TIDMIMM

RNS Number : 0175O

Immupharma PLC

30 September 2019

RNS: RELEASE | 30 SEPTEMBER 2019

ImmuPharma PLC

("ImmuPharma" or the "Company")

INTERIM RESULTS ANNOUNCEMENT

for the six months ended 30 June 2019

ImmuPharma PLC (LSE:IMM), ("ImmuPharma" or the "Company"), the specialist drug discovery and development company, is pleased to announce its interim results for the six months ended 30 June 2019 (the "Period").

Key Highlights (including post Period review)

Financials

   --    Stable financial performance over the Period 

o Cash balance of GBP2.3 million as at 30 June 2019 (31 December 2018: GBP4.9 million)

o Derivative financial asset of GBP1.9 million as at 30 June 2019 (31 December 2018: nil)

o Loss for the period of GBP3.9 million (30 June 2018: GBP4.1 million)

o Research and development expenses of GBP1.4 million (30 June 2018: GBP2.5 million)

o Basic and diluted loss per share of 2.80p (30 June 2018: 2.94p)

o Subscription agreement with Lanstead Capital Investors LP raising approximately GBP2.66 million

-- Lanstead retains a holding of over 16% in ImmuPharma

Lupuzor(TM)

-- Open label extension study - Following the completion of Lupuzor(TM) 's Phase III clinical trial in January 2019, ImmuPharma undertook an open label extension study. Analysis of results from Lupuzor's(TM) 'extension' open label study were announced on 28 June 2019

o 62 eligible patients enrolled throughout the US and Europe completing a 24-week treatment period

o Primary endpoint successfully achieved confirming the safety profile of Lupuzor(TM)

o No 'serious adverse events' related to Lupuzor(TM) reported

o Insights into the Phase III data allow an optimised Lupuzor(TM) phase III design to progress

-- Exploration within the P140 platform for different auto-immune indications outside of lupus continues

Other program developments

-- Within our two further platforms, Ureka Sarl (Peptide) and Elro Pharma (Nucant) , ImmuPharma continues to explore options to license, divest or 'spin-off' the technologies to unlock future potential and enhance value to shareholders

-- The peer reviewed research journal 'Nature Communications' paper published on the proprietary technology Urelix(TM) from Ureka - Superior GLP-1 analogues pave way for peptide types across many therapy areas

-- Negotiations with Incanthera Limited on the Nucant cancer programme and broader collaboration discussions terminated - ImmuPharma retains a 15% shareholding in Incanthera

Industry reports

   --      The Life Sciences Division published an initiation research note on ImmuPharma in May 2019 

Commenting on the statement and outlook Tim McCarthy, Chairman, said: "With further analysis gained from our Phase III results, together with our extension study successfully meeting its endpoint confirming its safety profile, we are focused on progressing Lupuzor(TM) into a further Phase III trial. Our plans to create further shareholder value within our Peptide Platform (Ureka) and Nucant (Elro Pharma) continue. We look forward to reporting on these developments. We would also like to take this opportunity to thank our shareholders, scientific advisors, corporate collaborators and the CNRS."

This announcement contains inside information for the purposes of Article 7 of Regulation (EU) 596/2014. ("MAR")

 
 
    For further information please contact: 
      ImmuPharma PLC (www.immupharma.com)             + 44 (0) 207 152 4080 
      Tim McCarthy, Chairman 
       Dimitri Dimitriou, Chief Executive Officer 
      Lisa Baderoon, Head of Investor Relations       + 44 (0) 7721 413496 
      SPARK Advisory Partners Limited (NOMAD) 
       Neil Baldwin                                   +44 (0) 203 368 8974 
       Vassil Kirtchev 
       Stanford Capital Partners (Joint Broker) 
       Patrick Claridge, John Howes                    +44 (0) 203 815 8880 
 
       SI Capital (Joint Broker) 
       Nick Emerson                                    +44 (0) 1483 413500 
 

ImmuPharma plc

Chairman's Statement

INTERIM HIGHLIGHTS

The first half of 2019 saw a number of developments for ImmuPharma including the announcement of results for the open label extension study for Lupuzor(TM) .

On 26 June 2019, the Company announced that it entered into a subscription agreement with Lanstead Capital Investors LP ('Lanstead'), an institutional investor, together with a sharing agreement, raising approximately GBP2.66 million.

