ENLV Enlivex Therapeutics Ltd

Exhibit 99.2

 

OPERATING AND FINANCIAL REVIEW AND PROSPECTS

 

This Operating and Financial Review and Prospects contains forward-looking statements, which may be identified by words such as “expects,” “plans,” “projects,” “will,” “may,” “anticipates,” “believes,” “should,” “would”, “could”, “intends,” “estimates,” “suggests,” “has the potential to” and other words and phrases of similar meaning, including, without limitation, statements regarding expected cash balances, market opportunities for the results of current clinical studies and preclinical experiments, and the effectiveness of, and market opportunities for, ALLOCETRA^TM programs, all of which statements are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995.  Investors are cautioned that forward-looking statements involve risks and uncertainties that may affect Enlivex’s business and prospects, including the risks that Enlivex may not succeed in generating any revenues or developing any commercial products; that the products in development may fail, may not achieve the expected results or effectiveness and/or may not generate data that would support the approval or marketing of these products for the indications being studied or for other indications; that ongoing studies may not continue to show substantial or any activity; and other risks and uncertainties that may cause results to differ materially from those set forth in the forward-looking statements. The results of clinical trials in humans may produce results that differ significantly from the results of clinical and other trials in animals. The results of early-stage trials may differ significantly from the results of more developed, later-stage trials. The development of any products using the ALLOCETRA^TM product line could also be affected by a number of other factors, including unexpected safety, efficacy or manufacturing issues, additional time requirements for data analyses and decision making, the impact of pharmaceutical industry regulation, the impact of competitive products and pricing and the impact of patents and other proprietary rights held by competitors and other third parties. In addition to the risk factors described above, investors should consider the economic, competitive, governmental, technological and other factors discussed in Enlivex’s filings with the Securities and Exchange Commission, including in its Annual Report on Form 20-F for the year ended December 31, 2022.  The forward-looking statements contained in this Operating and Financial Review and Prospects speak only as of the date the statements were made, and we do not undertake any obligation to update forward-looking statements, except as required under applicable law.

 

Overview

 

Enlivex Therapeutics, Ltd., a company organized under the laws of the State of Israel (including its consolidated subsidiaries, “we”, “us”, “our” or the “Company”), is a clinical-stage macrophage reprogramming immunotherapy company, developing Allocetra^TM, a universal, off-the-shelf cell therapy designed to reprogram macrophages into their homeostatic state. Resetting non-homeostatic macrophages into their homeostatic state is critical for immune system rebalancing and resolution of life-threatening conditions. Non-homeostatic macrophages contribute significantly to the severity of the respective diseases, which include solid tumors, sepsis and others.

 

We believe the Company’s primary innovative immunotherapy, Allocetra^TM, represents a paradigm shift in macrophage reprogramming, moving from targeting a specific subset of macrophages or a specific pathway effecting macrophages activity, to a fundamental view of macrophage homeostasis. Restoring macrophage homeostasis may induce the immune system to rebalance itself to normal levels of operation, thereby promoting disease resolution.

 

The Company is focused on two main clinical verticals: sepsis and solid tumors (the “Indications”). The Company believes that negatively-reprogrammed macrophages may be key contributors to disease severity across the Indications, and thus effective reprogramming of these previously negative-reprogrammed macrophages into their respective homeostatic states may provide diseases resolution for these Indications, some of which are considered “unmet medical needs”.

 

Financial Overview

 

Since inception, we have incurred significant losses in connection with our research and development and have not generated any revenue. We have funded our operations primarily through grants from the Israel Innovation Authority (the “IIA”) and the sale of equity and equity linked securities in public and private offerings. As of June 30, 2023, we had approximately $36 million in cash and cash equivalents and bank deposits and had an accumulated deficit of approximately $97 million, see “—Liquidity and Capital Resources” below.

 

 

Although we provide no assurance, we believe that our existing funds will be sufficient to continue our business and operations as currently conducted through the fourth quarter of 2024. During 2022, we introduced a Company-wide cost cutting program designed to extend our cash runway potentially into 2025. We expect that we will continue to incur operating losses, which may be substantial over the next several years, and we will require additional funds to further develop our research and development programs.

 

Costs and Operating Expenses

 

Our current costs and operating expenses consist of two components: (i) research and development expenses; and (ii) general and administrative expenses.

 

Research and Development Expenses

 

Our research and development expenses consist primarily of research and development activities at our laboratory in Israel, including drug and laboratory supplies and costs for facilities and equipment, outsourced development expenses, including the costs of regulatory consultants and certain other service providers, salaries and related personnel expenses (including share based compensation) and fees paid to external service providers and the costs of preclinical studies and clinical trials. We charge all research and development expenses to operations as they are incurred. We expect our research and development expenses to remain our primary expenses in the near future as we continue to develop our product candidates. Increases or decreases in research and development expenditures are attributable to the number and duration of our preclinical and clinical studies.

 

We expect that a large percentage of our research and development expenses in the future will be incurred in support of our current and future preclinical and clinical development projects. Due to the inherently unpredictable nature of preclinical and clinical development processes, we are unable to estimate with any certainty the costs we will incur in the continued development of our product candidates in our pipeline for potential commercialization. Furthermore, although we expect to apply for additional grants from the IIA, we cannot be certain that we will obtain such grants. Clinical development timelines, the probability of success and development costs can differ materially from expectations. We expect to continue to test our product candidates in preclinical studies for toxicology, safety and efficacy and to conduct additional clinical trials for our product candidates.

 

While we are currently focused on advancing our product development, our future research and development expenses will depend on the clinical success of our product candidates, as well as ongoing assessments of each candidate’s commercial potential. As we obtain results from clinical trials, we may elect to discontinue or delay clinical trials for our product candidates in certain of the Indications in order to focus our resources on more promising indications for any such product candidate. Completion of clinical trials may take several years or more, but the length of time generally varies according to the type, complexity, novelty and intended use of a product candidate.

 

We expect our research and development expenses to increase in the future as we continue the advancement of our clinical product development for the Indications and as we potentially pursue additional indications. The lengthy process of completing clinical trials and seeking regulatory approval for our product candidates requires the expenditure of substantial resources. Any failure or delay in completing clinical trials, or in obtaining regulatory approvals, could cause a delay in generating product revenue and cause our research and development expenses to increase and, in turn, have a material adverse effect on our operations.

 

General and Administrative Expenses

 

General and administrative expenses consist primarily of compensation (including share-based compensation) for employees in executive and operational roles, including accounting, finance, investor relations, information technology and human resources. Our other significant general and administrative expenses include facilities costs, professional fees for outside accounting and legal services, including legal work in connection with patent applications, travel costs and insurance premiums. We expect that our general and administrative expenses will increase over time, as we currently expect increases in the number of our executive, accounting and administrative personnel due to our anticipated growth.

 

 

Other expenses, net

 

Other expenses, net consists of bank fees, exchange rate differences and gains and losses resulting from our investments in bank deposits and marketable securities.

 

Critical Accounting Policies and Estimates

 

The preparation of financial statements in accordance with U.S. generally accepted accounting principles (“GAAP”) requires management to make estimates and assumptions that affect the amounts reported in our financial statements and accompanying notes. Management bases its estimates on historical experience, market and other conditions, and various other assumptions it believes to be reasonable. Although these estimates are based on management’s best knowledge of current events and actions that may impact us in the future, the estimation process is, by its nature, uncertain given that estimates depend on events over which we may not have control. If market and other conditions change from those that we anticipate, our financial statements may be materially affected. In addition, if our assumptions change, we may need to revise our estimates, or take other corrective actions, either of which may also have a material effect in our financial statements. We review our estimates, judgments, and assumptions used in our accounting practices periodically and reflect the effects of revisions in the period in which they are deemed to be necessary. We believe that these estimates are reasonable; however, our actual results may differ from these estimates.

 

We believe the following accounting policies to be the most critical to the judgments and estimates used in the preparation of our financial statements. For additional detail regarding our significant accounting policies, please see the notes to our audited consolidated financial statements contained in our Annual Report on Form 20-F for the year ended December 31, 2022 as filed with the SEC on April 10, 2023.

 

Share-Based Compensation

 

We have issued restricted stock units and options to purchase our ordinary shares. Share-based compensation cost is measured at the grant date based on the fair value of the award and is recognized as an expense over the requisite service/vesting period. Determining the appropriate fair value model and calculating the fair value of share-based payment awards require the use of highly subjective assumptions, including the expected life of the share-based payment awards and share price volatility.

 

We estimate the grant date fair value of share options and the related compensation expense, using the Black-Scholes option valuation model. This option valuation model requires the input of subjective assumptions including: (1) expected life (estimated period of time outstanding) of the options granted, (2) volatility, (3) risk-free rate and (4) dividends. In general, the assumptions used in calculating the fair value of share-based payment awards represent management’s best estimates, but the estimates involve inherent uncertainties and the application of management judgment.

 

Leases: 

 

We determine if an arrangement includes a lease at inception. Right-of-use assets represent our right to use an underlying asset for the lease term; and lease liabilities represent our obligation to make lease payments arising from the lease. Right-of-use assets and lease liabilities are recognized at the commencement date of the lease, renewal date of the lease or significant remodeling of the lease space based on the present value of the remaining future minimum lease payments. Leases with a term greater than one year are recognized on the balance sheet as right-of-use assets and short-term and long-term lease liabilities, as applicable.

 

Operating lease liabilities and their corresponding right-of-use assets are initially recorded based on the present value of lease payments over the expected remaining lease term. The interest rate implicit in lease contracts is typically not readily determinable. As a result, we utilize our incremental borrowing rate to discount lease payments, which reflects the fixed rate at which we could borrow on a collateralized basis the amount of the lease payments in the same currency, for a similar term, in a similar economic environment.

 

Our leases include options to extend or terminate the lease. In determining the lease term, management uses its judgement to determine whether or not an option would be reasonably certain to be exercised. Management considers all facts and circumstances, including their past practice and any cost that will be incurred to change the asset if an option to extend is not taken, to help determine the lease term. Extension options are only included in the lease term if the lease is reasonably certain to be extended.

