Initial Statement of Beneficial Ownership (3)

FORM 3	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES	OMB APPROVAL OMB Number: 3235-0104 Estimated average burden hours per response... 0.5
	Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person ^*

Wittouck Amaury

2. Date of Event Requiring Statement (MM/DD/YYYY) 1/11/2021

3. Issuer Name and Ticker or Trading Symbol

LEXICON PHARMACEUTICALS, INC. [LXRX]

(Last) (First) (Middle)

VALLEY PARK, 44, RUE DE LA VALLEE

4. Relationship of Reporting Person(s) to Issuer (Check all applicable)

__X__ Director ___X___ 10% Owner
_____ Officer (give title below) _____ Other (specify below)

(Street)

LUXEMBOURG, N4 L-2661

(City) (State) (Zip)

5. If Amendment, Date Original Filed(MM/DD/YYYY)

6. Individual or Joint/Group Filing(Check Applicable Line)

_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Stock	32259461	I	See Footnotes ⁽¹⁾⁽²⁾⁽⁵⁾
Common Stock	3516214	I	See Footnotes ⁽¹⁾⁽³⁾⁽⁵⁾
Common Stock	35402689	I	See Footnotes ⁽¹⁾⁽⁴⁾⁽⁵⁾

*Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)*
1. Title of Derivate Security (Instr. 4)	2. Date Exercisable and Expiration Date (MM/DD/YYYY)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
1. Title of Derivate Security (Instr. 4)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	4. Conversion or Exercise Price of Derivative Security		6. Nature of Indirect Beneficial Ownership (Instr. 5)

Explanation of Responses:
(1)	On January 11, 2021, the Reporting Person became the sole member of the board of Stichting Administratiekantoor Westend (the "Stichting"), and therefore, may be deemed to beneficially own the securities reported herein. The Reporting Person disclaims beneficial ownership over the securities reported herein, except to the extent of his pecuniary interest therein, and, pursuant to Rule 16a-1(a)(4) under the Exchange Act, the Reporting Person states that the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of the reported securities for purposes of Section 16 of the Exchange Act or for any other purpose.
(2)	These securities are directly held by Artal International S.C.A.
(3)	These securities are directly held by Invus Public Equities, L.P.
(4)	These securities are directly held by Invus, L.P.
(5)	The Reporting Person is the sole member of the board of the Stichting. The Stichting is the majority stockholder of Westend S.A. Westend S.A. is the parent company of Artal Group S.A. Artal Group S.A. is the sole stockholder of Artal International Management S.A., which is the managing partner of Artal International S.C.A. Artal International S.C.A. is the managing member of Invus Advisors, L.L.C. and through its Geneva branch is the sole stockholder of Artal Treasury Limited. Artal Treasury Limited is the managing member of Invus Public Equities Advisors, LLC. Invus Public Equities Advisors, LLC is the general partner of Invus Public Equities, L.P., and Invus Advisors, L.L.C. is the general partner of Invus, L.P.

Remarks:
Invus Partners, LLC directly holds 4,321,214 shares of Issuer common stock. Neither the Reporting Person nor any of the other entities listed in Footnote 5 hereof have any beneficial or pecuniary interest for purposes of Section 16 of the Exchange Act in the shares of Issuer common stock directly held by Invus Partners, LLC. For purposes of Section 16 of the Exchange Act, the Reporting Person and the other entities listed in Footnote 5 may be deemed to be directors by deputization of the Issuer by virtue of Invus, L.P.'s right to designate certain members of the Issuer's board of directors pursuant to a stockholders' agreement between the Issuer and Invus, L.P.

Reporting Owners
Reporting Owner Name / Address	Relationships
Reporting Owner Name / Address	Director	10% Owner	Officer	Other
Wittouck Amaury VALLEY PARK, 44, RUE DE LA VALLEE LUXEMBOURG, N4 L-2661	X	X