially from those contemplated,
expressed or implied by the forward-looking statements contained in, or incorporated by reference into, this prospectus supplement for
a variety of reasons.
We urge investors to review carefully risks contained
in the section of this prospectus entitled “Risk Factors” above as well as other risks and factors identified from time to
time in our SEC filings in evaluating the forward-looking statements contained in this prospectus supplement. We caution investors not
to place significant reliance on forward-looking statements contained in this document; such statements need to be evaluated in light
of all the information contained herein.
All forward-looking statements attributable to
us or persons acting on our behalf are expressly qualified in their entirety by the risk factors and other cautionary statements set forth,
or incorporated by reference, in this prospectus supplement. Except as required by law, we are under no obligation, and we do not intend,
to update any forward-looking statement, whether as result of new information, future events or otherwise.
DIVIDEND POLICY
We have never paid or declared any cash dividends
on our common stock, and we do not anticipate paying any cash dividends on our common stock in the foreseeable future. We intend to retain
all available funds and any future earnings to fund the development and expansion of our business. Any future determination to pay dividends
will be at the discretion of our board of directors and will depend upon a number of factors, including our results of operations, financial
condition, future prospects, contractual restrictions, restrictions imposed by applicable law and other factors that our board of directors
deems relevant.
USE OF PROCEEDS
We expect to receive net proceeds from this offering
of approximately $1.76 million, after deducting the Placement Agent fees and estimated offering expenses payable by us.
We currently intend to use the net proceeds from
the sale of the securities offered hereby for general corporate and working capital purposes. This expected use of net proceeds from this
offering and our existing cash represents our intentions based upon our current plans and business conditions, which could change in the
future as our plans and business conditions evolve. The amounts and timing of our actual expenditures may vary significantly depending
on numerous factors. As a result, our management will retain broad discretion over the allocation of the net proceeds from this offering.
As of the date of this prospectus supplement,
we cannot predict with certainty all the uses for the net proceeds to be received upon the completion of this offering or the amounts
we will spend on the uses set forth above.
DILUTION
If you purchase securities in the offering, you will experience immediate
dilution to the extent of the difference between the effective public offering price per share of $2.75 per share of common stock and
our as-adjusted pro forma net tangible book value per share immediately after the offering. Net tangible book value per share is equal
to the amount of our total tangible assets, less total liabilities, divided by the number of outstanding shares of our common stock. As
of March 31, 2024, our net tangible book value was approximately $5.3 million, or approximately $1.87 per share.
After giving effect to (i) our purchase of 30,065 shares of our common
stock pursuant to our stock repurchase program at a cost of $57,661 in April 2024; and (ii) our sale on June 6, 2024 of 883,395 shares
of common stock at an offering price of $2.18 per share and Pre-Funded Warrants exercisable for 34,037 shares of common stock at an offering
price of $2.1799 per Pre-Funded Warrant, including the exercise of such Pre-Funded Warrant on June 6, 2024 for which we received aggregate
net proceeds of approximately $1,664,051, our pro forma net tangible book value as of March 31, 2024 would have been $1.85 per share.
Based on the sale by us in this offering of 763,638
shares of common stock at an offering price of $2.75 per share after deducting estimated offering expenses and placement agent fees and
expenses payable by us, our as adjusted pro forma net tangible book value as of March 31, 2024 was approximately $8.7 Million, or $1.93
per share of our common stock. This represents an immediate increase in as adjusted pro forma net tangible book value to existing stockholders
of $0.08 per share of our common stock and an immediate dilution to purchasers in this offering of $0.82per share of our common stock.
The following table illustrates this per-share of our common stock
dilution:
Effective offering price per share of common stock | |
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$ | 2.75 | |
Pro forma net tangible book value per share as of March 31, 2024 | |
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$ | 1.85 | |
Increase in pro forma net tangible book value per share attributable to this offering | |
$ | 0.08 | | |
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As adjusted pro forma net tangible book value per share as of March 31,2024 after giving effect to this offering4 | |
$ | 1.93 | | |
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Dilution per share to the new investor in this offering | |
$ | 0.82 | | |
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The total number of shares of our common
stock reflected in the discussion and tables above is based on 2,833,451 shares of
our common stock outstanding as of March 31, 2024, but excludes the following as of such date:
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22,850 shares of Common Stock issuable upon exercise of options outstanding under the Silo Pharma, Inc. Amended and Restated 2020 Omnibus (the “2020 Plan”) with a weighted-average exercise price of $9.19 per share; |
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4,000 shares of Common Stock issuable upon exercise of non-plan options outstanding with a weighted-average exercise price of $0.005 per share; |
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447,150 shares of Common Stock reserved for future issuance under the 2020 Plan; |
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347,080 shares of Common Stock issuable upon the
exercise of warrants outstanding at an exercise price of $15.34 per share;
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57,500 shares of Common Stock issuable upon the exercise of warrants outstanding at an exercise price of $6.25 per share; |
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917,432 shares of common stock issuable upon exercise
of June 2024 Warrants outstanding at an exercise price of $2.06 per share;
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68,807 shares of common stock issuable upon exercise
of June 2024 Placement Agent Warrants issued as compensation to the Placement Agent in connection with this June 2024 Offering at an exercise
price of $2.725 per share;
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763,638 shares of common stock issuable upon exercise of Unregistered Warrants outstanding issued in the concurrent Private Placement at an exercise price of $2.75 per share; and |
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57,273 shares of common stock issuable upon exercise of Placement Agent Warrants to be issued as compensation to the Placement Agent in connection with this offering at an exercise price of $3.4375 per share. |
DESCRIPTION OF SECURITIES WE ARE OFFERING
We are offering shares of common stock. The following
description of our shares of common stock summarizes the material terms and provisions thereof, including the material terms of the shares
of common stock we are offering under this prospectus supplement and the accompanying prospectus.
Common Stock
For a description of the rights associated with
the common stock, see “Description of Capital Stock” in the accompanying prospectus. Our common stock is listed on The Nasdaq
Capital Market under the symbol “SILO.” Our transfer agent is West Coast Stock Transfer, Inc. whose address is 721 N. Vulcan
Avenue, Suite 106, Encinitas, CA 92024.
CONCURRENT PRIVATE PLACEMENT
In the concurrent Private Placement, we are selling
Unregistered Warrants to purchase up to 763,638 shares of our common stock. For each share of our common stock or Pre-Funded Warrant in
lieu thereof sold in this offering, an accompanying Unregistered Warrants will be issued to the purchaser thereof. Each Unregistered Warrant
will be exercisable for one share of our common stock at an exercise price of $2.75 per share, will be immediately exercisable upon issuance
and will expire five years from the date of issuance. The Unregistered Warrants are being offered for an aggregate purchase price of $95,455,
which amount is included in the aggregate gross proceeds for the offering set forth elsewhere in the prospectus supplement.
The Unregistered Warrants and Unregistered Warrant
Shares issuable upon the exercise of the Unregistered Warrants are not being registered under the Securities Act, nor are they being offered
pursuant to this prospectus supplement and accompanying prospectus. The Unregistered Warrants and Unregistered Warrant Shares are being
offered pursuant to the exemption provided in Section 4(a)(2) of the Securities Act and Regulation D promulgated thereunder.
Accordingly, the investors in the concurrent Private
Placement may exercise the Unregistered Warrants and sell the Unregistered Warrant Shares issuable upon the exercise of such security
only pursuant to an effective registration statement under the Securities Act covering the resale of those shares, an exemption under
Rule 144 under the Securities Act or another applicable exemption under the Securities Act or, if and only if there is no effective registration
statement registering the resale of the Unregistered Warrant Shares, or no current prospectus available for such shares, the investors
may exercise the Unregistered Warrants by means of a “cashless exercise.”
If a Fundamental Transaction (as defined in the
Unregistered Warrant Warrant) occurs, then, upon any subsequent exercise of the Unregistered Warrant, the holder shall have the right
to receive, for each Unregistered Warrant Share that would have been issuable upon such exercise immediately prior to the occurrence of
such Fundamental Transaction, at the option of the holder (without regard to any beneficial ownership limitation), the number of shares
of common stock of the successor or acquiring corporation or of our Company, if we are is the surviving corporation, and any additional
consideration (“Unregistered Alternative Consideration”) receivable as a result of such Fundamental Transaction. If holders
of common stock are given any choice as to the securities, cash or property to be received in a Fundamental Transaction, then the holder
shall be given the same choice as to the Unregistered Alternate Consideration it receives upon any exercise of the Unregistered Warrant
following such Fundamental Transaction. Additionally, as more fully described in the form of Unregistered Warrant, in the event of
certain Fundamental Transactions, the holders of the Unregistered Warrants will be entitled to receive consideration in an amount
equal to the Black Scholes Value (as defined in the Unregistered Warrant) of the Unregistered Warrant on the date of consummation of the
transaction.
A holder of Unregistered Warrants will not have
the right to exercise any portion thereof if the holder, together with its affiliates, would beneficially own in excess of 4.99% (or,
at the election of a holder prior to the date of issuance, 9.99%) of the number of shares of our common stock outstanding immediately
after giving effect to such exercise; provided, however, that upon notice to the Company, the holder may increase or decrease such beneficial
ownership limitation, provided that in no event shall such beneficial ownership limitation exceed 9.99% and any increase in the beneficial
ownership limitation will not be effective until 61 days following notice of such increase from the holder to us.
Except as otherwise provided in the Unregistered
Warrants or by virtue of such holder’s ownership of shares of our common stock, the holders of the Unregistered Warrants do not
have the rights or privileges of holders of our common stock, including any voting rights, until they exercise their Unregistered Warrants,
as applicable.
The Unregistered Warrants are not and will not
be listed for trading on any national securities exchange.
PLAN OF DISTRIBUTION
Pursuant to an engagement letter agreement, dated
as of April 23, 2024, we have engaged H.C. Wainwright & Co., LLC to act as our exclusive placement agent in connection with this offering.
Under the terms of the engagement letter agreement, the Placement Agent has agreed to act as our exclusive placement agent, on a reasonable
best efforts basis, in connection with the issuance and sale of our securities pursuant to this prospectus supplement and the accompanying
prospectus. Therefore, we may not sell the entire amount of securities being offered. The terms
of this offering were subject to market conditions and negotiations between us, the Placement Agent and
prospective investors. The engagement letter agreement does not give rise to any commitment by the Placement Agent to purchase
or sell any of our securities, and the Placement Agent will have no authority to bind us by virtue of the engagement letter agreement.
The Placement Agent may engage sub-agents or selected dealers to assist with the offering.
The Placement Agent proposes to arrange for the
sale of the securities we are offering pursuant to this prospectus supplement and accompanying prospectus to one or more institutional
or accredited investors through securities purchase agreements directly between the purchasers and us. We will only sell to such investors
who have entered into the securities purchase agreement with us.
We expect to deliver the securities being offered
pursuant to this prospectus supplement and accompanying prospectus on or about July 22, 2024, subject to satisfaction of customary closing
conditions.
Pursuant
to the terms of the securities purchase agreement and subject to certain exceptions, we are prohibited from entering into any agreement
to issue or announcing the issuance or proposed issuance of any shares of Common Stock or securities convertible or exercisable into Common
Stock for a period commencing on the date of this prospectus supplement and expiring 15 days from the closing date of this offering. Furthermore,
we are also prohibited from entering into any agreement to issue Common Stock or Common Stock Equivalent (as defined in the securities
purchase agreement) involving a Variable Rate Transaction (as defined in the securities purchase agreement), subject to certain exceptions,
for a period commencing on the date of this prospectus supplement and expiring
one year from the closing date of this offering.
Each of our executive officers and directors have
agreed, subject to certain exceptions, not to dispose of or hedge any shares of Common Stock or securities convertible into or exchangeable
for shares of Common Stock during the period from the date of the lock-up agreement continuing through the 15 days after the closing of
this offering.
We have agreed to pay the Placement Agent a total
cash fee equal to 7.5% of the gross proceeds of this offering. We will also pay the Placement Agent in connection with this offering a
management fee equal to 1.0% of the gross proceeds raised in the offering, $25,000 for non-accountable expenses, $50,000 for expenses
of legal counsel and other out-of-pocket expenses and $15,950 for clearing fees. We estimate that the total expenses of the offering payable
by us, excluding the placement agent’s fees and the reimbursement noted above, will be approximately $75,000. In addition, we have
agreed to issue to the Placement Agent, or its designees, Placement Agent Warrants to purchase up to 68,807 shares of Common Stock, which
represents 7.5% of the aggregate number of shares and Pre-Funded Warrants purchased in this offering. The Placement Agent Warrants will
have substantially the same terms as the Unregistered Warrants, except that the Placement Agent Warrants will have an exercise price equal
to $3.4375 per share, or 125% of the offering price per share, and will have a term of five years from the commencement of the sales pursuant
to this offering.
We have granted the Placement Agent a right of
first refusal for a period of twelve months following the closing of this offering to act as our sole book-running manager, sole manager,
sole placement agent or sole agent for any further capital raising transactions undertaken by us.
We also have granted the Placement Agent a tail
cash fee equal to 7.5% of the gross proceeds and Placement Agent Warrants to purchase shares of common stock equal to 7.5% of the aggregate
number of shares of securities sold in any offering, within 12 months following the termination or expiration of the engagement letter
agreement, to investors whom the Placement Agent contacted or introduced to us in connection with this offering.
We have agreed to indemnify the Placement Agent
and specified other persons against certain liabilities relating to or arising out of the Placement Agent’s activities under the
engagement letter agreement and to contribute to payments that the Placement Agent may be required to make in respect of such liabilities.
The Placement Agent may be deemed to be an underwriter
within the meaning of Section 2(a)(11) of the Securities Act, and any commissions received by it and any profit realized on the resale
of the securities sold by it while acting as principal might be deemed to be underwriting discounts or commissions under the Securities
Act. As an underwriter, the Placement Agent would be required to comply with the requirements of the Securities Act and the Exchange Act,
including, without limitation, Rule 415(a)(4) under the Securities Act and Rule 10b-5 and Regulation M under the Exchange Act. These rules
and regulations may limit the timing of purchases and sales of securities by Wainwright acting as principal. Under these rules and regulations,
the Placement Agent:
|
● |
may not engage in any stabilization activity in connection with our securities; and |
|
● |
may not bid for or purchase any of our securities or attempt to induce any person to purchase any of our securities, other than as permitted under the Exchange Act, until it has completed its participation in the distribution. |
The Placement Agent has provided in the past
and may provide in the future various advisory, investment and commercial banking and other services to us in the ordinary course of
business, for which they have received and may continue to receive customary fees and commissions. The Placement Agent acted as placement agent for the June 2024 Offering
and was paid compensation. However, except as disclosed in
this prospectus supplement, we have no present arrangements with the Placement Agent for any further services.
Our common stock is listed on The Nasdaq Capital Market under the symbol
“SILO.”
