RNS Number:1970S
Skyepharma PLC
18 November 2003


For Immediate Release                                         18 November 2003




                         SkyePharma PLC ("the Company")



                    Notification of Major Interest in Shares



In accordance with the Companies Act 1985 (as amended) the Company was informed
by Fidelity Investments on 17 November 2003 that FMR Corp and its direct and
indirect subsidiaries and Fidelity International Limited and its direct and
indirect subsidiaries, both being non-beneficial holders, had increased their
total holding to 33,799,441 ordinary shares of 10p each, representing 5.48% of
the issued share capital of the Company.



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