Lupuzor(TM) Phase III open label extension results and next steps

Following on from Lupuzor(TM) 's pivotal Phase III trial that was completed in 2018, in June 2019, the Company announced the results of Lupuzor(TM) 's open label extension study. There were 62 patients enrolled in the study throughout the US and Europe who completed a 24-week treatment period. The primary endpoint was successfully achieved confirming the safety profile of Lupuzor(TM) with no serious adverse events reported. Insights provided by the study allow an optimised Lupuzor(TM) phase III design to progress.

The open label extension study followed the pivotal Phase III clinical trial for Lupuzor(TM) , the results of which were announced in April 2018. The Phase III trial was a double-blind, randomised, placebo-controlled trial. The study involved patients being dosed for one year, receiving 0.2mg once per month subcutaneously. 293 patients were screened illustrating the demand from physicians for a new, safe and effective treatment for lupus. Of these, the required 202 patients were successfully recruited and randomised (dosed). Patients participated in the trial in 7 countries across 28 sites.

The clinical trial was undertaken primarily by Simbec-Orion, an international clinical research organisation, who specialises in rare and orphan conditions and has previous direct experience in lupus trials. This was a pivotal study designed to demonstrate the safety and efficacy of Lupuzor(TM) .

Lupuzor(TM) demonstrated a superior response rate over placebo (52.5% vs 44.6% "responders") in the primary analysis on the Full Analysis Set of all 202 patients. However, due to the high response rate in the placebo group, this superior response did not allow statistical significance to be reached (p = 0.2631) and the trial's primary end point was not met.

Across the whole study population, in those patients who had anti-dsDNA autoantibodies, Lupuzor(TM) demonstrated a superior response rate over placebo (61.5% vs 47.3%, p = 0.0967). Although these results were not statistically significant, further data analysis demonstrated that in the Europe cohort (130 patients) Lupuzor(TM) plus standard of care showed statistically significant reductions in disease activity compared to placebo plus standard of care in 79 patients who were anti-dsDNA autoantibody positive (71.1% vs 48.8%, p = 0.0218).

The study confirmed the outstanding safety profile of Lupuzor(TM) , with no serious adverse events reported.

Scientific literature indicates that approximately 60% - 70% of patients diagnosed for lupus are anti-dsDNA autoantibody positive. These proportions were seen in the Europe cohort (60.8% of patients) and could therefore be considered as representative of the overall lupus population.

In those patients who were anti-dsDNA autoantibody negative, there was almost no difference in disease activity reduction between the active group and the comparator group. Anti-dsDNA autoantibodies are a recognised biomarker for Systemic Lupus Erythematosus.

This finding indicates that the activity of Lupuzor(TM) could be correlated with the presence of anti-dsDNA autoantibodies in lupus patients. ImmuPharma believes that predictive biomarkers, such as anti-dsDNA autoantibodies, could allow identification of patients that are more likely to respond positively to treatment with Lupuzor(TM) .

Lupuzor(TM) next steps

ImmuPharma believes there are still a number of pathways to market for Lupuzor(TM) and, as such, continues to consult with regulatory advisors on these activities. The prime objective of any strategy would be to maximise shareholder return.

ImmuPharma also maintains a focus on exploring opportunities within the P140 platform for different auto-immune indications outside of lupus, based on encouraging pre-clinical data.

ImmuPharma has also taken steps toward the implementation of a Managed Access Program for Lupuzor(TM) . Recognising that lupus is a disease with significant unmet medical need and given the advanced level of clinical trial investigation completed, ImmuPharma would like to meet demand for access to Lupuzor(TM) through clinicians. These plans have been postponed while alternative options are explored.

Ureka

The Group's subsidiary Ureka sarl ('Ureka') has been developing lead compounds from its novel and patented peptide technology platform Urelix(TM) . Ureka is based at the Institut Europeen de Chimnie et Biologie (IECB) in Bordeaux, France which is under the joint authority of the CNRS, Inserm and the University of Bordeaux.

Urelix(TM) is focusing on oligourea foldamers as a tool to improve the pharmaceutical properties of peptides. One of the first focus areas of Ureka has been GLP-1 analogues for the treatment of Type II diabetes and NASH (Non-Alcoholic-Steato-Hepatitis) as proof of concept for its technology. In February 2019, the peer reviewed scientific research journal 'Nature Communications' published a paper on Ureka's technology.