LEGAL MATTERS
The validity of the shares of our common stock offered hereby will be passed upon for us by Sheppard, Mullin, Richter & Hampton LLP,
New York, New York. Ellenoff Grossman & Schole LLP, New York, New York is counsel to the placement agent in connection with this offering.
EXPERTS
Our consolidated financial statements as of and
for the years ended December 31, 2023 and 2022, incorporated by reference in this prospectus and the registration statement, of which
it forms a part, have been audited by Salberg & Company, P.A., independent registered public accounting firm, as set forth in their
report thereon incorporated by reference herein, and are included in reliance on such report given on the authority of such firm as experts
in accounting and auditing
WHERE YOU CAN FIND MORE INFORMATION
We have filed with the SEC a registration statement
on Form S-3 under the Securities Act, of which this prospectus supplement forms a part. The rules and regulations of the SEC
allow us to omit from this prospectus supplement and the accompanying prospectus certain information included in the registration statement.
For further information about us and the securities we are offering under this prospectus supplement, you should refer to the registration
statement and the exhibits and schedules filed with the registration statement. With respect to the statements contained in this prospectus
supplement and the accompanying prospectus regarding the contents of any agreement or any other document, in each instance, the statement
is qualified in all respects by the complete text of the agreement or document, a copy of which has been filed as an exhibit to the registration
statement.
We file reports, proxy statements and other information
with the SEC. The SEC maintains a website that contains reports, proxy and information statements and other information regarding issuers
that file electronically with the SEC. The address of the SEC’s website is www.sec.gov.
We make available free of charge on or through
our website at www.ir.silopharma.com, our Annual Reports on Form 10-K, Quarterly Reports on Form 10-Q, Current Reports on
Form 8-K and amendments to those reports filed or furnished pursuant to Section 13(a) or 15(d) of the Exchange Act, as soon as reasonably
practicable after we electronically file such material with or otherwise furnish it to the SEC. The information on, or accessible through,
our website is not part of, and is not incorporated into, this prospectus supplement or the accompanying prospectus and should not be
considered part of this prospectus supplement or the accompanying prospectus. You may also request a copy of these filings, at no cost,
by writing or telephoning us at: 677 N Washington Boulevard, Sarasota, Florida 34236, (718) 400-9031.
INCORPORATION OF DOCUMENTS
BY REFERENCE
The SEC allows us to incorporate by reference
into this prospectus supplement much of the information we file with the SEC, which means that we can disclose important information to
you by referring you to those publicly available documents. The information that we incorporate by reference is considered to be part
of this prospectus supplement and the accompanying prospectus. Because we are incorporating by reference future filings with the SEC,
this prospectus supplement and the accompanying prospectus are continually updated and those future filings may modify or supersede some
of the information included or incorporated in this prospectus supplement and the accompanying prospectus. This means that you must look
at all of the SEC filings that we incorporate by reference to determine if any of the statements in this prospectus supplement or the
accompanying prospectus or in any document previously incorporated by reference have been modified or superseded. This prospectus supplement
and the accompanying prospectus incorporate by reference the documents listed below and any future filings we make with the SEC under
Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act (in each case, other than those documents or the portions of those documents not
deemed to be filed) until the offering of the securities under the registration statement is terminated or completed:
| ● | our
Annual Report on Form 10-K for the year ended December 31, 2023 filed with the SEC on March 25, 2024; |
| ● | our
Quarterly Reports on Form 10-Q for the quarter ended March 31, 2024 filed with the SEC on May 13, 2024; |
| ● | our Current Reports on
Form 8-K filed with the SEC on January
9, 2024, January 11, 2024, February 1, 2024; April 5, 2024; June 4, 2024; June 6, 2024; June 27, 2024 and July 8, 2024;
and |
| ● | the
description of our common stock, par value $0.0001 per share, contained in Exhibit 4.1 to our Annual Report on Form 10-K filed with the
SEC on March 25, 2024, including any amendment or report filed for the purpose of updating such description. |
You may request, and we will provide you with,
a copy of these filings, at no cost, by calling us at (718) 400-9031 or by writing to us at the following address:
Silo Pharma, Inc.
677 N. Washington Boulevard
Sarasota, Florida 34236
Attn.: Secretary
PROSPECTUS
SILO PHARMA,
INC.
Common Stock
Preferred Stock
Debt Securities
Warrants
Units
We may offer and sell, from time to time in one
or more offerings, any combination of common stock, preferred stock, debt securities, warrants to purchase common stock, preferred stock
or debt securities, or any combination of the foregoing, either individually or as units comprised of one or more of the other securities,
having an aggregate initial offering price not exceeding $25,000,000.
This prospectus provides a general description
of the securities we may offer. Each time we sell a particular class or series of securities, we will provide specific terms of the securities
offered in a supplement to this prospectus. The prospectus supplement and any related free writing prospectus may also add, update or
change information contained in this prospectus. We may also authorize one or more free writing prospectuses to be provided to you in
connection with these offerings. You should read carefully this prospectus, the applicable prospectus supplement and any related free
writing prospectus, as well as any documents incorporated by reference herein or therein before you invest in any of our securities.
The specific terms of any securities to be offered,
and the specific manner in which they may be offered, will be described in one or more supplements to this prospectus. This prospectus
may not be used to consummate sales of any of these securities unless it is accompanied by a prospectus supplement. Before investing,
you should carefully read this prospectus and any related prospectus supplement.
Our common stock is presently listed on The Nasdaq
Capital Market under the symbol “SILO.” On January 22, 2024, the last reported sale price of our common stock was $1.40 per
share. The applicable prospectus supplement will contain information, where applicable, as to any other listing on The Nasdaq Capital
Market or any securities market or other exchange of the securities, if any, covered by the prospectus supplement. Prospective purchasers
of our securities are urged to obtain current information as to the market prices of our securities, where applicable.
These securities may be sold directly by us, through
dealers or agents designated from time to time, to or through underwriters, dealers, or through a combination of these methods on a continuous
or delayed basis. See “Plan of Distribution” in this prospectus. We may also describe the plan of distribution for
any particular offering of our securities in a prospectus supplement. If any agents, underwriters or dealers are involved in the sale
of any securities in respect of which this prospectus is being delivered, we will disclose their names and the nature of our arrangements
with them in a prospectus supplement. The price to the public of such securities and the net proceeds we expect to receive from any such
sale will also be included in a prospectus supplement.
Investing in our securities involves various
risks. See “Risk Factors” contained herein for more information on these risks. Additional risks will be described
in the related prospectus supplements under the heading “Risk Factors.” You should review that section of the related
prospectus supplements for a discussion of matters that investors in our securities should consider.
Neither the U.S. Securities and Exchange Commission
nor any state securities commission has approved or disapproved of these securities, or passed upon the adequacy or accuracy of this prospectus
or any accompanying prospectus supplement. Any representation to the contrary is a criminal offense.
The date of this prospectus is January 30 ,
2024.
TABLE OF CONTENTS
ABOUT THIS PROSPECTUS
This prospectus is part of a registration statement
that we filed with the U.S. Securities and Exchange Commission (“SEC”) using a “shelf” registration process. Under
this shelf registration statement, we may sell from time to time in one or more offerings of common stock and preferred stock, various
series of debt securities and/or warrants to purchase any of such securities, either individually or as units comprised of a combination
of one or more of the other securities in one or more offerings up to a total dollar amount of $25,000,000. This prospectus provides you
with a general description of the securities we may offer. Each time we sell any type or series of securities under this prospectus, we
will provide a prospectus supplement that will contain more specific information about the terms of that offering.
This prospectus does not contain all of the information
included in the registration statement. For a more complete understanding of the offering of the securities, you should refer to the registration
statement, including its exhibits. We may add, update or change, in a prospectus supplement or free writing prospectus, any of the information
contained in this prospectus or in the documents we have incorporated by reference into this prospectus. We may also authorize one or
more free writing prospectuses to be provided to you that may contain material information relating to these offerings. This prospectus,
together with the applicable prospectus supplement, any related free writing prospectus and the documents incorporated by reference into
this prospectus and the applicable prospectus supplement, will include all material information relating to the applicable offering. You
should carefully read both this prospectus and the applicable prospectus supplement and any related free writing prospectus, together
with the additional information described under “Where You Can Find More Information,” before buying any of the securities
being offered.
We have not authorized any dealer, agent or other
person to give any information or to make any representation other than those contained or incorporated by reference in this prospectus,
any accompanying prospectus supplement or any related free writing prospectus that we may authorize to be provided to you. You must not
rely upon any information or representation not contained or incorporated by reference in this prospectus or an accompanying prospectus
supplement, or any related free writing prospectus that we may authorize to be provided to you. This prospectus, the accompanying prospectus
supplement and any related free writing prospectus, if any, do not constitute an offer to sell or the solicitation of an offer to buy
any securities other than the registered securities to which they relate, nor do this prospectus, the accompanying prospectus supplement
or any related free writing prospectus, if any, constitute an offer to sell or the solicitation of an offer to buy securities in any jurisdiction
to any person to whom it is unlawful to make such offer or solicitation in such jurisdiction. You should not assume that the information
contained in this prospectus, any applicable prospectus supplement or any related free writing prospectus is accurate on any date subsequent
to the date set forth on the front of the document or that any information we have incorporated by reference is correct on any date subsequent
to the date of the document incorporated by reference (as our business, financial condition, results of operations and prospects may have
changed since that date), even though this prospectus, any applicable prospectus supplement or any related free writing prospectus is
delivered or securities are sold on a later date.
We further note that the representations, warranties
and covenants made by us in any agreement that is filed as an exhibit to any document that is incorporated by reference in this prospectus
were made solely for the benefit of the parties to such agreement, including, in some cases, for the purpose of allocating risk among
the parties to such agreements, and should not be deemed to be a representation, warranty or covenant to you. Moreover, such representations,
warranties or covenants were accurate only as of the date when made. Accordingly, such representations, warranties and covenants should
not be relied on as accurately representing the current state of our affairs.
This prospectus may not be used to consummate
sales of our securities, unless it is accompanied by a prospectus supplement. To the extent there are inconsistencies between any prospectus
supplement, this prospectus and any documents incorporated by reference, the document with the most recent date will control.
As permitted by the rules and regulations of the
SEC, the registration statement, of which this prospectus forms a part, includes additional information not contained in this prospectus.
You may read the registration statement and the other reports we file with the SEC at the SEC’s web site or at the SEC’s offices
described below under the heading “Where You Can Find More Information.”
Company References
In this prospectus “the Company,”
“we,” “us,” and “our” refer to Silo Pharma, Inc., a Nevada corporation, and its subsidiary, unless
the context otherwise requires.
SUMMARY
Overview
We are a developmental
stage biopharmaceutical company focused on merging traditional therapeutics with psychedelic research. We are committed to developing
innovative solutions to address a variety of underserved conditions. In these uncertain times, the mental health of the nation and
beyond is being put to the test. More than ever, creative new therapies are needed to address the health challenges of today. Combining
our resources with world-class medical research partners, we hope to make significant advances in the medical and psychedelic space.
Rare Disease Therapeutics
We seek to acquire and/or
develop intellectual property or technology rights from leading universities and researchers to treat rare diseases, including the use
of psychedelic drugs, such as psilocybin, and the potential benefits they may have in certain cases involving depression, mental health
issues and neurological disorders. We are focused on merging traditional therapeutics with psychedelic research for people suffering
from indications such as depression, post-traumatic stress disorder (“PTSD”), Parkinson’s, and other rare neurological
disorders. Our mission is to identify assets to license and fund the research which we believe will be transformative to the well-being
of patients and the health care industry.
Psilocybin is considered
a serotonergic hallucinogen and is an active ingredient in some species of mushrooms. Recent industry studies using psychedelics, such
as psilocybin, have been promising, and we believe there is a large unmet need with many people suffering from depression, mental health
issues and neurological disorders. While classified as a Schedule I substance under the Controlled Substances Act (“CSA”),
there is an accumulating body of evidence that psilocybin may have beneficial effects on depression and other mental health conditions.
Therefore, the U.S. Food and Drug Administration (“FDA”) and U.S. Drug Enforcement Agency (“DEA”) have permitted
the use of psilocybin in clinical studies for the treatment of a range of psychiatric conditions.
The potential of psilocybin
therapy in mental health conditions has been demonstrated in a number of academic-sponsored studies over the last decade. In these early
studies, it was observed that psilocybin therapy provided rapid reductions in depression symptoms after a single high dose, with antidepressant
effects lasting for up to at least six months for a number of patients. These studies assessed symptoms related to depression and anxiety
through a number of widely used and validated scales. The data generated by these studies suggest that psilocybin is generally well-tolerated
and may have the potential to treat depression when administered with psychological support.
We have engaged in discussions
with a number of world-renowned educational institutions and advisors regarding potential opportunities and have formed a scientific advisory
board that is intended to help advise management regarding potential acquisition and development of products.
In addition, as more
fully described below, we have entered into a license agreement with the University of Maryland, Baltimore, and have entered into a joint
venture with Zylö Therapeutics, Inc., with respect to certain intellectual property and technology that may be used for targeted
delivery of potential novel treatments. We have also entered into a sponsored research agreement with Columbia University pursuant to
which we have been granted an option to license certain patents and inventions relating to the treatment of Alzheimer’s disease
and stress-induced affective disorders using Ketamine in combination with certain other compounds.
We plan to actively pursue
the acquisition and/or development of intellectual property or technology rights to treat rare diseases, and to ultimately expand our
business to focus on this new line of business.
Our Vendor License
Agreements
Vendor License Agreement
with the University of Maryland, Baltimore for CNS Homing Peptide
On February 12, 2021,
we entered into a Master License Agreement (the “UMB License Agreement”) with the University of Maryland, Baltimore (“UMB”)
pursuant to which UMB granted us an exclusive, worldwide, sublicensable, royalty-bearing license to certain intellectual property (i)
to make, have made, use, sell, offer to sell, and import certain licensed products and (ii) to use the invention titled, “Central
nervous system-homing peptides in vivo and their use for the investigation and treatment of multiple sclerosis and other neuroinflammatory
pathology” (the “Invention”) and UMB’s confidential information to develop and perform certain licensed processes
for the therapeutic treatment of neuroinflammatory disease. The term of the License Agreement shall commence on the UMB Effective Date
and shall continue until the latest of (i) ten years from the date of First Commercial Sale (as defined in the Sublicense Agreement) of
the Licensed Product in such country and (ii) the date of expiration of the last to expire claim of the Patent Rights (as defined in the
UMB License Agreement) covering such Licensed Product in such country, or (iii) the expiration of data protection, new chemical entity,
orphan drug exclusivity, regulatory exclusivity, or other legally enforceable market exclusivity, if applicable, unless terminated earlier
pursuant to the terms of the agreement. Pursuant to the UMB License Agreement, we agreed to pay UMB (i) a license fee of $75,000, (ii)
certain event-based milestone payments, (iii) royalty payments, depending on net revenues, (iv) minimum royalty payments, and (v) a tiered
percentage of sublicense income. The UMB License Agreement will remain in effect until the later of: (a) the last patent covered under
the UMB License Agreement expires, (b) the expiration of data protection, new chemical entity, orphan drug exclusivity, regulatory exclusivity,
or other legally enforceable market exclusivity, if applicable, or (c) ten years after the first commercial sale of a licensed product
in that country, unless earlier terminated in accordance with the provisions of the UMB License Agreement. The term of the UMB License
Agreement shall expire 15 years after the effective date in which (a) there were never any patent rights, (b) there was never any data
protection, new chemical entity, orphan drug exclusivity, regulatory exclusivity, or other legally enforceable market exclusivity or (c)
there was never a first commercial sale of a licensed product.