 

 

Results of Operations

 

Six-Months Ended June 30, 2023 Compared to Six-Months Ended June 30, 2022 

 

The table below provides our results of operations for the six months ended June 30, 2023 and June 30, 2022  

 

		Six Months Ended June 30
		2023				2022
		(In thousands, except per share data) (unaudited)
Research and development expenses		$	10,211			$	8,792
General and administrative expenses			3,221				3,483
Operating loss			(13,432	)			(12,275	)
Other expense, net			(578	)			(5,863	)
Operating loss post other expenses, net			(14,010	)			(18,138	)
Taxes on income							-
Net loss			(14,010	)			(18,138	)
Basic loss per share		$	(0.76	)		$	(0.99	)
Diluted loss per share		$	(0.76	)		$	(0.99	)

  

Three-Months Ended June 30, 2023 Compared to Three-Months Ended June 30, 2022

 

The table below provides our results of operations for the three months ended June 30, 2023 and June 30, 2022:

 

		Three Months Ended June 30
		2023				2022
		(In thousands, except per share data) (unaudited)
Research and development expenses		$	5,035			$	4,110
General and administrative expenses			1,614				1,761
Operating loss			(6,649	)			(5,871	)
Other income(expenses), net			(143	)			(4,042	)
Operating loss post other expenses, net			(6,792	)			(9,913	)
Taxes on income
Net income (loss)			(6,792	)			(9,913	)
Basic loss per share		$	(0.37	)		$	(0.54	)
Diluted loss per share		$	(0.37	)		$	(0.54	)

 

 

Research and Development Expenses

 

For the six and three months ended June 30, 2023 and 2022, we incurred research and development expenses in the aggregate of $10,211,000, $5,035,000, $8,792,000 and $4,110,000, respectively. The increase of $1,419,000, or 16%, in research and development expenses for the six months ended June 30, 2023 as compared to the comparable six month period in 2022 was primarily due to a $2,054,000 increase in expenses for clinical studies and pre-clinical studies, partially offset by a $189,000 decrease in share based compensation expense and a $379,000 decrease in lease payments and overhead expenses related to our manufacturing plant space in Yavne Israel, which is intended to be used for the manufacture of Allocetra^TM. Due to our management’s decision in September 2022 to delay the use of this manufacturing plant space and to lease such space to potential clients for a period of approximately three years, all plant related expenses were classified as of that date to general and administrative expenses.

 

The increase of $925,000, or 22%, in research and development expenses for the three months ended June 30, 2023, as compared to the second quarter of 2022 was primarily due to a $1,137,000 increase in pre-clinical studies, clinical studies and consumption of materials, offset by a $219,000 decrease in lease payments and overhead expenses related to our manufacturing plant space.

 

General and Administrative Expenses

 

For the six and three months ended June 30, 2023 and 2022, we incurred general and administrative expenses in the aggregate of $3,221,000, $1,614,000, $3,483,000, and $1,761,000, respectively. The decrease of $262,000, or 8%, in general and administrative expenses for the six months ended June 30, 2023 as compared to the 2022 period was primarily due to a $150,000 decrease in stock-based compensation expense with respect to equity granted to employees and directors, a $119,000 decrease in insurance expenses, a $112,000 decrease in professional fees related to intellectual property regulatory expenses and a $165,000 decrease in payroll expenses, offset by a $345,000 increase in rent and maintenance expenses.

 

The decrease of $147,000, or 8%, in general and administrative expenses for the three months ended June 30, 2023 as compared to the 2022 period was primarily due to a $153,000 decrease in payroll expenses and a $125,000 decrease in professional fees related to intellectual property regulatory expenses, offset by a $159,000 increase in rent and maintenance expenses.

 

Operating Loss

 

Due to an increase in research and development expenses for the six and three month periods ended June 30, 2023, our operating loss was $13,432,000 and $6,649,000, respectively, representing an increase of $1,157,000 and $778,000, or 9% and 13%, respectively, as compared to our operating loss for the six and three month periods ended June 30, 2022. This increase resulted primarily from increased research and development expenses, including expenses relating to conducting clinical studies and trials.

 

Other Expenses, Net

 

Other expenses, net consists of the following:

  

●

Interest earned on our cash and cash equivalents;

 

	●	Expenses or income resulting from fluctuations of the NIS and Euro, in which a portion of our assets and liabilities are denominated, against the U.S. dollar; and
	●	Realized and unrealized gains and losses from marketable equity securities.

 

For the six and three months ended June 30, 2023 and 2022, we recorded other expenses, net of $578,000, $143,000, $5,863,000 and $4,042,000 respectively. The decrease of $5,285,000, or 90%, in other expenses, net for the six months ended June 30, 2023 as compared to the six months ended June 30, 2022 was primarily due to $884,000 of interest income from bank deposits in 2023, as compared to $145,000 in 2022, a loss of $1,983,000 from marketable securities in 2022 that was not repeated in 2023, as well as by a loss of $1,458,000 resulting from foreign exchange currency fluctuations on cash and cash equivalents in 2023 as compared to a loss of $4,025,000 in 2022.

 

 

The decrease of $3,899,000, or 96%, in other expenses, net for the three months ended June 30, 2023 as compared to the three months ended June 30, 2022 was primarily due to $422,000 of income from interest on bank deposits in 2023 as compared to $100,000 in 2022, as well as by a loss of $558,000 resulting from foreign exchange currency fluctuations on cash and cash equivalents in 2023 as compared to $4,142,000 in 2022.

 

Net Loss

 

For the six and three months ended June 30, 2023, our net loss was $14,010,000, $6,792,000, $18,138,000 and $9,913,000 respectively, representing a decrease of $4,128,000 and $3,121,000, or 22% and 32%, respectively, as compared to our net loss for the comparable prior year periods This decrease resulted primarily from a decrease in other expenses, net, which was partially offset by an increase in the costs of clinical and pre-clinical studies.

 

Cash Flows

 

Six Months Ended June 30, 2023 Compared to Six Months Ended June 20, 2022

 

For the six months ended June 30, 2023 and 2022, net cash used in operations was $12,807,000 and 12,542,000, respectively. The increase in net cash used in operations for 2023 was primarily due to an increase in research and development expenses as a result of increases in the costs of clinical and pre-clinical studies.

 

For the six months ended June 30, 2023 and 2022, net cash (used in) provided by investing activities was $(34,048,000) and $21,356,000 respectively. The decrease in net cash provided by investing activities for 2023 as compared to 2022 resulted primarily from net investment in bank deposits of $33,930,000 as compared to net proceeds from sales of marketable securities of $60,941,000 in the comparable prior year period.

 

For the six months ended June 30, 2023 and 2022, net cash provided by financing activities was $360,000 and $100,000, respectively. This increase in cash provided by financing activities for 2023 as compared to 2022 resulted primarily from net proceeds of $360,000 from our issuance of ordinary shares under the ATM Agreement (as defined below) as compared to proceeds of $100,000 from the exercise of options in the comparable prior year period.

 

Liquidity and Capital Resources

 

We have incurred substantial losses since our inception. As of June 30, 2023, we had an accumulated deficit of approximately $97 million and working capital (current assets less current liabilities) of approximately $25.8 million. An additional $7.1 of our cash was classified as a long-term interest-bearing bank deposit, resulting in total working capital and deposits which mature within the next 18 months of $32.9 million as of June 30, 2023. We expect to incur losses from operations for the foreseeable future, and we expect to incur increasing research and development expenses, including expenses related to the hiring of personnel, conducting preclinical studies and clinical trials and outsourcing of certain development activities. We expect that general and administrative expenses will also increase as we expand our finance and administrative staff and add infrastructure.

 

Developing product candidates, conducting clinical trials and commercializing products are expensive, and we will need to raise substantial additional funds to achieve our strategic objectives. We believe that our existing cash resources will be sufficient to fund our projected cash requirements approximately through the fourth quarter of 2024. During 2022, we introduced a Company-wide cost cutting program designed to extend our cash runway potentially into 2025. Nevertheless, we will require significant additional financing in the future to fund our operations, including if and when we progress into additional clinical trials, obtain regulatory approval for any of our product candidates and commercialize the same. We believe that we will need to raise significant additional funds before we have any cash flow from operations, if at all. Our future capital requirements will depend on many factors, including:

 

●

the progress and costs of our preclinical studies, clinical trials and other research and development activities;

 

●

the scope, prioritization and number of our clinical trials and other research and development programs;

 

●

the amount of revenues and contributions we receive under future licensing, development and commercialization arrangements with respect to our product candidates;

 

●

the costs of the development and expansion of our operational infrastructure;

 

●

the costs and timing of obtaining regulatory approval for our product candidates;

 

●

the costs of filing, prosecuting, enforcing and defending patent claims and other intellectual property rights;

 

●

the costs and timing of securing manufacturing arrangements for clinical or commercial production;

 

●

the costs of contracting with third parties to provide sales and marketing capabilities for us;

 

	●	the costs of acquiring or undertaking development and commercialization efforts for any future products, product candidates or platforms;
	●	the receipt of additional government grants;
	●	the magnitude of our general and administrative expenses; and

 

●

any cost that we may incur under future in- and out-licensing arrangements relating to our product candidates.

 

Other than under our ATM Agreement, we currently do not have any commitments for future external funding. In the future, we will need to raise additional funds, and we may decide to raise additional funds even before we need such funds if the conditions for raising capital are favorable. Until we can generate significant recurring revenues, we expect to satisfy our future cash needs through debt or equity financings, credit facilities or by out-licensing applications of our product candidates. The sale of equity, including under out ATM Agreement, or convertible debt securities may result in dilution to our existing shareholders. The incurrence of indebtedness would result in increased fixed obligations and could also subject us to covenants that restrict our operations. We cannot be certain that additional funding, whether through grants from the IIA, financings, credit facilities or out-licensing arrangements, will be available to us on acceptable terms, if at all. If sufficient funds are not available, we may be required to delay, reduce the scope of or eliminate research or development plans for, or commercialization efforts with respect to, one or more applications of our product candidates, or obtain funds through arrangements with collaborators or others that may require us to relinquish rights to certain potential products that we might otherwise seek to develop or commercialize independently.

 

ATM Agreement

 

On December 30, 2022 we entered into an agreement (the “ATM Agreement”) with Cantor Fitzgerald & Co. and JMP Securities LLC (each referred to as an “Agent”, and together, the “Agents”), as sales agents, pursuant to which we may elect to sell, but are not obligated to sell, ordinary shares having an aggregate offering price of up to $100,000,000 from time to time through the Agents. Our offer and sale of ordinary shares under the ATM Agreement may be made in transactions deemed to be “at-the-market” offerings as defined in Rule 415 under the Securities Act,  including sales made directly on or through the Nasdaq Capital Market, or any other existing trading market in the United States for the ordinary shares, sales made to or through a market maker other than on an exchange or otherwise, directly to an Agent as principal, in negotiated transactions, or in any other method permitted by law, which may include block trades. We have agreed to pay the Agents an aggregate commission of 3.0% of the gross sales price from each sale of ordinary shares under the ATM Agreement. Any sale of ordinary shares under the ATM Agreement will be made pursuant to our effective shelf registration statement on Form F-3, including the prospectus contained therein (File No. 333-264561). During the six months ended June 30, 2023, we received net proceeds of $360,000 from our issuance of ordinary shares under the ATM Agreement.