As announced in May 2019, the Company is pursuing plans to combine the Ureka and Elro subsidiaries. The intention is to maximise value from the combined entity whilst retaining an interest in any future commercial success.

Nucant Platform

A number of options have been under review to develop the Company's Nucant cancer programme.

In September 2018, the Company signed a Heads of Terms agreement with Incanthera ("Incanthera") regarding a potential collaboration on the Nucant program. At the same time, ImmuPharma invested GBP2 million to purchase 363,637 shares at GBP5.50 per share in Incanthera and received warrants for a further 363,637 shares at GBP5.50. In May 2019, following a period of wide-ranging discussions, ImmuPharma announced that discussions regarding a clinical development collaboration with Incanthera Limited had ceased. The Company continues to be supportive of Incanthera and retains a 15% shareholding.

Following a review of options for progressing this program, ImmuPharma is pursuing a strategy to combine Elro with the Group's Ureka subsidiary.

Lanstead Capital Subscription

On 26 June 2019, the Company announced that it entered into a subscription agreement with Lanstead Capital Investors LP ("Lanstead"), an institutional investor, together with a related sharing agreement ("Sharing Agreement"), raising approximately GBP2.66 million. Lanstead subscribed for 26,565,200 new ordinary shares of 10 pence each in the Company at an issue price of 10 pence per Subscription Share to raise gross proceeds of approximately GBP2.66 million, representing approximately 19% of the Company's existing share capital (the "Subscription"). The subscription represents a further supportive investment in the Company by Lanstead following the GBP4.43 million investment in February 2016, from which the Company ultimately received just over GBP5.0 million from Lanstead including the additional funds received through the Sharing Agreement over time.

The GBP2.66 million gross proceeds of the Subscription were pledged by the Company pursuant to the Sharing Agreement with Lanstead. The Sharing Agreement, details of which are contained in the Notes to the Interim Accounts, entitles the Company to receive back those proceeds on a pro rata monthly basis over a period of 24 months, structured to commence two months following the admission to AIM of the Subscription Shares, subject to adjustment upwards or downwards each month depending on the Company's share price at the time. The Sharing Agreement provides the opportunity for the Company to benefit from positive future share price performance.

The Company also agreed to issue Lanstead 1,328,290 ordinary shares in connection with entering into the Sharing Agreement.

Financial Review

ImmuPharma's cash balance at 30 June 2019 was GBP2.3 million (GBP4.9 million at 31 December 2018, GBP9.0 million at 30 June 2018). As a result of the Lanstead Subscription and Sharing Agreement, the Company had a derivative financial asset of GBP1.9 million at 30 June 2019 (30 June 2018: GBPnil). Basic and diluted loss per share were 2.80p and 2.80p respectively (30 June 2018: 2.94p and 2.94p). In line with the Company's current policy, no interim dividend is proposed.

Operating loss for the Period was GBP3.3 million (GBP4.1 million for the six months ended 30 June 2018). Research and development expenditure in the Period was GBP1.4 million (GBP2.5 million for the six months ended 30 June 2018) reflecting primarily the expenditure related to the Lupuzor(TM) Phase III clinical trial. Administrative expenses were GBP0.9 million during the Period (GBP1.0 million for the six months ended 30 June 2018). The share based expense was GBP1.0 million (GBP0.8 million for the six months ended 30 June 2018). Finance costs for the Period were GBP842k (GBP29k for the six months ended 30 June 2018). This primarily arose due to the calculation of fair value of the Lanstead Sharing Agreement based on the Company's share price at 30 June 2019. The restatement to fair value will be calculated at the end of each accounting period during the course of the Sharing Agreement and will vary according to the Company's share price performance.

Given the stage of ImmuPharma's development, the fact that losses have continued to be made is to be expected since there is minimal revenue and business activity is concerned with significant investment in the form of clinical development expenditure, in addition to maintaining the infrastructure of the Company.

Current Activities and Outlook

The Board has been focused on delivering a business strategy which provides the optimum route forward for ImmuPharma and its shareholders, based on its current assets, resources and knowhow. In the medium term, we remain focussed on achieving the full regulatory approval of Lupuzor(TM) which we believe has the potential to be a ground breaking drug for lupus patients with blockbuster potential in commercial terms.