As described below, we
have entered into an investigator sponsored research agreement with UMB related to a clinical study to examine a novel peptide-guided
drug delivery approach for the treatment of Multiple Sclerosis.
Commercial Evaluation
License and Option Agreement with UMB for Joint Homing Peptide
Effective as of February
26, 2021, we, through our wholly-subsidiary, Silo Pharma, Inc., and University of Maryland, Baltimore (“UMB”), entered into
a commercial evaluation license and option agreement (“License Agreement”), under which we were granted an exclusive, non-sublicensable,
non-transferable license to with respect to the exploration of the potential use of joint-homing peptides for use in the investigation
and treatment of arthritogenic processes. Under the License Agreement, we were also granted an exclusive option to negotiate and obtain
an exclusive, sublicensable, royalty-bearing license (“Exclusive Option”) with respect to the subject technology. The License
Agreement had a term of six months from the effective date. Both parties could have terminated the License Agreement within thirty days
by giving a written notice.
On July 6, 2021, we entered
into a First Amendment Agreement (the “Amended License Agreement”) with UMB to extend the term of the original License Agreement
by an additional six months such that the Amended License Agreement was effective until February 25, 2022. However, if we exercise the
Exclusive Option, the License Agreement shall expire at the end of the negotiation period (as defined in the License Agreement) or upon
execution of a master license agreement, whichever occurs first. We paid a license fee of $10,000 to UMB in March 2021 pursuant to the
License Agreement, which was expensed, since we could not conclude that such costs would be recoverable for this early-stage venture.
On January 28, 2022,
we entered into a second amendment to the License Agreement with UMB dated February 26, 2021 (the “Second Amendment”). The
Second Amendment extended the term of the License Agreement until December 31, 2022. However, if we exercise the Exclusive Option, the
License Agreement shall expire at the end of the negotiation period (as defined in the License Agreement) or upon execution of a master
license agreement, whichever occurs first.
On June 22, 2022, we
entered into a third amendment to the License Agreement with UMB dated February 26, 2021 (the “Third Amendment”) under which
UMB agreed, to expand the scope of the license granted in the CELA to add additional Patent Rights with respect to an invention generally
known as “Peptide-Targeted Liposomal Delivery for Treatment Diagnosis, and Imaging of Diseases and Disorders.”
On December 16, 2022,
we entered into a fourth amendment to License Agreement with UMB dated February 26, 2021 (the “Fourth Amendment”) to extend
the term of the License Agreement until March 31, 2023. In addition, the parties agreed in the Fourth Amendment to allow us to extend
the term of the License Agreement to June 30, 2023 by paying UMB a fee of $1,000 on or before February 28, 2022. This fee was paid and
thus the term of the License Agreement was extended to June 30, 2023.
On June 28, 2023, we
entered into a fifth amendment to License Agreement with UMB dated February 26, 2021 (the “Fifth Amendment”) to extend the
term of the License Agreement until September 30, 2023. We may, at our option, extend this Agreement until December 31, 2023, by providing
written notice to University on or before August 31, 2023, and by paying an additional license fee of $2,500. This fee was paid and the
term of the License Agreement was extended to December 31, 2023.
Joint Venture Agreement
with Zylö Therapeutics, Inc. for Z-pod™ Technology
On April 22, 2021, we
entered into a Joint Venture Agreement with Zylö Therapeutics, Inc. (“ZTI”) pursuant to which we agreed to form a joint
venture entity, to be named Ketamine Joint Venture, LLC, to, among other things, focus on the clinical development of ketamine using ZTI’s
Z-pod™ technology. Pursuant to the Joint Venture Agreement, we shall act as the manager of the Joint Venture. The Venture shall
terminate if the development program does not meet certain specifications and milestones as set forth in the Joint Venture Agreement within
30 days of the date set forth in the Joint Venture Agreement. Notwithstanding the foregoing, the Manager may, in its sole discretion,
terminate the Venture at any time.
Pursuant to the terms
of the Joint Venture Agreement, (A) we shall contribute (1) $225,000 and (2) our expertise and the expertise of its science advisory
board and (B) ZTI shall contribute (1) certain rights to certain of its patented technology as set forth in the JV Agreement, (2) a license
to the know-how and trade secrets with respect to its Z-pod™ technology for the loading and release of ketamine, (3) ketamine to
be used for clinical purposes, (4) reasonable use of its facilities and permits and (5) its expertise and know-how. Pursuant to the Joint
Venture Agreement, 51% of the interest in the Joint Venture shall initially be owned by us and 49% of the interest in the Joint Venture
shall initially be owned by ZTI, subject to adjustment in the event of additional contributions by either party. Notwithstanding the foregoing,
in no event shall either party own more than 60% of the interest in the Joint Venture. As of the date of this Prospectus, the joint venture
entity has not been formed yet.
Furthermore, pursuant
to the terms of the JV Agreement, ZTI shall grant the Joint Venture a sublicense pursuant to its license agreement (the “License
Agreement”) with Albert Einstein College of Medicine dated November 27, 2017, in the event that we or a third party makes a request
indicating that the patented technology (the “Patented Technology”) licensed to ZTI pursuant to the License Agreement is needed
to advance the development of the Joint Venture or it is contemplated or determined that the Patented Technology will be sold. Furthermore,
pursuant to the JV Agreement, ZTI granted us an exclusive option to enter into a separate joint venture for the clinical development of
psilocybin using ZTI’s Z-pod™ technology on the same terms and conditions set forth in the JV Agreement, which option expired
24 months after the JV Effective Date.
Our Investigator-Sponsored
Study Agreements
Sponsored Research
Agreement with Columbia University for the Study of Ketamine in Combination with Other Drugs for Treatment of Alzheimer’s and Depression
Disorders
On October 1, 2021, we
entered into a sponsored research agreement with Columbia University (“Columbia”) pursuant to which Columbia shall conduct
two different studies related to all uses of Ketamine or its metabolites in combination with Prucalopride, one of which is related to
Alzheimer’s and the other of which is related to Depression, PTSD and Stress Projects. In addition, Company has been granted an
option to license certain assets currently under development, including Alzheimer’s disease. The term of the option will commence
on the effective date of this agreement and will expire upon the earlier of (i) 90 days after the date of our receipt of a final research
report for each specific research proposal as defined in the agreement or (ii) termination of the research. If we elect to exercise the
option, both parties will commence negotiation of a license agreement and will execute a license agreement no later than 3 months after
the date of the exercise of the option. Columbia University and we will work towards developing a therapeutic treatment for patients suffering
from Alzheimer’s disease to posttraumatic stress disorder. During a one-year period from the date of this agreement, we shall pay
a total of $1,436,082 to Columbia University for the support of the research according to the payment schedule as follows: (i) 30% at
signing, (ii) 30% at four and half months after the start of the project, (iii) 30% at nine months after the start of the project and,
(iv) 10% at completion of the project. On October 13, 2022, we entered into an amendment of the sponsored research agreement pursuant
to which the parties agreed to extend the payment schedule until March 31, 2024. We paid the first payment of $430,825 in November 2021
and the second payment of $430,825 in July 2022. On October 13, 2022, we entered into an amendment to the Columbia Agreement (the “Columbia
Amendment”), pursuant to which the parties agreed to extend the payment schedule, whereby the third payment of $430,825 was due
in March 2023. In August 2023, we paid $100,000 of this balance and $330,825 of such payment remains unpaid as of September 30, 2023,
which is included in accounts payable on the accompanying unaudited consolidated balance sheet. The remaining payment of $143,607 is due
upon completion. As of September 30, 2023, we estimate that this research project is approximately 90% complete.
Sponsored Research
Agreement with University of Maryland, Baltimore for the Study of Targeted liposomal drug delivery for rheumatoid arthritis
On July 6, 2021, we entered
into a sponsored research agreement (the “July 2021 Sponsored Research Agreement”) with UMB pursuant to which UMB shall evaluate
the pharmacokinetics of dexamethasone delivered to arthritic rats via liposome. The research pursuant to the July 2021 Sponsored
Research Agreement commenced on September 1, 2021 and will continue until the substantial completion thereof, subject to renewal upon
written consent of the parties with a project timeline of twelve months. The July 2021 Sponsored Research Agreement may be terminated
by either party upon 30 days’ prior written notice to the other party. In addition, if either party commits any material breach
of or defaults with respect to any terms or conditions of the July 2021 Sponsored Research Agreement and fails to remedy such default
or breach within 10 business days after written notice from the other party, the party giving notice may terminate the July 2021 Sponsored
Research Agreement as of the date of receipt of such notice by the other party. If we terminate the July 2021 Sponsored Research Agreement
for any reason other than an uncured material breach by UMB, we shall relinquish any and all rights it may have in the Results (as defined
in the July 2021 Sponsored Research Agreement) to UMB. In addition, if the July 2021 Sponsored Research Agreement is terminated early,
we, among other things, will pay all costs incurred and accrued by UMB as of the date of termination. Pursuant to the terms of the July
2021 Sponsored Research Agreement, UMB granted us an option (the “Option”) to negotiate and obtain an exclusive license to
any UMB Arising IP (as defined in the July 2021 Sponsored Research Agreement) and UMB’s rights in any Joint Arising IP (as defined
in the July 2021 Sponsored Research Agreement) (collectively, the “UMB IP”). We may exercise the Option by giving UMB written
notice within 60 days after it receives notice from UMB of the UMB IP. We shall pay total fees of $276,285 as set forth in the July 2021
Sponsored Research Agreement. We paid the first payment of $92,095 on September 1, 2021 and on August 31, 2022, we paid the second payment
of $92,095. On September 30, 2023 and December 31, 2022, we owed UMB $92,095 which was included in accounts payable on the accompanying
unaudited consolidated balance sheets.
Sponsored Research
Agreement with The Regents of the University of California for the Effect of Psilocybin on Inflammation in the Blood
On June 1, 2021, we entered
into a sponsored research agreement (“Sponsored Research Agreement”) with The Regents of the University of California, on
behalf of its San Francisco Campus (“UCSF”) pursuant to which UCSF shall conduct a study to examine psilocybin’s effect
on inflammatory activity in humans to accelerate its implementation as a potential treatment for Parkinson’s Disease, chronic pain,
and bipolar disorder. The purpose of this is to show what effect psilocybin has on inflammation in the blood. We believe that this study
will help support the UMB homing peptide study. Pursuant to the Agreement, we shall pay UCSF a total fee of $342,850 to conduct the research
over the two-year period. The Agreement shall be effective for a period of two years from the effective date, subject to renewal or earlier
termination as set forth in the Sponsored Research Agreement.
Investigator-Sponsored
Study Agreement with UMB for CNS Homing Peptide
On January 5, 2021, we
entered into an investigator-sponsored study agreement with UMB. The research project is a clinical study to examine a novel peptide-guided
drug delivery approach for the treatment of Multiple Sclerosis (“MS”). More specifically, the study is designed to evaluate
(1) whether MS-1-displaying liposomes can effectively deliver dexamethasone to the central nervous system and (2) whether MS-1-displaying
liposomes are superior to plain liposomes, also known as free drug, in inhibiting the relapses and progression of Experimental Autoimmune
Encephalomyelitis. Pursuant to the agreement, the research commenced on March 1, 2021 and will continue until substantial completion,
subject to renewal upon mutual written consent of the parties. The total cost under the investigator-sponsored study agreement shall
not exceed $81,474 which is payable in two equal installments of $40,737 upon execution of the Sponsored Study Agreement and $40,737 upon
completion of the project with an estimated project timeline of nine months. We paid $40,737 on January 13, 2021. This project is postponed
until further notice and the second payment is not due.
Other License Agreements
Customer Patent License
Agreement with Aikido Pharma Inc.
On January 5, 2021, we
entered into a Patent License Agreement (the “Aikido License Agreement”) with our wholly-owned subsidiary, Silo Pharma, Inc.,
and Aikido Pharma Inc. (“Aikido”) pursuant to which we granted Aikido an exclusive, worldwide, sublicensable, royalty-bearing
license to certain intellectual property (i) to make, have made, use, provide, import, export, lease, distribute, sell, offer for sale,
develop and advertise certain licensed products and (ii) to develop and perform certain licensed processes for the treatment of cancer
and symptoms caused by cancer. The Aikido License Agreement relates to the rights which we had obtained under the UMB Option Agreement.
Pursuant to the Aikido License Agreement, we agreed that if we exercised the UMB Option, we would grant Aikido a non-exclusive sublicense
to certain UMB patent rights in the field of neuroinflammatory diseases occurring in patients diagnosed with cancer. The UMB Option was
exercised on January 13, 2021. Accordingly, on April 6, 2021, we entered into a sublicense agreement with Aikido pursuant to which we
granted Aikido a worldwide exclusive sublicense to our licensed patents under the UMB License Agreement (see below “Sublicense with
Aikido Pharma Inc.”).
Customer Sublicense
Agreement with Aikido Pharma Inc.
On April 6, 2021 (“Effective Date”),
we entered into a sublicense agreement (the “Sublicense Agreement”) with Aikido pursuant to which we granted Aikido an exclusive
worldwide sublicense to (i) make, have made, use, sell, offer to sell and import the Licensed Products (as defined below) and (ii) in
connection therewith to (A) use the Invention that was sublicensed to us pursuant to the UMB License Agreement and (B) practice certain
patent rights as set forth in the Sublicense Agreement (the “Patent Rights”) for the therapeutic treatment of neuroinflammatory
disease in cancer patients. “Licensed Products” means any product, service, or process, the development, making, use, offer
for sale, sale, importation, or providing of which: (i) is covered by one or more claims of the Patent Rights; or (ii) contains, comprises,
utilizes, incorporates, or is derived from the Invention or any technology disclosed in the Patent Rights. Pursuant to the Sublicense
Agreement, Aikido shall agree to pay us (i) an upfront license fee of $50,000, (ii) the same sales-based royalty payments that we
are subject to under the UMB License Agreement and (iii) total milestone payments of up to $1.9 million. The Sublicense Agreement shall
continue on a Licensed Product-by-Licensed Product and country-by-country basis until the later of (i) the date of expiration of the last
to expire claim of the Patent Rights covering such Licensed Product in such country, (ii) the expiration of data protection, new chemical
entity, orphan drug exclusivity, regulatory exclusivity or other legally enforceable market exclusivity, if applicable and (iii) 10 years
after the first commercial sale of a Licensed Product in that country, unless terminated earlier pursuant to the terms of the Sublicense
Agreement. Furthermore, the Sublicense Agreement shall expire 15 years after the Effective Date with respect to any country in which (i)
there were never any Patent Rights, (ii) there was never any data protection, new chemical entity, orphan drug exclusivity, regulatory
exclusivity or other legally enforceable market exclusivity with respect to a Licensed Product and (ii) there was never a commercial sale
of a Licensed Product, unless such agreement is earlier terminated pursuant to its terms. We collected the upfront license fee of $50,000
in April 2021.