 

Foreign Currency Exchange Risk

 

Our foreign currency exposures give rise to market risk associated with exchange rate movements of the U.S. dollar, mainly against the NIS, and vice versa, because a considerable portion of our expenses are denominated in the NIS. Our NIS expenses consist principally of payments made to employees, sub-contractors and consultants for preclinical studies, clinical trials, rent and other research and development activities. We anticipate that a sizable portion of our expenses will continue to be denominated in the NIS. Our financial position, results of operations and cash flow are subject to fluctuations due to changes in foreign currency exchange rates. Our results of operations and cash flow are, therefore, subject to fluctuations due to changes in foreign currency exchange rates and may be adversely affected in the future due to changes in foreign exchange rates.

 

 

 

7

 

v3.23.2

Document And Entity Information	6 Months Ended
	Jun. 30, 2023
Document Information Line Items
Entity Registrant Name	ENLIVEX THERAPEUTICS LTD.
Document Type	6-K
Current Fiscal Year End Date	--12-31
Amendment Flag	false
Entity Central Index Key	0001596812
Document Period End Date	Jun. 30, 2023
Document Fiscal Year Focus	2023
Document Fiscal Period Focus	Q2
Entity File Number	001-36578

v3.23.2

Condensed Consolidated Balance Sheets (Unaudited) - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Current Assets
Cash and cash equivalents	$ 3,458	$ 49,945
Short term interest-bearing bank deposits	25,443	299
Prepaid expenses and other receivables	1,884	2,086
Total Current Assets	30,785	52,330
Non-Current Assets
Long term interest-bearing bank deposits	7,159
Property and equipment, net	9,574	9,875
Other assets	5,510	5,437
Total Non-Current Assets	22,243	15,312
TOTAL ASSETS	53,028	67,642
Current Liabilities
Accounts payable	1,554	1,948
Accrued expenses and other liabilities	3,437	4,659
Total Current Liabilities	4,991	6,607
Non-Current Liabilities
Other long-term liabilities	3,702	4,194
Total Non-Current Liabilities	3,702	4,194
Commitments and Contingent Liabilities
TOTAL LIABILITIES	8,693	10,801
SHAREHOLDERS’ EQUITY
Ordinary shares of NIS 0.4 par value: Authorized: 45,000,000 shares as of June 30, 2023 and December 31, 2022; Issued and outstanding: 18,589,139 and 18,421,852 as of June 30, 2023 and December 31, 2022;	2,136	2,117
Additional paid in capital	138,133	136,648
Foreign currency translation adjustments	1,101	1,101
Accumulated deficit	(97,035)	(83,025)
TOTAL SHAREHOLDERS’ EQUITY	44,335	56,841
TOTAL LIABILITIES AND SHAREHOLDERS’ EQUITY	$ 53,028	$ 67,642

v3.23.2

Condensed Consolidated Balance Sheets (Unaudited) (Parentheticals) - ₪ / shares	Jun. 30, 2023	Dec. 31, 2022
Statement of Financial Position [Abstract]
Ordinary shares, par value (in New Shekels per share)	₪ 0.4	₪ 0.4
Ordinary shares, authorized	45,000,000	45,000,000
Ordinary shares, Issued	18,589,139	18,421,852
Ordinary shares, outstanding	18,589,139	18,421,852

v3.23.2

Condensed Consolidated Statements of Operations and Loss (Unaudited) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Income Statement [Abstract]
Revenues
Operating expenses:
Research and development expenses	5,035	4,110	10,211	8,792
General and administrative expenses	1,614	1,761	3,221	3,483
Total operating expenses	6,649	5,871	13,432	12,275
Operating loss	(6,649)	(5,871)	(13,432)	(12,275)
Other expenses, net	(143)	(4,042)	(578)	(5,863)
Net loss	$ (6,792)	$ (9,913)	$ (14,010)	$ (18,138)
Basic loss per share (in Dollars per share)	$ (0.37)	$ (0.54)	$ (0.76)	$ (0.99)
Weighted average number of shares outstanding (in Shares)	18,584,801	18,375,206	18,550,702	18,372,521

v3.23.2

Condensed Consolidated Statements of Operations and Loss (Unaudited) (Parentheticals) - $ / shares	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Income Statement [Abstract]
Diiluted loss per share	$ (0.37)	$ (0.54)	$ (0.76)	$ (0.99)

v3.23.2

Condensed Consolidated Statements of Changes in Shareholders' Equity (Unaudited) - USD ($) $ in Thousands	Ordinary Shares	Additional paid in capital	Currency translation reserve	Accumulated deficit	Total
Balance at Dec. 31, 2021	$ 2,107	$ 133,796	$ 1,101	$ (51,965)	$ 85,039
Balance (in Shares) at Dec. 31, 2021	18,331,507
Restricted stock units vested	$ 4	(4)
Restricted stock units vested (in Shares)	34,295
Exercise of options	$ 1	49			50
Exercise of options (in Shares)	7,625
Stock based compensation		788			788
Net loss				(8,225)	(8,225)
Balance at Mar. 31, 2022	$ 2,112	134,629	1,101	(60,190)	77,652
Balance (in Shares) at Mar. 31, 2022	18,373,427
Balance at Dec. 31, 2021	$ 2,107	133,796	1,101	(51,965)	85,039
Balance (in Shares) at Dec. 31, 2021	18,331,507
Net loss					(18,138)
Balance at Jun. 30, 2022	$ 2,113	135,375	1,101	(70,103)	68,486
Balance (in Shares) at Jun. 30, 2022	18,381,052
Balance at Mar. 31, 2022	$ 2,112	134,629	1,101	(60,190)	77,652
Balance (in Shares) at Mar. 31, 2022	18,373,427
Exercise of options	$ 1	49			50
Exercise of options (in Shares)	7,625
Stock based compensation		697			697
Net loss				(9,913)	(9,913)
Balance at Jun. 30, 2022	$ 2,113	135,375	1,101	(70,103)	68,486
Balance (in Shares) at Jun. 30, 2022	18,381,052
Balance at Dec. 31, 2022	$ 2,117	136,648	1,101	(83,025)	56,841
Balance (in Shares) at Dec. 31, 2022	18,421,852
Restricted stock units vested	$ 3	(3)
Restricted stock units vested (in Shares)	34,295
Issuance of shares for cash consideration	$ 13	305			318
Issuance of shares for cash consideration (in Shares)	110,115
Stock based compensation		633			633
Net loss				(7,218)	(7,218)
Balance at Mar. 31, 2023	$ 2,133	137,583	1,101	(90,243)	50,574
Balance (in Shares) at Mar. 31, 2023	18,566,262
Balance at Dec. 31, 2022	$ 2,117	136,648	1,101	(83,025)	56,841
Balance (in Shares) at Dec. 31, 2022	18,421,852
Net loss					(14,010)
Balance at Jun. 30, 2023	$ 2,136	138,133	1,101	(97,035)	44,335
Balance (in Shares) at Jun. 30, 2023	18,589,139
Balance at Mar. 31, 2023	$ 2,133	137,583	1,101	(90,243)	50,574
Balance (in Shares) at Mar. 31, 2023	18,566,262
Restricted stock units vested	$ 1	(1)
Restricted stock units vested (in Shares)	8,821
Exercise of options
Exercise of options (in Shares)
Issuance of shares for cash consideration	$ 2	40			42
Issuance of shares for cash consideration (in Shares)	14,056
Stock based compensation		511			511
Net loss				(6,792)	(6,792)
Balance at Jun. 30, 2023	$ 2,136	$ 138,133	$ 1,101	$ (97,035)	$ 44,335
Balance (in Shares) at Jun. 30, 2023	18,589,139

v3.23.2

Condensed Consolidated Statements of Changes in Shareholders' Equity (Unaudited) (Parentheticals) - USD ($) $ in Thousands	3 Months Ended
	Jun. 30, 2023	Mar. 31, 2023
Statement of Stockholders' Equity [Abstract]
Cash consideration	$ 43	$ 470
Net of issuance costs	$ 1	$ 152

v3.23.2

Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022
Cash flows from operating activities
Net (loss)	$ (14,010)	$ (18,138)
Adjustments required to reflect net cash used in operating activities:
Depreciation	421	364
Non-cash operating lease expenses	434	411
Share-based compensation	1,144	1,485
Loss on marketable securities and short-term bank deposits	1,626	4,886
Changes in operating asset and liability items:
Increase in prepaid expenses and other receivables	(169)	(205)
Decrease in accounts payable trade	(240)	(211)
Decrease in accrued expenses and other liabilities	(1,389)	(307)
Operating lease liabilities	(624)	(827)
Net cash used in operating activities	(12,807)	(12,542)
Cash flows from investing activities
Purchase of property and equipment	(200)	(4,351)
Proceeds from sale of property and equipment	82
Investment in short-term interest bearing bank deposits	(34,218)	(35,234)
Release of short-term interest bearing bank deposits	288
Purchases of marketable securities		(1,608)
Proceeds from sales of marketable securities		62,549
Net cash (used in) provided by investing activities	(34,048)	21,356
Cash flows from financing activities
Proceeds from issuance of shares, net	360
Proceeds from exercise of options		100
Net cash provided by financing activities	360	100
Increase (decrease) in cash and cash equivalents	(46,495)	8,914
Cash and cash equivalents - beginning of period	50,357	11,636
Cash and cash equivalents - end of period	3,862	20,550
Supplemental disclosures of cash flow information:
Cash paid for taxes
Cash paid (received) for interest, net	$ 233	$ 45

v3.23.2

General	6 Months Ended
	Jun. 30, 2023
General [Abstract]
GENERAL	NOTE 1 – GENERAL   a. Enlivex Therapeutics Ltd. (the “Parent” and, including its consolidated subsidiaries, “we”, “us”, “our” or the “Company”) is a clinical-stage macrophage reprogramming immunotherapy company originally incorporated on January 22, 2012 under the laws of the State of Israel.   The Company is developing AllocetraTM, a universal, off-the-shelf cell therapy designed to reprogram macrophages into their homeostatic state. Resetting non-homeostatic macrophages into their homeostatic state is critical for immune system rebalancing and resolution of life-threatening conditions. Non-homeostatic macrophages contribute significantly to the severity of certain diseases, which include solid tumors, sepsis and others.   AllocetraTM is based on the discoveries of Professor Dror Mevorach, an expert on immune activity, macrophage activation and clearance of dying (apoptotic) cells, in his laboratory in the Hadassah University Hospital located in the State of Israel.    The Company’s ordinary shares, par value of NIS 0.40 per share (“Ordinary Shares”), are traded under the symbol “ENLV” on both the Nasdaq Capital Market and on the Tel Aviv Stock Exchange.   b. Financial Resources   The Company devotes substantially all of its efforts toward research and development activities and raising capital to support such activities. The Company’s activities are subject to significant risks and uncertainties, including failing to secure additional funding before the Company achieves sustainable revenues and profit from operations.   Research and development activities have required significant capital investment since the Company’s inception. The Company expects that its operations will require additional cash investment to pursue the Company’s research and development activities, including preclinical studies, formulation development, clinical trials and related drug manufacturing. The Company has not generated any revenues or product sales and has not achieved profitable operations or positive cash flow from operations. The Company has incurred net losses since its inception, and, as of June 30, 2023, had an accumulated deficit of $97,035 thousand.   The Company expects to continue to incur losses for at least the next several years, and the Company will need to raise additional debt or equity financing or enter into partnerships to fund its development. If the Company is not able to achieve its funding requirements, it may be required to reduce discretionary spending, may not be able to continue the development of its product candidates or may be required to delay its development programs, which could have a material adverse effect on the Company’s ability to achieve its intended business objectives. There can be no assurances that additional financing will be secured or, if secured, will be on favorable terms. The ability of the Company to transition to profitability in the longer term is dependent on developing products and product revenues to support its expenses.   The Company’s management and board of directors (the “Board”) are of the opinion that the Company’s current financial resources will be sufficient to continue the development of the Company’s product candidates for at least twelve months from the date of filing of these financial statements on Form 6-K. The Company may determine, however, to raise additional capital during such period as the Board deems prudent. The Company’s management plans to finance its operations with issuances of the Company’s equity securities and, in the longer term, revenues. There are no assurances, however, that the Company will be successful in obtaining the financing necessary for its long-term development. The Company’s ability to continue to operate in the long term is dependent upon additional financial support.