Our Ureka subsidiary and Nucant programme have been part of our portfolio for a number of years. We are equally excited by the potential of both. We believe the strategy we are pursuing with the merger of Ureka and Elro will create enhanced value for shareholders going forward.

The Board would like to thank its shareholders for their support as well as its staff, corporate and scientific advisers including Simbec-Orion and the CNRS (Centre Nationale de la Recherche Scientifique) for their continued collaboration.

Tim McCarthy

Chairman

ImmuPharma plc

CONSOLIDATED INCOME STATEMENT

FOR THE PERIODED 30 JUNE 2019

 
                                    Note         Unaudited         Audited       Unaudited 
                                                  6 months            Year        6 months 
                                                     ended           ended           ended 
                                                   30 June     31 December         30 June 
                                                      2019            2018            2018 
                                                       GBP             GBP             GBP 
  Continuing operations 
  Revenue                            1           11,737             81,281          73,392 
  Research and development 
   expenses                                    (1,362,933)     (4,697,284)     (2,455,490) 
  Administrative expenses                        (931,761)     (1,660,408)       (992,085) 
  Share based expense                          (1,005,101)     (1,803,769)       (775,135) 
 
  Operating loss                               (3,288,058)     (8,080,180)     (4,149,318) 
 
  Finance costs                      4           (842,293)         (4,783)        (29,425) 
  Finance income                                     4,257         129,808           6,077 
 
 
  Loss before taxation                         (4,126,094)     (7,955,155)    (4,172,666) 
 
  Tax                                              225,250         748,606      110,237 
 
 
  Loss for the period                          (3,900,844)     (7,206,549)     (4,062,429) 
 
 
  Attributable to: 
  Equity holders of the parent 
   company                                     (3,900,844)     (7,206,549)     (4,062,429) 
 
 
  Loss per ordinary share 
 
  Basic and diluted                  2             (2.80)p         (5.19)p         (2.94)p 
 
 

ImmuPharma plc

CONSOLIDATED STATEMENT OF COMPREHENSIVE INCOME

FOR THE PERIODED 30 JUNE 2019

 
                                             Unaudited        Audited      Unaudited 
                                              6 months           Year       6 months 
                                                 ended       ended 31          ended 
                                               30 June       December        30 June 
                                                  2019           2018           2018 
                                                   GBP            GBP            GBP 
 
  Loss for the financial period            (3,900,844)    (7,206,549)    (4,062,429) 
 
 
  Other comprehensive income 
  Items that may be reclassified 
   subsequently to profit or loss: 
  Exchange differences on translation 
   of foreign operations                        75,594       (88,256)         29,459 
 
 
  Total items that may be reclassified 
   subsequently to profit or loss               75,594       (88,256)         29,459 
 
  Other comprehensive income/(loss) 
   for the period                               75,594       (88,256)         29,459 
 
 
  Total comprehensive loss for 
   the period                              (3,825,250)    (7,294,805)    (4,032,970) 
 
 

ImmuPharma plc

CONSOLIDATED STATEMENT OF FINANCIAL POSITION

AS AT 30 JUNE 2019

 
                                    Note       Unaudited                Audited             Unaudited 
                                                 30 June            31 December               30 June 
                                                    2019                   2018                  2018 
                                                     GBP                    GBP                   GBP 
  Non-current assets 
  Intangible assets                              500,077                483,039               481,667 
  Property, plant and equipment                  133,714                164,661               120,675 
   Financial asset                             2,000,000              2,000,000                     - 
  Derivative financial asset         4         1,014,592                      -                     - 
 
 
  Total non-current assets                     3,648,383              2,647,700               602,342 
 
 
  Current assets 
  Trade and other receivables                    257,216                331,487             1,174,720 
  Cash and cash equivalents                    2,258,951              4,911,448             9,015,630 
  Current tax asset                              978,921                767,121                     - 
  Derivative financial asset                     857,298                      -                     - 
 
 
  Total current assets                         4,352,386              6,010,056            10,190,350 
 