Risks Associated with Our Business
Our ability to execute on our business strategy
is subject to a number of risks, which are discussed more fully in the section titled “Risk Factors.” Investors should carefully
consider these risks before making an investment in our common stock. These risks include, among others, the following:
Risk Related to our Financial Position and Need for Capital
| ● | We
have only a limited history upon which an evaluation of our prospects and future performance can be made and have no history of profitable
operations. |
| ● | We
will require additional financing in the future to fund our operations, and. |
| ● | Raising
additional capital may cause dilution to holders of our stockholders, restrict our operations or require us to relinquish certain rights. |
Risk Related to Product Development, Regulatory
Approval, Manufacturing and Commercialization
| ● | Clinical
drug development is a lengthy and expensive process with uncertain timelines and uncertain outcomes. If clinical trials of any future
therapeutic candidates are prolonged or delayed, we or our current or future collaborators may be unable to obtain required regulatory
approvals, and therefore we will be unable to commercialize our future therapeutic candidates on a timely basis or at all, which will
adversely affect our business. |
| ● | Any
therapeutic candidates we may develop in the future may be subject to controlled substance laws and regulations in the territories where
the product will be marketed, and failure to comply with these laws and regulations, or the cost of compliance with these laws and regulations,
may adversely affect the results of our business operations and our financial condition. |
| ● | Psilocybin
and psilocin are listed as Schedule I controlled substances under the Controlled Substances Act in the U.S., and similar controlled substance
legislation in other countries and any significant breaches in our compliance with these laws and regulations, or changes in the laws
and regulations may result in interruptions to our development activity or business continuity |
| ● | Our
product candidates may contain controlled substances, the use of which may generate public controversy. Adverse publicity or public perception
regarding psilocybin or our current or future investigational therapies using psilocybin may negatively influence the success of these
therapies. |
| ● | Even
if any of our future therapeutic candidates obtain regulatory approval, we will be subject to ongoing obligations and continued regulatory
review, which may result in significant additional expense or penalties if we fail to comply with regulatory requirements or experience
unanticipated problems with any of our future therapeutic candidates. |
| ● | We
will depend on enrollment of patients in our clinical trials for our future therapeutic candidates. If we are unable to enroll patients
in our clinical trials, our research and development efforts and business, financial condition and results of operations could be materially
adversely affected. |
| ● | We
have never commercialized a therapeutic candidate before and may lack the necessary expertise, personnel and resources to successfully
commercialize our therapies on our own or with suitable collaborators. |
| ● | The
future commercial success of our future therapeutic candidates will depend on the degree of market access and acceptance of our potential
therapies among healthcare professionals, patients, healthcare payors, health technology assessment bodies and the medical community
at large. |
| ● | We
may become exposed to costly and damaging liability claims, and our product liability insurance may not cover all damages from such claims. |
| ● | Enacted
and future legislation may increase the difficulty and cost for us to obtain marketing approval of and commercialize any of our future
therapeutic candidates and could have a material adverse effect on our business. |
| ● | Our
business operations and current and future relationships with investigators, health care professionals, consultants, third-party payors
and customers may be subject, directly or indirectly, to U.S. federal and state healthcare fraud and abuse laws, false claims laws, health
information privacy and security laws, other healthcare laws and regulations and other foreign privacy and security laws. If we are unable
to comply, or have not fully complied, with such laws, we could face substantial penalties. |
Risk Relating to our Intellectual Property
Rights
| ● | The
failure to obtain or maintain patents, licensing agreements and other intellectual property could materially impact our ability to compete
effectively. |
| ● | If
we are unable to obtain and maintain patent protection for our products, or if the scope of the patent protection obtained is not sufficiently
broad, competitors could develop and commercialize products similar or identical to ours, and our ability to successfully commercialize
our products could be impaired. |
| ● | If
we fail to comply with our obligations in the agreements under which we may license intellectual property rights from third parties or
otherwise experience disruptions to our business relationships with our licensors, we could lose rights that are important to our business. |
Risks Related to our Securities
| ● | We
have never paid cash dividends and have no plans to pay cash dividends in the future. |
| ● | Our
compliance with complicated U.S. regulations concerning corporate governance and public disclosure is expensive and diverts management’s
attention from our core business, which could adversely affect our business, results of operations, and financial condition. |
| ● | Market
and economic conditions may negatively impact our business, financial condition and share price. |
| ● | Future
sales and issuances of our securities could result in additional dilution of the percentage ownership of our shareholders and could cause
our share price to fall. |
| ● | Failure
to maintain effective internal control over our financial reporting in accordance with Section 404 of the Sarbanes-Oxley Act could cause
our financial reports to be inaccurate.. |
| ● | Nasdaq
Capital Market may subsequently delist our common stock if we fail to comply with ongoing listing standards. |
Corporate History and Information
We were incorporated as in the State of New York
on July 13, 2010. On January 24, 2013, we changed our state of incorporation from New York to Delaware. On December 19, 2023, we changed
our state of incorporation from Delaware to Nevada. Our principal executive offices are located at 677 N Washington Boulevard, Sarasota,
Florida 34236. and our telephone number is (718) 400-9031. Our website address is www.silopharma.com. The information contained
on our website is not incorporated by reference into this prospectus, and you should not consider any information contained on, or that
can be accessed through, our website as part of this prospectus or in deciding whether to purchase our securities.
The Securities We May Offer
We may offer shares of our common stock and preferred
stock, various series of debt securities and warrants to purchase any of such securities, either individually or in units, from time to
time under this prospectus, together with any applicable prospectus supplement and related free writing prospectus, at prices and on terms
to be determined by market conditions at the time of offering. If we issue any debt securities at a discount from their original stated
principal amount, then, for purposes of calculating the total dollar amount of all securities issued under this prospectus, we will treat
the initial offering price of the debt securities as the total original principal amount of the debt securities. Each time we offer securities
under this prospectus, we will provide offerees with a prospectus supplement that will describe the specific amounts, prices and other
important terms of the securities being offered, including, to the extent applicable:
| ● | designation
or classification; |
| ● | aggregate
principal amount or aggregate offering price; |
| ● | maturity,
if applicable; |
| ● | original
issue discount, if any; |
| ● | rates
and times of payment of interest or dividends, if any; |
| ● | redemption,
conversion, exchange or sinking fund terms, if any; |
| ● | conversion
or exchange prices or rates, if any, and, if applicable, any provisions for changes to or adjustments in the conversion or exchange prices
or rates and in the securities or other property receivable upon conversion or exchange; |
| ● | restrictive
covenants, if any; |
| ● | voting
or other rights, if any; and |
| ● | important
United States federal income tax considerations. |
A prospectus supplement and any related free writing
prospectus that we may authorize to be provided to you may also add, update, or change information contained in this prospectus or in
documents we have incorporated by reference. However, no prospectus supplement or free writing prospectus will offer a security that is
not registered and described in this prospectus at the time of the effectiveness of the registration statement of which this prospectus
is a part.
We may sell the securities to or through underwriters,
dealers or agents or directly to purchasers. We, as well as any agents acting on our behalf, reserve the sole right to accept and to reject
in whole or in part any proposed purchase of securities. Each prospectus supplement will set forth the names of any underwriters, dealers
or agents involved in the sale of securities described in that prospectus supplement and any applicable fee, commission or discount arrangements
with them, details regarding any over-allotment option granted to them, and net proceeds to us. The following is a summary of the securities
we may offer with this prospectus.
Common Stock
We currently have authorized 100,000,000 shares
of common stock, par value $0.0001 per share. As of January 23, 2024, 2,886,001 shares of our common stock were outstanding (273,095 shares
held in treasury). We may offer shares of our common stock either alone or underlying other registered securities convertible into or
exercisable for our common stock. Holders of our common stock are entitled to such dividends as our board of directors (the “Board
of Directors” or “Board”) may declare from time to time out of legally available funds, subject to the preferential
rights of the holders of any shares of our preferred stock that are outstanding or that we may issue in the future. Currently, we do not
pay any dividends on our common stock. Each holder of our common stock is entitled to one vote per share held on all matters submitted
to a vote of our shareholders. In this prospectus, we provide a general description of, among other things, the rights and restrictions
that apply to holders of our common stock.
Preferred Stock
We currently have authorized 5,000,000 shares
of preferred stock, par value $0.0001, none of which are issued and outstanding.
Any authorized and undesignated shares of preferred
stock may be issued from time to time in one or more series pursuant to a resolution or resolutions providing for such issue duly adopted
by our Board of Directors (authority to do so being hereby expressly vested in the Board of Directors). The Board of Directors is further
authorized, subject to limitations prescribed by law, to fix by resolution or resolutions the designations, powers, preferences and rights,
and the qualifications, limitations or restrictions thereof, of any wholly unissued series of preferred stock, including, without limitation,
authority to fix by resolution or resolutions the dividend rights, dividend rate, conversion rights, voting rights, rights and terms of
redemption (including sinking fund provisions), redemption price or prices, and liquidation preferences of any such series, and the number
of shares constituting any such series and the designation thereof, or any of the foregoing.
The rights, preferences, privileges, and restrictions
granted to or imposed upon any series of preferred stock that we offer and sell under this prospectus and applicable prospectus supplements
will be set forth in a certificate of designation relating to the series. We will incorporate by reference into the registration statement
of which this prospectus is a part the form of any certificate of designation that describes the terms of the series of preferred stock
we are offering before the issuance of shares of that series of preferred stock. You should read any prospectus supplement and any free
writing prospectus that we may authorize to be provided to you related to the series of preferred stock being offered, as well as the
complete certificate of designation that contains the terms of the applicable series of preferred stock.
Debt Securities
We may offer general debt obligations, which may
be secured or unsecured, senior or subordinated, and convertible into shares of our common stock or preferred stock. In this prospectus,
we refer to the senior debt securities and the subordinated debt securities together as the “debt securities.” We may issue
debt securities under a note purchase agreement or under an indenture to be entered between us and a trustee. The indentures do not limit
the amount of securities that may be issued under them and provide that debt securities may be issued in one or more series. The senior
debt securities will have the same rank as all of our other indebtedness that is not subordinated. The subordinated debt securities will
be subordinated to our senior debt on terms set forth in the applicable prospectus supplement. In addition, the subordinated debt securities
will be effectively subordinated to creditors and preferred shareholders of our subsidiaries. Our Board of Directors will determine the
terms of each series of debt securities being offered. This prospectus contains only general terms and provisions of the debt securities.
The applicable prospectus supplement will describe the particular terms of the debt securities offered thereby. You should read any prospectus
supplement and any free writing prospectus that we may authorize to be provided to you related to the series of debt securities being
offered, as well as the complete note agreements and/or indentures that contain the terms of the debt securities. The forms of senior
and subordinated indentures have been filed as exhibits to the registration statement of which this prospectus is a part, and supplemental
indentures and forms of debt securities containing the terms of debt securities being offered will be incorporated by reference into the
registration statement of which this prospectus is a part from reports we file with the SEC.
Warrants
We may offer warrants for the purchase of shares
of our common stock or preferred stock or of debt securities. We may issue the warrants by themselves or together with common stock, preferred
stock or debt securities, and the warrants may be attached to or separate from any offered securities. Any warrants issued under this
prospectus may be evidenced by warrant certificates. Warrants may be issued under a separate warrant agreement to be entered into between
us and the investors or a warrant agent. Our Board of Directors will determine the terms of the warrants. This prospectus contains only
general terms and provisions of the warrants. The applicable prospectus supplement will describe the particular terms of the warrants
being offered thereby. You should read any prospectus supplement and any free writing prospectus that we may authorize to be provided
to you related to the series of warrants being offered, as well as the complete warrant agreements that contain the terms of the warrants.
Specific warrant agreements will contain additional important terms and provisions and will be incorporated by reference into the registration
statement of which this prospectus is a part from reports we file with the SEC.
Units
We may offer units consisting of our common stock
or preferred stock, debt securities and/or warrants to purchase any of these securities in one or more series. We may evidence each series
of units by unit certificates that we will issue under a separate agreement. We may enter into unit agreements with a unit agent. Each
unit agent will be a bank or trust company that we select. We will indicate the name and address of the unit agent in the applicable prospectus
supplement relating to a particular series of units. This prospectus contains only a summary of certain general features of the units.
The applicable prospectus supplement will describe the particular features of the units being offered thereby. You should read any prospectus
supplement and any free writing prospectus that we may authorize to be provided to you related to the series of units being offered, as
well as the complete unit agreements that contain the terms of the units. Specific unit agreements will contain additional important terms
and provisions and will be incorporated by reference into the registration statement of which this prospectus is a part from reports we
file with the SEC.
RISK FACTORS
An investment in our securities involves a high
degree of risk. This prospectus contains, and the prospectus supplement applicable to each offering of our securities will contain, a
discussion of the risks applicable to an investment in our securities. Prior to making a decision about investing in our securities, you
should carefully consider the specific factors discussed under the heading “Risk Factors” in this prospectus and the applicable
prospectus supplement, together with all of the other information contained or incorporated by reference in the prospectus supplement
or appearing or incorporated by reference in this prospectus. You should also consider the risks, uncertainties and assumptions discussed
under Item 1A, “Risk Factors,” in our Annual Report on Form 10-K for the fiscal year ended December 31, 2022, filed with the
SEC on March 24, 2023, and incorporated herein by reference, as may be amended, supplemented or superseded from time to time by other
reports we file with the SEC in the future and any prospectus supplement related to a particular offering. The risks and uncertainties
we have described are not the only ones we face. Additional risks and uncertainties not presently known to us or that we currently deem
immaterial may also affect our operations. The occurrence of any of these known or unknown risks might cause you to lose all or part of
your investment in the offered securities.
