RNS Number:5038H
ISIS Asset Management PLC
14 February 2003

                                                        FORM SAR 3


                                       Date of disclosure   14TH FEBRUARY 2003

                 DISCLOSURE UNDER RULE 3 OF THE RULES GOVERNING
                   SUBSTANTIAL ACQUISITIONS OF SHARES ("SARs")

                 
Date of acquisition     12TH FEBRUARY 2003

Acquisition in     I&S ISIS INVESTMENT TRUST      (name of company)


(1) Class of voting shares    Number of shares/rights   If rights over shares
    (eg ordinary shares)      over shares acquired      acquired, as opposed
                                                        to the shares
                                                        themselves, specify
                                                        nature of rights

    ORDINARY 1P SHARES        850,000          shares    

                                               rights


(2) Resultant total holding   Resultant total holding   Total percentage
    of voting shares (and %   of rights over shares
    of total voting shares    (and % of total voting
    in issue)                 shares in issue)

    14,768,585                                          19.57   


(3) Party making disclosure     ISIS ASSET MANAGEMENT 

(4)  (a)  Name of person acquiring shares or rights over shares 
          and, if different, beneficial owner

     (b)  Names of any other persons acting by
          agreement or understanding (see SAR 5)


Signed, for and on behalf of the party named in (3) above

(Also print name of signatory)     PETER TAYLOR

Telephone and extension number     VIVIEN CRICHTON  0131 465 1093

Note. Under SAR 5, the holdings of and acquisitions by persons acting by
agreement or understanding must be aggregated and treated as a holding of or
acquisition by one person.  Note 3 on SAR 5 requires persons who must aggregate
holdings to disclose certain disposals.

For full details of the SARs disclosure requirements, see Rules 3 and 5 of the
SARs.  If in doubt, contact the Panel on Takeovers and Mergers, Monitoring 
Section, Tel. No: 020 7638 0129.



                      This information is provided by RNS
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