v3.23.2

Significant Accounting Policies	6 Months Ended
	Jun. 30, 2023
Accounting Policies [Abstract]
SIGNIFICANT ACCOUNTING POLICIES	NOTE 2 – SIGNIFICANT ACCOUNTING POLICIES   These unaudited condensed consolidated financial statements include the accounts of the Company and have been prepared in accordance with U.S. generally accepted accounting principles (“U.S. GAAP”) for interim financial information. Accordingly, certain information and footnote disclosures normally included in financial statements prepared in accordance with U.S. GAAP have been condensed or omitted. In the opinion of management, all adjustments (consisting of normal recurring adjustments) considered necessary for a fair presentation have been made.   These unaudited condensed consolidated financial statements should be read in conjunction with the Company’s audited annual financial statements and notes thereto included in the Company’s 2022 Annual Report on Form 20-F, as filed with the SEC on April 10, 2023. The results of operations for the interim periods presented herein are not necessarily indicative of the operating results for any future period. The December 31, 2022 financial information has been derived from the Company’s audited financial statements.   Use of Estimates   The preparation of interim financial statements in conformity with U.S. GAAP requires management to make certain estimates, judgments and assumptions that affect the reported amounts in the consolidated balance sheets and statements of operations, it also requires that management exercise its judgment in applying the Company’s accounting policies. On an ongoing basis, management evaluates its estimates, including estimates related to its stock-based compensation expense and implicit interest rate on new lease liabilities. Significant estimates in these interim financial statements include estimates made for accrued research and development expenses and stock-based compensation expenses.   Functional Currency and Translation to The Reporting Currency   The functional currency of the Company is the U.S. dollar because the U.S. dollar is the currency of the primary economic environment in which the Company operates and expects to continue to operate in the foreseeable future.   Balances related to non-monetary assets and liabilities are based on translated amounts as of the date of the change, and non-monetary assets acquired and liabilities were translated at the approximate exchange rate prevailing at the date of the transaction. Transactions included in the statement of income were translated at the approximate exchange rate in effect at the time of the applicable transaction.   1 U.S. dollar = 3.7 NIS and 3.519 NIS as of June 30, 2023 and December 31, 2022, respectively.   The U.S. dollar increased against the NIS: 2.35%, 5.14%, 10.2% and 12.54% in the three and six month periods ended June 30, 2023 and 2022, respectively.   Recently Adopted Accounting Standards   During the six months ended June 30, 2023, the Company was not required to adopt any recently issued accounting standards.   Recently Issued Accounting Pronouncements Not Yet Adopted   The Company has evaluated other recently issued accounting pronouncements and does not currently believe that any of these pronouncements will have a material impact on its condensed consolidated financial statements and related disclosures.   Significant Accounting Policies   There have been no material changes to the significant accounting policies previously disclosed in the Company’s Annual Report on Form 20-F for the year ended December 31, 2022.   Marketable Securities.   The Company has an investment policy that includes guidelines on acceptable investment securities, minimum credit quality, maturity parameters, and concentration and diversification. The Company from time-to-time invests a portion of its excess cash in mutual funds that are classified based on the nature of their underlying securities and their availability for use in current operations. The Company’s marketable equity securities are measured at fair value with gains and losses recognized in other expense, net.   Net (loss) realized on equity securities for the three and six month periods ended June 30, 2023 and 2022 was $0, $0, $0 and $(1,982) thousand, respectively.

v3.23.2

Cash, Cash Equivalents and Restricted Cash	6 Months Ended
	Jun. 30, 2023
Cash and Cash Equivalents [Abstract]
CASH, CASH EQUIVALENTS AND RESTRICTED CASH	NOTE 3 – CASH, CASH EQUIVALENTS AND RESTRICTED CASH       June 30,     December 31,   (in thousands)   2023     2022   Cash held in banks   $ 1,024     $ 2,123   Bank deposits in U.S.$ (annual average interest rates 4.29%% and 0.1%)     2,434       47,822   Total cash and cash equivalents     3,458       49,945   Restricted cash – current – Prepaid expenses and other receivables     113       113   Restricted cash – noncurrent – Other assets     291       299   Total cash, cash equivalents and restricted cash shown in the statement of cash flows   $ 3,862     $ 50,357

v3.23.2

Short Term Interest-Bearing Bank Deposits	6 Months Ended
	Jun. 30, 2023
Short Term Interest-Bearing Bank Deposits [Abstract]
SHORT TERM INTEREST-BEARING BANK DEPOSITS	NOTE 4 – SHORT TERM INTEREST-BEARING BANK DEPOSITS       June 30,     December 31,   (in thousands)   2023     2022   Bank deposits in U.S.$ (annual average interest rates 5.94% and 0.3%)   $ 6,165     $ 299   Bank deposits in NIS (annual average interest rates 4.31%)     19,278       -   Total short-term deposits   $ 25,443     $ 299

v3.23.2

Long Term Interest-Bearing Bank Deposits	6 Months Ended
	Jun. 30, 2023
Long Term Interest-Bearing Bank Deposits [Abstract]
LONG TERM INTEREST-BEARING BANK DEPOSITS	NOTE 5 – LONG TERM INTEREST-BEARING BANK DEPOSITS       June 30,     December 31,   (in thousands)   2023     2022   Bank deposits in U.S.$ (annual average interest rates 4.22%)   $ 7,159     $        -   Total long-term interest-bearing bank deposits   $ 7,159     $ -

v3.23.2

Property and Equipment	6 Months Ended
	Jun. 30, 2023
Property, Plant and Equipment [Abstract]
PROPERTY AND EQUIPMENT	NOTE 6 – PROPERTY AND EQUIPMENT   Property and equipment, net consisted of the following:     June 30,     December 31,   (in thousands)   2023     2022                 Cost:             Laboratory equipment   $ 2,837     $ 2,851   Computers     276       276   Office furniture & equipment     317       249   Leasehold improvements     8,672       8,606         12,102       11,982   Accumulated depreciation:                 Laboratory equipment     1,690       1,432   Computers     242       203   Office furniture & equipment     34       28   Leasehold improvements     562       444         2,528       2,107   Depreciated cost   $ 9,574     $ 9,875     Depreciation expenses for the three and six month periods ended June 30, 2023 and 2022 were $212, $421, $176 and $364 thousand, respectively.

v3.23.2

Other Assets	6 Months Ended
	Jun. 30, 2023
Other Assets [Abstract]
OTHER ASSETS	NOTE 7 – OTHER ASSETS       June 30,     December 31,   (in thousands)   2023     2022                 Restricted cash   $ 291     $ 299   Long-term prepaid expenses     485       113   Right-of-Use assets, net     4,734       5,025       $ 5,510     $ 5,437

v3.23.2

Accrued Expenses and Other Liabilities	6 Months Ended
	Jun. 30, 2023
Accrued Expenses and Other Liabilities [Abstract]
ACCRUED EXPENSES AND OTHER LIABILITIES	NOTE 8 – ACCRUED EXPENSES AND OTHER LIABILITIES       June 30,     December 31,   (in thousands)   2023     2022                 Vacation, convalescence and bonus accruals   $ 461     $ 759   Employees and payroll related     612       539   Short term operating lease liabilities     667       653   Accrued expenses and other     1,697       2,708       $ 3,437     $ 4,659

v3.23.2

Leases	6 Months Ended
	Jun. 30, 2023
Leases [Abstract]
LEASES	NOTE 9 – LEASES   The Company is a party to operating leases for its corporate offices, laboratory space and vehicles. The Company’s real property operating leases have remaining lease terms of up to 3.25 years, some of which include options to extend the leases for up to five years.       Six months ended June 30,   (in thousands)   2023     2022                 The components of lease expense were as follows:             Operating leases expenses   $ 522     $ 517   Supplemental consolidated cash flow information related to operating leases follows:                 Cash used in operating activities   $ 520     $ 478   Non-cash activity:                 Right of use assets obtained in exchange for new operating lease liabilities   $ 145     $ 91         June 30,     December 31,   (in thousands)   2023     2022   Supplemental information related to operating leases, including location of amounts reported in the accompanying consolidated balance sheets, follows:             Other assets - Right-of-Use assets   $ 6,590     $ 6,445   Accumulated amortization     1,856       1,420   Operating lease Right-of-Use assets, net   $ 4,734     $ 5,025   Lease liabilities – current - Accounts payable and accrued liabilities   $ 667     $ 653   Lease liabilities – noncurrent     3,702       4,194   Total operating lease liabilities   $ 4,369     $ 4,847   Weighted average remaining lease term in years     7.1       7.6   Weighted average annual discount rate     3.4 %     3.4 %   Maturities of operating lease liabilities as of June 30, 2022, were as follows:   2023(after June 30)   $ 344   2024     696   2025     717   2026     581   2027     551   2028 and onwards     2,069   Total undiscounted lease liability   $ 4,958   Less: Imputed interest   $ (589 ) Present value of lease liabilities   $ 4,369

v3.23.2

Commitments and Contingent Liabilities	6 Months Ended
	Jun. 30, 2023
Commitments and Contingencies Disclosure [Abstract]
COMMITMENTS AND CONTINGENT LIABILITIES	NOTE 10 – COMMITMENTS AND CONTINGENT LIABILITIES   The Company is required to pay royalties to the State of Israel (represented by the Israeli Innovation Authority (the “IIA”)), computed on the basis of proceeds from the sale or license of products for which development was supported by IIA grants. These royalties are generally 3% - 5% of sales until repayment of 100% of the grants (linked to the dollar) received by the Company plus accrued interest   The gross amount of grants received by the Company from the IIA, including accrued interest as of June 30, 2023, was approximately $9.6 million. As of June 30, 2023, the Company had not paid any royalties to the IIA.