DISCLOSURE REGARDING FORWARD-LOOKING STATEMENTS
This prospectus, any accompanying prospectus supplement,
any related free writing prospectus and the documents incorporated by reference herein or therein contain, in addition to historical information,
certain forward-looking statements within the meaning of Section 27A of the Securities Act or 1933, as amended (the “Securities
Act”), and Section 21E of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), that include information
relating to future events, future financial performance, strategies, expectations, competitive environment, regulatory environment and
availability of resources. Such forward-looking statements include those that express plans, anticipation, intent, contingency, goals,
targets or future development and/or otherwise are not statements of historical fact. These forward-looking statements are based on our
current expectations and projections about future events and they are subject to risks and uncertainties known and unknown that could
cause actual results and developments to differ materially from those expressed or implied in such statements.
In some cases, you can identify forward-looking
statements by terminology, such as “expects,” “anticipates,” “intends,” “estimates,” “plans,”
“believes,” “seeks,” “may,” “should”, “could” or the negative of such terms
or other similar expressions. Accordingly, these statements involve estimates, assumptions and uncertainties that could cause actual results
to differ materially from those expressed in them. Any forward-looking statements are qualified in their entirety by reference to the
factors discussed throughout this prospectus, any accompanying prospectus supplement or incorporated herein by reference.
Risks, uncertainties and other factors that may
cause our actual results, performance or achievements to be different from those expressed or implied in our written or oral forward-looking
statements may be found in this prospectus and any accompanying prospectus supplement under the heading “Risk Factors” and
in our Annual Report on Form 10-K for the year ended December 31, 2022 under the headings “Risk Factors” and “Business,”
as may be amended, supplemented or superseded from time to time by other reports we file with the SEC in the future and any prospectus
supplement related to a particular offering.
Forward-looking statements speak only as of the
date they are made. You should not put undue reliance on any forward-looking statements. We assume no obligation to update forward-looking
statements to reflect actual results, changes in assumptions or changes in other factors affecting forward-looking information, except
to the extent required by applicable securities laws. If we do update one or more forward-looking statements, no inference should be drawn
that we will make additional updates with respect to those or other forward-looking statements.
New factors emerge from time to time, and it is
not possible for us to predict which factors will arise. In addition, we cannot assess the impact of each factor on our business or the
extent to which any factor, or combination of factors, may cause actual results to differ materially from those contained in any forward-looking
statements. We qualify all of the information presented in this prospectus, any accompanying prospectus supplement and incorporated herein
by reference, and particularly our forward-looking statements, by these cautionary statements.
USE OF PROCEEDS
Except as described in any prospectus supplement
and any free writing prospectus in connection with a specific offering, we currently intend to use the net proceeds from the sale of the
securities offered under this prospectus for general corporate purposes, including the development and commercialization of our products,
research and development, general and administrative expenses, license or technology acquisitions, and working capital and capital expenditures.
We may also use the net proceeds to invest in or acquire complementary businesses, products, or technologies, although we have no current
commitments or agreements with respect to any such investments or acquisitions as of the date of this prospectus. We have not determined
the amount of net proceeds to be used specifically for the foregoing purposes. As a result, our management will have broad discretion
in the allocation of the net proceeds and investors will be relying on the judgment of our management regarding the application of the
proceeds of any sale of the securities.
Each time we offer securities under this prospectus,
we will describe the intended use of the net proceeds from that offering in the applicable prospectus supplement. The actual amount of
net proceeds we spend on a particular use will depend on many factors, including, our future capital expenditures, the amount of cash
required by our operations, and our future revenue growth, if any. Therefore, we will retain broad discretion in the use of the net proceeds.
DESCRIPTION OF CAPITAL STOCK
General
The following description of our capital stock,
together with any additional information we include in any applicable prospectus supplement or any related free writing prospectus, summarizes
the material terms and provisions of our common stock and the preferred stock that we may offer under this prospectus. While the terms
we have summarized below will apply generally to any future common stock or preferred stock that we may offer, we will describe the particular
terms of any class or series of these securities in more detail in the applicable prospectus supplement. For the complete terms of our
common stock and preferred stock, please refer to our Articles of Incorporation, as amended, and our Bylaws, as amended, are incorporated
by reference into the registration statement of which this prospectus is a part or may be incorporated by reference in this prospectus
or any applicable prospectus supplement. The terms of these securities may also be affected by the Nevada Revised Statutes. The summary
below and that contained in any applicable prospectus supplement or any related free writing prospectus are qualified in their entirety
by reference to our Articles of Incorporation and our Bylaws.
As of the date of this prospectus, our authorized
capital stock consisted of 100,000,000 shares of common stock, $0.0001 par value per share, and 5,000,000 shares of preferred stock, $0.0001
par value per share. Our Board may establish the rights and preferences of the preferred stock from time to time. As of January 23, 2024,
there were 2,886,001 shares of our common stock outstanding (273,095 shares held in treasury) and no shares of our preferred stock outstanding.
Common Stock
Holders of our common stock are entitled to one
vote per share on all matters voted on by our shareholders, including the election of directors. Our Articles of Incorporation and Bylaws
do not provide for cumulative voting in the election of directors. Holders of our common stock are entitled, subject to the rights, privileges,
restrictions and conditions attaching to any other class of shares ranking in priority to our common stock, to receive any dividend declared
by our Board of Directors. If we are voluntarily or involuntarily liquidated, dissolved or wound-up, the holders of our common stock will
be entitled to receive, after distribution in full of the preferential amounts, if any, all of the remaining assets available for distribution
ratably in proportion to the number of shares of our common stock held by them.
Preferred Stock
Our Board of Directors has the authority, without
further action by our shareholders, to issue up to 5,000,000 shares of preferred stock in one or more series and to fix the designations,
powers, preferences, privileges, and relative participating, optional, or special rights as well as the qualifications, limitations, or
restrictions of the preferred stock, including dividend rights, conversion rights, voting rights, terms of redemption, and liquidation
preferences, any or all of which may be greater than the rights of the common stock. Our Board of Directors, without shareholder approval,
can issue preferred stock with voting, conversion, or other rights that could adversely affect the voting power and other rights of the
holders of common stock. Preferred stock could be issued quickly with terms calculated to delay or prevent a change of control or make
removal of management more difficult. Additionally, the issuance of preferred stock may have the effect of decreasing the market price
of our common stock, and may adversely affect the voting and other rights of the holders of common stock. At present, we have no plans
to issue any shares of preferred stock following this offering.
Applicable Anti-Takeover Law
Set forth below is a summary of the provisions
of our Articles of Incorporation and Bylaws that could have the effect of delaying or preventing a change in control of our Company. The
following description is only a summary, and it is qualified by reference to the Articles of Incorporation, Bylaws and relevant provisions
of the Nevada Revised Statutes.
Board of Directors Vacancies
Our Bylaws authorize only our Board of Directors
to fill vacant directorships. In addition, the number of directors constituting our Board of Directors may be set only by resolution of
the majority of the incumbent directors.
Special Meeting of Shareholders
Our Bylaws provide that special meetings of our
shareholders may be called by our president, our Board of Directors or a committee of our Board of Directors that has been duly designated
by our Board of Directors and whose powers and authority include the power to call such meetings.
Advance Notice Requirements for Shareholder
Proposals and Director Nominations
Our Bylaws provide that shareholders seeking to
bring business before our annual meeting of shareholders, or to nominate candidates for election as directors at our annual meeting of
shareholders, must provide timely notice of their intent in writing. To be timely, a shareholder’s notice must be delivered to our
secretary at our principal executive offices not later than the close of business on the 90th day nor earlier than the close of business
on the 120th day prior to the first anniversary of the preceding year’s annual meeting; provided, however, that in the event
the date of the annual meeting is not within 25 days before or after such anniversary date, notice by the shareholder to be timely must
be so delivered not later than the close of business on the 10th day following the day on which such notice of the date
of annual meeting was mailed or public disclosure of the date of the annual meeting was made, whichever occurs first. These provisions
may preclude our shareholders from bringing matters before our annual meeting of shareholders or from making nominations for directors
at our annual meeting of shareholders.
Authorized but Unissued Share
Our authorized but unissued shares of common stock
and preferred stock are available for future issuance without shareholder approval and may be utilized for a variety of corporate purposes,
including future public offerings to raise additional capital, corporate acquisitions and employee benefit plans. The existence of authorized
but unissued and unreserved common stock and preferred stock could render more difficult or discourage an attempt to obtain control of
our Company by means of a proxy contest, tender offer, merger or otherwise.
Mandatory Forum
Our Articles of Incorporation provide to the fullest
extent permitted by law, and unless we consent in writing to the selection of an alternative forum, the Eighth Judicial District Court
of Clark County, Nevada, shall be the sole and exclusive forum for each of the following: (a) any derivative action or proceeding brought
in the name or right of the corporation or on its behalf, (b) any action asserting a claim for breach of any fiduciary duty owed by any
director, officer, employee or agent of the corporation to the corporation or the corporation’s stockholders, (c) any action arising
or asserting a claim arising pursuant to any provision of the NRS Chapters 78 or 92A or any provision of these Articles of Incorporation
or the bylaws of the corporation or (d) any action asserting a claim governed by the internal affairs doctrine, including, without limitation,
any action to interpret, apply, enforce or determine the validity of our Articles of Incorporation or our bylaws. Any person or entity
purchasing or otherwise acquiring any interest in shares of our capital stock shall be deemed to have notice of and consented to these
provisions. The enforceability of similar exclusive forum provisions in other corporations’ bylaws has been challenged in legal
proceedings, and it is possible that a court could rule that this provision in our Bylaws is inapplicable or unenforceable.
Listing
Our common stock is listed on The Nasdaq Capital
Market under the trading symbol “SILO.”
Transfer Agent and Registrar
Our transfer agent and registrar is West Coast
Stock Transfer, Inc., located at 721 N. Vulcan Ave. Suite 106 Encinitas, CA 92024.
DESCRIPTION OF DEBT SECURITIES
The following description, together with the additional
information we include in any applicable prospectus supplements or free writing prospectuses, summarizes the material terms and provisions
of the debt securities that we may offer under this prospectus. We may issue debt securities, in one or more series, as either senior
or subordinated debt or as senior or subordinated convertible debt. While the terms we have summarized below will apply generally to any
future debt securities we may offer under this prospectus, we will describe the particular terms of any debt securities that we may offer
in more detail in the applicable prospectus supplement or free writing prospectus. The terms of any debt securities we offer under a prospectus
supplement may differ from the terms we describe below. However, no prospectus supplement shall fundamentally change the terms that are
set forth in this prospectus or offer a security that is not registered and described in this prospectus at the time of its effectiveness.
As of the date of this prospectus, we have no outstanding registered debt securities. Unless the context requires otherwise, whenever
we refer to the “indentures,” we also are referring to any supplemental indentures that specify the terms of a particular
series of debt securities.
We will issue any senior debt securities under
the senior indenture that we will enter into with the trustee named in the senior indenture. We will issue any subordinated debt securities
under the subordinated indenture and any supplemental indentures that we will enter into with the trustee named in the subordinated indenture.
We have filed forms of these documents as exhibits to the registration statement, of which this prospectus is a part, and supplemental
indentures and forms of debt securities containing the terms of the debt securities being offered will be filed as exhibits to the registration
statement of which this prospectus is a part or will be incorporated by reference from reports that we file with the SEC.
The indentures will be qualified under the Trust
Indenture Act of 1939, as amended (the “Trust Indenture Act”). We use the term “trustee” to refer to either the
trustee under the senior indenture or the trustee under the subordinated indenture, as applicable.
The following summaries of material provisions
of the senior debt securities, the subordinated debt securities and the indentures are subject to, and qualified in their entirety by
reference to, all of the provisions of the indenture and any supplemental indentures applicable to a particular series of debt securities.
We urge you to read the applicable prospectus supplements and any related free writing prospectuses related to the debt securities that
we may offer under this prospectus, as well as the complete indentures that contains the terms of the debt securities. Except as we may
otherwise indicate, the terms of the senior indenture and the subordinated indenture are identical.
General
The terms of each series of debt securities will
be established by or pursuant to a resolution of our Board of Directors and set forth or determined in the manner provided in an officers’
certificate or by a supplemental indenture. Debt securities may be issued in separate series without limitation as to aggregate principal
amount. We may specify a maximum aggregate principal amount for the debt securities of any series. We will describe in the applicable
prospectus supplement the terms of the series of debt securities being offered, including:
| ● | the
principal amount being offered, and if a series, the total amount authorized and the total amount outstanding; |
| ● | any
limit on the amount that may be issued; |
| ● | whether
or not we will issue the series of debt securities in global form, and, if so, the terms and who the depositary will be; |
| ● | whether
and under what circumstances, if any, we will pay additional amounts on any debt securities held by a person who is not a United States
person for tax purposes, and whether we can redeem the debt securities if we have to pay such additional amounts; |
| ● | the
annual interest rate, which may be fixed or variable, or the method for determining the rate and the date interest will begin to accrue,
the dates interest will be payable and the regular record dates for interest payment dates or the method for determining such dates; |
| ● | whether
or not the debt securities will be secured or unsecured, and the terms of any secured debt; |
| ● | the
terms of the subordination of any series of subordinated debt; |
| ● | the
place where payments will be made; |
| ● | restrictions
on transfer, sale or other assignment, if any; |
| ● | our
right, if any, to defer payment of interest and the maximum length of any such deferral period; |
| ● | the
date, if any, after which, and the price at which, we may, at our option, redeem the series of debt securities pursuant to any optional
or provisional redemption provisions and the terms of those redemption provisions; |
| ● | provisions
for a sinking fund purchase or other analogous fund, if any, including the date, if any, on which, and the price at which we are obligated,
pursuant thereto or otherwise, to redeem, or at the holder’s option, to purchase, the series of debt securities and the currency
or currency unit in which the debt securities are payable; |
| ● | whether
the indenture will restrict our ability or the ability of our subsidiaries, if any, to: |
| ● | incur
additional indebtedness; |
| ● | issue
additional securities; |
| ● | pay
dividends or make distributions in respect of our capital stock or the capital stock of our subsidiaries; |
| ● | place
restrictions on our subsidiaries’ ability to pay dividends, make distributions or transfer assets; |
| ● | make
investments or other restricted payments; |
| ● | sell
or otherwise dispose of assets; |
| ● | enter
into sale-leaseback transactions; |
| ● | engage
in transactions with shareholders or affiliates; |
| ● | issue
or sell stock of our subsidiaries; or |
| ● | effect
a consolidation or merger; |
| ● | whether
the indenture will require us to maintain any interest coverage, fixed charge, cash flow-based, asset-based or other financial ratios; |
| ● | a
discussion of certain material or special United States federal income tax considerations applicable to the debt securities; |
| ● | information
describing any book-entry features; |
| ● | the
applicability of the provisions in the indenture on discharge; |
| ● | whether
the debt securities are to be offered at a price such that they will be deemed to be offered at an “original issue discount”
as defined in paragraph (a) of Section 1273 of the Internal Revenue Code of 1986, as amended; |
| ● | the
denominations in which we will issue the series of debt securities, if other than denominations of $1,000 and any integral multiple thereof; |
| ● | the
currency of payment of debt securities if other than U.S. dollars and the manner of determining the equivalent amount in U.S. dollars;
and |
| ● | any
other specific terms, preferences, rights or limitations of, or restrictions on, the debt securities, including any additional events
of default or covenants provided with respect to the debt securities, and any terms that may be required by us or advisable under applicable
laws or regulations. |
Conversion or Exchange Rights
We will set forth in the applicable prospectus
supplement the terms under which a series of debt securities may be convertible into or exchangeable for our common stock, our preferred
stock or other securities (including securities of a third party). We will include provisions as to whether conversion or exchange is
mandatory, at the option of the holder or at our option. We may include provisions pursuant to which the number of shares of our common
stock, our preferred stock or other securities (including securities of a third party) that the holders of the series of debt securities
receive would be subject to adjustment.
