As filed with the Securities and Exchange Commission on June 16,
2023
Registration No. 333-________
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-1
REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933
APTOSE BIOSCIENCES INC. |
(Exact Name of Registrant As Specified In Its Charter) |
Canada |
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2836 |
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98-1136802 |
(State or other jurisdiction of incorporation or organization) |
|
(Primary Standard Industrial
Classification Code Number) |
|
(I.R.S. Employer
Identification Number) |
251 Consumers Road, Suite 1105
Toronto, Ontario, Canada M2J 4R3
(647) 479-9828
(Address, including zip code, and telephone number, including area
code, of registrant’s principal executive offices) |
|
Aptose Biosciences U.S. Inc.
Unit 120, 12770 High Bluff Drive
San Diego, California 92130
(858) 926-2730 |
(Name, address, including zip code, and telephone number, including area code, of
agent for service) |
COPIES TO:
Daniel M. Miller
Dorsey & Whitney LLP
Suite 1070, 1095 West Pender Street
Vancouver, British Columbia
Canada V6E 2M6
|
Fletcher Payne
Chief Financial Officer
Aptose Biosciences Inc.
251 Consumers Road, Suite 1105
Toronto, Ontario
Canada M2J 4R3
(647) 479-9828 |
From time to time after the effective
date of this Registration Statement |
(Approximate date of commencement of proposed sale to the public) |
If any of the securities being registered on this Form are to be offered
on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, please check the following box. ☒
If this Form is used to register additional securities for an offering
pursuant to Rule 462(b) under the Securities Act, check the following box and list the Securities Act registration statement number of
the earlier effective registration statement for the same offering. ☐
If this Form is a post-effective amendment filed pursuant to Rule 462(d)
under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective
registration statement for the same offering. ☐
Indicate by check mark whether the Company is a large accelerated filer,
an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of “large accelerated filer,”
“accelerated filer” and “smaller reporting company” in Rule 12b-2 of the Exchange Act. (Check one):
Large accelerated filer |
☐ |
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Accelerated filer |
☐ |
Non-accelerated filer |
☒ |
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Smaller reporting company |
☒ |
Emerging growth company |
☐ |
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If an emerging growth company, indicate by check mark if the Company has
elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant
to Section 7(a)(2)(B) of the Securities Act. ☐
The Company hereby amends this registration statement on such date
or date(s) as may be necessary to delay its effective date until the Company shall file a further amendment which specifically states
that this registration statement shall thereafter become effective in accordance with Section 8(a) of the Securities Act of 1933, or
until the registration statement shall become effective on such date as the Commission acting pursuant to said Section 8(a) may determine.
The information in this prospectus is not complete and may
be changed. These securities may not be sold until the registration statement filed with the Securities and Exchange Commission of which
this prospectus is a part becomes effective. This prospectus is not an offer to sell these securities and it is not soliciting an offer
to buy these securities in any state where the offer or sale is not permitted.
Subject to Completion, Dated June 16, 2023
PRELIMINARY PROSPECTUS
1,257,785 Common Shares
This prospectus relates to the resale of up to 1,257,785
Common Shares, no par value, of Aptose Biosciences Inc. (the “Common Shares”), which may be offered by Keystone Capital Partners,
LLC (“Keystone”, “Keystone Capital Partners” or the “Selling Shareholder”). The Common Shares being
offered by the Selling Shareholder are outstanding or issuable pursuant to the Common Share Purchase Agreement dated May 25, 2023 (the
“Purchase Agreement”). See “The Keystone Capital Transaction” for a description of the Purchase Agreement. Also,
please refer to “Selling Shareholder” beginning on page 16. Such registration does not mean that Keystone will actually offer
or sell any of these Common Shares. We will not receive any proceeds from the sales of the above Common Shares by the Selling Shareholder;
however, we will receive proceeds under the Purchase Agreement if we sell Common Shares to the Selling Shareholder.
Our Common Shares are listed on the Nasdaq Capital
Market (“Nasdaq”), under the symbol “APTO” and on the Toronto Stock Exchange (“TSX”) under the symbol
“APS”. On June 14, 2023, the last reported sale price of the Common Shares on Nasdaq was $5.97 per Common Share and on the
TSX was C$7.94.
The Selling Shareholder is an “underwriter”
within the meaning of the Securities Act of 1933. The Selling Shareholder is offering these Common Shares. The Selling Shareholder may
sell all or a portion of these Common Shares from time to time in market transactions through any market on which our Common Shares is
then traded, in negotiated transactions or otherwise, and at prices and on terms that will be determined by the then prevailing market
price or at negotiated prices directly or through a broker or brokers, who may act as agent or as principal or by a combination of such
methods of sale. The Selling Shareholder will receive all proceeds from the sale of the Common Shares. For additional information on
the methods of sale, you should refer to the section entitled “Plan of Distribution.”
Investing in our Common Shares involves a high degree
of risk. Review the risk factors beginning on page 8 of this prospectus carefully before you make an investment in our securities. You
should read this prospectus, together with additional information described under the headings “Incorporation of Certain Information
by Reference” and “Where You Can Find More Information,” carefully before you invest in any of our securities.
Neither the Securities and Exchange Commission nor
any state securities commission has approved or disapproved of these securities or passed upon the adequacy or accuracy of this prospectus.
Any representation to the contrary is a criminal offense.
The date of this prospectus is
, 2023
INDEX
Page No.
ABOUT
THIS PROSPECTUS
This prospectus is part of a registration statement
that we have filed with the Securities and Exchange Commission (the “SEC”) pursuant to which the Selling Shareholder named
herein may, from time to time, offer and sell or otherwise dispose of the securities covered by this prospectus. You should not assume
that the information contained in this prospectus is accurate on any date subsequent to the date set forth on the front cover of this
prospectus or that any information we have incorporated by reference is correct on any date subsequent to the date of the document incorporated
by reference, even though this prospectus is delivered or securities are sold or otherwise disposed of on a later date. It is important
for you to read and consider all information contained in this prospectus, including the Information Incorporated by Reference herein,
in making your investment decision. You should also read and consider the information in the documents to which we have referred you
under the captions “Where You Can Find More Information” and “Incorporation of Certain Information by Reference”
in this prospectus.
Neither we nor the Selling Shareholder have authorized
any dealer, salesman or other person to give any information or to make any representation other than those contained or incorporated
by reference in this prospectus. You must not rely upon any information or representation not contained or incorporated by reference
in this prospectus. This prospectus does not constitute an offer to sell or the solicitation of an offer to buy any of our securities
other than the securities covered hereby, nor does this prospectus constitute an offer to sell or the solicitation of an offer to buy
any securities in any jurisdiction to any person to whom it is unlawful to make such offer or solicitation in such jurisdiction. Persons
who come into possession of this prospectus in jurisdictions outside the United States are required to inform themselves about, and to
observe, any restrictions as to the offering and the distribution of this prospectus applicable to those jurisdictions.
We further note that the representations, warranties
and covenants made in any agreement that is filed as an exhibit to any document that is incorporated by reference in the accompanying
prospectus were made solely for the benefit of the parties to such agreement, including, in some cases, for the purpose of allocating
risk among the parties to such agreements, and should not be deemed to be a representation, warranty or covenant to you. Moreover, such
representations, warranties or covenants were accurate only as of the date when made. Accordingly, such representations, warranties and
covenants should not be relied on as accurately representing the current state of our affairs.
The information in this prospectus is accurate as
of the date on the front cover. Information incorporated by reference into this prospectus is accurate as of the date of the document
from which the information is incorporated. You should not assume that the information contained in this prospectus is accurate as of
any other date.
As used in this prospectus and in any prospectus supplement,
unless the context otherwise requires, the terms “Aptose,” the “Company,” “we,” “us,”
and “our” refer to Aptose Biosciences Inc., and, unless the context requires otherwise, the subsidiaries through which it
conducts business.
As described below, in order to qualify for listing
on Nasdaq, the Company has effected a Reverse Stock Split (as defined below) on a fifteen (15) to one (1) share basis, and Common Shares
commenced trading on a post-Reverse Stock Split basis at market open on Tuesday, June 6, 2023. All share and per share amounts in this
prospectus have been adjusted retroactively to reflect the Reverse Stock Split as if it had occurred at the beginning of the earliest
period presented.
Unless stated otherwise or if the context otherwise
requires, all references to dollar amounts in this prospectus are references to U.S. dollars.
CAUTIONARY
STATEMENT REGARDING FORWARD-LOOKING STATEMENTS
This prospectus, including
the documents incorporated by reference herein, contains forward-looking statements within the meaning of the United States Private Securities
Litigation Reform Act of 1995 and “forward-looking information” within the meaning of applicable Canadian securities law.
We refer to such forward-looking statements and forward-looking information collectively as “forward-looking statements”.
These statements relate to future events or future performance and reflect our expectations and assumptions regarding our growth, results
of operations, performance and business prospects and opportunities. Such forward-looking statements reflect our current beliefs and
are based on information currently available to us. In some cases, forward-looking statements can be identified by terminology such as
“may”, “would”, “could”, “will”, “should”, “expect”, “plan”,
“intend”, “anticipate”, “believe”, “estimate”, “predict”, “potential”,
“continue” or the negative of these terms or other similar expressions concerning matters that are not historical facts.
The forward-looking statements
contained in this prospectus and in the documents incorporated by reference reflect our current views with respect to future events,
are subject to significant risks and uncertainties, and are based upon a number of estimates and assumptions that, while considered reasonable
by us, are inherently subject to significant business, economic, competitive, political and social uncertainties and contingencies. Many
factors could cause our actual results, performance or achievements to be materially different from any future results, performance,
or achievements that may be expressed or implied by such forward-looking statements, including, among others:
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our lack of product revenues and net losses and a history of operating losses; |
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our early stage of development, particularly the inherent risks and uncertainties associated with
(i) developing new drug candidates generally, (ii) demonstrating the safety and efficacy
of these drug candidates in clinical studies in humans, and (iii) obtaining regulatory approval to commercialize these drug candidates; |
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our need to raise substantial additional capital in the future and that we may be unable to raise
such funds when needed and on acceptable terms; |
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further equity financing, which may substantially dilute the interests of our existing
shareholders; |
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clinical studies and regulatory approvals of our drug candidates are subject to
delays, and may not be completed or granted on expected timetables, if at all, and such delays may increase our costs and could substantially
harm our business; |
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our reliance on external contract research/manufacturing organizations for certain
activities and if we are subject to quality, cost, or delivery issues with the preclinical and clinical grade materials supplied
by contract manufacturers, our business operations could suffer significant harm; |
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clinical studies are long, expensive
and uncertain processes and the United States Food and Drug Administration, or “FDA”,
or other similar foreign regulatory agency that we are required to report to, may ultimately
not approve any of our product candidates; |
| · | our
ability to comply with applicable regulations and standards; |
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our inability to achieve our projected development goals in the time frames we announce
and expect; |
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difficulties in enrolling patients for clinical trials may lead to delays or cancellations
of our clinical trials; |
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our reliance on third-parties to conduct and monitor our preclinical studies; |
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our ability to attract and retain key personnel, including key executives and scientists; |
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any misconduct or improper activities by our employees; |
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our exposure to exchange rate risk; |
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our ability to commercialize our business attributed to negative results from clinical
trials; |
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the marketplace may not accept our products or product candidates due to the intense
competition and technological change in the biotechnical and pharmaceuticals, and we may not be able to compete successfully against
other companies in our industries and achieve profitability; |
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our ability to obtain and maintain patent protection; |
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our ability to afford substantial costs incurred with defending our intellectual
property; |
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our ability to protect our intellectual property rights and not infringe on the
intellectual property rights of others; |
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our business is subject to potential product liability and other claims; |
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potential exposure to legal actions and potential need to take action against other
entities; |
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commercialization limitations imposed by intellectual property rights owned or controlled
by third parties; |
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our ability to maintain adequate insurance at acceptable costs; |
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our ability to find and enter into agreements with potential partners; |
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extensive government regulation; |
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data security incidents and privacy breaches could result in increased costs and
reputational harm; |
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our Common Share price has been and is likely to continue to be volatile; |
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future sales of our Common Shares by us or by our existing shareholders could cause
our Common Share price to drop; |
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changing global market and financial conditions; |
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changes in an active trading market in our Common Shares; |
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difficulties by non-Canadian investors to obtain and enforce judgments against us
because of our Canadian incorporation and presence; |
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potential adverse U.S. federal tax consequences for U.S. shareholders because we
are a “passive foreign investment company”; |
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our “smaller reporting company” status; |
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any failures to maintain an effective system of internal controls may result in
material misstatements of our financial statements, or cause us to fail to meet our reporting obligations or fail to prevent fraud; |
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our broad discretion in how we use the proceeds of the sale of Common Shares; |
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our ability to expand our business through the acquisition of companies or businesses;
and |
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other risks detailed from time-to-time in our on-going filings with the SEC and
Canadian securities regulators, and those which are discussed under the heading “Risk Factors” in this prospectus and
in the documents incorporated by reference. |
Should one or more of these
risks or uncertainties materialize, or should the assumptions described in the sections entitled “Risk Factors” in this prospectus
and in the documents incorporated by reference underlying those forward-looking statements prove incorrect, actual results may vary materially
from those described in the forward-looking statements.