 
  Current liabilities 
  Financial liabilities - 
   borrowings                                   (96,961)               (98,340)             (138,214) 
  Trade and other payables                     (444,398)              (913,907)             (737,035) 
 
 
  Total current liabilities                    (541,359)            (1,012,247)             (875,249) 
 
 
  Net current assets                           3,811,027              4,997,809             9,315,101 
 
 
  Non-current liabilities 
  Financial liabilities - 
   borrowings                                          -               (22,470)              (61,209) 
 
 
  Net assets                                   7,459,410              7,623,039             9,856,234 
 
 
  EQUITY 
  Ordinary shares                             13,946,744             13,946,744            13,946,744 
  Share premium                               27,320,145             27,320,145            27,320,143 
  Merger reserve                                 106,148                106,148               106,148 
  Other reserves                               2,745,217              (991,998)           (1,902,921) 
  Retained earnings                         (36,658,844)           (32,758,000)          (29,613,880) 
 
 
  Total equity                                 7,459,410              7,623,039             9,856,234 
 
 

ImmuPharma plc

CONSOLIDATED STATEMENT OF CHANGES IN EQUITY

FOR THE PERIODED 30 JUNE 2019

 
 
                                                                                                        Other        Other 
                                                                                                     reserves    reserves- 
                                                                   Other                   Other            -          New 
                                                              reserves -                reserves       Equity       equity 
                                                  Merger     Acquisition                       -       shares       shares        Retained 
                      Share            Share     reserve         reserve             Translation        to be        to be        Earnings                          Total 
                      capital        premium                                             Reserve       issued       issued                                         equity 
                           GBP           GBP         GBP             GBP                     GBP          GBP          GBP             GBP                            GBP 
   At 1 January 
    2018            13,252,299    18,728,519     106,148     (3,541,203)             (1,701,241)    2,281,427            -    (25,551,451)                      3,574,498 
   Loss for the 
    financial 
    period                   -             -           -               -                       -            -            -     (4,062,429)                    (4,062,429) 
   Exchange 
    differences 
    on 
    translation 
    of foreign 
    operations               -             -           -               -                  29,459            -            -               -                         29,459 
   New issue of 
    equity 
    capital            694,445     9,305,555           -               -                       -            -            -               -                     10,000,000 
   Cost of new 
    issue of 
    equity 
    capital                  -     (713,931)           -               -                       -            -            -               -                      (713,931) 
   Share based 
    payments                 -             -           -               -                       -    1,028,637            -               -                      1,028,637 
                  ------------  ------------  ----------  --------------  ----------------------  -----------  -----------  --------------  ----------------------------- 
 
   At 30 June 
    2018            13,946,744    27,320,143     106,148     (3,541,203)             (1,671,782)    3,310,064            -    (29,613,880)                      9,856,234 
                  ============  ============  ==========  ==============  ======================  ===========  ===========  ==============  ============================= 
 
   At 1 January 
    2018            13,252,299    18,728,519     106,148     (3,541,203)             (1,701,241)    2,281,427            -    (25,551,451)                      3,574,498 
 
   Loss for the 
    financial 
    year                     -             -           -               -                       -            -            -     (7,206,549)                    (7,206,549) 
   Exchange 
    differences 
    on 
    translation 
    of foreign 
    operations               -             -           -               -                (88,256)            -            -               -                       (88,256) 
   Transactions 
    with owners: 
    Share based 
    payments                 -             -           -               -                       -    2,057,275            -               -                      2,057,275 
   New issue of 
    equity 
    capital            694,445     9,305,555           -               -                       -            -            -               -                   (10,000,000) 
   Cost of new 
    issue of 
    equity 
    capital                  -     (713,929)           -               -                       -            -            -               -                      (713,929) 
 
   At 31 
    December 
    2018 
    & 1 January 
    2019            13,946,744    27,320,145     106,148     (3,541,203)             (1,789,497)    4,338,702            -    (32,758,000)                      7,623,039 
 
   Loss for the 
    financial 
    period                   -             -           -               -                       -            -            -     (3,900,844)                    (3,900,844) 
   Exchange 
    differences 
    on 
    translation 
    of foreign 
    operations               -             -           -               -                  75,594            -            -               -                         75,594 
   Transactions 
    with owners: 
    Share based 
    payments                 -             -           -               -                       -    1,005,101            -               -                      1,005,101 
   New shares to 
    be issued                -             -           -               -                       -            -    2,656,520               -                      2,656,520 
 