Consolidation, Merger or Sale
Unless we provide otherwise in the prospectus
supplement applicable to a particular series of debt securities, the indentures will not contain any covenant that restricts our ability
to merge or consolidate, or sell, convey, transfer or otherwise dispose of all or substantially all of our assets. However, any successor
to or acquirer of such assets must assume all of our obligations under the indentures or the debt securities, as appropriate. If the debt
securities are convertible into or exchangeable for our other securities or securities of other entities, the person with whom we consolidate
or merge or to whom we sell all of our property must make provisions for the conversion of the debt securities into securities that the
holders of the debt securities would have received if they had converted the debt securities before the consolidation, merger or sale.
Events of Default under the Indenture
Unless we provide otherwise in the prospectus
supplement applicable to a particular series of debt securities, the following are events of default under the indentures with respect
to any series of debt securities that we may issue:
| ● | if
we fail to pay interest when due and payable and our failure continues for 90 days and the time for payment has not been extended; |
| ● | if
we fail to pay the principal, premium or sinking fund payment, if any, when due and payable at maturity, upon redemption or repurchase
or otherwise, and the time for payment has not been extended; |
| ● | if
we fail to observe or perform any other covenant contained in the debt securities or the indentures, other than a covenant specifically
relating to another series of debt securities, and our failure continues for 90 days after we receive notice from the trustee or we and
the trustee receive notice from the holders of at least 25% in aggregate principal amount of the outstanding debt securities of the applicable
series; and |
| ● | if
specified events of bankruptcy, insolvency or reorganization occur. |
We will describe in each applicable prospectus
supplement any additional events of default relating to the relevant series of debt securities.
If an event of default with respect to debt securities
of any series occurs and is continuing, other than an event of default specified in the last bullet point above, the trustee or the holders
of at least 25% in aggregate principal amount of the outstanding debt securities of that series, by notice to us in writing, and to the
trustee if notice is given by such holders, may declare the unpaid principal, premium, if any, and accrued interest, if any, due and payable
immediately. If an event of default arises due to the occurrence of certain specified bankruptcy, insolvency or reorganization events,
the unpaid principal, premium, if any, and accrued interest, if any, of each issue of debt securities then outstanding shall be due and
payable without any notice or other action on the part of the trustee or any holder.
The holders of a majority in principal amount
of the outstanding debt securities of an affected series may waive any default or event of default with respect to the series and its
consequences, except defaults or events of default regarding payment of principal, premium, if any, or interest, unless we have cured
the default or event of default in accordance with the indenture. Any waiver shall cure the default or event of default.
Subject to the terms of the indentures, if an
event of default under an indenture shall occur and be continuing, the trustee will be under no obligation to exercise any of its rights
or powers under such indenture at the request or direction of any of the holders of the applicable series of debt securities, unless such
holders have offered the trustee reasonable indemnity or security satisfactory to it against any loss, liability or expense. The holders
of a majority in principal amount of the outstanding debt securities of any series will have the right to direct the time, method and
place of conducting any proceeding for any remedy available to the trustee, or exercising any trust or power conferred on the trustee,
with respect to the debt securities of that series, provided that:
| ● | the
direction so given by the holder is not in conflict with any law or the applicable indenture; and |
| ● | subject
to its duties under the Trust Indenture Act, the trustee need not take any action that might involve it in personal liability or might
be unduly prejudicial to the holders not involved in the proceeding. |
The indentures will provide that if an event of
default has occurred and is continuing, the trustee will be required in the exercise of its powers to use the degree of care that a prudent
person would use in the conduct of its own affairs. The trustee, however, may refuse to follow any direction that conflicts with law or
the indenture, or that the trustee determines is unduly prejudicial to the rights of any other holder of the relevant series of debt securities,
or that would involve the trustee in personal liability. Prior to taking any action under the indentures, the trustee will be entitled
to indemnification against all costs, expenses and liabilities that would be incurred by taking or not taking such action.
A holder of the debt securities of any series
will have the right to institute a proceeding under the indentures or to appoint a receiver or trustee, or to seek other remedies only
if:
| ● | the
holder has given written notice to the trustee of a continuing event of default with respect to that series; |
| ● | the
holders of at least 25% in aggregate principal amount of the outstanding debt securities of that series have made a written request and
such holders have offered reasonable indemnity to the trustee or security satisfactory to it against any loss, liability or expense or
to be incurred in compliance with instituting the proceeding as trustee; and |
| ● | the
trustee does not institute the proceeding, and does not receive from the holders of a majority in aggregate principal amount of the outstanding
debt securities of that series other conflicting directions within 90 days after the notice, request and offer. |
These limitations do not apply to a suit instituted
by a holder of debt securities if we default in the payment of the principal, premium, if any, or interest on, the debt securities, or
other defaults that may be specified in the applicable prospectus supplement.
We will periodically file statements with the
trustee regarding our compliance with specified covenants in the indentures.
The indentures will provide that if a default
occurs and is continuing and is actually known to a responsible officer of the trustee, the trustee must mail to each holder notice of
the default within the earlier of 90 days after it occurs and 30 days after it is known by a responsible officer of the trustee or written
notice of it is received by the trustee, unless such default has been cured or waived. Except in the case of a default in the payment
of principal or premium of, or interest on, any debt security or certain other defaults specified in an indenture, the trustee shall be
protected in withholding such notice if and so long as the Board of Directors, the executive committee or a trust committee of directors,
or responsible officers of the trustee, in good faith determine that withholding notice is in the best interests of holders of the relevant
series of debt securities.
Modification of Indenture; Waiver
Subject to the terms of the indenture for any
series of debt securities that we may issue, we and the trustee may change an indenture without the consent of any holders with respect
to the following specific matters:
| ● | to
fix any ambiguity, defect or inconsistency in the indenture; |
| ● | to
comply with the provisions described above under “Description of Debt Securities — Consolidation, Merger or Sale;” |
| ● | to
comply with any requirements of the SEC in connection with the qualification of any indenture under the Trust Indenture Act; |
| ● | to
add to, delete from or revise the conditions, limitations and restrictions on the authorized amount, terms or purposes of issue, authentication
and delivery of debt securities, as set forth in the indenture; |
| ● | to
provide for the issuance of, and establish the form and terms and conditions of, the debt securities of any series as provided under
“Description of Debt Securities — General,” to establish the form of any certifications required to be furnished
pursuant to the terms of the indenture or any series of debt securities, or to add to the rights of the holders of any series of debt
securities; |
| ● | to
evidence and provide for the acceptance of appointment hereunder by a successor trustee; |
| ● | to
provide for uncertificated debt securities and to make all appropriate changes for such purpose; |
| ● | to
add such new covenants, restrictions, conditions or provisions for the benefit of the holders, to make the occurrence, or the occurrence
and the continuance, of a default in any such additional covenants, restrictions, conditions or provisions an event of default or to
surrender any right or power conferred to us in the indenture; or |
| ● | to
change anything that does not adversely affect the interests of any holder of debt securities of any series in any material respect. |
In addition, under the indentures, the rights
of holders of a series of debt securities may be changed by us and the trustee with the written consent of the holders of at least a majority
in aggregate principal amount of the outstanding debt securities of each series that is affected. However, subject to the terms of the
indenture for any series of debt securities that we may issue or otherwise provided in the prospectus supplement applicable to a particular
series of debt securities, we and the trustee may only make the following changes with the consent of each holder of any outstanding debt
securities affected:
| ● | extending
the stated maturity of the series of debt securities; |
| ● | reducing
the principal amount, reducing the rate of or extending the time of payment of interest, or reducing any premium payable upon the redemption
or repurchase of any debt securities; or |
| ● | reducing
the percentage of debt securities, the holders of which are required to consent to any amendment, supplement, modification or waiver. |
Discharge
Each indenture provides that, subject to the terms
of the indenture and any limitation otherwise provided in the prospectus supplement applicable to a particular series of debt securities,
we may elect to be discharged from our obligations with respect to one or more series of debt securities, except for specified obligations,
including obligations to:
| ● | register
the transfer or exchange of debt securities of the series; |
| ● | replace
stolen, lost or mutilated debt securities of the series; |
| ● | maintain
paying agencies; |
| ● | hold
monies for payment in trust; |
| ● | recover
excess money held by the trustee; |
| ● | compensate
and indemnify the trustee; and |
| ● | appoint
any successor trustee. |
In order to exercise our rights to be discharged,
we will deposit with the trustee money or government obligations sufficient to pay all the principal of, and any premium and interest
on, the debt securities of the series on the dates payments are due.
Form, Exchange and Transfer
We will issue the debt securities of each series
only in fully registered form without coupons and, unless we otherwise specify in the applicable prospectus supplement, in denominations
of $1,000 and any integral multiple thereof. The indentures will provide that we may issue debt securities of a series in temporary or
permanent global form and as book-entry securities that will be deposited with, or on behalf of, The Depository Trust Company or another
depositary named by us and identified in a prospectus supplement with respect to that series. See “Legal Ownership of Securities”
below for a further description of the terms relating to any book-entry securities.
At the option of the holder, subject to the terms
of the indentures and the limitations applicable to global securities described in the applicable prospectus supplement, the holder of
the debt securities of any series can exchange the debt securities for other debt securities of the same series, in any authorized denomination
and of like tenor and aggregate principal amount.
Subject to the terms of the indentures and the
limitations applicable to global securities set forth in the applicable prospectus supplement, holders of the debt securities may present
the debt securities for exchange or for registration of transfer, duly endorsed or with the form of transfer endorsed thereon duly executed
if so required by us or the security registrar, at the office of the security registrar or at the office of any transfer agent designated
by us for this purpose. Unless otherwise provided in the debt securities that the holder presents for transfer or exchange, we will make
no service charge for any registration of transfer or exchange, but we may require payment of any taxes or other governmental charges.
We will name in the applicable prospectus supplement
the security registrar, and any transfer agent in addition to the security registrar, that we initially designate for any debt securities.
We may at any time designate additional transfer agents or rescind the designation of any transfer agent or approve a change in the office
through which any transfer agent acts, except that we will be required to maintain a transfer agent in each place of payment for the debt
securities of each series.
If we elect to redeem the debt securities of any
series, we will not be required to:
| ● | issue,
register the transfer of, or exchange any debt securities of that series during a period beginning at the opening of business 15 days
before the day of mailing of a notice of redemption of any debt securities that may be selected for redemption and ending at the close
of business on the day of the mailing; or |
| ● | register
the transfer of or exchange any debt securities so selected for redemption, in whole or in part, except the unredeemed portion of any
debt securities we are redeeming in part. |
Information Concerning the Trustee
The trustee, other than during the occurrence
and continuance of an event of default under an indenture, undertakes to perform only those duties as are specifically set forth in the
applicable indenture and is under no obligation to exercise any of the powers given it by the indentures at the request of any holder
of debt securities unless it is offered reasonable security and indemnity against the costs, expenses and liabilities that it might incur.
However, upon an event of default under an indenture, the trustee must use the same degree of care as a prudent person would exercise
or use in the conduct of his or her own affairs.
Payment and Paying Agents
Unless we otherwise indicate in the applicable
prospectus supplement, we will make payment of the interest on any debt securities on any interest payment date to the person in whose
name the debt securities, or one or more predecessor securities, are registered at the close of business on the regular record date for
the interest payment.
We will pay principal of and any premium and interest
on the debt securities of a particular series at the office of the paying agents designated by us, except that unless we otherwise indicate
in the applicable prospectus supplement, we will make interest payments by check that we will mail to the holder or by wire transfer to
certain holders. Unless we otherwise indicate in the applicable prospectus supplement, we will designate the corporate trust office of
the trustee as our sole paying agent for payments with respect to debt securities of each series. We will name in the applicable prospectus
supplement any other paying agents that we initially designate for the debt securities of a particular series. We will maintain a paying
agent in each place of payment for the debt securities of a particular series.
All money we pay to a paying agent or the trustee
for the payment of the principal of or any premium or interest on any debt securities that remains unclaimed at the end of two years after
such principal, premium or interest has become due and payable will be repaid to us, and the holder of the debt security thereafter may
look only to us for payment thereof.
Governing Law
The indentures and the debt securities will be
governed by and construed in accordance with the laws of the State of New York, except to the extent that the Trust Indenture Act is applicable.
Ranking Debt Securities
The subordinated debt securities will be unsecured
and will be subordinate and junior in priority of payment to certain other indebtedness to the extent described in a prospectus supplement.
The subordinated indenture does not limit the amount of subordinated debt securities that we may issue. It also does not limit us from
issuing any other secured or unsecured debt.
The senior debt securities will be unsecured and
will rank equally in right of payment to all our other senior unsecured debt. The senior indenture does not limit the amount of senior
debt securities that we may issue. It also does not limit us from issuing any other secured or unsecured debt.
DESCRIPTION OF WARRANTS
The following description, together with the additional
information we may include in any applicable prospectus supplements and free writing prospectuses, summarizes the material terms and provisions
of the warrants that we may offer under this prospectus, which may consist of warrants to purchase common stock, preferred stock or debt
securities and may be issued in one or more series. Warrants may be offered independently or together with common stock, preferred stock
or debt securities offered by any prospectus supplement, and may be attached to or separate from those securities. While the terms we
have summarized below will apply generally to any warrants that we may offer under this prospectus, we will describe the particular terms
of any series of warrants that we may offer in more detail in the applicable prospectus supplement and any applicable free writing prospectus.
The terms of any warrants offered under a prospectus supplement may differ from the terms described below. However, no prospectus supplement
will fundamentally change the terms that are set forth in this prospectus or offer a security that is not registered and described in
this prospectus at the time of its effectiveness.
We may issue the warrants under a warrant agreement
that we will enter into with a warrant agent to be selected by us. If selected, the warrant agent will act solely as an agent of ours
in connection with the warrants and will not act as an agent for the holders or beneficial owners of the warrants. If applicable, we will
file as exhibits to the registration statement of which this prospectus is a part, or will incorporate by reference from a Current Report
on Form 8-K that we file with the SEC, the form of warrant agreement, including a form of warrant certificate, that describes the terms
of the particular series of warrants we are offering before the issuance of the related series of warrants. The following summaries of
material provisions of the warrants and the warrant agreements are subject to, and qualified in their entirety by reference to, all the
provisions of the warrant agreement and warrant certificate applicable to a particular series of warrants. We urge you to read the applicable
prospectus supplement and any applicable free writing prospectus related to the particular series of warrants that we sell under this
prospectus, as well as the complete warrant agreements and warrant certificates that contain the terms of the warrants.