More detailed information about these and other factors
is included in this prospectus under the section entitled “Risk Factors” and in the documents incorporated by reference into
this prospectus. Although we have attempted to identify factors that could cause actual actions, events or results to differ materially
from those described in forward-looking statements, there may be other factors that cause actions, events or results not to be as anticipated,
estimated or intended. Forward-looking statements are based upon our beliefs, estimates and opinions at the time they are made and we
undertake no obligation to update forward-looking statements if these beliefs, estimates and opinions or circumstances should change,
except as required by applicable law. There can be no assurance that forward-looking statements will prove to be accurate, as actual
results and future events could differ materially from those anticipated in such statements. Accordingly, readers should not place undue
reliance on forward-looking statements.
Forward-looking statements
contained in this prospectus are made as of the date of this prospectus. Forward-looking statements made in a document incorporated by
reference into this prospectus are made as of the date of the original document and have not been updated by us except as expressly provided
for in this prospectus.
Except as required under
applicable securities legislation, we undertake no obligation to publicly update or revise forward-looking statements, whether as a result
of new information, future events or otherwise. We qualify all the forward-looking statements contained in this prospectus and
the documents incorporated by reference in this prospectus by the foregoing cautionary statements.
ENFORCEABILITY
OF CIVIL LIABILITIES
We are incorporated under the laws of Canada. Many
of our directors and officers and the experts named in this prospectus are residents of countries other than the United States, and all
or a substantial portion of their assets and some of our assets are located outside the United States. We have appointed Aptose Biosciences
U.S. Inc. as our agent for service of process in the United States, but it may be difficult for holders of securities who reside in the
United States to effect service within the United States upon those directors, officers and experts who are not residents of the United
States. Additionally, it may not be possible for you to enforce judgments obtained in U.S. courts based upon the civil liability provisions
of the U.S. federal securities laws or other laws of the United States. In addition, there is doubt as to whether an original action
could be brought in Canada against us or our directors or officers based solely upon U.S. federal or state securities laws and as to
the enforceability in Canadian courts of judgments of U.S. courts obtained in actions based upon the civil liability provisions of U.S.
federal or state securities laws.
PROSPECTUS
SUMMARY
This summary highlights information contained elsewhere
in this prospectus or incorporated by reference. It may not contain all of the information that you should consider before investing
in our securities. You should read this entire prospectus carefully, including the “Risk Factors”, “Management’s
Discussion and Analysis of Financial Condition and Results of Operations” sections, and the financial statements and related
notes included or incorporated by reference herein. This prospectus includes forward-looking statements that involve risks and uncertainties.
See “Cautionary Statement Regarding Forward-Looking Statements.”
Aptose Biosciences Inc.
Company Overview
Aptose Biosciences Inc. is
a science-driven biotechnology company advancing targeted agents to treat life-threatening cancers, such as acute myeloid leukemia (“AML”),
high-risk myelodysplastic syndromes (“MDS”), chronic lymphocytic leukemia and other hematologic malignancies. Based on insights
into the genetic and epigenetic profiles of certain cancers and patient populations, Aptose is building a pipeline of novel oncology
therapies directed at dysregulated processes and signaling pathways. Aptose is developing targeted medicines for precision treatment
of these diseases to optimize efficacy and quality of life by minimizing the side effects associated with conventional therapies. We
currently have in development two molecules: tuspetinib (HM43239) and luxeptinib (CG-806), both being evaluated for safety, tolerability,
pharmacokinetics, and signals of efficacy in Phase 1 clinical trials, and a third clinical asset available for partnering (APTO-253).
Each molecule is described below.
Tuspetinib is a once daily
oral potent myeloid kinase inhibitor, targeting a constellation of kinases operative in myeloid malignancies and known to be involved
in tumor proliferation, resistance to therapy, and differentiation but avoiding kinase that typically cause toxicities associated with
other kinase inhibitors. Tuspetinib has completed the dose escalation and dose exploration stages of an international Phase 1/2 clinical
trial designed to assess the safety, tolerability, pharmacokinetics, pharmacodynamic responses, and efficacy of tuspetinib as a single
agent in patients with relapsed or refractory AML (“R/R AML”). Complete remissions (“CRs”) without dose limiting
toxicities (“DLT”) were achieved at four dose levels across a broad diversity of mutationally-defined AML populations and
with a favorable safety profile. Moreover, tuspetinib to date has caused no QTc prolongations or differentiation syndrome in treated
patients and has caused no myelosuppression with continuous dosing of patients in remission. These findings led to advancement of tuspetinib
into the APTIVATE expansion trial of the Phase 1/2 program to collect responses in R/R AML patient populations enriched with specific
genotypic backgrounds when treated with single agent tuspetinib or when combined with the venetoclax BCL-2 inhibitor, with the intent
to guide selection of mutationally-defined AML populations for single agent Phase 2 Accelerated Approval Trial(s) and to position tuspetinib
for dual and triple combination studies in later and early lines of therapy. Based on the safety and efficacy profile of tuspetinib,
we believe that tuspetinib, if approved, can reach greater than $1 billion in annual sales by 2035 because we believe tuspetinib could
(1) become the preferred kinase inhibitor for inclusion in triplet combination for front line AML patients with FLT3 mutations and for
patients with wild type FLT3, (2) become the preferred kinase inhibitor for inclusion in doublet combination with venetoclax for second
line AML patients, (3) serve as an effective agent for maintenance therapy to prevent relapse in patients who achieved a complete remission
through a stem cell transplant or through drug-based therapy, and 4) serve as an effective agent for the treatment of third line FLT3
mutated patients failed by prior therapy with other FLT3 inhibitors. In addition, we plan to test tuspetinib for efficacy
and safety in patients with MDS, and, if found active and safe in this population, the market potential of tuspetinib could be increased
well beyond $1 billion sales annually. However, our belief is based on management’s current assumptions and estimates, which are
subject to change, and there can be no assurance that tuspetinib will ever be approved or successfully commercialized and, if approved
and commercialized, that it will ever generate significant revenues. See our “Risk Factors – “We
are an early stage development company with no revenues from product sales.” and “We
have a history of operating losses. We expect to incur net losses and we may never achieve or maintain profitability.”
din our Annual Report on Form 10-K for the year ended December 31, 2022.”
Luxeptinib is a novel, oral,
highly potent lymphoid and myeloid kinase inhibitor that selectively targets defined clusters of kinases operative in myeloid and lymphoid
hematologic malignancies. This small molecule anticancer agent has been evaluated in a Phase 1a/b study for the treatment of patients
having B-cell leukemias and lymphomas that are resistant/refractory/intolerant to other therapies. Under a separate Investigational New
Drug, luxeptinib has been evaluated in a Phase 1a/b study for the treatment of patients with relapsed/refractory AML or high risk MDS.
These studies with the original formulation demonstrated tumor shrinkage among B-cell cancer patients, including a very recent report
of a CR in a diffuse large B-cell lymphoma patient that was determined via biopsy analysis at the end of Cycle 22 with 900mg two times
a day (“BID”) dosing of the original G1 formulation. Likewise, a CR in one R/R AML patient occurred with 450mg BID dosing
of the original G1 formulation. While these CRs were important, poor absorption of the original G1 formulation hampered the effectiveness
of luxeptinib. To address the limited absorption of the G1 formulation, a new G3 formulation was developed and demonstrated improved
absorption properties. The new G3 formulation is now being tested under conditions of twice daily continuous oral dosing in R/R AML patients.
It is hoped the G3 formulation of luxeptinib can serve patients across lymphoid and myeloid malignancies and combine well with other
agents to extend its application to multiple lines of therapy.
APTO-253 is a small molecule
MYC oncogene inhibitor at the Phase 1a/b clinical trial stage of development for the treatment of patients with relapsed or refractory
blood cancers, including AML and high-risk MDS. The clinical program was discontinued effective December 20, 2021, following a prioritization
of the Company’s other more advanced pipeline assets.
Corporate Information
We were incorporated under
the Business Corporations Act (Ontario) on September 5, 1986 under the name RML Medical Laboratories Inc. On October 28,
1991, we amalgamated with Mint Gold Resources Ltd., which caused us to become a reporting issuer in Ontario. On August 25, 1992,
we changed our name to IMUTEC Corporation. On November 27, 1996, we changed our name to Imutec Pharma Inc., and on November 19,
1998, we changed our name to Lorus Therapeutics Inc. On October 1, 2005, we continued under the Canada Business Corporations
Act and on July 10, 2007 we completed a plan of arrangement and corporate reorganization with, among others, 6650309 Canada
Inc., 6707157 Canada Inc. and Pinnacle International Lands, Inc. On May 25, 2010, we consolidated our outstanding Common Shares
on the basis of one post-consolidation Common Share for each 30 pre-consolidation Common Shares.
On August 28, 2014 we
changed our name from Lorus Therapeutics Inc. to Aptose Biosciences Inc. and on October 1, 2014 we consolidated our outstanding
Common Shares on the basis of one (1) post-consolidation Common Share for each twelve (12) pre-consolidation Common Shares.
On May 24, 2023, we consolidated our outstanding Common Shares on the basis of one (1) post-consolidation Common Share for each fifteen
(15) pre-consolidation Common Share.
We have two subsidiaries:
Aptose Biosciences U.S. Inc., a corporation incorporated under the laws of Delaware; and NuChem Pharmaceuticals Inc., a corporation incorporated
under the laws of Ontario, Canada. Aptose Biosciences Inc. owns 100% of the issued and outstanding voting share capital of Aptose Biosciences
U.S. Inc., and 80% of the issued and outstanding voting share capital of NuChem Pharmaceuticals Inc.
Our head, registered and
records office is located at 251 Consumers Road, Suite 1105, Toronto, Ontario, Canada, M2J 4R3.
Our executive office is located at 12770 High Bluff Drive, Suite 120, San Diego, CA 92130. We maintain a website at www.aptose.com. Information
contained on our website is not part of this prospectus.
Recent Developments
Reverse Stock Split
On May 23, 2023, our shareholders voted to approve
special resolutions providing for an amendment to our articles to effect a reverse stock split of our outstanding Common Shares at a
ratio in the range of 1-for-10 to 1-for-20, such amendment to become effective at an exact ratio and a date to be determined by our board
of directors. Our Board of Directors then approved a ratio of 15-to-1 on May 23, 2023.
On May 24, 2023, we filed articles of amendment under
the Canada Business Corporations Act to give effect to the reverse stock split (consolidation) of our Common Shares on the basis
of one post-consolidation Common Share for each 15 pre-consolidation Common Shares (the “Reverse Stock Split”). The Common
Shares commenced trading on a post-Reverse Stock Split basis at market open on Tuesday, June 6, 2023.
All share and per share amounts in this prospectus
have been adjusted retroactively to reflect the Reverse Stock Split as if it had occurred at the beginning of the earliest period presented.
Clinical Update
We previously announced an up-to-date review of clinical
data for Aptose’s two investigational products for hematologic malignancies: tuspetinib and luxeptinib.
Tuspetinib (HM43239)
| · | Completed
tuspetinib dose escalation and dose exploration Phase 1/2 trial in 77 R/R AML patients: |
| o | Tuspetinib
demonstrated a favorable safety profile; and |
| o | Tuspetinib
delivered monotherapy responses across four dose levels with no DLT in mutationally diverse
and difficult to treat R/R AML populations, including TP53-mutated patients with a complete
remission or complete remission with partial hematologic recovery (“CR/CRh”)
of 20% and RAS-mutated patients with a CR/CRh of 22%. |
| · | Completed
successful End of Phase 1 Meeting with the United States Food and Drug Administration for
tuspetinib, and a monotherapy RP2D was selected as 80mg daily, and all development paths
remain open, including the single arm accelerated path. |
| · | Initiated
tuspetinib APTIVATE expansion trial with R/R AML patients: |
| o | Tuspetinib
is being administered as a monotherapy and as a combination doublet with TUS/VEN, and enrollment
has been brisk; and |
| o | TUS/VEN
doublet has been well tolerated, all patients remain on study, and preliminary CR activity
has already been reported in patients previously treated with venetoclax. |
Luxeptinib
(CG-806)
| · | 50mg
G3 formulation with continuous dosing achieves roughly equivalent pharmacokinetic profile
as 900mg original G1 formulation; and |
| · | Expect
to dose escalate G3 formulation with continuous dosing in patients soon. |
Intellectual Property
We believe that
our issued patents and pending applications are important in establishing and maintaining a competitive position with respect to our
products and technology.
Tuspetinib (HM43239)
In November
2021, we licensed the exclusive rights to research, develop and commercialize HM43229. Under the terms of the agreement, Hanmi has granted
us exclusive worldwide rights to HM43239 for all indications. We are now the exclusive licensee of composition of matter and use patents
covering HM43229, and HM43239 analogs. We believe that we now own rights to a strong and defensive intellectual property position.
As of June 1,
2023, we own rights in 41 issued patents, including 4 issued U.S. patents, and 23 patents validated in countries in Europe, that are
in force and cover the HM43239 compound, or analog compounds. These patents are expected to provide protection until 2038 through 2039.
Patent applications are also pending in the United States and in contracting states to the Patent Cooperation Treaty for coverage of
HM43239 and analog compounds, with expected expiry dates between 2038 and 2042.
