Merck Phase 3 Keytruda Study Misses Main Endpoint in HNSCC
July 20 2022 - 7:36AM
Dow Jones News
By Colin Kellaher
Merck & Co. on Wednesday said a Phase 3 study of its
blockbuster cancer drug Keytruda missed its primary endpoint in
patients with unresected locally advanced head and neck squamous
cell carcinoma, or HNSCC.
The Kenilworth, N.J., drugmaker said patients receiving Keytruda
with concurrent chemoradiation therapy followed by Keytruda as
maintenance therapy showed improvement in event-free survival, but
the results didn't meet statistical significance.
Merck said the study results show that locally advanced HNSCC
remains very challenging to treat, adding that it is committed to
investigating Keytruda-based regimens in earlier stages of the
disease.
Keytruda, a cancer drug that harnesses a patient's immune system
to fight tumors, is approved in dozens of indications around the
world, including some HNSCC indications.
Sales of Keytruda topped $17 billion last year.
Write to Colin Kellaher at colin.kellaher@wsj.com
(END) Dow Jones Newswires
July 20, 2022 07:21 ET (11:21 GMT)
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