RNS Number:5460P
ISIS Asset Management PLC
09 September 2003

To: London Stock Exchange

Attention: RNS

Date: 9 September 2003

From: ISIS Asset Management plc (the "Company")




Notification of interests of directors and connected persons


Monthly investment in the ISIS Asset Management plc Share Incentive Plan ("SIP")


On 8 September 2003, the trustees (the "Trustees") of the SIP acquired a total
of 4,496 ordinary shares of 0.1 pence each in the Company (the "Shares") at a
price of 258 pence per Share.


The Company has today received notification from Messrs Carter, Arthur, Back,
Criticos, Paterson Brown and Talbut that, as executive directors of the Company,
they have an interest in the Shares held in trust under the Scheme.


The Company has also today received notification from Messrs Carter, Arthur,
Back, Criticos and Paterson Brown that of the 4,496 Shares acquired by the
Trustees, 49 Shares each (a total of 245 Shares) were acquired on their behalf
as partnership shares under the SIP.


The SIP is an Inland Revenue approved Share Incentive Plan.











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