Luxeptinib (CG-806)
In May 2018
and June 2018, we licensed from Crystal Genomics, Inc. (“CG”) an exclusive license to research, develop and commercialize
luxeptinib in all countries of the world except the Republic of Korea and China, for all fields of use (collectively, the “Rights”)
to CG-806, by exercising an option we obtained through a June 2016 option-license agreement with CG that had granted us an exclusive
option to research, develop and commercialize CG-806. In June 2018, we entered into a separate license agreement with CG for us to gain
a license for rights to CG-806 in China (including the People’s Republic of China, Hong Kong, and Macau)(the “China Rights”).
We now own worldwide Rights to CG-806, including an issued patent in China but excluding any Rights in Korea.
As of June 1, 2023,
we owned rights to 47 issued patents, including 3 issued U.S. patents, and 30 patents validated n countries in Europe, that are in
force and cover numerous compounds, including the CG-806 compound, pharmaceutical compositions comprising the CG-806 compound, and
methods of use for treating various diseases by administering various compounds, including the CG-806 compound. These patents are
expected to provide protection until 2033-2038. Patent applications are also pending in the United States and in contracting states
to the Patent Cooperation Treaty for coverage of CG-806, with expected expiry dates between 2038-2039.
The Keystone Capital Transaction
On May 25, 2023, the Company and Keystone entered
into the Purchase Agreement, which provides that subject to the terms and conditions set forth therein, the Company may sell to Keystone
up to the lesser of (i) $25 million of the Common Shares and (ii) the Exchange Cap (as defined below) (subject to certain exceptions
provided in the Purchase Agreement) (the “Total Commitment”), from time to time during the two year term of the Purchase
Agreement.
Additionally, on May 25, 2023, the Company and Keystone
entered into the Registration Rights Agreement, pursuant to which the Company agreed to file a registration statement with the SEC covering
the resale of Common Shares that are issued to Keystone under the Purchase Agreement.
Under the terms and subject to the satisfaction of
the conditions set forth in the Purchase Agreement, the Company has the right, but not the obligation, to sell to Keystone, and Keystone
is obligated to purchase, up to the Total Commitment. Such sales of Common Shares by the Company, if any, will be subject to certain
limitations as set forth in the Purchase Agreement, and may occur from time to time, at the Company’s sole discretion, over a 24-month
period commencing on the date that all of the conditions to the Company’s right to commence such sales are satisfied, including
that the registration statement referred to above is declared effective by the SEC. Such date is referred to hereinafter as the “Commencement
Date”. Keystone has no right to require the Company to sell any Common Shares to Keystone, but Keystone is obligated to make purchases
as the Company directs, subject to satisfaction of the conditions set forth in the Purchase Agreement.
Upon entering into the Purchase Agreement, the Company
agreed to issue to Keystone an aggregate of 25,156 Common Shares (the “Commitment Shares”) as consideration for Keystone’s
commitment to purchase Common Shares upon the Company’s direction under the Purchase Agreement. The Company issued 7,547 Common
Shares, or 30% of the Commitment Shares, on the date of the Purchase Agreement (the “Initial Commitment Shares”). An additional
7,547 Common Shares, or 30% of the Commitment Shares, shall be issued to Keystone 90 days following the Commencement Date (the “First
Back-End Commitment Shares”). The remaining 10,062 Common Shares, or 40% of the Commitment Shares, shall be issued to Keystone
180 days following the Commencement Date (the “Second Back-End Commitment Shares”, together with the First Back-End Commitment
Shares, the “Back-End Commitment Shares”). The Company also agreed to pay Keystone up to $25,000 for its reasonable expenses
under the Purchase Agreement.
Under the Purchase Agreement, the Company may, at
its discretion, from time to time from and after the Commencement Date, direct Keystone to purchase (a “Fixed Purchase”)
up to 3,333 Common Shares on any trading day on which the closing sale price of the Common Shares is not below $0.25 per Common
Share on Nasdaq; provided, however that, Keystone’s committed obligation under any single Fixed Purchase shall not exceed $50,000.
In addition to Fixed Purchases, and provided that
the Company has directed Keystone to purchase the maximum allowable amount of 3,333 Common Shares in a Fixed Purchase, the Company
also may, at its discretion, from time to time from and after the Commencement Date, direct Keystone to purchase additional Common Shares
on the trading day immediately following the purchase date for such Fixed Purchase (each, a “VWAP Purchase”) and, under certain
circumstances set forth in the Purchase Agreement, direct Keystone to purchase additional Common Shares on the same trading day as such
VWAP Purchase (each, an “Additional VWAP Purchase”), in each case upon the terms and subject to the conditions set forth
in the Purchase Agreement. Hereinafter the Fixed Purchase, the VWAP Purchase and the Additional VWAP Purchase are collectively referred
to as a “Purchase”.
Under applicable rules of Nasdaq, in no event may
the Company issue or sell to Keystone under the Purchase Agreement more than 1,257,785 Common Shares (including the Commitment Shares),
which number of Common Shares is equal to 19.99% of the Common Shares outstanding immediately prior to the execution of the Purchase
Agreement (the “Exchange Cap”), unless (i) the Company first obtains stockholder approval to issue Common Shares in excess
of the Exchange Cap in accordance with applicable Nasdaq listing rules, or (ii) at the time we have issued Common Shares equal to the
Exchange Cap and at all times thereafter, the average price per Common Share for all Common Shares sold by us to Keystone under the Purchase
Agreement equals or exceeds $6.60 per Common Share, such that the Exchange Cap limitation would no longer apply to issuances and sales
of Common Shares by us to Keystone under the Purchase Agreement under applicable Nasdaq listing rules.
The Purchase Agreement also prohibits the Company
from directing Keystone to purchase any Common Shares if those Common Shares, when aggregated with all other Common Shares then beneficially
owned by Keystone and its affiliates, would result in Keystone having beneficial ownership of more than 4.99% of the outstanding Common
Shares or if such Common Shares proposed to be issued and sold would materially affect control of the company pursuant to the rules
of the TSX.
The net proceeds under the Purchase Agreement to the
Company will depend on the frequency of sales and the number of Common Shares sold to Keystone and prices at which the Company sells
Common Shares to Keystone. The Company expects that any net proceeds received by the Company from such sales to Keystone will be used
for working capital and general corporate purposes. Management of the Company believes that it is in the Company’s best interests
to have the flexibility to sell Common Shares pursuant to the Purchase Agreement, subject to market conditions.
The Offering
This prospectus relates to the resale by the Selling
Shareholder identified in this prospectus of up to 1,257,785 Common Shares. All of the Common Shares, if and when sold, will be sold
by the Selling Shareholder. The Selling Shareholder may sell the Common Shares from time to time at market prices prevailing at the time
of sale, at prices related to the prevailing market price, or at negotiated prices. We will not receive any proceeds from the sale of
Shares by the Selling Shareholder. On June 6, 2023, we effected the Reverse Stock Split on a fifteen (15) to one (1) share basis. All
information in this section have been updated to reflect the Reverse Stock Split unless provided otherwise.
Issuer |
|
Aptose Biosciences Inc. |
|
|
|
Common Shares offered by the Selling
Stockholder |
|
Up to 1,257,785 Common Shares, consisting of:
up to 1,232,629 Common Shares that
we may sell to the Selling Shareholder, from time to time at our sole discretion, pursuant to the Purchase Agreement, described below;
and
25,156 Common Shares issued or issuable
to the Selling Shareholder as consideration for its commitment to purchase Common Shares under the Purchase Agreement. |
|
|
|
Common Shares outstanding prior to this offering1 |
|
6,299,545 Common Shares |
|
|
|
Common Shares outstanding immediately after this offering |
|
7,549,783 Common Shares, assuming the sale of 1,232,629 Common Shares to Keystone
and issuance of the Back-End Commitment Shares. The actual number of Common Shares issued will vary depending on the sales prices
under this offering, but will not be greater than an aggregate of 1,257,785 Common Shares (inclusive of the Commitment Shares and
other Common Shares issued in connection with the Purchase Agreement), representing 19.99% of the Common Shares outstanding on the
date of the Purchase Agreement, in accordance with Nasdaq rules, unless as otherwise set forth herein. |
|
|
|
Stock symbol |
|
Our Common Shares are listed on Nasdaq under the symbol
“APTO” and on the TSX under the symbol “APS”. |
|
|
|
Use of proceeds |
|
The Selling Shareholder will receive all of the proceeds from the
sale of the Common Shares offered for sale by it under this prospectus. We will not receive proceeds from the sale of the Common
Shares by the Selling Shareholder through this prospectus. However, we may receive up to $25 million in gross proceeds from the sale
of our Common Shares to the Selling Shareholder under the Purchase Agreement.
We did not receive any cash proceeds from the issuance of the Commitment
Shares to the Selling Shareholder under the Purchase Agreement. We intend to use any proceeds from the Selling Shareholder that we
receive under the Purchase Agreement for working capital and general corporate purposes. See “Use of Proceeds” on page
9 for more information. |
|
|
|
Risk factors |
|
Investing in our securities involves a high degree of risk.
As an investor you should be prepared to lose your entire investment See “Risk Factors” beginning on page 8. |
________
1
The number of Common Shares to be outstanding prior to and after this offering is based on 6,299,545 Common Shares outstanding as of June 12, 2023 (including the 7,547 Initial Commitment Shares (as defined below),
and excludes:
|
● |
1,293,101 stock options outstanding as of June 12, 2023, at a weighted
average exercise price of $45.68 per Common Share; and |
|
● |
270,187 Common Shares that have been reserved for issuance in connection with future
grants under our security-based compensation plans. |
RISK FACTORS
You should carefully consider the following risk
factors in addition to other information in this prospectus before purchasing our Common Shares. The risks and uncertainties described
below are those that we currently deem to be material and that we believe are specific to our company, our industry and this offering.
These risks and uncertainties are not the only ones facing us. Additional risks of which we are not presently aware or that we currently
believe are immaterial may also harm our business and results of operations. The trading price of our Common Shares could decline due
to the occurrence of any of these risks, and investors could lose all or part of their investment.
In evaluating the Company, its business and any investment
in the Company, readers should carefully consider the following factors, together with the additional risk factors incorporated by reference
from Item 1A of the Company’s Annual Report on Form 10-K as filed with the SEC on March 24, 2023 (see “Incorporation of Certain
Information by Reference”).
Risks Related to this Offering
The sale or issuance of our Common Shares to Keystone may cause
dilution and the sale of the Common Shares acquired by Keystone, or the perception that such sales may occur, could cause the price of
our Common Shares to fall.
On May 25, 2023, we entered into the Purchase Agreement
with Keystone, pursuant to which Keystone has committed to purchase up to $25 million of our Common Shares. Upon the execution of the
Purchase Agreement, we issued 7,547 Common Shares as the Initial Commitment Shares to Keystone as consideration for its commitment to
purchase Common Shares under the Purchase Agreement. The 17,609 Back-End Commitment Shares will be issued in the future at 90 days and
180 days, respectively, following the Commencement Date. The remaining 1,232,629 Common Shares being registered for resale hereunder
that may be issued under the Purchase Agreement may be sold by us to Keystone at our discretion from time to time over a 24-month period
commencing after the satisfaction of certain conditions set forth in the Purchase Agreement, including that the SEC has declared effective
the registration statement that includes this prospectus. The purchase price for the Common Shares that we may sell to Keystone under
the Purchase Agreement will fluctuate based on the price of our Common Shares. Thus the actual gross proceeds from the sale of all Common
Shares by us to Keystone may be substantially less than the $25 million total purchase commitment available to us under the Purchase
Agreement, which could materially adversely affect our liquidity. In addition, depending on market liquidity at the time, sales of such
Common Shares may cause the trading price of our Common Shares to fall.
We generally have the right to control the timing
and amount of any future sales of our Common Shares to Keystone. Sales of our Common Shares, if any, to Keystone will depend upon market
conditions and other factors to be determined by us. We may ultimately decide to sell to Keystone all, some or none of the additional
Common Shares that may be available for us to sell pursuant to the Purchase Agreement. Therefore, sales to Keystone by us could result
in substantial dilution to the interests of other holders of our Common Shares. Additionally, the sale of a substantial number of Common
Shares to Keystone, or the anticipation of such sales, could make it more difficult for us to sell equity or equity-related securities
in the future at a time and at a price that we might otherwise wish to effect sales. If and when we do sell Common Shares to Keystone,
after Keystone has acquired the Common Shares, Keystone may resell all, some or none of those Common Shares at any time or from time
to time in its discretion.
If it becomes necessary for us to issue and sell to
Keystone the Common Shares in excess of the Exchange Cap under the Purchase Agreement in order to receive aggregate gross proceeds equal
to $25 million under the Purchase Agreement, then for so long as the Exchange Cap continues to apply to issuances and sales of Common
Shares under the Purchase Agreement, we must first obtain shareholder approval to issue Common Shares in excess of the Exchange Cap in
accordance with applicable Nasdaq listing rules. Furthermore, if we elect to issue and sell to Keystone more than the 1,232,629 Common
Shares that we may elect to issue and sell to Keystone under the Purchase Agreement that are being registered for resale by Keystone
hereunder, which we have the right, but not the obligation, to do, we must first file with the SEC one or more additional registration
statements to register under the Securities Act for resale by Keystone such additional Common Shares we wish to sell from time to time
under the Purchase Agreement, which the SEC must declare effective, in each case before we may elect to sell any additional Common Shares
to Keystone under the Purchase Agreement. Any issuance and sale by us under the Purchase Agreement of a substantial amount of Common
Shares in addition to the 1,232,629 Common Shares that we may elect to issue and sell to Keystone under the Purchase Agreement that are
being registered for resale by Keystone hereunder could cause additional substantial dilution to our stockholders. The number of our
Common Shares ultimately offered for sale by Keystone is dependent upon the number of Common Shares, if any, we ultimately sell to Keystone
under the Purchase Agreement, and the sale of Common Shares under the Purchase Agreement may cause the trading price of our Common Shares
to decline.