   At 30 June 
    2019            13,946,744    27,320,145     106,148     (3,541,203)             (1,713,903)    5,343,803    2,656,520    (36,658,844)                      7,549,410 
                  ============  ============  ==========  ==============  ======================  ===========  ===========  ==============  ============================= 
   Attributable 
   to:- 
 
   Equity 
    holders of 
    the 
    parent 
    company         13,946,744    27,320,145     106,148     (3,541,203)             (1,713,903)    5,343,803    2,656,520    (36,658,844)                      7,549,410 
                  ============  ============  ==========  ==============  ======================  ===========  ===========  ==============  ============================= 
 
 

ImmuPharma plc

CONSOLIDATED STATEMENT OF CASHFLOWS

FOR THE PERIODED 30 JUNE 2019

 
                                        Note             Unaudited         Audited            Unaudited 
                                                          6 months            Year             6 months 
                                                             ended           ended                ended 
                                                           30 June     31 December              30 June 
                                                              2019            2018                 2018 
                                                               GBP             GBP                  GBP 
  Cash flows from operating 
   activities 
  Cash used in operations                3          (2,687,173)        (5,606,138)          (3,150,500) 
  Tax                                                           -          889,787              213,724 
  Interest paid                                         (1,581)            (4,783)              (2,423) 
 
   Net cash used in operating 
    activities                                         (2,688,754)     (4,721,134)          (2,939,199) 
 
 
  Investing activities 
  Purchase of property, 
   plant and equipment                                  (4,502)          (102,880)              (7,946) 
  Purchase of investments                                      -       (2,000,000)                    - 
  Interest received                                       4,257             12,491                6,077 
 
 
  Net cash used in investing 
   activities                                              (245)       (2,090,389)              (1,869) 
 
 
  Financing activities 
  (Decrease)/increase in bank 
   overdraft                                               (110)              (72)                (122) 
  Loan repayments                                      (23,739)          (138,809)             (58,615) 
  Gross proceeds from issue 
   of new share capital                                         -       10,000,000           10,000,000 
  Share capital issue costs                                      -       (713,929)            (713,931) 
 
 
  Net cash generated from financing 
   activities                                             (23,849)       9,147,190            9,227,332 
 
 
  Net increase in cash and 
   cash equivalents                                    (2,712,848)       2,335,667            6,286,264 
  Cash and cash equivalents 
   at start of period                                    4,911,448       2,729,468            2,729,468 
   Effects of exchange rates 
    on cash and 
    cash equivalents                                        60,351       (153,687)                (102) 
 
   Cash and cash equivalents 
    at end of period                                     2,258,951       4,911,448            9,015,630 
 
 
 

ImmuPharma plc

NOTES TO THE CONSOLIDATED INTERIM ACCOUNTS FOR THE PERIOD ENDED 30 JUNE 2019

   1          ACCOUNTING POLICIES 

Basis of preparation

The interim financial information in this report has been prepared using accounting policies consistent with IFRS as adopted by the European Union. IFRS is subject to amendment and interpretation by the International Accounting Standards Board (IASB) and the IFRS Interpretations Committee and there is an ongoing process of review and endorsement by the European Commission. The financial information has been prepared on the basis of IFRS to be adopted by the European Union and applicable as at 31 December 2019. The Group has chosen not to adopt IAS 34 "Interim Financial Statements" in preparing the interim financial information.

The accounting policies applied are consistent with those that were applied to the financial statements for the year ending 31 December 2018, with the exception of IFRS 16 "Leases" which is a new standard applicable for the year ending 31 December 2019. The adoption of the new standard did not have a material impact on the interim financial information set out in this report.

Non-Statutory accounts

The financial information set out in this interim report does not constitute the Group's statutory accounts, within the meaning of Section 434 of the Companies Act 2006. The statutory accounts for the year ended 31 December 2018 have been filed with Registrar of Companies. The auditors reported on those accounts; their report was unqualified, did not contain a statement under either Section 498 (2) or Section 498 (3) of the Companies Act 2006 but did include an emphasis of matter paragraph relating to the uncertainty over the fair value of the investment in Incanthera Limited. The financial information for the 6 months ended 30 June 2019 and 30 June 2018 is unaudited.

