Arecor Therapeutics PLC Arecor presents positive data for AT247 at ADA
June 26 2023 - 2:00AM
RNS Non-Regulatory
TIDMAREC
Arecor Therapeutics PLC
26 June 2023
Arecor Therapeutics plc
("Arecor", the "Company" or the "Group")
Arecor presents positive data from US phase I clinical trial of
ultra-rapid acting insulin candidate AT247 delivered via insulin
pump at ADA annual meeting
- Data presented at the American Diabetes Association 83(rd) Scientific Sessions
- AT247 delivers significantly accelerated insulin absorption
and early exposure (PK profile) compared with NovoLog(R) and
Fiasp(R)
- Further supports potential to enable more effective disease
management for people with Type I diabetes via fully automated
closed loop insulin pump delivery (artificial pancreas)
Cambridge, UK, 26 June 2023: Arecor Therapeutics plc (AIM:
AREC), the biopharmaceutical company advancing today's therapies to
enable healthier lives, today announces that positive results from
its second Phase I clinical trial investigating ultra-rapid acting
insulin product candidate, AT247, have been shared in a poster
presentation at the American Diabetes Association (ADA) 83(rd)
Scientific Sessions meeting, being held until today in San Diego,
California and online.
The poster, "Double blind cross over study of ultra-rapid AT247
compared with NovoLog(R) and Fiasp(R) during continuous
subcutaneous infusion (CSII) assessed by a hyperinsulinemic
euglycemic clamp", is displayed in the meeting's Poster Hall and
available as an ePoster for virtual attendees.
Dr Marcus Hompesch, MD. President and Chief Executive Officer of
ProSciento Inc, said: "AT247 has demonstrated faster insulin
absorption when delivered by continuous infusion via an insulin
pump, compared to other rapid acting insulins currently available
to patients. Its PK profile offers the potential to further improve
blood glucose control, and may play an important role in
facilitating a fully closed loop artificial pancreas - a life
changing treatment approach for people living with diabetes."
Sarah Howell, Chief Executive Officer of Arecor, added: "These
data reinforce AT247's potential to enable even more effective
disease management for people with Type I diabetes. The
availability of a truly ultra-rapid acting insulin will be a key
component in the move towards a fully closed loop artificial
pancreas system, a potentially life changing treatment option for
people living with diabetes, improving health outcomes and reducing
the significant burden of managing this chronic disease. With
AT247, Arecor has the ability to significantly advance the diabetic
treatment landscape and, ultimately, deliver better health outcomes
for patients."
AT247 is a 100U/mL ultra-rapid acting novel formulation of
insulin that has been designed to accelerate the absorption of
insulin following subcutaneous injection, to enable more effective
management of blood glucose levels for people living with
diabetes.
In the Phase I trial, faster absorption of AT247 resulted in
higher early insulin exposure than with gold standard insulins
NovoLog(R) and Fiasp(R) following bolus dose delivery during
continuous subcutaneous infusion. The demonstrated PK profile of
AT247 supports further investigation into its potential to further
improve automated insulin delivery and builds on the superior PK/PD
profile of a single AT247 dose compared with NovoLog(R) and
Fiasp(R), previously demonstrated in an earlier Phase I study.
Headline results from the ARE-AT247-103 clinical trial were
announced by the Company on 11 October 2022.
-ENDS-
For more information, please contact:
Arecor Therapeutics plc www.arecor.com
Dr Sarah Howell, Chief Executive Tel: +44 (0) 1223 426060
Officer Email: info@arecor.com
Susan Lowther, Chief Financial Officer Tel: +44 (0) 1223 426060
Email: info@arecor.com
Mo Noonan, Communications Tel: +44 (0) 7876 444977
Email: mo.noonan@arecor.com
Panmure Gordon (UK) Limited (NOMAD Tel: +44 (0) 20 7886 2500
and Broker)
Freddy Crossley, Emma Earl (Corporate
Finance)
Rupert Dearden (Corporate Broking)
Consilium Strategic Communications
Chris Gardner, David Daley, Angela Tel: +44 (0) 20 3709 5700
Gray Email: arecor@consilium-comms.com
Notes to Editors
About Arecor
Arecor Therapeutics plc is a globally focused biopharmaceutical
company transforming patient care by bringing innovative medicines
to market through the enhancement of existing therapeutic products.
By applying our innovative proprietary formulation technology
platform, Arestat(TM), we are developing an internal portfolio of
proprietary products in diabetes and other indications, as well as
working with leading pharmaceutical and biotechnology companies to
deliver enhanced formulations of their therapeutic products. The
Arestat(TM) platform is supported by an extensive patent
portfolio.
For further details please see our website, www.arecor.com
This information is provided by Reach, the non-regulatory press
release distribution service of RNS, part of the London Stock
Exchange. Terms and conditions relating to the use and distribution
of this information may apply. For further information, please
contact rns@lseg.com or visit www.rns.com.
RNS may use your IP address to confirm compliance with the terms
and conditions, to analyse how you engage with the information
contained in this communication, and to share such analysis on an
anonymised basis with others as part of our commercial services.
For further information about how RNS and the London Stock Exchange
use the personal data you provide us, please see our Privacy
Policy.
END
NRABUGDLBUDDGXX
(END) Dow Jones Newswires
June 26, 2023 02:00 ET (06:00 GMT)
Arecor Therapeutics (LSE:AREC)
Historical Stock Chart
From Jun 2024 to Jul 2024
Arecor Therapeutics (LSE:AREC)
Historical Stock Chart
From Jul 2023 to Jul 2024