Our management might apply the net proceeds from this offering in
ways with which you do not agree and in ways that may impair the value of your investment.
We currently intend to use the net proceeds from this
offering for general corporate purposes. Our management has broad discretion as to the use of these proceeds and you will be relying
on the judgment of our management regarding the application of these proceeds. We might apply these proceeds in ways with which you do
not agree, or in ways that do not yield a favorable return. If our management applies these proceeds in a manner that does not yield
a significant return, if any, on our investment of these net proceeds, it could compromise our ability to pursue our growth strategy
and adversely affect the market price of our Common Shares.
It is not possible to predict the actual number of Common Shares
we will sell under the Purchase Agreement to the Selling Shareholder, or the actual gross proceeds resulting from those sales.
Subject to certain limitations in the Purchase Agreement
and compliance with applicable law, we have the discretion to deliver notices to Keystone at any time throughout the term of the Purchase
Agreement. The actual number of Common Shares that are sold to the Selling Shareholder may depend based on a number of factors, including
the market price of the Common Shares during the sales period. Actual gross proceeds may be nominal, which may impact our future liquidity.
Because the price per Common Share of each Common Share sold to Keystone will fluctuate during the sales period, it is not currently
possible to predict the number of Common Shares that will be sold or the actual gross proceeds to be raised in connection with those
sales.
Investors who buy Common Shares at different times will likely pay
different prices, and the sale of the Common Shares acquired by Keystone could cause the price of our Common Shares to decline.
Pursuant to the Purchase Agreement, we will have discretion,
subject to market demand, to vary the timing, prices, and numbers of Common Shares sold to Keystone. If and when we do elect to sell
our Common Shares to Keystone pursuant to the Purchase Agreement, after Keystone has acquired such Common Shares, Keystone may resell
all, some or none of such Common Shares at any time or from time to time in its discretion and at different prices. As a result, investors
who purchase Common Shares from Keystone in this offering at different times will likely pay different prices for those Common Shares,
and so may experience different levels of dilution and in some cases substantial dilution and different outcomes in their investment
results. Investors may experience a decline in the value of the Common Shares they purchase from Keystone in this offering as a result
of future sales made by us to Keystone at prices lower than the prices such investors paid for their Common Shares in this offering.
USE OF
PROCEEDS
This prospectus relates to our Common Shares that
may be offered and sold from time to time by Keystone pursuant to the Purchase Agreement. We will not receive any proceeds from the resale
of Common Shares by Keystone.
Assuming our average sales price is $5.97 (our closing
price on June 14, 2023), we will receive approximately $7.4 million in gross proceeds pursuant to the Purchase Agreement. See “Plan
of Distribution” elsewhere in this prospectus for more information.
We intend to use any proceeds from the Selling Shareholder
that we receive under the Purchase Agreement for working capital and general corporate purposes. We cannot specify with certainty all
of the particular uses for the net proceeds that we will have from the sale of our Common Shares pursuant to the Purchase Agreement.
Therefore, our management will have broad discretion to determine the specific use for the net proceeds and we may use the proceeds for
purposes that are not contemplated at the time of this offering.
We will incur all costs associated with this prospectus
and the registration statement of which it is a part.
DILUTION
The sale of Common Shares to the Selling Shareholder
pursuant to the Purchase Agreement will have a dilutive impact on our shareholders. In addition, the lower the price of our Common Shares
is at the time we exercise our right to issue and sell Common Shares to Selling Shareholder, the more of our Common Shares we will issue
to raise our desired amount of proceeds from the sale, and the greater the dilution to our existing shareholders.
The price that the Selling Shareholder will receive
for our Common Shares when resold pursuant to this prospectus will depend upon the timing of sales and will fluctuate based on the trading
price of our Common Shares.
We calculate net tangible book value per Common Share
by dividing our net tangible book value, which is tangible assets less total liabilities, by the number of our outstanding Common Shares.
Dilution represents the difference between the portion of the amount per Common Share paid by purchasers of Common Shares in this offering
and the as adjusted net tangible book value per Common Share immediately after giving effect to this offering. As of March 31, 2023,
we had a net tangible book value of $24,775,000, or $4.00 per Common Share.
After giving effect to (i) the sale of 1,232,629 Common
Shares to the Selling Shareholder for which we will receive cash proceeds pursuant to the Purchase Agreement at an assumed price of $5.97
per Common Share, the closing price of our Common Shares on Nasdaq on June 14, 2023, (ii) the issuance of 25,156 Commitment Shares, and
(iii) deducting estimated offering expenses of approximately $150,000 payable by us, and without giving effect to the Beneficial Ownership
Cap under the Purchase Agreement, our as adjusted net tangible book value (deficit) as of March 31, 2023, would have been approximately
$31,984,000, or $4.29 per Common Share. This represents an immediate decrease in net tangible book value of $0.29 per Common Share to
existing stockholders and an immediate dilution of $1.68 per Common Share to new investors.
The following table illustrates this dilution on a per Common Share basis:
Assumed public offering price per Common Share |
|
|
$ |
5.97 |
Net tangible book value per Common Share as of March 31, 2023 |
$ |
4.00 |
|
|
Decrease in net tangible book value per Common Share attributable to new investors |
$ |
0.29 |
|
|
As adjusted net tangible book value per Common Share as of March 31, 2023, after giving effect to
this offering |
|
|
$ |
4.29 |
Dilution per Common Share to new investors purchasing Common Shares in this offering |
|
|
$ |
1.68 |
The number of our Common Shares outstanding referenced
above is based on 6,200,352 Common Shares outstanding as of March 31, 2023, and excludes the following as of March 31, 2023:
|
● |
1,293,101 stock options outstanding as of March 31, 2023, at a weighted average exercise
price of $45.68 per Common Share; and |
|
● |
270,187 Common Shares that have been reserved for issuance in connection with future grants under
our security-based compensation plans. |
Unless otherwise indicated, all information contained
in this prospectus assumes or gives effect to no exercise of the outstanding options described above.
THE KEYSTONE
CAPITAL TRANSACTION
General
On May 25, 2023, the Company and Keystone entered
into the Purchase Agreement, which provides that subject to the terms and conditions set forth therein, the Company may sell to Keystone
up to the Total Commitment, which is equal to the lesser of (i) $25 million of the Common Shares and (ii) the Exchange Cap (subject to
certain exceptions provided in the Purchase Agreement), from time to time during the term of the Purchase Agreement.
Additionally, on May 25, 2023, the Company and Keystone
entered into the Registration Rights Agreement, pursuant to which the Company agreed to file a registration statement with the SEC covering
the resale of Common Shares that are issued to Keystone under the Purchase Agreement.
Under the terms and subject to the satisfaction of
the conditions set forth in the Purchase Agreement, the Company has the right, but not the obligation, to sell to Keystone, and Keystone
is obligated to purchase, up to Total Commitment. Such sales of Common Shares by the Company, if any, will be subject to certain limitations
as set forth in the Purchase Agreement, and may occur from time to time, at the Company’s sole discretion, over a 24-month period
commencing on the date that all of the conditions to the Company’s right to commence such sales are satisfied, including that the
registration statement referred to above is declared effective by the SEC. Keystone has no right to require the Company to sell any Common
Shares to Keystone, but Keystone is obligated to make purchases as the Company directs, subject to satisfaction of the conditions set
forth in the Purchase Agreement.
Upon entering into the Purchase Agreement, the Company
agreed to issue to Keystone an aggregate of 25,156 Commitment Shares as consideration for Keystone’s commitment to purchase Common
Shares upon the Company’s direction under the Purchase Agreement. The Company issued 7,547 Common Shares, or 30% of the Commitment
Shares, on the date of the Purchase Agreement as the Initial Commitment Shares. An additional 7,547 Common Shares, or 30% of the Commitment
Shares, shall be issued to Keystone 90 days following the Commencement Date as the First Back-End Commitment Shares. The remaining 10,062
Common Shares, or 40% of the Commitment Shares, shall be issued to Keystone 180 days following the Commencement Date as the Second Back-End
Commitment Shares. The Company also agreed to pay Keystone up to $25,000 for its reasonable expenses under the Purchase Agreement.
Under the Purchase Agreement, the Company may, at
its discretion, from time to time from and after the Commencement Date, direct Keystone to purchase a Fixed Purchase of up to
3,333 Common Shares on any trading day on which the closing sale price of the Common Shares is not below $0.25 per Common Share
on Nasdaq; provided, however that, Keystone’s committed obligation under any single Fixed Purchase shall not exceed
$50,000.
In addition to Fixed Purchases, and provided that
the Company has directed Keystone to purchase the maximum allowable amount of 3,333 Common Shares in a Fixed Purchase, the
Company also may, at its discretion, from time to time from and after the Commencement Date, direct Keystone to purchase additional
Common Shares on the trading day immediately following the purchase date for such Fixed Purchase in a VWAP Purchase and, under
certain circumstances set forth in the Purchase Agreement, direct Keystone to purchase additional Common Shares on the same trading
day as such VWAP Purchase in an Additional VWAP Purchase, in each case upon the terms and subject to the conditions set forth in the
Purchase Agreement.
Purchase Price for Each Purchase
There is no upper limit on the price per Common Share
that Keystone may be obligated to pay for the Common Shares in any of the Purchases. The purchase price per Common Share for each Purchase
is as follows:
|
● |
Fixed Purchase - the lesser of (i) 95% of the daily
volume weighted average price of Common Shares on Nasdaq, as reported by Bloomberg Financial LP using the AQR function for the five
trading days immediately preceding the applicable date for such Fixed Purchase and (ii) the closing sale price of a Common Share
on the applicable date for such Fixed Purchase during the full trading day on Nasdaq on such applicable purchase date. |
|
● |
VWAP Purchase - the lesser of (i) 95% of the closing
sale price of the Common Shares on the date of the applicable VWAP Purchase and (ii) the VWAP during the applicable VWAP Purchase
Period (as defined under the Purchase Agreement). |
|
● |
Additional VWAP Purchase - lower of (i) 95% of the VWAP
for the applicable Additional VWAP Purchase Period (as defined under the Purchase Agreement) during the applicable Additional VWAP
purchase date for such Additional VWAP Purchase, and (ii) the closing sale price of the Common Shares on such applicable date of
Additional VWAP Purchase for such Additional VWAP Purchase. |
Maximum Number of Common Shares to be Purchased under each Applicable
Purchase
Each Purchase has a maximum number of Common Shares
or dollar amount that may be purchased by Keystone for each applicable Purchase. The maximum number of Common Shares, purchase prices
and the closing sale prices will be adjusted for any reorganization, recapitalization, non-cash dividend, stock split, reverse stock
split or other similar transaction occurring after the date of the Purchase Agreement, such as the Reverse Stock Split mentioned above.
|
● |
Fixed Purchase - may not exceed $50,000. |
|
● |
VWAP Purchase - lesser of (i) 300% of the number of
Common Shares directed by the Company to be purchased by Keystone pursuant to the corresponding Fixed Purchase and (ii) 30% of the
trading volume in the Common Shares on Nasdaq during the applicable VWAP Purchase Period. |
|
● |
Additional VWAP Purchase - lesser of (i) 300% of the
number of Common Shares directed by the Company to be purchased by Keystone pursuant to the corresponding Fixed Purchase and (ii)
a number of Common Shares equal to (A) 30% multiplied by (B) the trading volume of the Common Shares on Nasdaq during the applicable
Additional VWAP Purchase Period. |
Provided, however that, Keystone’s maximum purchase
commitment in any single VWAP Purchase, together with any one or more Additional VWAP Purchases that are effected on the same trading
day as such VWAP Purchase, may not exceed $1,000,000 in the aggregate for such VWAP Purchase and Additional VWAP Purchases.
Under applicable rules of Nasdaq, in no event may
the Company issue or sell to Keystone under the Purchase Agreement more than the Exchange Cap, or 1,257,785 Common Shares (including
the Commitment Shares), which number of Common Shares is equal to 19.99% of the Common Shares outstanding immediately prior to the execution
of the Purchase Agreement, unless (i) the Company first obtains stockholder approval to issue Common Shares in excess of the Exchange
Cap in accordance with applicable Nasdaq listing rules, or (ii) at the time we have issued Common Shares equal to the Exchange Cap and
at all times thereafter, the average price per Common Share for all Common Shares sold by us to Keystone under the Purchase Agreement
equals or exceeds $6.60 per Common Share, such that the Exchange Cap limitation would no longer apply to issuances and sales of Common
Shares by us to Keystone under the Purchase Agreement under applicable Nasdaq listing rules.
The Purchase Agreement also prohibits the Company
from directing Keystone to purchase any Common Shares if those Common Shares, when aggregated with all other Common Shares then beneficially
owned by Keystone and its affiliates, would result in Keystone having beneficial ownership of more than 4.99% of the outstanding Common
Shares or if such Common Shares proposed to be issued and sold would materially affect control of the company pursuant to the rules
of the TSX.
