Patents Granted

RNS Number : 3059G
Immupharma PLC
21 October 2008

For Immediate Release 21 October 2008

LupuzorTM patents allowed in US and approved in Japan, Australia
- other countries expected to follow -

ImmuPharma PLC (LSE:IMM), ("ImmuPharma or the "Company") the specialist drug discovery and development company, is pleased to announce
that the LupuzorTM patent was approved in Japan and Australia and received notice of allowance from in the US Patent Office. LupuzorTM is
ImmuPharma's lead drug compound for the potential treatment of Lupus, a chronic, life-threatening autoimmune disease.

In addition, the mechanism of action of LupuzorTM has been identified by researchers working with ImmuPharma at the Centre National de
la Recherche Scientifique in Strasbourg. LupuzorTM has shown that it modulates, through a unique mechanism, a specific subset of CD4 T cells
which play a critical role in the physiopathology of Lupus. A new patent which covers this discovery is being filed. This mechanism is
consistent with and explains the very favourable safety profile of LupuzorTM (maintenance of the overall immune system while being
effective) and its activity as a specific immune-modulator.

Dr. Robert Zimmer, President & Chief Scientific Officer said: "The recent progress on the patents of LupuzorTM are a key milestone in
the Company's efforts to bring an innovative drug candidate for treating patients suffering from Lupus. . Importantly the mechanism of
action of LupuzorTM has been identified, providing further confidence in its development."

For further information please contact:

ImmuPharma PLC:
Dimitri Dimitriou, Chief Executive Officer +44 20 7152 4080
Richard Warr, Chairman +44 20 7152 4080
Dr Robert Zimmer, President & Chief Scientific Officer + 33 389 32 76 50

Buchanan Communications:
Lisa Baderoon + 44 20 7466 5000
Rebecca Skye Dietrich + 44 20 7466 5000

Panmure Gordon & Co +44 151 243 0963
Andrew Burnett

More information on the Company can be found at www.immupharma.com

Notes to Editors:

About ImmuPharma

ImmuPharma PLC is a drug discovery and development company headquartered in London, UK and quoted on AIM of the London Stock Exchange
(LSE:IMM). It has research operations in France (ImmuPharma (France) SA) and Switzerland (ImmuPharma AG). ImmuPharma is dedicated to the
development of novel drugs, largely based on peptide therapeutics, to treat serious medical conditions such as autoimmune diseases
characterised by:

* blockbuster potential in niche markets
* low promotional costs in few specialised physicians and centres and
* lower risk of drug development and lower development costs

ImmuPharma is a currently developing drug candidates for five different medical conditions, each of which would represent a significant
breakthrough in its field. The furthest advanced drug candidate targets Lupus, a disease for which there is currently no cure or specific
treatment. The other four address 1) cancer, 2) moderate to severe pain (such as that experienced by cancer sufferers and post-operative
patients), 3) MRSA and similar severe hospital-acquired resistant infections and 4) inflammation.

All five have significant sales potential as well as low marketing costs and a relatively low risk of development failure. One or more
have the potential to be fast-tracked by the US Food and Drug Administration according to "Guidance for Industry: Fast Track Drug
Development Programs - Designation, Development and Application Review" issued July 2004 and could therefore obtain their market
authorization by 2010.

Key to the potential success of ImmuPharma is its unique collaborative agreement with Centre National de la Recherche Scientifique,
France's scientific research institution. This agreement grants ImmuPharma worldwide exclusive rights to exploit certain key discoveries.

In addition to its five leading drug candidates, ImmuPharma has a drug development pipeline using its rights to a virtual chemical
library of hundreds of thousands of molecules as well as an innovative technology for converting peptides to drug candidates.

ImmuPharma has the option to commercialise its assets itself or to license them to other pharmaceutical companies at an earlier stage.

The products

Treatment of Lupus (LupuzorTM)

This is a long-term treatment for Lupus, a chronic, life-threatening autoimmune disease where the immune system attacks healthy cells.
There is currently no cure and existing medications only treat the symptoms whereas ImmuPharma's drug candidate has the potential to produce
remission of the disease in a substantial proportion of patients.

Based on independent forecasts, the value of ImmuPharma's Lupus drug is estimated to be "substantial" with peak annual sales forecast to
generate in excess of $4 billion.

Cancer (IPP-204106)

IPP-204106 has a dual mechanism of action, acting both in preventing angiogenesis as well as proliferation. IPP-204106 is a nucleolin
antagonist, the lead molecule in a family of pseudopeptides designed to block the activity of a protein called nucleolin. Located
essentially in the nucleus of normal cells where it is protected, nucleolin is much more abundant at the surface of the cells which are
proliferating as well as the surface of active endothelial cells where it can be a target for antagonist peptides.

Cell surface expressed nucleolin is involved in the proliferation processes as well as in cell transformation. It is also a receptor for
many growth factors and plays a key role in angiogenesis. Nucleolin antagonists have therefore both anti-angiogenic and anti-proliferative
properties.

Preclinical data have shown that nucleolin antagonists inhibit the growth of tumours and metastasis in many cancer types. They prevent
the implantation of tumours and block angiogenesis. They also inhibit the proliferation of certain types of leukaemia cells. Based on the
mechanism of action nucleolin antagonists are active as long as surface nucleolin is present, irrespective of the type of cancer.
Preliminary data have also shown the absence of toxicity.

Severe pain relief (IPP-102199)

ImmuPharma is developing a non-addictive compound for relieving moderate to severe pain, such as experienced by cancer sufferers and
post-surgical patients. Most existing treatments are opioid-based (explain) and tend to have serious side effects. ImmuPharma's new
treatment is based on met-enkephalin, the body's internal analgesic. IPP-102199 is being developed to have major advantages over morphine
such as longer pain relief duration and reduced side effects. The market for chronic opioids in the US currently exceeds $3.5 billion and is
growing by more than 10 to 20 per cent a year.

Antibiotic for MRSA and similar highly resistant infections (IPP-203101)

This is a novel antibiotic to counter the effects of MRSA and other severe hospital-acquired, resistant infections which affect some two
million people in the US, according to the US Centers for Disease Control and Prevention. ImmuPharma's drug candidate uniquely uses an
electrical charge rather than biochemical methods against MRSA and other bacterial strains. It is hoped this novel approach will reduce
their potential to become resistant.

This information is provided by RNS
The company news service from the London Stock Exchange

END

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