DOW JONES NEWSWIRES 
 

Amgen Inc.'s (AMGN) second-quarter earnings rose 40% despite a small revenue decline as unusual items skewed comparisons.

The pharmaceutical company also raised its earnings guidance to $4.80 to $4.95 a share from $4.55 to $4.75 a share, while it sees revenue at the high end of its previously reduced forecast.

That, plus the second-quarter's results topping analysts' expectations, helped send shares up 3.8% to $66.01 in after-hours trading. The stock is now down only about 5% from its 52-week high in September.

It has been a rough year for drug companies, as patients economize and the stronger dollar slows sales overseas. Market research firm IMS Health Inc. (RX) has said the U.S. pharmaceutical market will likely shrink this year for the first time in decades, a scenario borne out by recent results from drug giants.

Still, Amgen got a bit of good news earlier this month when a study found its denosumab bone drug was superior to a rival treatment from Novartis AG (NVS). On Monday, Amgen entered a pact for GlaxoSmithKline PLC (GSK) to commercialize the compound for postmenopausal osteoporosis indications in Europe, Australia, New Zealand and Mexico. Amgen will retain full rights in other areas.

"We are optimistic about our financial performance in 2009 and are focused on making denosumab a success," said Amgen Chairman and Chief Executive Kevin Sharer.

The company reported earnings of $1.27 billion, or $1.25 a share, compared with $906 million, or 84 cents a share, a year earlier. Excluding items such as acquisition-related and stock-compensation costs, earnings rose to $1.29 a share from $1.14.

Revenue fell 1% to $3.71 billion.

Analysts polled by Thomson Reuters were looking for per-share earnings of $1.16, excluding items, on revenue of $3.58 billion.

U.S. product sales fell slightly, while international sales dropped 6%. The international figure rose 1% excluding currency fluctuations.

Worldwide sales of anemia drug Aranesp fell 16%, while Epogen sales rose 2.6%. The drugs' sales have been hurt since a Food and Drug Administration panel last year recommended curbing their use because of concerns the drugs speed cancer tumor growth and shorten survival times.

Sales of the rheumatoid arthritis drug Enbrel, which Amgen sells in North America and Wyeth Inc. (WYE) distributes elsewhere, rose 6.9%. Last week, Wyeth said international sales of Enbrel climbed 6% to $736 million.

Combined sales of Neulasta and Neupogen, which are used to prevent infections in patients receiving chemotherapy, were down 3.6%.

-By Jay Miller, Dow Jones Newswires; 212-416-2355; jay.miller@dowjones.com