The Purchase Agreement contains customary representations,
warranties, covenants, indemnification and termination provisions. Keystone has covenanted not to cause or engage in any manner whatsoever,
any direct or indirect short selling or hedging of the Common Shares. There are no limitations on use of proceeds, financial or business
covenants, restrictions on future financings (other than restrictions on the Company’s ability to enter into additional “variable
rate transactions” or substantially similar transactions as the transactions contemplated by the Purchase Agreement, subject to
certain exceptions, during certain periods beginning prior to the applicable purchase dates for any Fixed Purchase, VWAP Purchase and
Additional VWAP Purchase and ending after the dates on which such purchases are fully settled, as set forth in the Purchase Agreement),
rights of first refusal, participation rights, penalties or liquidated damages in the Purchase Agreement. The Purchase Agreement may
be terminated by the Company at any time, at the Company’s sole discretion, without any cost or penalty (subject to the Company
issuing the Commitment Shares), on one (1) trading day prior written notice to Keystone. Neither the Company, nor Keystone, may assign
or transfer its rights and obligations under the Purchase Agreement, and no provision of the Purchase Agreement or the Registration Rights
Agreement may be modified or waived by the parties from and after the date that is one (1) trading day immediately preceding the date
on which a registration statement is initially filed with the SEC pursuant to the Registration Rights Agreement.
The net proceeds under the Purchase Agreement to the
Company will depend on the frequency of sales and the number of Common Shares sold to Keystone and prices at which the Company sells
Common Shares to Keystone. The Company expects that any net proceeds received by the Company from such sales to Keystone will be used
for working capital and general corporate purposes. Management of the Company believes that it is in the Company’s best interests
to have the flexibility to sell Common Shares pursuant to the Purchase Agreement, subject to market conditions.
Conditions to Commencement and for Delivery of Fixed Purchase Notices,
VWAP Purchase Notices and Additional VWAP Purchase Notices
The Company’s ability to deliver Fixed Purchase
notices, VWAP Purchase notices, and Additional VWAP Purchase Notices to Keystone under the Purchase Agreement are subject to the satisfaction,
both at the time of Commencement and at the time of delivery by the Company of any Fixed Purchase notice, VWAP Purchase notice or Additional
VWAP Purchase Notice to Keystone, of certain conditions, all of which are entirely outside of Keystone’s control, including the
following:
|
● |
the accuracy in all material respects of the representations and warranties of the Company included
in the Purchase Agreement; |
|
|
|
|
● |
the Company having performed, satisfied and complied in all material respects with all covenants,
agreements and conditions required by the Purchase Agreement to be performed, satisfied or complied with by the Company; |
|
|
|
|
● |
the registration statement that includes this prospectus (and any one or more additional registration
statements filed with the SEC that include Common Shares that may be issued and sold by the Company to Keystone under the Purchase
Agreement) having been declared effective under the Securities Act by the SEC, and Keystone being able to utilize this prospectus
(and the prospectus included in any one or more additional registration statements filed with the SEC under the Registration Rights
Agreement) to resell all of the Common Shares included in this prospectus (and included in any such additional prospectuses); |
|
|
|
|
● |
the SEC shall not have issued any stop order suspending the effectiveness of the registration statement
that includes this prospectus (or any one or more additional registration statements filed with the SEC that include Common Shares
that may be issued and sold by the Company to Keystone under the Purchase Agreement) or prohibiting or suspending the use of this
prospectus (or the prospectus included in any one or more additional registration statements filed with the SEC under the Registration
Rights Agreement), and the absence of any suspension of qualification or exemption from qualification of the Common Shares for offering
or sale in any jurisdiction; |
|
● |
there shall not have occurred any event and there shall not exist any condition or state of facts,
which makes any statement of a material fact made in the registration statement that includes this prospectus (or in any one or more
additional registration statements filed with the SEC that include Common Shares that may be issued and sold by the Company to Keystone
under the Purchase Agreement) untrue or which requires the making of any additions to or changes to the statements contained therein
in order to state a material fact required by the Securities Act to be stated therein or necessary in order to make the statements
then made therein (in the case of this prospectus or the prospectus included in any one or more additional registration statements
filed with the SEC under the Registration Rights Agreement, in light of the circumstances under which they were made) not misleading; |
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● |
this prospectus, in final form, shall have been filed with the SEC under the Securities Act prior
to Commencement, and all reports, schedules, registrations, forms, statements, information and other documents required to have been
filed by the Company with the SEC pursuant to the reporting requirements of the Securities Exchange Act of 1934, as amended (the
“Exchange Act”), shall have been filed with the SEC; |
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|
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|
● |
trading in the Common Shares shall not have been suspended by the SEC or Nasdaq, the Company shall
not have received any final and non-appealable notice that the listing or quotation of the Common Shares on Nasdaq shall be terminated
on a date certain (unless, prior to such date, the Common Shares is listed or quoted on any other Eligible Market, as such term is
defined in the Purchase Agreement), and there shall be no suspension of, or restriction on, accepting additional deposits of the
Common Shares, electronic trading or book-entry services by DTC with respect to the Common Shares; |
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● |
the Company shall have complied with all applicable federal, state and local governmental laws, rules,
regulations and ordinances in connection with the execution, delivery and performance of the Purchase Agreement and the Registration
Rights Agreement; |
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|
● |
the absence of any statute, regulation, order, decree, writ, ruling or injunction by any court or
governmental authority of competent jurisdiction which prohibits the consummation of or that would materially modify or delay any
of the transactions contemplated by the Purchase Agreement or the Registration Rights Agreement; |
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● |
the absence of any action, suit or proceeding before any arbitrator or any court or governmental
authority seeking to restrain, prevent or change the transactions contemplated by the Purchase Agreement or the Registration Rights
Agreement, or seeking material damages in connection with such transactions; |
|
|
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|
● |
all of the Common Shares that may be issued pursuant to the Purchase Agreement shall have been approved
for listing or quotation on Nasdaq (or any Eligible Market as defined in the Purchase Agreement), subject only to notice of issuance; |
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|
● |
no condition, occurrence, state of facts or event constituting a material adverse effect shall have
occurred and be continuing; |
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|
● |
the absence of any bankruptcy proceeding against the Company commenced by a third party, and the
Company shall not have commenced a voluntary bankruptcy proceeding, consented to the entry of an order for relief against it in an
involuntary bankruptcy case, consented to the appointment of a custodian of the Company or for all or substantially all of its property
in any bankruptcy proceeding, or made a general assignment for the benefit of its creditors; and |
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|
● |
the receipt by Keystone of the opinions, bring-down opinions and negative assurances from outside
counsel to the Company in the forms mutually agreed to by the Company and Keystone prior to the date of the Purchase Agreement. |
Termination of the Purchase Agreement
Unless earlier terminated as provided in the Purchase
Agreement, the Purchase Agreement will terminate automatically on the earliest to occur of:
|
● |
the first day of the month next following the 24-month anniversary of the Commencement Date; |
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● |
the date on which Keystone shall have purchased the Total Commitment pursuant to the Purchase Agreement; |
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● |
the date on which the Common Shares shall have failed to be listed or quoted on Nasdaq or any other
Eligible Market; and |
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● |
thirtieth (30th) trading day next following the date on which the Company commences a
voluntary bankruptcy case or any third party commences a bankruptcy proceeding against the Company, a custodian is appointed for
the Company in a bankruptcy proceeding for all or substantially all of its property, or the Company makes a general assignment for
the benefit of its creditors. |
We have the right to terminate the Purchase Agreement
at any time after Commencement, at no cost or penalty (subject to the issuance of the Commitment Shares), upon one trading day’s
prior written notice to Keystone.
No Short-Selling or Hedging by Keystone
Keystone has agreed that neither it nor any of its
affiliates shall engage in any direct or indirect short-selling or hedging of our Common Shares during any time prior to the termination
of the Purchase Agreement.
Prohibition on Variable Rate Transactions
Subject to specified exceptions included in the Purchase
Agreement, we are limited in our ability to enter into specified variable rate transactions during the term of the Purchase Agreement.
Such transactions include, among others, the issuance of convertible securities with a conversion or exercise price that is based upon
or varies with the trading price of our Common Shares after the date of issuance.
Effect of Performance of the Purchase Agreement on our Stockholders
All Common Shares registered in this offering that
may be issued or sold by us to Keystone under the Purchase Agreement are expected to be freely tradable. Common Shares registered in
this offering may be sold by us to Keystone over a period of up to 24 months commencing on the date of this registration statement of
which this prospectus is a part becomes effective. The resale by Keystone of a significant amount of Common Shares registered in this
offering at any given time, or the perception that these sales may occur, could cause the market price of our Common Shares to decline
and to be highly volatile. Sales of our Common Shares to Keystone, if any, will depend upon market conditions and other factors to be
determined by us. We may ultimately decide to sell to Keystone all, some or none of the additional Common Shares that may be available
for us to sell pursuant to the Purchase Agreement. If and when we do sell Common Shares to Keystone, after Keystone has acquired the
Common Shares, Keystone may resell all, some or none of those Common Shares at any time or from time to time in its discretion. Therefore,
sales to Keystone by us under the Purchase Agreement may result in substantial dilution to the interests of other holders of our Common
Shares. In addition, if we sell a substantial number of Common Shares to Keystone under the Purchase Agreement, or if investors expect
that we will do so, the actual sales of Common Shares or the mere existence of our arrangement with Keystone may make it more difficult
for us to sell equity or equity-related securities in the future at a time and at a price that we might otherwise wish to effect such
sales. However, we have the right to control the timing and amount of any additional sales of our Common Shares to Keystone and the Purchase
Agreement may be terminated by us at any time at our discretion without any cost to us.
Pursuant to the terms of the Purchase Agreement, we
have the right, but not the obligation, to direct Keystone to purchase up to 1,232,629 Common Shares, subject to certain limitations.
We have registered only a portion of the Common Shares issuable under the Purchase Agreement and, therefore, we may seek to issue and
sell to Keystone under the Purchase Agreement more Common Shares than are offered under this prospectus. If we choose to do so, we must
first register for resale under the Securities Act any such additional Common Shares, which could cause additional substantial dilution
to our stockholders. The number of Common Shares ultimately offered for resale under this prospectus is dependent upon the number of
Common Shares we direct Keystone to purchase under the Purchase Agreement.
The following table sets forth the amount of gross
proceeds we would receive from Keystone from our sale of Common Shares to Keystone under the Purchase Agreement at varying purchase prices:
Assumed Purchase
Price Per Share ($) (4) | |
Number of Registered
Shares to be Purchased if Full Purchase (1)(4) | |
Percentage of Outstanding
Shares After Giving Effect to the Issuance to Keystone (2) | |
Gross Proceeds from
the Sale of Shares to Keystone Under the Purchase Agreement ($) |
| |
| |
| |
|
| 4.00 | | |
| 1,232,629 | | |
| 16.4 | % | |
| 4,930,516 | |
| 5.00 | | |
| 1,232,629 | | |
| 16.4 | % | |
| 6,163,145 | |
| 5.97 (3) | | |
| 1,232,629 | | |
| 16.4 | % | |
| 7,358,795 | |
| 7.00 | | |
| 1,232,629 | | |
| 16.4 | % | |
| 8,628,403 | |
| 8.00 | | |
| 1,232,629 | | |
| 16.4 | % | |
| 9,861,032 | |
| 9.00 | | |
| 1,232,629 | | |
| 16.4 | % | |
| 11,093,661 | |
(1) |
Although the Purchase Agreement provides that we may sell up to $25 million of our Common
Shares to Keystone, we are only registering 1,257,785 Common Shares for resale under the registration statement of which this prospectus
forms a part, including the 25,156 Commitment Shares issued or issuable to Keystone on in consideration of Keystone’s commitment
to purchase our Common Shares at our direction under the Purchase Agreement, for which we will receive no cash proceeds. Therefore,
only 1,232,629 of such Common Shares represent Common Shares that we may issue and sell to Keystone for cash consideration in purchases
under the Purchase Agreement from time to time, at our sole discretion, during the 24-month period commencing on the Commencement
Date, which may or may not cover all the Common Shares we ultimately sell to Keystone under the Purchase Agreement, if any, depending
on the purchase price per Common Share. We have included in this column only the 1,232,629 Common Shares that we may issue and sell
to Keystone for cash consideration in purchases under the Purchase Agreement that are being registered for resale in the offering
made by this prospectus (excluding the 25,156 Commitment Shares), without regard for the Beneficial Ownership Cap. |
(2) |
The denominator is based on 6,299,545 Common Shares outstanding as of June 12, 2023
(including the 7,547 Initial Common Shares issued to Keystone on May 25, 2023, but excluding the 17,609 Back End Commitment Shares
to be issued under the Purchase Agreement), adjusted to include the issuance of the number of Common Shares set forth in the adjacent
column that we would have sold to Keystone, assuming the average purchase price in the first column. The numerator is based on the
number of Common Shares issuable under the Purchase Agreement at the corresponding assumed average purchase price set forth in the
first column. |
(3) |
The closing sale price of our Common Shares on June 14, 2023. |
(4) |
We effected a reverse stock split of our Common Shares on a fifteen (15) to one (1) basis,
and the Common Shares commenced trading on a post-reverse stock split basis at market open on Tuesday, June 6, 2023. All information
in this table have been updated to reflect the reverse stock split unless provided otherwise. |
SELLING
SHAREHOLDER
This prospectus relates to the possible resale from
time to time by Keystone Capital Partners of any or all of the Common Shares that may be issued by us to Keystone Capital Partners under
the Purchase Agreement. For additional information regarding the issuance of Common Shares covered by this prospectus, see the section
entitled “The Keystone Capital Transaction” above. We are registering the Common Shares pursuant to the provisions of the
Registration Rights Agreement we entered into with Keystone Capital Partners on May 25, 2023 in order to permit the Selling Shareholder
to offer the Common Shares for resale from time to time. Except for the transactions contemplated by the Purchase Agreement and the Registration
Rights Agreement, Keystone Capital Partners has not had any material relationship with us within the past three years. As used in this
prospectus, the term “Selling Shareholder” means Keystone Capital Partners, LLC.
