RNS Number:4991K
Alizyme PLC
29 April 2003


For Immediate Release                                           29 April 2003



                                 ALIZYME plc


                   NOTIFICATION OF MAJOR INTERESTS IN SHARES



Cambridge, UK, 29 April 2003: Alizyme plc (London Stock Exchange: AZM) announces
that it received, yesterday, the following "Notification of Interest" from ISIS
Asset Management plc.





"In accordance with the provisions of Sections 198-202 of the Companies Act
1985, we give notice that, as a result of a purchase of 100,000 ordinary shares
of 2p each in the relevant share capital of your company ("Shares") on 25th
April 2003 the following fund management companies in the Friends Provident
group are interested in the Shares referred to below through client holdings:



ISIS Asset Management plc is interested in the following shares:


No. of shares                                          %
15,100,555                                             11.031



Such interest includes the material interests of the clients of ISIS Asset
Management plc referred to below:


Name of Client                                    No. of Shares      %     Name of Registered Holder
The Aim Trust                                         5,294,896 3.8677     Chase Nominees Ltd
3PC Investment Trust                                  2,142,143 1.5647     Chase Nominees Ltd
ISIS MPF UK Smaller                                     459,571 0.3357     Citifriends
ISIS UK Smaller Co Fund                                 700,000 0.5113     Chase Nominees Ltd
The Aim VCT Trust                                     1,847,344 1.3494     Chase Nominees Ltd



Such interest includes the material interest of the clients of Friends Provident
Unit Managers referred to below:


Name of Client                                    No. of Shares      %     Name of Registered Holder
UK Mid/Small Cap Fund                                 4,146,874 3.0291     Citifriends
UK Equity Fund                                          207,112 0.1512     Citifriends
FISIS ICV UK Smaller Markets Fund                       302,615 0.2210     Citifriends



In addition, ISIS Asset Management plc, as the holding company of the company(s)
referred to in the paragraph(s) above is also interested in those Shares.
Futhermore, Friends Provident Life Office, as the holding company of ISIS Asset
Management plc is also interested in the Shares referred to above.



This notification supersedes all previous notifications given by members of the
Friends Provident group in relation to Shares. (It also supersedes all previous
notifications given by members of the Friends Provident group on behalf of the
client(s) named above in relation to Shares)."





For further information, please contact:




Mr Tim McCarthy, Finance Director

ALIZYME plc                                     Tel No: + 44 (0)1223 896000

Lisa Baderoon

BUCHANAN COMMUNICATIONS                         Tel No: + 44 (0) 20 7466 5000



Further information on Alizyme can be found on the Company's website:
www.alizyme.com


                      This information is provided by RNS
            The company news service from the London Stock Exchange
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