Copies of this statement will be available on the Company's website - www.immupharma.com.

ImmuPharma plc

NOTES TO THE CONSOLIDATED INTERIM ACCOUNTS FOR THE PERIOD ENDED 30 JUNE 2019

(Continued)

   2              LOSS PER SHARE 
 
                                          Unaudited         Audited      Unaudited 
                                           6 months      Year ended       6 months 
                                           ended 30     31 December          ended 
                                          June 2019            2018        30 June 
                                                                              2018 
                                                GBP             GBP            GBP 
 
  Loss 
  Loss for the purposes of basic 
   and diluted loss per share 
   being net loss attributable 
   to equity shareholders               (3,900,844)     (7,206,549)    (4,062,429) 
 
 
  Number of shares 
  Weighted average number of 
   ordinary shares for the purposes 
   of basic loss per share              139,467,430     138,839,576    138,201,316 
 
 
   Basic loss per share                     (2.80)p         (5.19)p        (2.94)p 
 
 
 
  Diluted loss per share                    (2.80)p         (5.19)p        (2.94)p 
 
 
 

There is no difference between basic loss per share and diluted loss per share as the share options and warrants are anti-dilutive.

ImmuPharma plc

NOTES TO THE CONSOLIDATED INTERIM ACCOUNTS FOR THE PERIOD ENDED 30 JUNE 2019

(Continued)

 
  3                                 CASH USED IN OPERATIONS 
                                                Unaudited         Audited          Unaudited 
                                                 6 months      Year ended           6 months 
                                                    ended     31 December              ended 
                                                  30 June            2018            30 June 
                                                     2019                               2018 
                                                      GBP             GBP                GBP 
 
   Operating loss                             (3,288,058)     (8,080,180)        (4,149,318) 
   Depreciation & amortisation                     50,946         133,080              81,424 
   Share based payments                         1,005,101       2,057,275          1,028,637 
   Decrease in trade & other 
    receivables                                    72,517         404,725            358,921 
   (Decrease)/increase in trade 
    & other payables                            (469,509)          15,151          (189,656) 
   (Decrease)/increase 
    in provisions                                       -       (253,506)          (253,506) 
   Gain/(loss) on foreign 
    exchange                                     (58,170)         117,317           (27,002) 
 
    Cash used in operations                   (2,687,173)     (5,606,138)        (3,150,500) 
 
 
 

ImmuPharma plc

NOTES TO THE CONSOLIDATED INTERIM ACCOUNTS FOR THE PERIOD ENDED 30 JUNE 2019

(Continued)

 
  4    DERIVATIVE FINANCIAL ASSET 
        In June 2019, as part of a placing that raised, in aggregate, 
        GBP2.66 million (before expenses) from new and existing 
        shareholders, the Company issued 26,565,200 new ordinary 
        shares to Lanstead Capital LP ('Lanstead') at a price of 
        10p per share for GBP2.66 million. All of the shares with 
        full voting rights were allotted to Lanstead on 2 July 2019. 
        The Company simultaneously entered into a Sharing Agreement 
        with Lanstead for 100% of these shares with a reference 
        price of 13.33p per share. The Sharing Agreement is for 
        a 24 month period. The actual consideration is variable 
        depending upon the Company's share price. The Sharing Agreement 
        is treated as a derivative financial asset and valued at 
        fair value through the income statement with reference to 
        the Company's share price as at the end of the accounting 
        period. 
        On 2 July 2019, the Company also issued, in aggregate, a 
        further 1,328,290 new ordinary shares to Lanstead as a value 
        payment in connection with the Share Subscription and the 
        Sharing Agreement. 
        At the end of the accounting period the amount receivable 
        is restated to fair value based upon the share price of 
        the Company at that date. Any change in the fair value of 
        the derivative financial asset is reflected in the income 
        statement. As at 30 June 2019, the Company completed a calculation 
        of fair value of the derivative financial asset that resulted 
        in a finance loss of GBP785k which was recorded in the income 
        statement. The restatement to fair value will be calculated 
        at the end of each accounting period during the course of 
        the Sharing Agreement and will vary according to the Company's 
        share price performance. 
 

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END

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September 30, 2019 02:00 ET (06:00 GMT)

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