The table below presents information regarding the
Selling Shareholder and the Common Shares that it may offer from time to time under this prospectus. This table is prepared based on
information supplied to us by the Selling Shareholder, and reflects holdings as of June 12, 2023. The number of Common Shares in the
column “Maximum Number of Common Shares to be Offered Pursuant to this Prospectus” represents all of the Common Shares that
the Selling Shareholder may offer under this prospectus. The Selling Shareholder may sell some, all or none of its Common Shares in this
offering. We do not know how long the Selling Shareholder will hold the Common Shares before selling them, and we currently have no agreements,
arrangements or understandings with the Selling Shareholder regarding the sale of any of the Common Shares.
Beneficial ownership is determined in accordance with
Rule 13d-3(d) promulgated by the SEC under the Exchange Act, and includes Common Shares with respect to which the Selling Shareholder
has voting and investment power. The percentage of Common Shares beneficially owned by the Selling Shareholder prior to the offering
shown in the table below is based on an aggregate of 6,299,545 Common Shares outstanding on June 12, 2023. Because the purchase price
of the Common Shares issuable under the Purchase Agreement is determined on each Fixed Purchase Date, with respect to a Fixed Purchase,
on the applicable VWAP Purchase Date, with respect to a VWAP Purchase, and on the applicable Additional VWAP Purchase Date, with respect
to an Additional VWAP Purchase, the number of Common Shares that may actually be sold by the Company to Keystone Capital under the Purchase
Agreement may be fewer than the number of Common Shares being offered by this prospectus. The fourth column assumes the sale of all of
the Common Shares offered by the Selling Shareholder pursuant to this prospectus.
Name of Selling Shareholder | |
Number of Common
Shares Owned Prior to Offering | |
Maximum Number of
Common Shares to be Offered Pursuant to this Prospectus Number | |
Number of Common
Shares Owned After Offering |
| |
| |
| |
| |
| |
|
| |
| Number(1) | | |
Percent(2) | |
| | | |
| Number(3) | | |
| Percent(2) | |
Keystone Capital Partners, LLC(4) | |
| 7,457 | | |
* | |
| 1,257,785 | | |
| 0 | | |
| -- | |
_____________
*
Represents beneficial ownership of less than 1% of the outstanding Common Shares.
(1) |
This number represents the 7,457 Common Shares we issued to Keystone Capital Partners
on May 25, 2023 as the Initial Commitment Shares in consideration for entering into the Purchase Agreement with us. In addition,
we have agreed to issue to Keystone Capital Partners an additional 17,609 Common Shares as the Back-End Commitment Shares. In accordance
with Rule 13d-3(d) under the Exchange Act, we have excluded from the number of Common Shares beneficially owned prior to the offering
all of the Common Shares that Keystone Capital may be required to purchase under the Purchase Agreement, because the issuance of
such Common Shares is solely at our discretion and is subject to conditions contained in the Purchase Agreement, the satisfaction
of which are entirely outside of Keystone Capital’s control, including the registration statement that includes this prospectus
becoming and remaining effective. Furthermore, the Fixed Purchases, VWAP Purchase, or Additional VWAP Purchase, as applicable, of
Common Shares are subject to certain agreed upon maximum amount limitations set forth in the Purchase Agreement. Also, the Purchase
Agreement prohibits us from issuing and selling any of our Common Shares to Keystone Capital to the extent such Common
Shares, when aggregated with all other Common Shares then beneficially owned by Keystone Capital, would cause Keystone
Capital’s beneficial ownership of our Common Shares to exceed the 4.99% Beneficial Ownership Cap. |
(2) |
Applicable percentage ownership is based on 6,299,545 Common Shares outstanding as of
June 12, 2023. |
(3) |
Assumes the sale of all Common Shares being offered pursuant to this prospectus. |
(4) |
The business address of Keystone Capital Partners, LLC is 139 Fulton Street, Suite 412,
New York, NY 10038. Keystone Capital Partners, LLC’s principal business is that of a private investor. Ranz Group, LLC, a Delaware
limited liability company, is the managing member of Keystone Capital Partners, LLC and the beneficial owner of 97% of the membership
interests in Keystone Capital Partners, LLC. Fredric G. Zaino is the managing member of Ranz Group, LLC and has sole voting control
and investment discretion over securities beneficially owned directly by Keystone Capital, LLC and indirectly by Ranz Group, LLC.
We have been advised that none of Mr. Zaino, Ranz Group, LLC or Keystone Capital Partners, LLC is a member of the Financial Industry
Regulatory Authority, or FINRA, or an independent broker-dealer, or an affiliate or associated person of a FINRA member or independent
broker-dealer. The foregoing should not be construed in and of itself as an admission by Mr. Zaino as to beneficial ownership of
the securities beneficially owned directly by Keystone Capital Partners, LLC and indirectly by Ranz Group, LLC. |
(5) |
We effected a reverse stock split of our Common Shares on a fifteen (15) to one (1) basis,
and the Common Shares commenced trading on a post-reverse stock split basis at market open on Tuesday, June 6, 2023. All information
in this table have been updated to reflect the reverse stock split unless provided otherwise. |
PLAN
OF DISTRIBUTION
The Common Shares offered by this prospectus are being
offered by the Selling Shareholder, Keystone Capital Partners, LLC. The Common Shares may be sold or distributed from time to time by
the Selling Shareholder directly to one or more purchasers or through brokers, dealers, or underwriters who may act solely as agents
at market prices prevailing at the time of sale, at prices related to the prevailing market prices, at negotiated prices, or at fixed
prices, which may be changed. The sale of our Common Shares offered by this prospectus could be effected in one or more of the following
methods:
|
· |
ordinary brokers’ transactions; |
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· |
transactions involving cross or block trades; |
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· |
through brokers, dealers, or underwriters who may act solely as agents; |
|
· |
“at the market” into an existing market for our Common Shares; |
|
· |
in other ways not involving market makers or established business markets, including direct sales
to purchasers or sales effected through agents; |
|
· |
in privately negotiated transactions; or |
|
· |
any combination of the foregoing. |
In order to comply with the securities laws of certain
states, if applicable, the Common Shares may be sold only through registered or licensed brokers or dealers. In addition, in certain
states, the Common Shares may not be sold unless they have been registered or qualified for sale in the state or an exemption from the
state’s registration or qualification requirement is available and complied with.
None of our Common Shares issued pursuant to the Purchase
Agreement will be offered for sale or sold by us or the Selling Shareholder on the TSX or to purchasers resident in Canada.
Keystone Capital Partners, LLC is an “underwriter”
within the meaning of Section 2(a)(11) of the Securities Act.
Keystone Capital Partners has informed us that it
intends to use one or more registered broker-dealers to effectuate all sales, if any, of our Common Shares that it has acquired and may
in the future acquire from us pursuant to the Purchase Agreement. Such sales will be made at prices and at terms then prevailing or at
prices related to the then current market price. Each such registered broker-dealer will be an underwriter within the meaning of Section
2(a)(11) of the Securities Act. Keystone Capital Partners has informed us that each such broker-dealer will receive commissions from
Keystone Capital Partners that will not exceed customary brokerage commissions.
Brokers, dealers, underwriters or agents participating
in the distribution of our Common Shares offered by this prospectus may receive compensation in the form of commissions, discounts, or
concessions from the purchasers, for whom the broker-dealers may act as agent, of the Common Shares sold by the Selling Shareholder through
this prospectus. The compensation paid to any such particular broker-dealer by any such purchasers of our Common Shares sold by the Selling
Shareholder may be less than or in excess of customary commissions. Neither we nor the Selling Shareholder can presently estimate the
amount of compensation that any agent will receive from any purchasers of our Common Shares sold by the Selling Shareholder.
We know of no existing arrangements between the Selling
Shareholder or any other shareholder, broker, dealer, underwriter or agent relating to the sale or distribution of our Common Shares
offered by this prospectus.
We may from time to time file with the SEC one or
more supplements to this prospectus or amendments to the registration statement of which this prospectus forms a part to amend, supplement
or update information contained in this prospectus, including, if and when required under the Securities Act, to disclose certain information
relating to a particular sale of Common Shares offered by this prospectus by the Selling Shareholder, including the names of any brokers,
dealers, underwriters or agents participating in the distribution of such Common Shares by the Selling Shareholder, any compensation
paid by the Selling Shareholder to any such brokers, dealers, underwriters or agents, and any other required information.
We will pay the expenses incident to the registration
under the Securities Act of the offer and sale of our Common Shares covered by this prospectus by the Selling Shareholder. As consideration
for its irrevocable commitment to purchase our Common Shares under the Purchase Agreement, we have issued to Keystone Capital Partners
7,547 Common Shares as the Initial Commitment Shares in accordance with the Purchase Agreement and have agreed to issue to Keystone Capital
Partners an additional 17,609 Common Shares as the Back-End Commitment Shares. We have also paid to Keystone Capital Partners $25,000
in cash as reimbursement for the reasonable, out-of-pocket expenses incurred by Keystone Capital Partners, including the legal fees and
disbursements of Keystone Capital Partners’ legal counsel, in connection with its due diligence investigation of the Company and
in connection with the preparation, negotiation and execution of the Purchase Agreement.
We also have agreed to indemnify Keystone Capital
Partners and certain other persons against certain liabilities in connection with the offering of our Common Shares offered hereby, including
liabilities arising under the Securities Act or, if such indemnity is unavailable, to contribute amounts required to be paid in respect
of such liabilities. Keystone Capital Partners has agreed to indemnify us against liabilities under the Securities Act that may arise
from certain written information furnished to us by Keystone Capital Partners specifically for use in this prospectus or, if such indemnity
is unavailable, to contribute amounts required to be paid in respect of such liabilities. Insofar as indemnification for liabilities
arising under the Securities Act may be permitted to our directors, officers, and controlling persons, we have been advised that in the
opinion of the SEC this indemnification is against public policy as expressed in the Securities Act and is therefore, unenforceable.
We estimate that the total expenses for the offering
will be approximately $150,000.
Keystone Capital Partners has represented to us that
at no time prior to the date of the Purchase Agreement has Keystone Capital Partners or its agents, representatives or affiliates engaged
in or effected, in any manner whatsoever, directly or indirectly, any short sale (as such term is defined in Rule 200 of Regulation SHO
of the Exchange Act) of our Common Shares or any hedging transaction, which establishes a net short position with respect to our Common
Shares. Keystone Capital Partners has agreed that during the term of the Purchase Agreement, neither Keystone Capital Partners, nor any
of its agents, representatives or affiliates will enter into or effect, directly or indirectly, any of the foregoing transactions.
We have advised the Selling Shareholder that it is
required to comply with Regulation M promulgated under the Exchange Act. With certain exceptions, Regulation M precludes the Selling
Shareholder, any affiliated purchasers, and any broker-dealer or other person who participates in the distribution from bidding for or
purchasing, or attempting to induce any person to bid for or purchase any security which is the subject of the distribution until the
entire distribution is complete. Regulation M also prohibits any bids or purchases made in order to stabilize the price of a security
in connection with the distribution of that security. All of the foregoing may affect the marketability of the securities offered by
this prospectus.
This offering will terminate on the date that all
of our Common Shares offered by this prospectus have been sold by the Selling Shareholder.
Our Common Shares are currently listed on Nasdaq under
the symbol “APTO” and on the TSX under the symbol “APS”.
MANAGEMENT’S
DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS
Our discussion and analysis of financial condition
and results of operations is incorporated by reference from Part II, Item 7 of the Company’s Annual Report on Form 10-K as filed
with the SEC on March 24, 2023 and from Part II, Item 2 of the Company’s Quarterly Report on Form 10-Q as filed with the SEC on
May 8, 2023 (see “Incorporation of Certain Information by Reference”).
BUSINESS
The description of our business is incorporated by
reference from Part I, Item 1 of the Company’s Annual Report on Form 10-K as filed with the SEC on March 24, 2023 (see “Incorporation
of Certain Information by Reference”).
DESCRIPTION
OF OUR COMMON SHARES
We are offering our Common
Shares. The following description of the Common Shares summarizes the material terms and provisions thereof, including the material terms
of the Common Shares we are offering under this prospectus supplement and the accompanying prospectus.
Authorized Capital
Our authorized share capital consists of an unlimited
number of Common Shares, no par value, of which 6,299,545 were issued and outstanding as at June 12, 2023. None of our Common Shares
are held by us or on our behalf.