v3.23.2

Equity	6 Months Ended
	Jun. 30, 2023
Equity [Abstract]
EQUITY	NOTE 11 – EQUITY   All Company warrants are classified as a component of shareholders’ equity because such warrants are free standing financial instruments that are legally detachable, separately exercisable, do not embody an obligation for the Company to repurchase its own shares, and permit the holders to receive a fixed number of Ordinary Shares upon exercise, requires physical settlement and do not provide any guarantee of value or return.       Number  of Warrants     Weighted average exercise price   Outstanding January 1, 2023     202,251     $ 23.31   Outstanding and exercisable June 30, 2023     202,251     $ 23.31     Composed of the following:   Number of Warrants     Exercise Price Per Share       Issuance date     Expiration date     22,750     $ 10     February 26, 2020   February 24, 2025   160,727     $ 25     February 12, 2021   February 9, 2026   18,774     $ 25     February 17, 2021   February 9, 2026   202,251

v3.23.2

Share-Based Compensation	6 Months Ended
	Jun. 30, 2023
Share-Based Payment Arrangement [Abstract]
SHARE-BASED COMPENSATION	NOTE 12 – SHARE-BASED COMPENSATION   a) As of June 30, 2023, 5,028,704 Ordinary Shares were authorized for issuance to employees, directors and consultants under the 2019 Equity Incentive Plan, of which 1,537,973 shares were available for future grant.   b) The following table contains information concerning options granted under the existing equity incentive plan:       Three months ended June 30,       2023     2022       Number of options     Weighted average exercise price     Number of options     Weighted average exercise price   Outstanding at beginning of period     2,929,868     $ 5.84       2,399,622     $ 5.95   Forfeited and expired     (14,375 )   $ 6.82       (3,000 )   $ 5.34   Exercised     -     $ -       (7,625 )   $ 6.49   Outstanding at end of period     2,915,493     $ 5.84       2,388,997     $ 5.95   Exercisable at end of period     2,090,378     $ 5.59       1,728,623     $ 5.10                                     Non-vested at beginning of period     876,851     $ 6.48       722,749     $ 7.67   Vested     (37,861 )   $ 11.13       (59,375 )   $ (8.78 ) Forfeited     (13,875 )   $ 5.90       (3,000 )   $ (5.34 ) Non-vested at the end of period     825,115     $ 6.27       660,374     $ 7.59         Six months ended June 30,       2023     2022       Number of options     Weighted average exercise price     Number of options     Weighted average exercise price   Outstanding at beginning of period     2,939,434     $ 5.85       2,142,547     $ 6.02   Granted     -             $ 264,700     $ 5.48   Forfeited and expired     (23,941 )   $ 6.71       (3,000 )   $ 5.34   Exercised     -             $ (15,250 )   $ 6.49   Outstanding at end of period     2,915,493     $ 5.84       2,388,997     $ 5.95   Exercisable at end of period     2,090,378     $ 5.59       1,728,623     $ 5.10                                     Non vested at beginning of period     986,005     $ 6.46       529,082     $ 8.69   Granted     -     $ -       264,700     $ 5.48   Forfeited and expired     (15,375 )   $ 6.73       (3,000 )   $ 5.34   vested     (145,515 )   $ 7.44       (130,408 )   $ 7.82   Outstanding at end of period     825,115     $ 6.27       660,374     $ 7.59     During the three and six month periods ended June 30, 2023 and 2022, the Company recognized $427, $957, $509 and $1,074 thousand, respectively, of share-based compensation expenses related to stock options.   As of June 30, 2023, the total unrecognized estimated compensation cost related to outstanding non-vested stock options was $1,766 thousand, which is expected to be recognized over a weighted average period of 1.32 years.   c) Set forth below is data regarding the range of exercise prices and remaining contractual life for all options outstanding on June 30, 2023:   Exercise price     Number of options outstanding     Remaining contractual Life (in years)     Intrinsic Value of Options Outstanding (in thousands)     No. of options exercisable   $ 2.69       649,883       1.92               -       649,883   $ 3.66       250,000       6.84       -       250,000   $ 4.68       48,750       6.75       -       36,563   $ 5.34       208,825       8.75       -       53,800   $ 5.34       445,792       9.38       -       69,263   $ 5.96       150,000       9.38       -       -   $ 6.22       634,177       4.00       -       634,177   $ 8.19       150,000       6.38       -       112,500   $ 8.23       12,500       8.38       -       5,000   $ 9.02       40,500       7.38       -       20,250   $ 10.12       12,126       5.43       -       12,126   $ 12.23       250,000       7.91       -       194,444   $ 14.00       60,500       7.82       -       50,417   $ 21.40       1,940       6.07       -       1,455   $ 90.16       500       1.42       -       500             2,915,493               -       2,090,378     d) The following table contains information concerning restricted stock units granted under the existing equity incentive plan:       Three months ended June 30,       2023     2022       Number of shares     Weighted average grant date fair value     Number of shares     Weighted average grant date fair value   Nonvested at beginning of period     114,329     $ 9.97       184,787     $ 10.02   Vested     (3,438 )   $ 10.28       (3,437 )   $ 10.28   Forfeited     (313 )   $ 14.67       -     $ -   Nonvested at end of period     110,578     $ 9.95       181,350     $ 10.02         Six months ended June 30,       2023     2022       Number of shares     Weighted average grant date fair value     Number of shares     Weighted average grant date fair value   Nonvested at beginning of period     157,560     $ 10.02       229,331     $ 10.08   Vested     (46,544 )   $ 10.15       (47,981 )   $ 10.29   Forfeited     (438 )   $ 14.67       -     $ -   Nonvested at end of period     110,578     $ 9.95       181,350     $ 10.02     The Company estimates the fair value of restricted stock units based on the closing sales price of the Ordinary Shares on the date of grant (or the closing bid price, if no sales were reported). For the three and six month periods ended June 30, 2023 and 2022, the Company recognized $84, $187, $188 and $411 thousand, respectively, of share-based compensation expense related to restricted stock units. Total share-based compensation expense related to restricted stock units not yet recognized as of June 30, 2023 was $331 thousand, which is expected to be recognized over a weighted average period of 0.66 years.    e) The following table summarizes share-based compensation expenses related to grants under the existing equity incentive plan included in the statements of operations:       Three months ended June 30,     Six months ended June 30,   (in thousands)   2023     2022     2023     2022   Research & development   $ 122     $ 119     $ 318     $ 509   General & administrative     389       578       826       976   Total   $ 511     $ 697     $ 1,144     $ 1,485

v3.23.2

Fair Value Measurement	6 Months Ended
	Jun. 30, 2023
Fair Value Disclosures [Abstract]
FAIR VALUE MEASUREMENT	NOTE 13 – FAIR VALUE MEASUREMENT   The Company’s financial assets and liabilities measured at fair value on a recurring basis consisted of the following types of instruments as of June 30, 2023 and December 31, 2022:   (in thousands)   June 30, 2023       Total     Level 1     Level 2     Level 3   Cash and cash equivalents   $ 3,862     $ 3,862     $        -     $       -   Short term deposits     25,443       25,443       -       -   Long term deposits     7,159       7,159       -       -   Restricted cash current     113       113       -       -   Restricted cash non-current     291       291       -       -   Total financial assets   $ 38,868     $ 38,868     $ -     $ -     (in thousands)   December 31, 2022       Total     Level 1     Level 2     Level 3   Cash and cash equivalents   $ 49,945     $ 49,945     $       -     $       -   Short term deposits     299       299       -       -   Restricted cash current     113       113       -       -   Restricted cash non-current     299       299       -       -   Total financial assets   $ 50,656     $ 50,656     $ -     $ -

v3.23.2

Events Subsequent to the Balance Sheet Date	6 Months Ended
	Jun. 30, 2023
Subsequent Events [Abstract]
EVENTS SUBSEQUENT TO THE BALANCE SHEET DATE	NOTE 14 – EVENTS SUBSEQUENT TO THE BALANCE SHEET DATE   The Company evaluated all events and transactions that occurred subsequent to the balance sheet date and prior to the date on which these unaudited condensed consolidated financial statements were issued and determined that no subsequent event necessitated disclosure.

v3.23.2

Accounting Policies, by Policy (Policies)	6 Months Ended
	Jun. 30, 2023
Accounting Policies [Abstract]
Use of Estimates	Use of Estimates The preparation of interim financial statements in conformity with U.S. GAAP requires management to make certain estimates, judgments and assumptions that affect the reported amounts in the consolidated balance sheets and statements of operations, it also requires that management exercise its judgment in applying the Company’s accounting policies. On an ongoing basis, management evaluates its estimates, including estimates related to its stock-based compensation expense and implicit interest rate on new lease liabilities. Significant estimates in these interim financial statements include estimates made for accrued research and development expenses and stock-based compensation expenses.
Functional Currency and Translation to The Reporting Currency	Functional Currency and Translation to The Reporting Currency The functional currency of the Company is the U.S. dollar because the U.S. dollar is the currency of the primary economic environment in which the Company operates and expects to continue to operate in the foreseeable future. Balances related to non-monetary assets and liabilities are based on translated amounts as of the date of the change, and non-monetary assets acquired and liabilities were translated at the approximate exchange rate prevailing at the date of the transaction. Transactions included in the statement of income were translated at the approximate exchange rate in effect at the time of the applicable transaction. 1 U.S. dollar = 3.7 NIS and 3.519 NIS as of June 30, 2023 and December 31, 2022, respectively. The U.S. dollar increased against the NIS: 2.35%, 5.14%, 10.2% and 12.54% in the three and six month periods ended June 30, 2023 and 2022, respectively.
Recently Adopted Accounting Standards	Recently Adopted Accounting Standards During the six months ended June 30, 2023, the Company was not required to adopt any recently issued accounting standards.
Recently Issued Accounting Pronouncements Not Yet Adopted	Recently Issued Accounting Pronouncements Not Yet Adopted The Company has evaluated other recently issued accounting pronouncements and does not currently believe that any of these pronouncements will have a material impact on its condensed consolidated financial statements and related disclosures.
Significant Accounting Policies	Significant Accounting Policies There have been no material changes to the significant accounting policies previously disclosed in the Company’s Annual Report on Form 20-F for the year ended December 31, 2022.
Marketable Securities.	Marketable Securities. The Company has an investment policy that includes guidelines on acceptable investment securities, minimum credit quality, maturity parameters, and concentration and diversification. The Company from time-to-time invests a portion of its excess cash in mutual funds that are classified based on the nature of their underlying securities and their availability for use in current operations. The Company’s marketable equity securities are measured at fair value with gains and losses recognized in other expense, net. Net (loss) realized on equity securities for the three and six month periods ended June 30, 2023 and 2022 was $0, $0, $0 and $(1,982) thousand, respectively.

