Initial Statement of Beneficial Ownership (3)

FORM 3	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES	OMB APPROVAL OMB Number: 3235-0104 Estimated average burden hours per response... 0.5
	Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person ^*

Papadimas Elias D.

2. Date of Event Requiring Statement (MM/DD/YYYY) 6/1/2021

3. Issuer Name and Ticker or Trading Symbol

EXICURE, INC. [XCUR]

(Last) (First) (Middle)

C/O EXICURE, INC., 2430 N. HALSTED ST.

4. Relationship of Reporting Person(s) to Issuer (Check all applicable)

_____ Director _____ 10% Owner
___X___ Officer (give title below) _____ Other (specify below)
Chief Accounting Officer /

(Street)

CHICAGO, IL 60614

(City) (State) (Zip)

5. If Amendment, Date Original Filed(MM/DD/YYYY)

6. Individual or Joint/Group Filing(Check Applicable Line)

_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Stock	6537	D

*Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)*
1. Title of Derivate Security (Instr. 4)	2. Date Exercisable and Expiration Date (MM/DD/YYYY)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
1. Title of Derivate Security (Instr. 4)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	4. Conversion or Exercise Price of Derivative Security		6. Nature of Indirect Beneficial Ownership (Instr. 5)
Employee Stock Option (right to buy)	⁽¹⁾	5/21/2025	Common Stock	49649	$1.03	D
Employee Stock Option (right to buy)	⁽¹⁾	1/3/2027	Common Stock	4964	$4.21	D
Employee Stock Option (right to buy)	⁽²⁾	2/14/2028	Common Stock	37004	$3.00	D
Employee Stock Option (right to buy)	⁽³⁾	12/9/2029	Common Stock	100000	$2.99	D
Employee Stock Option (right to buy)	⁽⁴⁾	4/26/2031	Common Stock	120000	$1.90	D
Employee Stock Option (right to buy)	⁽⁴⁾	4/26/2031	Common Stock	63800	$1.90	D

Explanation of Responses:
(1)	Fully vested and exercisable.
(2)	The shares subject to the option vested or will vest as to 1/48th of the underlying shares monthly from the vesting commencement date of January 2, 2018, provided the Reporting Person remains in continuous service on each vesting date.
(3)	The shares subject to the option vested or will vest as to 1/48th of the underlying shares monthly from the vesting commencement date of December 10, 2019, provided the Reporting Person remains in continuous service on each vesting date.
(4)	The shares subject to the option vested or will vest as to 1/48th of the underlying shares monthly from the vesting commencement date of April 27, 2021, provided the Reporting Person remains in continuous service on each vesting date.

Remarks:
Exhibit List - Exhibit 24 - Power of Attorney

Reporting Owners
Reporting Owner Name / Address	Relationships
Reporting Owner Name / Address	Director	10% Owner	Officer	Other
Papadimas Elias D. C/O EXICURE, INC. 2430 N. HALSTED ST. CHICAGO, IL 60614			Chief Accounting Officer