Common Shares
The holders of our Common Shares are entitled to receive
notice of and to attend and vote at all annual and special meetings of our shareholders. Our Common Shares carry one vote per Common
Share and do not have cumulative voting rights. The holders of our Common Shares are entitled, at the discretion of our board of directors,
to receive out of any or all of our profits or surplus properly available for the payment of dividends, any dividend declared by the
board of directors and payable by us on our Common Shares. The holders of our Common Shares will participate on a pro rata basis in any
distribution of our remaining property upon our liquidation, dissolution or winding-up or any other return of capital or distribution
of our assets among our shareholders for the purpose of winding up our affairs.
Dividend Policy
We have not paid any dividends since our incorporation.
At the discretion of our board of directors, we will consider paying dividends in the future as our operational circumstances may permit,
having regard to, among other things, our earnings, cash flow and financial requirements. It is the current policy of our board of directors
to retain all earnings to finance our business plan.
Listings
Our Common Shares are listed on Nasdaq under the symbol
“APTO” and on the TSX under the symbol “APS”.
DISCLOSURE
OF COMMISSION POSITION ON INDEMNIFICATION FOR SECURITIES ACT LIABILITIES
Insofar as indemnification for liabilities arising
under the Securities Act may be permitted to our directors, officers and controlling persons pursuant to the foregoing provisions, we
have been informed that in the opinion of the SEC such indemnification is against public policy as expressed in the Securities Act and
is, therefore, unenforceable.
PROPERTIES
The description of our properties is incorporated
by reference from Part I, Item 2 of the Company’s Annual Report on Form 10-K as filed with the SEC on March 24, 2023 (see “Incorporation
of Certain Information by Reference”).
LEGAL
PROCEEDINGS
The description of our legal proceedings is incorporated
by reference from Part I, Item 3 of the Company’s Annual Report on Form 10-K as filed with the SEC on March 24, 2023 (see “Incorporation
of Certain Information by Reference”).
DIRECTORS,
EXECUTIVE OFFICERS AND CORPORATE GOVERNANCE
The description of directors, executive officers and
corporate governance is incorporated by reference from the Company’s definitive proxy statement on Schedule 14A filed with the
SEC on April 19, 2023 (see “Incorporation of Certain Information by Reference”).
EXECUTIVE
COMPENSATION
The description of our executive compensation is incorporated
by reference from the Company’s definitive proxy statement on Schedule 14A filed with the SEC on April 19, 2023 (see “Incorporation
of Certain Information by Reference”).
SECURITY
OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT AND RELATED STOCKHOLDER MATTERS
The description of our security ownership of beneficial
owners and management is incorporated by reference from the Company’s definitive proxy statement on Schedule 14A filed with the
SEC on April 19, 2023 (see “Incorporation of Certain Information by Reference”).
CERTAIN
RELATIONSHIPS AND RELATED TRANSACTIONS AND DIRECTOR INDEPENDENCE
The description of certain relationships and related
transactions and director independence is incorporated by reference from the Company’s definitive proxy statement on Schedule 14A
filed with the SEC on April 19, 2023 (see “Incorporation of Certain Information by Reference”).
LEGAL
MATTERS
The validity of the securities being offered hereby
is being passed upon for us by McCarthy Tétrault LLP, Toronto, Ontario, with respect to matters of Canadian law.
EXPERTS
The consolidated financial statements of Aptose Biosciences
Inc. as of December 31, 2022 and 2021, and for each of the years then ended, have been incorporated by reference from our Annual Report
on Form 10-K as filed with the SEC on March 24, 2023, in reliance upon the report of KPMG LLP, an independent registered public accounting
firm. Such report is incorporated by reference upon the authority of said firm as an expert in accounting and auditing.
WHERE
YOU CAN FIND MORE INFORMATION
We are subject to the information requirements of
the Securities Exchange Act of 1934 and, accordingly, we file reports with and furnish other information to the SEC. This
prospectus forms part of a registration statement we have filed with the SEC relating to, among other things, the Common Shares. As permitted
by SEC rules, this prospectus does not contain all of the information contained in the registration statement that we filed. For further
information regarding us and the securities covered by this prospectus, you may desire to review the full registration statement, including
its exhibits. The registration statement, including its exhibits, as well as the documents that we file with the SEC, may be inspected
and copied at the public reference facilities maintained by the SEC at 100 F Street, N.E., Room 1580, Washington, D.C. 20549. You may
obtain information on the operation of the public reference room by calling 1-800-SEC-0330. Copies of such materials are also available
by mail from the Public Reference Branch of the SEC at 100 F Street, N.E., Washington, D.C. 20549 at prescribed rates. In addition, the
SEC maintains a website (http://www.sec.gov) from which interested persons can electronically access the registration statement, including
the exhibits to the registration statement.
INCORPORATION
OF CERTAIN INFORMATION BY REFERENCE
The SEC allows us to “incorporate by reference”
information we file with the SEC. This means that we can disclose important information to you by referring you to those documents.
We incorporate by reference into this prospectus the
documents listed below:
|
● |
Annual Report on Form
10-K for the fiscal year ended December 31, 2022 filed with the SEC on March 24, 2023; |
|
|
|
|
● |
Quarterly Report on Form
10-Q filed with the SEC on May 8, 2023; |
|
|
|
|
● |
Our definitive proxy statement on Schedule
14A filed on April 19, 2023; and |
|
|
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|
● |
Our Current Reports on Form 8-K filed with the SEC on January
6, 2023, May 23, 2023,
May 26, 2023, and June
5, 2023 (other than current reports furnished under Item 2.02 or Item 7.01 of Form 8-K and exhibits that are related to such
item). |
In addition, all documents filed by us under Sections
13(a), 13(c), 14 or 15(d) of the Securities Exchange Act of 1934, after the date of this prospectus but before the termination of
the offering of the securities covered by this prospectus, are hereby incorporated by reference into this prospectus.
We have not authorized anyone to provide you with
any different or additional information other than that contained in or incorporated by reference into this prospectus. We take no responsibility
for, and can provide no assurance as to the reliability of, any information that others may provide.
Any statement contained in a document incorporated
or deemed to be incorporated by reference into this prospectus will be deemed to be modified or superseded for purposes of this prospectus
to the extent that a statement contained in this prospectus or any other subsequently filed document that is deemed to be incorporated
by reference into this prospectus modifies or supersedes the statement. Any statement so modified or superseded will not be deemed, except
as so modified or superseded, to constitute a part of this prospectus.
The documents incorporated by reference into this
prospectus are available from us upon request. We will provide a copy of any and all of the information that is incorporated by reference
into this prospectus to any person, including a beneficial owner, to whom a prospectus is delivered, without charge, upon written or
oral request. If exhibits to the documents incorporated by reference into this prospectus are not themselves specifically incorporated
by reference in this prospectus, then the exhibits will not be provided.
Requests for any of these documents should be directed
to:
Investor Relations
Aptose Biosciences Inc.
251 Consumers Road, Suite 1105
Toronto, Ontario, Canada M2J 4R3
(647) 479-9828
PROSPECTUS
Aptose Biosciences Inc.
Offering of 1,257,785 Common Shares
, 2023
PART II
INFORMATION
NOT REQUIRED IN THE PROSPECTUS
Item 13. Other Expenses of Issuance and Distribution.
The following table sets forth all expenses to be
paid by the Company, other than underwriting discounts and commissions, upon the completion of this offering. All amounts shown are estimates
except for the SEC filing fee.
| |
Approximate
Amount |
SEC registration fee | |
$ | 839.27 | |
Legal fees and expenses | |
| 100,000 | |
Accounting fees and expenses | |
| 30,000 | |
Transfer agent and registrar fees | |
| 6,000 | |
Miscellaneous | |
| 13,000 | |
| |
| | |
Total | |
$ | 149,839.27 | |
Item 14. Indemnification of Directors and Officers.
Under the Canada
Business Corporations Act, or the “CBCA”, the Company may indemnify its current or former directors or officers or another
individual who acts or acted at the Company’s request as a director or officer, or an individual acting in a similar capacity,
of another entity, against all costs, charges and expenses, including an amount paid to settle an action or satisfy a judgment, reasonably
incurred by the individual in respect of any civil, criminal, administrative, investigative or other proceeding in which the individual
is involved because of his or her association with the Company or another entity, and the individual seeking indemnity shall have a right
to such indemnity if such individual was not judged by the court or other competent authority to have committed any fault or omitted
to do anything that such individual ought to have done. The CBCA also provides that the Company may advance moneys to such an individual
for the costs, charges and expenses of such a proceeding.
The CBCA also provides that
the Company may with the approval of a court, indemnify such an individual or advance moneys against all costs, charges and expenses
reasonably incurred by the individual in connection with an action by or on behalf of the Company or other entity to procure a judgment
in its favour, to which the individual is made a party because of the individual’s association with the Company or other entity
at the Company’s request.
However, indemnification
under any of the foregoing circumstances is prohibited under the CBCA unless the individual:
|
· |
acted honestly and in good faith with a view to the Company’s best interests, or the best interests
of the other entity for which the individual acted as director or officer or in a similar capacity at the Company’s request;
and |
|
· |
in the case of a criminal or administrative action or proceeding that is enforced by a monetary penalty,
the individual had reasonable grounds for believing that his or her conduct was lawful. |
The Company’s by-law
No. 2 provides that the Company will indemnify its directors or officers, former directors or officers or other individuals who act or
have acted at the Company’s request as a director or officer, or in a similar capacity, of another entity, and his or her heirs
and legal representatives to the extent permitted by the CBCA.
The Company’s by-law
No. 2 further provides that, except as otherwise required by the CBCA, the Company may from time to time indemnify and save harmless
any person who was or is a party or is threatened to be made a party to any threatened, pending or completed action, suit or proceeding,
whether civil, criminal, administrative or investigative (other than an action by or in the right of the Company) by reason of the fact
that he or she is or was an employee or agent of the Company, or is or was serving at the request of the Company as an employee, agent
of or participant in another entity against expenses (including legal fees), judgments, fines and any amount actually and reasonably
incurred by him or her in connection with such action, suit or proceeding if he or she acted honestly and in good faith with a view to
the best interests of the Company or, as the case may be, to the best interests of the other entity for which he or she served at the
Company’s request and, with respect to any criminal or administrative action or proceeding that is enforced by a monetary penalty,
had reasonable grounds for believing that his or her conduct was lawful. The termination of any action, suit or proceeding by judgment,
order, settlement or conviction will not, of itself, create a presumption that the person did not act honestly and in good faith with
a view to the best interests of the Company or other entity and, with respect to any criminal or administrative action or proceeding
that is enforced by a monetary penalty, had no reasonable grounds for believing that his or her conduct was lawful.
The Company has entered into
indemnity agreements with its directors and certain officers pursuant to which it has agreed to indemnify its officers and directors
for:
|
(a) |
all costs, charges and expenses, including an amount paid to settle an action or satisfy a judgment,
reasonably incurred by them in respect of any civil, criminal or administrative action or proceeding to which they are made a party
by reason of being or having been a director and/or officer of the Company, if (i) they acted honestly and in good faith with a view
to the best interests of the Company, and (ii) in the case of a criminal or administrative action or proceeding that is enforced
by a monetary penalty, they had reasonable grounds for believing that their conduct was lawful. |
|
(b) |
all costs, charges and expenses reasonably incurred by them in connection with any action by or on
behalf of the Company to procure a judgment in the Company’s favour to which they are made a party by reason of being or having
been a director and/or officer of the Company. |
|
(c) |
all costs, charges and expenses reasonably incurred by them in connection with the defense of any
civil, criminal or administrative proceeding to which they are made a party by reason of being or having been a director and/or officer
of the Company if they have been substantially successful on the merits in their defense of the action or proceeding and they fulfil
the conditions set forth in the two foregoing clauses (a)(i) and (a)(ii) above. |
Insofar as indemnification
for liabilities arising under the Securities Act of 1933 may be permitted to directors, officers or persons controlling the
Company pursuant to the foregoing provisions, the Company has been informed that in the opinion of the Securities and Exchange Commission
such indemnification is against public policy as expressed in the Securities Act of 1933 and is therefore unenforceable.
Item 15. Recent Sales of Unregistered Securities.
We sold the
securities described below within the past three years which were not registered under the Securities Act.
On May 25, 2023,
we entered into Purchase Agreement with Keystone, pursuant to which Keystone has committed to purchase from us, at our direction, up
to $25 million Common Shares, subject to the terms and conditions specified in such purchase agreement. Pursuant to the Purchase Agreement,
we issued to Lincoln Park 7,547 Initial Commitment Shares concurrently with our execution
of the Purchase Agreement as consideration for its irrevocable commitment to purchase the Common Shares thereunder, subject the terms
and conditions contained therein. As of the date hereof, other than the Commitment Shares, we have not issued and sold any Common Shares
under such the Purchase Agreement. The securities were issued pursuant to an exemption from registration provided for under Section
4(a)(2) of the Securities Act. We relied on this exemption from registration based in part on representations made by the investor.
Item 16. Exhibits and Financial Statement Schedules.
(a) See the Exhibit Index on the page immediately preceding the signature
page hereto for a list of exhibits filed as part of this registration statement on Form S-1, which Exhibit Index is incorporated herein
by reference.
(b) No financial statement schedules are provided because the information
called for is not required or is shown either in the financial statements or the notes thereto.
Item 17. Undertakings.