v3.23.2

Cash, Cash Equivalents and Restricted Cash (Tables)	6 Months Ended
	Jun. 30, 2023
Cash and Cash Equivalents [Abstract]
Schedule of Cash and Cash Equivalents and Restricted Cash	CASH, CASH EQUIVALENTS AND RESTRICTED CASH     June 30,     December 31,   (in thousands)   2023     2022   Cash held in banks   $ 1,024     $ 2,123   Bank deposits in U.S.$ (annual average interest rates 4.29%% and 0.1%)     2,434       47,822   Total cash and cash equivalents     3,458       49,945   Restricted cash – current – Prepaid expenses and other receivables     113       113   Restricted cash – noncurrent – Other assets     291       299   Total cash, cash equivalents and restricted cash shown in the statement of cash flows   $ 3,862     $ 50,357

v3.23.2

Short Term Interest-Bearing Bank Deposits (Tables)	6 Months Ended
	Jun. 30, 2023
Short Term Interest-Bearing Bank Deposits [Abstract]
Schedule of Short Term Deposits	SHORT TERM INTEREST-BEARING BANK DEPOSITS     June 30,     December 31,   (in thousands)   2023     2022   Bank deposits in U.S.$ (annual average interest rates 5.94% and 0.3%)   $ 6,165     $ 299   Bank deposits in NIS (annual average interest rates 4.31%)     19,278       -   Total short-term deposits   $ 25,443     $ 299

v3.23.2

Long Term Interest-Bearing Bank Deposits (Tables)	6 Months Ended
	Jun. 30, 2023
Long Term Interest-Bearing Bank Deposits [Abstract]
Schedule of Long Term Interest-Bearing Bank Deposits	LONG TERM INTEREST-BEARING BANK DEPOSITS     June 30,     December 31,   (in thousands)   2023     2022   Bank deposits in U.S.$ (annual average interest rates 4.22%)   $ 7,159     $        -   Total long-term interest-bearing bank deposits   $ 7,159     $ -

v3.23.2

Property and Equipment (Tables)	6 Months Ended
	Jun. 30, 2023
Property, Plant and Equipment [Abstract]
Schedule of Property and Equipment	Property and equipment, net consisted of the following:   June 30,     December 31,   (in thousands)   2023     2022                 Cost:             Laboratory equipment   $ 2,837     $ 2,851   Computers     276       276   Office furniture & equipment     317       249   Leasehold improvements     8,672       8,606         12,102       11,982   Accumulated depreciation:                 Laboratory equipment     1,690       1,432   Computers     242       203   Office furniture & equipment     34       28   Leasehold improvements     562       444         2,528       2,107   Depreciated cost   $ 9,574     $ 9,875

v3.23.2

Other Assets (Tables)	6 Months Ended
	Jun. 30, 2023
Other Assets [Abstract]
Schedule of Other Assets	OTHER ASSETS     June 30,     December 31,   (in thousands)   2023     2022                 Restricted cash   $ 291     $ 299   Long-term prepaid expenses     485       113   Right-of-Use assets, net     4,734       5,025       $ 5,510     $ 5,437

v3.23.2

Accrued Expenses and Other Liabilities (Tables)	6 Months Ended
	Jun. 30, 2023
Accrued Expenses and Other Liabilities [Abstract]
Schedule of Accrued Expenses and Other Liabilities	ACCRUED EXPENSES AND OTHER LIABILITIES     June 30,     December 31,   (in thousands)   2023     2022                 Vacation, convalescence and bonus accruals   $ 461     $ 759   Employees and payroll related     612       539   Short term operating lease liabilities     667       653   Accrued expenses and other     1,697       2,708       $ 3,437     $ 4,659

v3.23.2

Leases (Tables)	6 Months Ended
	Jun. 30, 2023
Leases [Abstract]
Schedule of Operating Lease	The Company is a party to operating leases for its corporate offices, laboratory space and vehicles. The Company’s real property operating leases have remaining lease terms of up to 3.25 years, some of which include options to extend the leases for up to five years.     Six months ended June 30,   (in thousands)   2023     2022                 The components of lease expense were as follows:             Operating leases expenses   $ 522     $ 517   Supplemental consolidated cash flow information related to operating leases follows:                 Cash used in operating activities   $ 520     $ 478   Non-cash activity:                 Right of use assets obtained in exchange for new operating lease liabilities   $ 145     $ 91
Schedule of Supplemental Information Related to Operating Leases	June 30,     December 31,   (in thousands)   2023     2022   Supplemental information related to operating leases, including location of amounts reported in the accompanying consolidated balance sheets, follows:             Other assets - Right-of-Use assets   $ 6,590     $ 6,445   Accumulated amortization     1,856       1,420   Operating lease Right-of-Use assets, net   $ 4,734     $ 5,025   Lease liabilities – current - Accounts payable and accrued liabilities   $ 667     $ 653   Lease liabilities – noncurrent     3,702       4,194   Total operating lease liabilities   $ 4,369     $ 4,847   Weighted average remaining lease term in years     7.1       7.6   Weighted average annual discount rate     3.4 %     3.4 %
Schedule of Maturities of Operating Lease Liabilities	Maturities of operating lease liabilities as of June 30, 2022, were as follows: 2023(after June 30)   $ 344   2024     696   2025     717   2026     581   2027     551   2028 and onwards     2,069   Total undiscounted lease liability   $ 4,958   Less: Imputed interest   $ (589 ) Present value of lease liabilities   $ 4,369

v3.23.2

Equity (Tables)	6 Months Ended
	Jun. 30, 2023
Equity [Abstract]
Schedule of Number of Ordinary Shares Upon Exercise	All Company warrants are classified as a component of shareholders’ equity because such warrants are free standing financial instruments that are legally detachable, separately exercisable,     Number  of Warrants     Weighted average exercise price   Outstanding January 1, 2023     202,251     $ 23.31   Outstanding and exercisable June 30, 2023     202,251     $ 23.31
Schedule of Changes in Exercisable Ordinary Shares Warrants	Composed of the following Number of Warrants     Exercise Price Per Share       Issuance date     Expiration date     22,750     $ 10     February 26, 2020   February 24, 2025   160,727     $ 25     February 12, 2021   February 9, 2026   18,774     $ 25     February 17, 2021   February 9, 2026   202,251

v3.23.2

Share-Based Compensation (Tables)	6 Months Ended
	Jun. 30, 2023
Share-Based Payment Arrangement [Abstract]
Schedule of Employees and Directors Stock Options	The following table contains information concerning options granted under the existing equity incentive plan     Three months ended June 30,       2023     2022       Number of options     Weighted average exercise price     Number of options     Weighted average exercise price   Outstanding at beginning of period     2,929,868     $ 5.84       2,399,622     $ 5.95   Forfeited and expired     (14,375 )   $ 6.82       (3,000 )   $ 5.34   Exercised     -     $ -       (7,625 )   $ 6.49   Outstanding at end of period     2,915,493     $ 5.84       2,388,997     $ 5.95   Exercisable at end of period     2,090,378     $ 5.59       1,728,623     $ 5.10                                     Non-vested at beginning of period     876,851     $ 6.48       722,749     $ 7.67   Vested     (37,861 )   $ 11.13       (59,375 )   $ (8.78 ) Forfeited     (13,875 )   $ 5.90       (3,000 )   $ (5.34 ) Non-vested at the end of period     825,115     $ 6.27       660,374     $ 7.59         Six months ended June 30,       2023     2022       Number of options     Weighted average exercise price     Number of options     Weighted average exercise price   Outstanding at beginning of period     2,939,434     $ 5.85       2,142,547     $ 6.02   Granted     -             $ 264,700     $ 5.48   Forfeited and expired     (23,941 )   $ 6.71       (3,000 )   $ 5.34   Exercised     -             $ (15,250 )   $ 6.49   Outstanding at end of period     2,915,493     $ 5.84       2,388,997     $ 5.95   Exercisable at end of period     2,090,378     $ 5.59       1,728,623     $ 5.10                                     Non vested at beginning of period     986,005     $ 6.46       529,082     $ 8.69   Granted     -     $ -       264,700     $ 5.48   Forfeited and expired     (15,375 )   $ 6.73       (3,000 )   $ 5.34   vested     (145,515 )   $ 7.44       (130,408 )   $ 7.82   Outstanding at end of period     825,115     $ 6.27       660,374     $ 7.59
Schedule of Exercise Prices and Remaining Contractual Life	Set forth below is data regarding the range of exercise prices and remaining contractual life for all options outstanding on June 30, 2023 Exercise price     Number of options outstanding     Remaining contractual Life (in years)     Intrinsic Value of Options Outstanding (in thousands)     No. of options exercisable   $ 2.69       649,883       1.92               -       649,883   $ 3.66       250,000       6.84       -       250,000   $ 4.68       48,750       6.75       -       36,563   $ 5.34       208,825       8.75       -       53,800   $ 5.34       445,792       9.38       -       69,263   $ 5.96       150,000       9.38       -       -   $ 6.22       634,177       4.00       -       634,177   $ 8.19       150,000       6.38       -       112,500   $ 8.23       12,500       8.38       -       5,000   $ 9.02       40,500       7.38       -       20,250   $ 10.12       12,126       5.43       -       12,126   $ 12.23       250,000       7.91       -       194,444   $ 14.00       60,500       7.82       -       50,417   $ 21.40       1,940       6.07       -       1,455   $ 90.16       500       1.42       -       500             2,915,493               -       2,090,378
Schedule of Restricted Stock Units	The following table contains information concerning restricted stock units granted under the existing equity incentive plan     Three months ended June 30,       2023     2022       Number of shares     Weighted average grant date fair value     Number of shares     Weighted average grant date fair value   Nonvested at beginning of period     114,329     $ 9.97       184,787     $ 10.02   Vested     (3,438 )   $ 10.28       (3,437 )   $ 10.28   Forfeited     (313 )   $ 14.67       -     $ -   Nonvested at end of period     110,578     $ 9.95       181,350     $ 10.02       Six months ended June 30,       2023     2022       Number of shares     Weighted average grant date fair value     Number of shares     Weighted average grant date fair value   Nonvested at beginning of period     157,560     $ 10.02       229,331     $ 10.08   Vested     (46,544 )   $ 10.15       (47,981 )   $ 10.29   Forfeited     (438 )   $ 14.67       -     $ -   Nonvested at end of period     110,578     $ 9.95       181,350     $ 10.02
Schedule of Share-Based Compensation Expenses Related to Grants Under the Equity Incentive Plan	The following table summarizes share-based compensation expenses related to grants under the existing equity incentive plan included in the statements of operations     Three months ended June 30,     Six months ended June 30,   (in thousands)   2023     2022     2023     2022   Research & development   $ 122     $ 119     $ 318     $ 509   General & administrative     389       578       826       976   Total   $ 511     $ 697     $ 1,144     $ 1,485

