UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

NOTICE OF EFFECTIVENESS

Effective Date: March 31, 2023 4:30 P.M.
Form: S-3
CIK: 0001347858
Company Name: 22nd Century Group, Inc.
File Number: 333-270473
22nd Century (AMEX:XXII)
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