The undersigned registrant hereby undertakes:
(1) To file, during any period in which offers or
sales are being made, a post-effective amendment to this registration statement:
(i) To include any prospectus required by section
10(a)(3) of the Securities Act;
(ii) To reflect in the prospectus any facts or events
arising after the effective date of the registration statement (or the most recent post-effective amendment thereof) which, individually
or in the aggregate, represent a fundamental change in the information set forth in the registration statement. Notwithstanding the foregoing,
any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which
was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus
filed with the Securities and Exchange Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent
no more than a 20 percent change in the maximum aggregate offering price set forth in the “Calculation of Registration Fee”
table in the effective registration statement; and
(iii) To include any material information with respect
to the plan of distribution not previously disclosed in the registration statement or any material change to such information in the
registration statement.; provided, however, that paragraphs (1)(i), (1)(ii) and (1)(iii) above do not apply if the information required
to be included in a post-effective amendment by those paragraphs is contained in reports filed with or furnished to the Securities and
Exchange Commission by the Company pursuant to Section 13 or Section 15(d) of the Securities Exchange Act of 1934 that are incorporated
by reference in the registration statement, or is contained in a form of prospectus filed pursuant to Rule 424(b) that is part of the
registration statement.
(2) That, for the purpose of determining any liability
under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities
offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.
(3) To remove from registration by means of a post-effective
amendment any of the securities being registered which remain unsold at the termination of the offering.
(4) That, for the purpose of determining liability
under the Securities Act to any purchaser:
(A) Each prospectus filed by the Company pursuant
to Rule 424(b)(3) shall be deemed to be part of the registration statement as of the date the filed prospectus was deemed part of and
included in the registration statement; and
(B) Each prospectus required to be filed pursuant
to Rule 424(b)(2), (b)(5) or (b)(7) as part of a registration statement in reliance on Rule 430B relating to an offering made pursuant
to Rule 415(a)(1)(i), (vii), or (x) for the purpose of providing the information required by Section 10(a) of the Securities Act shall
be deemed to be part of and included in the registration statement as of the earlier of the date such form of prospectus is first used
after effectiveness or the date of the first contract of sale of securities in the offering described in the prospectus. As provided
in Rule 430B, for liability purposes of the issuer and any person that is at that date an underwriter, such date shall be deemed to be
a new effective date of the registration statement relating to the securities in the registration statement to which that prospectus
relates, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof. Provided, however,
that no statement made in a registration statement or prospectus that is part of the registration statement or made in a document incorporated
or deemed incorporated by reference into the registration statement or prospectus that is part of the registration statement will, as
to a purchaser with a time of contract of sale prior to such effective date, supersede or modify any statement that was made in the registration
statement or prospectus that was part of the registration statement or made in any such document immediately prior to such effective
date.
(5) That, for purposes of determining any liability
under the Securities Act, each filing of the Company’s annual report pursuant to Section 13(a) or 15(d) of the Exchange Act (and,
where applicable, each filing of an employee benefit plan’s annual report pursuant to Section 15(d) of the Exchange Act) that is
incorporated by reference in the registration statement shall be deemed to be a new registration statement relating to the securities
offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.
(6) Insofar as indemnification for liabilities arising
under the Securities Act may be permitted to directors, officers and controlling persons of the Company pursuant to any charter provision,
by law or otherwise, the Company has been advised that in the opinion of the Securities and Exchange Commission such indemnification
is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification
against such liabilities (other than payment by the Company of expenses incurred or paid by a director, officer or controlling person
of the Company in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person
in connection with the securities being registered, the Company will, unless in the opinion of its counsel the matter has been settled
by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public
policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.
EXHIBIT INDEX
The following documents are being filed with the Commission as exhibits
to this registration statement on Form S-1.
Exhibit
Number |
|
Description of Document |
|
|
|
3.1 |
|
Articles of
Incorporation, Arrangement and Amendment (incorporated herein by reference to Exhibit 99.3 to the Company’s Current Report
on Form 6-K filed with the SEC on June 12, 2015) |
|
|
|
3.2 |
|
Certificate
of Amendment (incorporated herein by reference to Exhibit 3.1 to the Company’s Current Report on Form 8-K filed with the SEC
on June 5, 2023) |
|
|
|
3.3 |
|
By-law #2 of
the Company (incorporated herein by reference to Exhibit 99.2 to the Company’s Current Report on Form 6-K filed with the SEC
on June 12, 2015) |
|
|
|
4.1 |
|
Description
of Securities (incorporated by reference to Exhibit 4.1 to the Company's Annual report on Form 10-K filed with the SEC on March 22,
2022) |
|
|
|
5.1* |
|
Opinion of McCarthy Tétrault LLP |
|
|
|
10.1 |
|
Indemnification
Agreement dated July 10, 2007 between Lorus Therapeutics Inc. and the Company (incorporated herein by reference to Exhibit 99.1
to the Company’s Current Report on Form 6-K filed with the SEC on September 4, 2007) |
|
|
|
10.2+ |
|
Amended
and Restated Executive Employment Agreement between the Company and Dr. William G. Rice dated August 19, 2014 (incorporated
herein by reference to Exhibit 4.9A to the Company’s Annual Report on Form 20-F filed with the SEC on March 4, 2015) |
|
|
|
10.3+ |
|
Share Option
Plan as amended May 5, 2015 (incorporated herein by reference to Exhibit 99.2 to the Company’s Current Report on Form 6-K filed
with the SEC on June 12, 2015) |
|
|
|
10.4+ |
|
Stock Incentive
Plan as adopted May 5, 2015 (incorporated herein by reference to Exhibit 99.1 to the Company’s Current Report on Form 6-K filed
with the SEC on June 12, 2015) |
|
|
|
10.5+ |
|
Form
of Executive Employment Agreement, dated December 4, 2019, between the Company and Dr. Rafael Bejar (incorporated herein by reference
to Exhibit 10.7 to the Company’s Annual Report filed on Form 10-K filed with the SEC on March 10, 2020) |
|
|
|
10.6 |
|
License
agreement dated June 13, 2018 by and between the Company and CrystalGenomics, Inc. (incorporated herein by reference to Exhibit 1.1
to the Company’s Current Report on Form 6-K filed with the SEC filed on June 22, 2018) |
|
|
|
10.7 |
|
Option and
License Agreement between the Company and CrystalGenomics, Inc. dated March 21, 2016 (incorporated herein by reference on Form
10-KA/3 filed with the SEC on April 22, 2019) |
|
|
|
10.8 |
|
Amendment
to Option and License Agreement between the Company and CrystalGenomics, Inc., dated April 26, 2016 (incorporated herein by reference
to Exhibit 99.2 to the Company’s Current Report on Form 6-K filed with the SEC on June 8, 2016) |
|
|
|
10.9 |
|
Second
Amendment to Option and License Agreement between the Company and CrystalGenomics, Inc., dated May 13, 2016 (incorporated herein
by reference to Exhibit 99.3 to the Company’s Current Report on Form 6-K filed with the SEC on June 8, 2016) |
|
|
|
10.10 |
|
Third Amendment
to Option and License Agreement between the Company and CrystalGenomics, Inc., dated May 19, 2016 (incorporated herein by reference
to Exhibit 99.4 to the Company’s Current Report on Form 6-K filed with the SEC on June 8, 2016) |
|
|
|
10.11 |
|
Fourth Amendment
to Option and License Agreement between the Company and CrystalGenomics, Inc., dated June 1, 2016 (incorporated herein by reference
to Exhibit 99.5 to the Company’s Current Report on Form 6-K filed with the SEC on June 8, 2016) |
|
|
|
10.12 |
|
License
Agreement dated as of March 6, 2018 by and between the Company and Ohm Oncology Inc. (incorporated herein by reference to Exhibit
99.2 on Form 6-K filed with the SEC filed on March 8, 2018) |
|
|
|
10.13+ |
|
Aptose
Biosciences Inc. 2021 Employee Stock Purchase Plan (incorporated by reference to the Definitive Proxy statement on Schedule 14A filed
with the SEC on April 1, 2021) |
|
|
|
10.14+ |
|
Aptose
Biosciences Inc. 2021 Employee Stock Incentive Plan (incorporated by reference to the Definitive Proxy statement on Schedule 14A
filed with the SEC on April 1, 2021) |
|
|
|
10.15 |
|
Exclusive
License Agreement, dated November 4, 2021, by and between Hanmi Pharmaceutical Co. Ltd. and Aptose Biosciences Inc. (incorporated
herein by reference to Exhibit 10.1 to the Company’s Current Report filed on Form 8-K on November 4, 2021) |
|
|
|
10.16 |
|
Employment
Agreement dated June 3, 2019 between Aptose Biosciences Inc. and Philippe Ledru (incorporated herein by reference to Exhibit 10.1
to the Company’s Current Report filed on Form 8-K on April 11, 2022) |
|
|
|
10.17 |
|
Employment
Agreement, dated June 27, 2022, between Aptose Biosciences Inc. and Fletcher Payne (incorporated herein by reference to Exhibit 10.1
to the Company’s Current Report filed on Form 8-K on June 28, 2022) |
|
|
|
10.18 |
|
Equity Distribution
Agreement, dated December 9, 2022, among Aptose Biosciences Inc. and JonesTrading Institutional Services LLC (incorporated
herein by reference to Exhibit 10.1 to the Company’s Current Report filed on Form 8-K on December 12, 2022) |
|
|
|
21.1 |
|
List
of Subsidiaries (incorporated herein by reference to Exhibit 21.1 to the Company’s Current Report filed on Form 10-K on March
24, 2023) |
|
|
|
23.1* |
|
Consent of Independent Registered Public Accounting Firm (KPMG) |
|
|
|
23.2* |
|
Consent of McCarthy Tétrault LLP (included in Exhibit 5.1) |
|
|
|
24.1* |
|
Powers of Attorney (included on signature page) |
|
|
|
107* |
|
Filing Fees |
+ Indicates management contract or compensatory plan.
* Filed herewith.
SIGNATURES
Pursuant to the requirements of the Securities Act
of 1933, the Company certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-1
and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City
of Toronto, Ontario, Canada on June 16, 2023.
|
Aptose Biosciences Inc. |
|
|
|
|
|
|
By: |
/s/ Fletcher Payne |
|
|
|
Fletcher Payne |
|
|
|
Senior Vice President and Chief Financial Officer |
|
POWER OF
ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS, that each
person whose signature appears below hereby constitutes and appoints William G. Rice and Fletcher Payne, and each of them, either of
whom may act without the joinder of the other, as his or her true and lawful agent, proxy and attorney-in-fact, with full power
of substitution and resubstitution, for him or her and in his or her name, place and stead, in any and all capacities, to (i) act on,
sign and file with the Securities and Exchange Commission any and all amendments (including post-effective amendments) to this registration
statement together with all schedules and exhibits thereto and any subsequent registration statement filed pursuant to Rule 462(b) under
the Securities Act of 1933, as amended, together with all schedules and exhibits thereto, (ii) act on, sign and file such certificates,
instruments, agreements and other documents as may be necessary or appropriate in connection therewith, (iii) act on and file any
supplement to any prospectus included in this registration statement or any such amendment or any subsequent registration statement filed
pursuant to Rule 462(b) under the Securities Act of 1933, as amended, and (iv) take any and all actions which may be necessary or appropriate
to be done, as fully for all intents and purposes as he might or could do in person, hereby approving, ratifying and confirming all that
such agent, proxy and attorney-in-fact or any of his substitutes may lawfully do or cause to be done by virtue thereof.
Pursuant to the requirements of the Securities Act
of 1933, this registration statement has been signed by the following persons in the capacities and on the dates indicated.
Name |
|
Positions |
|
Date |
|
|
|
|
|
/s/ William G. Rice
William G. Rice |
|
President, Chief Executive Officer and Chairman of the Board of Directors (Principal Executive Officer) |
|
June 16, 2023 |
|
|
|
|
|
/s/ Fletcher Payne
Fletcher Payne |
|
Senior Vice President and Chief Financial Officer (Principal Financial and Accounting Officer) |
|
June 16, 2023 |
|
|
|
|
|
/s/ Denis Burger
Denis Burger |
|
Director |
|
June 16, 2023 |
|
|
|
|
|
/s/ Carol Ashe
Carol Ashe |
|
Director |
|
June 16, 2023 |
|
|
|
|
|
/s/ Dr. Erich M. Platzer
Dr. Erich M. Platzer |
|
Director |
|
June 16, 2023 |
|
|
|
|
|
/s/ Dr. Bernd R. Seizenger
Dr. Bernd R. Seizenger |
|
Director |
|
June 16, 2023 |
|
|
|
|
|
/s/ Dr. Mark Vincent
Dr. Mark Vincent |
|
Director |
|
June 16, 2023 |
|
|
|
|
|
/s/ Warren Whitehead
Warren Whitehead |
|
Director |
|
June 16, 2023 |
AUTHORIZED REPRESENTATIVE
Pursuant to the requirements of Section 6(a) of the
Securities Act of 1933, the undersigned has signed this registration statement, solely in the capacity of the duly authorized representative
of Aptose Biosciences Inc. in the United States, on this 16th day of June, 2023.
|
APTOSE BIOSCIENCES U.S. INC. |
|
|
|
|
|
By: |
/s/ Fletcher Payne |
|
|
Name: |
Fletcher Payne |
|
|
Title: |
Senior Vice President and
Chief Financial Officer |
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