v3.23.2

Fair Value Measurement (Tables)	6 Months Ended
	Jun. 30, 2023
Fair Value Disclosures [Abstract]
Schedule of Financial Assets and Liabilities Measured at Fair Value on a Recurring Basis	The Company’s financial assets and liabilities measured at fair value on a recurring basis consisted of the following types of instruments as of June 30, 2023 and December 31, 2022: (in thousands)   June 30, 2023       Total     Level 1     Level 2     Level 3   Cash and cash equivalents   $ 3,862     $ 3,862     $        -     $       -   Short term deposits     25,443       25,443       -       -   Long term deposits     7,159       7,159       -       -   Restricted cash current     113       113       -       -   Restricted cash non-current     291       291       -       -   Total financial assets   $ 38,868     $ 38,868     $ -     $ -   (in thousands)   December 31, 2022       Total     Level 1     Level 2     Level 3   Cash and cash equivalents   $ 49,945     $ 49,945     $       -     $       -   Short term deposits     299       299       -       -   Restricted cash current     113       113       -       -   Restricted cash non-current     299       299       -       -   Total financial assets   $ 50,656     $ 50,656     $ -     $ -

v3.23.2

General (Details) $ in Thousands	Jun. 30, 2023 USD ($)	Jun. 30, 2023 ₪ / shares	Dec. 31, 2022 USD ($)
General (Textual)
Aggregate of ordinary shares | ₪ / shares		₪ 0.4
Accumulated deficit	$ (97,035)		$ (83,025)
Financial Resources [Member]
General (Textual)
Accumulated deficit	$ 97,035

v3.23.2

Significant Accounting Policies (Details) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023 USD ($)	Jun. 30, 2022 USD ($)	Jun. 30, 2023 USD ($)	Jun. 30, 2022 USD ($)	Dec. 31, 2022
Significant Accounting Policies (Details) [Line Items]
Functional currency amount (in Dollars)			$ 1
Functional currency increased percentage	2.35%	10.20%	5.14%	12.54%
Net (loss) realized on equity securities (in Dollars)	$ 0	$ 0	$ 0	$ (1,982)
NIS [Member]
Significant Accounting Policies (Details) [Line Items]
Exchange rate	3.7		3.7		3.519

v3.23.2

Cash, Cash Equivalents and Restricted Cash (Details) - Schedule of Cash and Cash Equivalents and Restricted Cash - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Schedule of Cash and Cash Equivalents and Restricted Cash [Abstract]
Cash held in banks	$ 1,024	$ 2,123
Bank deposits in U.S.$ (annual average interest rates 4.29%% and 0.1%)	2,434	47,822
Total cash and cash equivalents	3,458	49,945
Restricted cash – current – Prepaid expenses and other receivables	113	113
Restricted cash – noncurrent – Other assets	291	299
Total cash, cash equivalents and restricted cash shown in the statement of cash flows	$ 3,862	$ 50,357

v3.23.2

Cash, Cash Equivalents and Restricted Cash (Details) - Schedule of Cash and Cash Equivalents and Restricted Cash (Parentheticals)	Jun. 30, 2023	Dec. 31, 2022
Schedule of Cash and Cash Equivalents and Restricted Cash [Abstract]
Annual average interest rates	4.29%	0.10%

v3.23.2

Short Term Interest-Bearing Bank Deposits (Details) - Schedule of Short Term Deposits - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Short-Term Debt [Line Items]
Bank deposits	$ 7,159
Total short-term deposits	25,443	299
U.S. [Member]
Short-Term Debt [Line Items]
Bank deposits	6,165	299
NIS [Member]
Short-Term Debt [Line Items]
Bank deposits	$ 19,278

v3.23.2

Short Term Interest-Bearing Bank Deposits (Details) - Schedule of Short Term Deposits (Parentheticals)	6 Months Ended	12 Months Ended
	Jun. 30, 2023	Dec. 31, 2022
U.S. [Member]
Short-Term Debt [Line Items]
Average annual interest rates	5.94%	0.30%
NIS [Member]
Short-Term Debt [Line Items]
Average annual interest rates	4.31%	4.31%

v3.23.2

Long Term Interest-Bearing Bank Deposits (Details) - Schedule of Long Term Interest-Bearing Bank Deposits - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Schedule of Long Term Interest Bearing Bank Deposits [Abstract]
Bank deposits	$ 7,159
Total long-term interest-bearing bank deposits	$ 7,159

v3.23.2

Long Term Interest-Bearing Bank Deposits (Details) - Schedule of Long Term Interest-Bearing Bank Deposits (Parentheticals)	6 Months Ended	12 Months Ended
	Jun. 30, 2023	Dec. 31, 2022
Schedule of Long Term Interest Bearing Bank Deposits [Abstract]
Annual average interest rates	4.22%	4.22%

v3.23.2

Property and Equipment (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Property, Plant and Equipment [Abstract]
Depreciation expenses	$ 212	$ 176	$ 421	$ 364

v3.23.2

Property and Equipment (Details) - Schedule of Property and Equipment - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Property, Plant and Equipment [Line Items]
Cost	$ 12,102	$ 11,982
Total accumulated depreciation	2,528	2,107
Depreciated cost	9,574	9,875
Laboratory equipment [Member]
Property, Plant and Equipment [Line Items]
Cost	2,837	2,851
Total accumulated depreciation	1,690	1,432
Computers [Member]
Property, Plant and Equipment [Line Items]
Cost	276	276
Total accumulated depreciation	242	203
Office furniture & equipment [Member]
Property, Plant and Equipment [Line Items]
Cost	317	249
Total accumulated depreciation	34	28
Leasehold improvements [Member]
Property, Plant and Equipment [Line Items]
Cost	8,672	8,606
Total accumulated depreciation	$ 562	$ 444

v3.23.2

Other Assets (Details) - Schedule of Other Assets - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Schedule of Other Assets [Abstract]
Restricted cash	$ 291	$ 299
Long-term prepaid expenses	485	113
Right-of-Use assets, net	4,734	5,025
Total	$ 5,510	$ 5,437

v3.23.2

Accrued Expenses and Other Liabilities (Details) - Schedule of Accrued Expenses and Other Liabilities - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Schedule of Accrued Expenses and Other Liabilities [Abstract]
Vacation, convalescence and bonus accruals	$ 461	$ 759
Employees and payroll related	612	539
Short term operating lease liabilities	667	653
Accrued expenses and other	1,697	2,708
Accrued expenses and other liabilities, Total	$ 3,437	$ 4,659

v3.23.2

Leases (Details)	Jun. 30, 2023
Leases (Details) [Line Items]
Extend the leases period	5 years
Leases [Member]
Leases (Details) [Line Items]
Operating leases have remaining lease terms	3 years 3 months

v3.23.2

Leases (Details) - Schedule of Operating Lease - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022
The components of lease expense were as follows:
Operating leases expenses	$ 522	$ 517
Supplemental consolidated cash flow information related to operating leases follows:
Cash used in operating activities	520	478
Non-cash activity:
Right of use assets obtained in exchange for new operating lease liabilities	$ 145	$ 91

v3.23.2

Leases (Details) - Schedule of Supplemental Information Related to Operating Leases - USD ($) $ in Thousands	6 Months Ended	12 Months Ended
	Jun. 30, 2023	Dec. 31, 2022
Schedule of Operating Lease Related Activities [Abstract]
Other assets - Right-of-Use assets	$ 6,590	$ 6,445
Accumulated amortization	1,856	1,420
Operating lease Right-of-Use assets, net	4,734	5,025
Lease liabilities – current - Accounts payable and accrued liabilities	667	653
Lease liabilities – noncurrent	3,702	4,194
Total operating lease liabilities	$ 4,369	$ 4,847
Weighted average remaining lease term in years	7 years 1 month 6 days	7 years 7 months 6 days
Weighted average annual discount rate	3.40%	3.40%

v3.23.2

Leases (Details) - Schedule of Maturities of Operating Lease Liabilities $ in Thousands	Jun. 30, 2022 USD ($)
Schedule of Maturities of Operating Lease Liabilities [Abstract]
2023(after June 30)	$ 344
2024	696
2025	717
2026	581
2027	551
2028 and onwards	2,069
Total undiscounted lease liability	4,958
Less: Imputed interest	(589)
Present value of lease liabilities	$ 4,369

v3.23.2

Commitments and Contingent Liabilities (Details) $ in Millions	6 Months Ended
	Jun. 30, 2023 USD ($)
Commitments and Contingent Liabilities (Details) [Line Items]
Repayment of grants percentage	100.00%
Accrued interest amount (in Dollars)	$ 9.6
Minimum [Member]
Commitments and Contingent Liabilities (Details) [Line Items]
Percentage of royalties in sales	3.00%
Maximum [Member]
Commitments and Contingent Liabilities (Details) [Line Items]
Percentage of royalties in sales	5.00%

v3.23.2

Equity (Details) - Schedule of Number of Ordinary Shares Upon Exercise - Warrants [Member] - $ / shares	Jun. 30, 2023	Jun. 30, 2022
Equity (Details) - Schedule of Number of Ordinary Shares Upon Exercise [Line Items]
Number of Warrants Outstanding beginning balance		202,251
Weighted average exercise price Outstanding beginning balance		$ 23.31
Number of Warrants Outstanding ending balance	202,251
Weighted average exercise price Outstanding ending balance	$ 23.31

v3.23.2

Equity (Details) - Schedule of Changes in Exercisable Ordinary Shares Warrants	6 Months Ended
	Jun. 30, 2023 $ / shares shares
Class of Warrant or Right [Line Items]
Number of Warrants	202,251
Exercise Price 10 [Member]
Class of Warrant or Right [Line Items]
Number of Warrants	22,750
Exercise price per share | $ / shares	$ 10
Issuance date	Feb. 26, 2020
Expiration date	Feb. 24, 2025
Exercise Price 25 [Member]
Class of Warrant or Right [Line Items]
Number of Warrants	160,727
Exercise price per share | $ / shares	$ 25
Issuance date	Feb. 12, 2021
Expiration date	Feb. 09, 2026
Exercise Price 25 [Member]
Class of Warrant or Right [Line Items]
Number of Warrants	18,774
Exercise price per share | $ / shares	$ 25
Issuance date	Feb. 17, 2021
Expiration date	Feb. 09, 2026

v3.23.2

Share-Based Compensation (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Share-Based Compensation (Details) [Line Items]
Ordinary shares authorized (in Shares)	5,028,704		5,028,704
Share-based compensation expenses	$ 427	$ 957	$ 509	$ 1,074
Employees' Stock Option [Member]
Share-Based Compensation (Details) [Line Items]
Total unrecognized estimated compensation cost			$ 1,766
Weighted average period			1 year 3 months 25 days
Consultants' Stock Options [Member]
Share-Based Compensation (Details) [Line Items]
Total unrecognized estimated compensation cost			$ 331
Weighted average period			7 months 28 days
2019 Equity Incentive Plan [Member]
Share-Based Compensation (Details) [Line Items]
Future grant share (in Shares)	1,537,973		1,537,973
Restricted Stock [Member]
Share-Based Compensation (Details) [Line Items]
Share-based compensation expenses	$ 84	$ 187	$ 188	$ 411