General
We will describe in the applicable prospectus
supplement the terms relating to a series of warrants, including:
| ● | the
offering price and aggregate number of warrants offered; |
| ● | the
currency for which the warrants may be purchased; |
| ● | if
applicable, the designation and terms of the securities with which the warrants are issued and the number of warrants issued with each
such security or each principal amount of such security; |
| ● | if
applicable, the date on and after which the warrants and the related securities will be separately transferable; |
| ● | in
the case of warrants to purchase debt securities, the principal amount of debt securities purchasable upon exercise of one warrant and
the price at, and currency in which, this principal amount of debt securities may be purchased upon such exercise; |
| ● | in
the case of warrants to purchase common stock or preferred stock, the number of shares of common stock or preferred stock, as the case
may be, purchasable upon the exercise of one warrant and the price at which these shares may be purchased upon such exercise; |
| ● | the
effect of any merger, consolidation, sale or other disposition of our business on the warrant agreements and the warrants; |
| ● | the
terms of any rights to redeem or call the warrants; |
| ● | any
provisions for changes to or adjustments in the exercise price or number of securities issuable upon exercise of the warrants; |
| ● | the
dates on which the right to exercise the warrants will commence and expire; |
| ● | the
manner in which the warrant agreements and warrants may be modified; |
| ● | United
States federal income tax consequences of holding or exercising the warrants; |
| ● | the
terms of the securities issuable upon exercise of the warrants; and |
| ● | any
other specific terms, preferences, rights or limitations of or restrictions on the warrants. |
Before exercising their warrants, holders of warrants
will not have any of the rights of holders of the securities purchasable upon such exercise, including:
| ● | in
the case of warrants to purchase debt securities, the right to receive payments of principal of, or premium, if any, or interest on,
the debt securities purchasable upon exercise or to enforce covenants in the applicable indenture; or |
| ● | in
the case of warrants to purchase common stock or preferred stock, the right to receive dividends, if any, or, payments upon our liquidation,
dissolution or winding up or to exercise voting rights, if any. |
Exercise of Warrants
Each warrant will entitle the holder to purchase
the securities that we specify in the applicable prospectus supplement at the exercise price that we describe in the applicable prospectus
supplement. Unless we otherwise specify in the applicable prospectus supplement, holders of the warrants may exercise the warrants at
any time up to the specified time on the expiration date that we set forth in the applicable prospectus supplement. After the close of
business on the expiration date, unexercised warrants will become void.
Holders of the warrants may exercise the warrants
by delivering the warrant certificate representing the warrants to be exercised together with specified information, and paying the required
amount to the warrant agent in immediately available funds, as provided in the applicable prospectus supplement. We will set forth on
the reverse side of the warrant certificate and in the applicable prospectus supplement the information that the holder of the warrant
will be required to deliver to us or the warrant agent as applicable.
Upon receipt of the required payment and the warrant
certificate properly completed and duly executed at the corporate trust office of the warrant agent or any other office indicated in the
applicable prospectus supplement, we will issue and deliver the securities purchasable upon such exercise. If fewer than all of the warrants
represented by the warrant certificate are exercised, then we will issue a new warrant certificate for the remaining amount of warrants.
If we so indicate in the applicable prospectus supplement, holders of the warrants may surrender securities as all or part of the exercise
price for warrants.
Enforceability of Rights by Holders of Warrants
If selected, each warrant agent will act solely
as our agent under the applicable warrant agreement and will not assume any obligation or relationship of agency or trust with any holder
of any warrant. A single bank or trust company may act as warrant agent for more than one issue of warrants. A warrant agent will have
no duty or responsibility in case of any default by us under the applicable warrant agreement or warrant, including any duty or responsibility
to initiate any proceedings at law or otherwise, or to make any demand upon us. Any holder of a warrant may, without the consent of the
related warrant agent or the holder of any other warrant, enforce by appropriate legal action its right to exercise, and receive the securities
purchasable upon exercise of, its warrants.
DESCRIPTION OF UNITS
The following description, together with the additional
information we may include in any applicable prospectus supplements and free writing prospectuses, summarizes the material terms and provisions
of the units that we may offer under this prospectus.
While the terms we have summarized below will
apply generally to any units that we may offer under this prospectus, we will describe the particular terms of any series of units in
more detail in the applicable prospectus supplement. The terms of any units offered under a prospectus supplement may differ from the
terms described below. However, no prospectus supplement will fundamentally change the terms that are set forth in this prospectus or
offer a security that is not registered and described in this prospectus at the time of its effectiveness.
We will file as exhibits to the registration statement
of which this prospectus is a part, or will incorporate by reference from a Current Report on Form 8-K that we file with the SEC, the
form of unit agreement that describes the terms of the series of units we are offering, and any supplemental agreements, before the issuance
of the related series of units. The following summaries of material terms and provisions of the units are subject to, and qualified in
their entirety by reference to, all the provisions of the unit agreement and any supplemental agreements applicable to a particular series
of units. We urge you to read the applicable prospectus supplements related to the particular series of units that we sell under this
prospectus, as well as the complete unit agreement and any supplemental agreements that contain the terms of the units.
General
We may issue units comprised of one or more debt
securities, shares of common stock, shares of preferred stock and warrants in any combination. Each unit will be issued so that the holder
of the unit is also the holder of each security included in the unit. Thus, the holder of a unit will have the rights and obligations
of a holder of each included security. The unit agreement under which a unit is issued may provide that the securities included in the
unit may not be held or transferred separately, at any time or at any time before a specified date.
We will describe in the applicable prospectus
supplement the terms of the series of units, including:
| ● | the
designation and terms of the units and of the securities comprising the units, including whether and under what circumstances those securities
may be held or transferred separately; |
| ● | any
provisions of the governing unit agreement that differ from those described below; and |
| ● | any
provisions for the issuance, payment, settlement, transfer or exchange of the units or of the securities comprising the units. |
The provisions described in this section, as well
as those described under “Description of Capital Stock,” “Description of Debt Securities” and “Description
of Warrants” will apply to each unit and to any common stock, preferred stock, debt security or warrant included in each unit,
respectively.
Unit Agent
The name and address of the unit agent, if any,
for any units we offer will be set forth in the applicable prospectus supplement.
Issuance in Series
We may issue units in such amounts and in numerous
distinct series as we determine.
Enforceability of Rights by Holders of Units
Each unit agent will act solely as our agent under
the applicable unit agreement and will not assume any obligation or relationship of agency or trust with any holder of any unit. A single
bank or trust company may act as unit agent for more than one series of units. A unit agent will have no duty or responsibility in case
of any default by us under the applicable unit agreement or unit, including any duty or responsibility to initiate any proceedings at
law or otherwise, or to make any demand upon us. Any holder of a unit may, without the consent of the related unit agent or the holder
of any other unit, enforce by appropriate legal action its rights as holder under any security included in the unit.
We, the unit agents and any of their agents may
treat the registered holder of any unit certificate as an absolute owner of the units evidenced by that certificate for any purpose and
as the person entitled to exercise the rights attaching to the units so requested, despite any notice to the contrary. See “Legal
Ownership of Securities.”
LEGAL OWNERSHIP OF SECURITIES
We can issue securities in registered form or
in the form of one or more global securities. We describe global securities in greater detail below. We refer to those persons who have
securities registered in their own names on the books that we or any applicable trustee or depositary or warrant agent maintain for this
purpose as the “holders” of those securities. These persons are the legal holders of the securities. We refer to those persons
who, indirectly through others, own beneficial interests in securities that are not registered in their own names, as “indirect
holders” of those securities. As we discuss below, indirect holders are not legal holders, and investors in securities issued in
book-entry form or in street name will be indirect holders.
Book-Entry Holders
We may issue securities in book-entry form only,
as we will specify in the applicable prospectus supplement. This means securities may be represented by one or more global securities
registered in the name of a financial institution that holds them as depositary on behalf of other financial institutions that participate
in the depositary’s book-entry system. These participating institutions, which are referred to as participants, in turn, hold beneficial
interests in the securities on behalf of themselves or their customers.
Only the person in whose name a security is registered
is recognized as the holder of that security. Global securities will be registered in the name of the depositary or its participants.
Consequently, for global securities, we will recognize only the depositary as the holder of the securities, and we will make all payments
on the securities to the depositary. The depositary passes along the payments it receives to its participants, which in turn pass the
payments along to their customers who are the beneficial owners. The depositary and its participants do so under agreements they have
made with one another or with their customers; they are not obligated to do so under the terms of the securities.
As a result, investors in a global security will
not own securities directly. Instead, they will own beneficial interests in a global security, through a bank, broker or other financial
institution that participates in the depositary’s book-entry system or holds an interest through a participant. As long as the securities
are issued in global form, investors will be indirect holders, and not legal holders, of the securities.
Street Name Holders
We may terminate a global security or issue securities
that are not issued in global form. In these cases, investors may choose to hold their securities in their own names or in “street
name.” Securities held by an investor in street name would be registered in the name of a bank, broker or other financial institution
that the investor chooses, and the investor would hold only a beneficial interest in those securities through an account he or she maintains
at that institution.
For securities held in street name, we or any
applicable trustee or depositary will recognize only the intermediary banks, brokers and other financial institutions in whose names
the securities are registered as the holders of those securities, and we or any such trustee or depositary will make all payments on
those securities to them. These institutions pass along the payments they receive to their customers who are the beneficial owners, but
only because they agree to do so in their customer agreements or because they are legally required to do so. Investors who hold securities
in street name will be indirect holders, not legal holders, of those securities.
Legal Holders
Our obligations, as well as the obligations of
any applicable trustee or third party employed by us or a trustee, run only to the legal holders of the securities. We do not have obligations
to investors who hold beneficial interests in global securities, in street name or by any other indirect means. This will be the case
whether an investor chooses to be an indirect holder of a security or has no choice because we are issuing the securities only in global
form.
For example, once we make a payment or give a
notice to the holder, we have no further responsibility for the payment or notice even if that holder is required, under agreements with
its participants or customers or by law, to pass it along to the indirect holders but does not do so. Similarly, we may want to obtain
the approval of the holders to amend an indenture, to relieve us of the consequences of a default or of our obligation to comply with
a particular provision of an indenture, or for other purposes. In such an event, we would seek approval only from the legal holders, and
not the indirect holders, of the securities. Whether and how the legal holders contact the indirect holders is up to the legal holders.
Special Considerations for Indirect Holders
If you hold securities through a bank, broker
or other financial institution, either in book-entry form because the securities are represented by one or more global securities or in
street name, you should check with your own institution to find out:
| ● | how
it handles securities payments and notices; |
| ● | whether
it imposes fees or charges; |
| ● | how
it would handle a request for the holders’ consent, if ever required; |
| ● | whether
and how you can instruct it to send you securities registered in your own name so you can be a legal holder, if that is permitted in
the future; |
| ● | how
it would exercise rights under the securities if there were a default or other event triggering the need for holders to act to protect
their interests; and |
| ● | if
the securities are in book-entry form, how the depositary’s rules and procedures will affect these matters. |
Global Securities
A global security is a security that represents
one or any other number of individual securities held by a depositary. Generally, all securities represented by the same global securities
will have the same terms.
Each security issued in book-entry form will be
represented by a global security that we issue to, deposit with and register in the name of a financial institution or its nominee that
we select. The financial institution that we select for this purpose is called the depositary. Unless we specify otherwise in the applicable
prospectus supplement, The Depository Trust Company, New York, NY, known as DTC, will be the depositary for all securities issued in book-entry
form.
A global security may not be transferred to or
registered in the name of anyone other than the depositary, its nominee or a successor depositary, unless special termination situations
arise. We describe those situations below under “— Special Situations When A Global Security Will Be Terminated.”
As a result of these arrangements, the depositary, or its nominee, will be the sole registered owner and legal holder of all securities
represented by a global security, and investors will be permitted to own only beneficial interests in a global security. Beneficial interests
must be held by means of an account with a broker, bank or other financial institution that in turn has an account with the depositary
or with another institution that does. Thus, an investor whose security is represented by a global security will not be a legal holder
of the security, but only an indirect holder of a beneficial interest in the global security.
If the prospectus supplement for a particular
security indicates that the security will be issued as a global security, then the security will be represented by a global security at
all times unless and until the global security is terminated. If termination occurs, we may issue the securities through another book-entry
clearing system or decide that the securities may no longer be held through any book-entry clearing system.
Special Considerations For Global Securities
As an indirect holder, an investor’s rights
relating to a global security will be governed by the account rules of the investor’s financial institution and of the depositary,
as well as general laws relating to securities transfers. We do not recognize an indirect holder as a holder of securities and instead
deal only with the depositary that holds the global security.
If securities are issued only as global securities,
an investor should be aware of the following:
| ● | an
investor cannot cause the securities to be registered in his or her name, and cannot obtain non-global certificates for his or her interest
in the securities, except in the special situations we describe below; |
| ● | an
investor will be an indirect holder and must look to his or her own bank or broker for payments on the securities and protection of his
or her legal rights relating to the securities, as we describe above; |
| ● | an
investor may not be able to sell interests in the securities to some insurance companies and to other institutions that are required
by law to own their securities in non-book-entry form; |
| ● | an
investor may not be able to pledge his or her interest in the global security in circumstances where certificates representing the securities
must be delivered to the lender or other beneficiary of the pledge in order for the pledge to be effective; |
| ● | the
depositary’s policies, which may change from time to time, will govern payments, transfers, exchanges and other matters relating
to an investor’s interest in the global security. We and any applicable trustee have no responsibility for any aspect of the depositary’s
actions or for its records of ownership interests in the global security. We and the trustee also do not supervise the depositary in
any way; |
| ● | the
depositary may, and we understand that DTC will, require that those who purchase and sell interests in the global security within its
book-entry system use immediately available funds, and your broker or bank may require you to do so as well; and |
| ● | financial
institutions that participate in the depositary’s book-entry system, and through which an investor holds its interest in the global
security, may also have their own policies affecting payments, notices and other matters relating to the securities. There may be more
than one financial intermediary in the chain of ownership for an investor. We do not monitor and are not responsible for the actions
of any of those intermediaries. |
Special Situations When A Global Security Will
Be Terminated
In a few special situations described below, a
global security will terminate and interests in it will be exchanged for physical certificates representing those interests. After that
exchange, the choice of whether to hold securities directly or in street name will be up to the investor. Investors must consult their
own banks or brokers to find out how to have their interests in securities transferred to their own names, so that they will be direct
holders. We have described the rights of holders and street name investors above.
A global security will terminate when the following
special situations occur:
| ● | if
the depositary notifies us that it is unwilling, unable or no longer qualified to continue as depositary for that global security and
we do not appoint another institution to act as depositary within 90 days; |
| ● | if
we notify any applicable trustee that we wish to terminate that global security; or |
| ● | if
an event of default has occurred with regard to securities represented by that global security and has not been cured or waived. |
The applicable prospectus supplement may also
list additional situations for terminating a global security that would apply only to the particular series of securities covered by the
prospectus supplement. When a global security terminates, the depositary, and neither we, nor any applicable trustee, is responsible for
deciding the names of the institutions that will be the initial direct holders.
PLAN OF DISTRIBUTION
We may sell the securities being offered hereby
in one or more of the following ways from time to time:
| ● | through
agents to the public or to investors; |
| ● | to
underwriters for resale to the public or to investors; |
| ● | negotiated
transactions; |
| ● | directly
to investors; or |
| ● | through
a combination of any of these methods of sale. |
As set forth in more detail below, the securities
may be distributed from time to time in one or more transactions:
| ● | at
a fixed price or prices, which may be changed; |
| ● | at
market prices prevailing at the time of sale; |
| ● | at
prices related to such prevailing market prices; or |
We will set forth in a prospectus supplement the
terms of that particular offering of securities, including:
| ● | the
name or names of any agents or underwriters; |
| ● | the
purchase price of the securities being offered and the proceeds we will receive from the sale; |
| ● | any
over-allotment options under which underwriters may purchase additional securities from us; |
| ● | any
agency fees or underwriting discounts and other items constituting agents’ or underwriters’ compensation; |
| ● | any
initial public offering price; |
| ● | any
discounts or concessions allowed or re-allowed or paid to dealers; and |
| ● | any
securities exchanges or markets on which such securities may be listed. |
Only underwriters named in an applicable prospectus
supplement are underwriters of the securities offered by that prospectus supplement.
If underwriters are used in an offering, we will
execute an underwriting agreement with such underwriters and will specify the name of each underwriter and the terms of the transaction
(including any underwriting discounts and other terms constituting compensation of the underwriters and any dealers) in a prospectus supplement.
The securities may be offered to the public either through underwriting syndicates represented by managing underwriters or directly by
one or more investment banking firms or others, as designated. If an underwriting syndicate is used, the managing underwriter(s) will
be specified on the cover of the prospectus supplement. If underwriters are used in the sale, the offered securities will be acquired
by the underwriters for their own accounts and may be resold from time to time in one or more transactions, including negotiated transactions,
at a fixed public offering price or at varying prices determined at the time of sale. Any public offering price and any discounts or concessions
allowed or re-allowed or paid to dealers may be changed from time to time. Unless otherwise set forth in the prospectus supplement, the
obligations of the underwriters to purchase the offered securities will be subject to conditions precedent and the underwriters will be
obligated to purchase all of the offered securities if any are purchased.
We may grant to the underwriters options to purchase
additional securities to cover over-allotments, if any, at the public offering price, with additional underwriting commissions or discounts,
as may be set forth in a related prospectus supplement. The terms of any over-allotment option will be set forth in the prospectus supplement
for those securities.
If we use a dealer in the sale of the securities
being offered pursuant to this prospectus or any prospectus supplement, we will sell the securities to the dealer, as principal. The dealer
may then resell the securities to the public at varying prices to be determined by the dealer at the time of resale. The names of the
dealers and the terms of the transaction will be specified in a prospectus supplement.
We may sell the securities directly or through
agents we designate from time to time. We will name any agent involved in the offering and sale of securities and we will describe any
commissions we will pay the agent in the prospectus supplement. Unless the prospectus supplement states otherwise, any agent will act
on a best-efforts basis for the period of its appointment.
We may authorize agents or underwriters to solicit
offers by institutional investors to purchase securities from us at the public offering price set forth in the prospectus supplement pursuant
to delayed delivery contracts providing for payment and delivery on a specified date in the future. We will describe the conditions to
these contracts and the commissions we must pay for solicitation of these contracts in the prospectus supplement.
In connection with the sale of the securities,
underwriters, dealers or agents may receive compensation from us or from purchasers of the common stock for whom they act as agents in
the form of discounts, concessions or commissions. Underwriters may sell the securities to or through dealers, and those dealers may receive
compensation in the form of discounts, concessions or commissions from the underwriters or commissions from the purchasers for whom they
may act as agents. Underwriters, dealers and agents that participate in the distribution of the securities, and any institutional investors
or others that purchase common stock directly and then resell the securities, may be deemed to be underwriters, and any discounts or commissions
received by them from us and any profit on the resale of the common stock by them may be deemed to be underwriting discounts and commissions
under the Securities Act.
We may provide agents and underwriters with indemnification
against particular civil liabilities, including liabilities under the Securities Act, or contribution with respect to payments that the
agents or underwriters may make with respect to such liabilities. Agents and underwriters may engage in transactions with, or perform
services for, us in the ordinary course of business.
We may engage in at the market offerings into
an existing trading market in accordance with Rule 415(a)(4) under the Securities Act. In addition, we may enter into derivative transactions
with third parties (including the writing of options), or sell securities not covered by this prospectus to third parties in privately
negotiated transactions. If the applicable prospectus supplement indicates, in connection with such a transaction, the third parties may,
pursuant to this prospectus and the applicable prospectus supplement, sell securities covered by this prospectus and the applicable prospectus
supplement. If so, the third party may use securities borrowed from us or others to settle such sales and may use securities received
from us to close out any related short positions. We may also loan or pledge securities covered by this prospectus and the applicable
prospectus supplement to third parties, who may sell the loaned securities or, in an event of default in the case of a pledge, sell the
pledged securities pursuant to this prospectus and the applicable prospectus supplement. The third party in such sale transactions will
be an underwriter and will be identified in the applicable prospectus supplement or in a post-effective amendment.
To facilitate an offering of a series of securities,
persons participating in the offering may engage in transactions that stabilize, maintain, or otherwise affect the market price of the
securities. This may include over-allotments or short sales of the securities, which involves the sale by persons participating in the
offering of more securities than have been sold to them by us. In those circumstances, such persons would cover such over-allotments or
short positions by purchasing in the open market or by exercising the over-allotment option granted to those persons. In addition, those
persons may stabilize or maintain the price of the securities by bidding for or purchasing securities in the open market or by imposing
penalty bids, whereby selling concessions allowed to underwriters or dealers participating in any such offering may be reclaimed if securities
sold by them are repurchased in connection with stabilization transactions. The effect of these transactions may be to stabilize or maintain
the market price of the securities at a level above that which might otherwise prevail in the open market. Such transactions, if commenced,
may be discontinued at any time. We make no representation or prediction as to the direction or magnitude of any effect that the transactions
described above, if implemented, may have on the price of our securities.
Unless otherwise specified in the applicable prospectus
supplement, each class or series of securities will be a new issue with no established trading market, other than our common stock, which
is listed on The Nasdaq Capital Market. We may elect to list any other class or series of securities on any exchange or market, but we
are not obligated to do so. It is possible that one or more underwriters may make a market in a class or series of securities, but the
underwriters will not be obligated to do so and may discontinue any market making at any time without notice. We cannot give any assurance
as to the liquidity of the trading market for any of the securities.
In order to comply with the securities laws of
some U.S. states or territories, if applicable, the securities offered pursuant to this prospectus will be sold in those states only through
registered or licensed brokers or dealers. In addition, in some states securities may not be sold unless they have been registered or
qualified for sale in the applicable state or an exemption from the registration or qualification requirement is available and complied
with.
Any underwriter may engage in overallotment, stabilizing
transactions, short covering transactions and penalty bids in accordance with Regulation M under the Exchange Act. Overallotment involves
sales in excess of the offering size, which create a short position. Stabilizing transactions permit bids to purchase the underlying security
so long as the stabilizing bids do not exceed a specified maximum. Short covering transactions involve purchases of the securities in
the open market after the distribution is completed to cover short positions. Penalty bids permit the underwriters to reclaim a selling
concession from a dealer when the securities originally sold by the dealer are purchased in a covering transaction to cover short positions.
Those activities may cause the price of the securities to be higher than it would otherwise be. If commenced, the underwriters may discontinue
any of these activities at any time.
Any underwriters who are qualified market makers
on The Nasdaq Capital Market may engage in passive market making transactions in the securities on The Nasdaq Capital Market in accordance
with Rule 103 of Regulation M, during the business day prior to the pricing of the offering, before the commencement of offers or sales
of the securities. Passive market makers must comply with applicable volume and price limitations and must be identified as passive market
makers. In general, a passive market maker must display its bid at a price not in excess of the highest independent bid for such security.
If all independent bids are lowered below the passive market maker’s bid, however, the passive market maker’s bid must then
be lowered when certain purchase limits are exceeded.
LEGAL MATTERS
The validity of the issuance of the securities
offered hereby will be passed upon for us by Sheppard, Mullin, Richter & Hampton LLP, New York, NY. Additional legal matters may be
passed upon for us or any underwriters, dealers or agents, by counsel that we will name in the applicable prospectus supplement.
EXPERTS
Our consolidated financial statements as of and
for the years ended December 31, 2022 and 2021, incorporated by reference in this prospectus and the registration statement, of which
it forms a part, have been audited by Salberg & Company, P.A., independent registered public accounting firm, as set forth in their
report thereon incorporated by reference herein, and are included in reliance on such report given on the authority of such firm as experts
in accounting and auditing.
WHERE YOU CAN FIND MORE INFORMATION
This prospectus constitutes a part of the registration
statement on Form S-3 that we have filed with the SEC under the Securities Act. As permitted by the SEC’s rules, this prospectus
and any accompanying prospectus supplement, which forms a part of the registration statement, do not contain all of the information that
is included in the registration statement. You will find additional information about us in the registration statement. Any statement
made in this prospectus or any accompanying prospectus supplement concerning legal documents are not necessarily complete and you should
read the documents that are filed as exhibits to the registration statement or otherwise filed with the SEC for a more complete understanding
of the document or matter.
We are subject to the reporting requirements of
the Exchange Act and file annual, quarterly and current reports, proxy statements and other information with the SEC. You can read our
SEC filings, including the registration statement, over the internet at the SEC’s website at http://www.sec.gov. We
also maintain a website at www.silopharma.com, at which you may access these materials free of charge as soon as reasonably
practicable after they are electronically filed with, or furnished to, the SEC. The information contained in, or that can be accessed
through, our website is not part of this prospectus.
You may also read and copy any document we file
with the SEC at its public reference facilities at 100 F Street, N.E., Room 1580, Washington, DC 20549. You may also obtain copies of
these documents at prescribed rates by writing to the Public Reference Section of the SEC at 100 F Street, N.E., Washington, D.C. 20549.
Please call the SEC at 1-800-SEC-0330 for further information on the operation of the public reference facilities. You may also request
a copy of these filings, at no cost, by writing or telephoning us at: 677 N Washington Boulevard, Sarasota, Florida 34236, (718) 400-9031.
INCORPORATION OF DOCUMENTS BY REFERENCE
This prospectus is part of the registration statement,
but the registration statement includes and incorporates by reference additional information and exhibits. The SEC permits us to “incorporate
by reference” the information contained in documents we file with the SEC, which means that we can disclose important information
to you by referring you to those documents rather than by including them in this prospectus. Information that is incorporated by reference
is considered to be part of this prospectus and you should read it with the same care that you read this prospectus and any subsequent
prospectus supplement. Information that we file later with the SEC will automatically update and supersede the information that is either
contained, or incorporated by reference, in this prospectus, and will be considered to be a part of this prospectus from the date those
documents are filed.
We incorporate by reference the documents listed
below, all filings filed by us pursuant to the Exchange Act after the date of the registration statement of which this prospectus and
any accompanying prospectus supplement forms a part, and any future filings we make with the SEC under Sections 13(a), 13(c), 14 or 15(d)
of the Exchange Act prior to the time that all securities covered by this prospectus have been sold; provided, however, that we are not
incorporating any information furnished under either Item 2.02 or Item 7.01 of any Current Report on Form 8-K and exhibits furnished on
such form that relate to such items:
| ● | our
Annual Report on Form 10-K for the year ended December 31, 2022 filed with the SEC on March 24, 2023; |
| ● | our
Quarterly Report on Form 10-Q for the quarter ended March 31, 2023 filed with the SEC on May 12, 2023; |
| ● | our
Quarterly Report on Form 10-Q for the quarter ended June 30, 2023 filed with the SEC on August 11, 2023; |
| ● | our
Quarterly Report on Form 10-Q for the quarter ended September 30, 2023 filed with the SEC on November 13, 2023; |
| ● | our
Current Reports on Form 8-K filed with the SEC on January 31, 2023; February 3, 2023; February 15, 2023; March 27, 2023; June 29, 2023;
August 31, 2023; November 14, 2023; December 4, 2023; December 5, 2023; December 11, 2023; December 20, 2023; January 9, 2024 and January 11, 2024; |
| ● | our
definitive Proxy Statement on Schedule 14A for our 2023 Annual Meeting of Shareholders filed with the SEC on October 23, 2023; and |
| ● | the
description of our common stock contained in our Registration Statement on Form 8-A filed with the SEC on September 26, 2022, including
Exhibit 4.1 to our Current Report on Form 8-K12B filed with the SEC on December 20, 2023 and any other amendments or reports filed with
the SEC for the purposes of updating such description. |
Any statements made in a document incorporated
by reference in this prospectus are deemed to be modified or superseded for purposes of this prospectus to the extent that a statement
in this prospectus or in any other subsequently filed document, which is also incorporated by reference, modifies or supersedes the statement.
Any statement made in this prospectus is deemed to be modified or superseded to the extent a statement in any subsequently filed document,
which is incorporated by reference in this prospectus, modifies or supersedes such statement. Any statement so modified or superseded
will not be deemed, except as so modified or superseded, to constitute a part of this prospectus.
The information relating to us contained in this
prospectus should be read together with the information in the documents incorporated by reference. In addition, certain information,
including financial information, contained in this prospectus or incorporated by reference in this prospectus should be read in conjunction
with documents we have filed with the SEC.
We will provide to each person, including any
beneficial holder, to whom a prospectus is delivered, at no cost, upon written or oral request, a copy of any or all of the information
that has been incorporated by reference in the prospectus but not delivered with the prospectus. Requests for documents should be by writing
to or telephoning us at the following address: Silo Pharma, Inc., 677 N Washington Boulevard, Sarasota, Florida 34236, (718) 400-9031.
Exhibits to these filings will not be sent unless those exhibits have been specifically incorporated by reference in such filings.
Silo Pharma, Inc.
763,638 Shares of Common Stock
PROSPECTUS SUPPLEMENT
H.C. Wainwright & Co.
July 18, 2024
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