v3.23.2

Share-Based Compensation (Details) - Schedule of Employees and Directors Stock Options - $ / shares	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Schedule of Employees and Directors Stock Options [Abstract]
Number of options, Outstanding at beginning of period	2,929,868	2,399,622	2,939,434	2,142,547
Weighted average exercise price, Outstanding at beginning of period	$ 5.84	$ 5.95	$ 5.85	$ 6.02
Number of options, Granted				264,700
Weighted average exercise price, Granted				$ 5.48
Number of options, Forfeited and expired	(14,375)	(3,000)	(23,941)	(3,000)
Weighted average exercise price, Forfeited and expired	$ 6.82	$ 5.34	$ 6.71	$ 5.34
Number of options, Exercised		(7,625)		(15,250)
Weighted average exercise price, Exercised		$ 6.49		$ 6.49
Number of options, Outstanding at end of period	2,915,493	2,388,997	2,915,493	2,388,997
Weighted average exercise price, Outstanding at end of period	$ 5.84	$ 5.95	$ 5.84	$ 5.95
Number of options, Exercisable at end of period	2,090,378	1,728,623	2,090,378	1,728,623
Weighted average exercise price, Exercisable at end of period	$ 5.59	$ 5.1	$ 5.59	$ 5.1
Number of options, Non-vested at beginning of period	876,851	722,749	986,005	529,082
Weighted average exercise price, Non-vested at beginning of period	$ 6.48	$ 7.67	$ 6.46	$ 8.69
Number of options, Vested	(37,861)	(59,375)	(145,515)	(130,408)
Weighted average exercise price, Vested	$ 11.13	$ (8.78)	$ 7.44	$ 7.82
Number of options, Forfeited	(13,875)	(3,000)	(15,375)	(3,000)
Weighted average exercise price, Forfeited	$ 5.9	$ (5.34)	$ 6.73	$ 5.34
Number of options, Non-vested at the end of period	825,115	660,374	825,115	660,374
Weighted average exercise price, Non-vested at the end of period	$ 6.27	$ 7.59	$ 6.27	$ 7.59

v3.23.2

Share-Based Compensation (Details) - Schedule of Exercise Prices and Remaining Contractual Life - Stock Options [Member]	6 Months Ended
	Jun. 30, 2023 USD ($) $ / shares shares
Share-Based Payment Arrangement, Option, Exercise Price Range [Line Items]
Number of options outstanding	2,915,493
Intrinsic Value of Options Outstanding (in Dollars) | $
No. of options exercisable	2,090,378
Exercise Price One [Member]
Share-Based Payment Arrangement, Option, Exercise Price Range [Line Items]
Exercise price (in Dollars per share) | $ / shares	$ 2.69
Number of options outstanding	649,883
Remaining contractual Life (in years)	1 year 11 months 1 day
Intrinsic Value of Options Outstanding (in Dollars) | $
No. of options exercisable	649,883
Exercise Price Two [Member]
Share-Based Payment Arrangement, Option, Exercise Price Range [Line Items]
Exercise price (in Dollars per share) | $ / shares	$ 3.66
Number of options outstanding	250,000
Remaining contractual Life (in years)	6 years 10 months 2 days
Intrinsic Value of Options Outstanding (in Dollars) | $
No. of options exercisable	250,000
Exercise Price Three [Member]
Share-Based Payment Arrangement, Option, Exercise Price Range [Line Items]
Exercise price (in Dollars per share) | $ / shares	$ 4.68
Number of options outstanding	48,750
Remaining contractual Life (in years)	6 years 9 months
Intrinsic Value of Options Outstanding (in Dollars) | $
No. of options exercisable	36,563
Exercise Price Four [Member]
Share-Based Payment Arrangement, Option, Exercise Price Range [Line Items]
Exercise price (in Dollars per share) | $ / shares	$ 5.34
Number of options outstanding	208,825
Remaining contractual Life (in years)	8 years 9 months
Intrinsic Value of Options Outstanding (in Dollars) | $
No. of options exercisable	53,800
Exercise Price Five [Member]
Share-Based Payment Arrangement, Option, Exercise Price Range [Line Items]
Exercise price (in Dollars per share) | $ / shares	$ 5.34
Number of options outstanding	445,792
Remaining contractual Life (in years)	9 years 4 months 17 days
Intrinsic Value of Options Outstanding (in Dollars) | $
No. of options exercisable	69,263
Exercise Price Six [Member]
Share-Based Payment Arrangement, Option, Exercise Price Range [Line Items]
Exercise price (in Dollars per share) | $ / shares	$ 5.96
Number of options outstanding	150,000
Remaining contractual Life (in years)	9 years 4 months 17 days
Intrinsic Value of Options Outstanding (in Dollars) | $
No. of options exercisable
Exercise Price Seven [Member]
Share-Based Payment Arrangement, Option, Exercise Price Range [Line Items]
Exercise price (in Dollars per share) | $ / shares	$ 6.22
Number of options outstanding	634,177
Remaining contractual Life (in years)	4 years
Intrinsic Value of Options Outstanding (in Dollars) | $
No. of options exercisable	634,177
Exercise Price Eight [Member]
Share-Based Payment Arrangement, Option, Exercise Price Range [Line Items]
Exercise price (in Dollars per share) | $ / shares	$ 8.19
Number of options outstanding	150,000
Remaining contractual Life (in years)	6 years 4 months 17 days
Intrinsic Value of Options Outstanding (in Dollars) | $
No. of options exercisable	112,500
Exercise Price Nine [Member]
Share-Based Payment Arrangement, Option, Exercise Price Range [Line Items]
Exercise price (in Dollars per share) | $ / shares	$ 8.23
Number of options outstanding	12,500
Remaining contractual Life (in years)	8 years 4 months 17 days
Intrinsic Value of Options Outstanding (in Dollars) | $
No. of options exercisable	5,000
Exercise Price Ten [Member]
Share-Based Payment Arrangement, Option, Exercise Price Range [Line Items]
Exercise price (in Dollars per share) | $ / shares	$ 9.02
Number of options outstanding	40,500
Remaining contractual Life (in years)	7 years 4 months 17 days
Intrinsic Value of Options Outstanding (in Dollars) | $
No. of options exercisable	20,250
Exercise Price Eleven [Member]
Share-Based Payment Arrangement, Option, Exercise Price Range [Line Items]
Exercise price (in Dollars per share) | $ / shares	$ 10.12
Number of options outstanding	12,126
Remaining contractual Life (in years)	5 years 5 months 4 days
Intrinsic Value of Options Outstanding (in Dollars) | $
No. of options exercisable	12,126
Exercise Price Twelve [Member]
Share-Based Payment Arrangement, Option, Exercise Price Range [Line Items]
Exercise price (in Dollars per share) | $ / shares	$ 12.23
Number of options outstanding	250,000
Remaining contractual Life (in years)	7 years 10 months 28 days
Intrinsic Value of Options Outstanding (in Dollars) | $
No. of options exercisable	194,444
Exercise Price Thirteen [Member]
Share-Based Payment Arrangement, Option, Exercise Price Range [Line Items]
Exercise price (in Dollars per share) | $ / shares	$ 14
Number of options outstanding	60,500
Remaining contractual Life (in years)	7 years 9 months 25 days
Intrinsic Value of Options Outstanding (in Dollars) | $
No. of options exercisable	50,417
Exercise Price Fourteen [Member]
Share-Based Payment Arrangement, Option, Exercise Price Range [Line Items]
Exercise price (in Dollars per share) | $ / shares	$ 21.4
Number of options outstanding	1,940
Remaining contractual Life (in years)	6 years 25 days
Intrinsic Value of Options Outstanding (in Dollars) | $
No. of options exercisable	1,455
Exercise Price Fifteen [Member]
Share-Based Payment Arrangement, Option, Exercise Price Range [Line Items]
Exercise price (in Dollars per share) | $ / shares	$ 90.16
Number of options outstanding	500
Remaining contractual Life (in years)	1 year 5 months 1 day
Intrinsic Value of Options Outstanding (in Dollars) | $
No. of options exercisable	500

v3.23.2

Share-Based Compensation (Details) - Schedule of Restricted Stock Units - $ / shares	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Schedule of Restricted Stock Units [Abstract]
Number of shares, Nonvested at beginning of period	114,329	184,787	157,560	229,331
Weighted average grant date fair value, Nonvested at beginning of period	$ 9.97	$ 10.02	$ 10.02	$ 10.08
Number of shares, Vested	(3,438)	(3,437)	(46,544)	(47,981)
Weighted average grant date fair value, Vested	$ 10.28	$ 10.28	$ 10.15	$ 10.29
Number of shares, Forfeited	(313)		(438)
Weighted average grant date fair value, Forfeited	$ 14.67		$ 14.67
Number of shares, Nonvested at end of period	110,578	181,350	110,578	181,350
Weighted average grant date fair value, Nonvested at end of period	$ 9.95	$ 10.02	$ 9.95	$ 10.02

v3.23.2

Share-Based Compensation (Details) - Schedule of Share-Based Compensation Expenses Related to Grants Under the Equity Incentive Plan - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Total	$ 511	$ 697	$ 1,144	$ 1,485
Research & development [Member]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Total	122	119	318	509
General & administrative [Member]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Total	$ 389	$ 578	$ 826	$ 976

v3.23.2

Fair Value Measurement (Details) - Schedule of Financial Assets and Liabilities Measured at Fair Value on a Recurring Basis - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Fair Value Measurement (Details) - Schedule of Financial Assets and Liabilities Measured at Fair Value on a Recurring Basis [Line Items]
Cash and cash equivalents	$ 3,862	$ 49,945
Short term deposits	25,443	299
Long term deposits	7,159
Restricted cash current	113	113
Restricted cash non-current	291	299
Total financial assets	38,868	50,656
Level 1 [Member]
Fair Value Measurement (Details) - Schedule of Financial Assets and Liabilities Measured at Fair Value on a Recurring Basis [Line Items]
Cash and cash equivalents	3,862	49,945
Short term deposits	25,443	299
Long term deposits	7,159
Restricted cash current	113	113
Restricted cash non-current	291	299
Total financial assets	38,868	50,656
Level 2 [Member]
Fair Value Measurement (Details) - Schedule of Financial Assets and Liabilities Measured at Fair Value on a Recurring Basis [Line Items]
Cash and cash equivalents
Short term deposits
Long term deposits
Restricted cash current
Restricted cash non-current
Total financial assets
Level 3 [Member]
Fair Value Measurement (Details) - Schedule of Financial Assets and Liabilities Measured at Fair Value on a Recurring Basis [Line Items]
Cash and cash equivalents
Short term deposits
Long term deposits
Restricted cash current
Restricted cash non-current
Total financial assets

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