RNS Number : 8204U
  Immupharma PLC
  20 May 2008
   

 For Immediate Release  20 May 2008

        
    ImmuPharma PLC

    ImmuPharma's cancer drug candidate IPP- 204106 shows complete response to tumours in multiple human cancer cell lines

    ImmuPharma PLC (LSE:IMM), ("ImmuPharma" or the "Company"), the specialist drug discovery and development company, announces today
pre-clinical data on its new cancer drug, IPP-204106.

    Data on ImmuPharma's anti-cancer nucleolin antagonist ("Nucant") peptide programme, IPP-204106 have been obtained confirming the ability
of the compounds to effectively control and stop the growth of a large panel of human cancer cell lines both "in vitro" and "in vivo".
Collectively the studies comprised breast cancer, prostate cancer, melanoma, glioblastoma, leukaemia, colon cancer and pancreatic cancer
cell lines.  

    The schedule of administration was typically 10 injections over 2 weeks at doses in the range of 1 mg/kg body weight. "In vivo" studies
showed that the majority of tumours were completely eradicated and survival time increased without additional treatment.

    ImmuPharma has filed appropriate patents on the composition of matter relating to the peptides covering a large variety of Nucant
structures. Manufacturing processes transferable to large scale production have also been successfully developed.

    Due to the considerable progress made, ImmuPharma has initiated the regulatory studies necessary for the development program of
IPP-204106, and ImmuPharma is pursuing grant opportunities from the French national research agencies.

    In addition to cancer indications, ImmuPharma believes that Nucants could have use in other areas such as psoriasis, wound healing and
diabetic retinopathy and these are currently under investigation in research programs conducted by the CNRS teams and ImmuPharma.

    Richard Warr, ImmuPharma's Chairman, commented: 
"We are delighted by the pre-clinical data shown in our proprietary candidate for oncology. Furthermore, this exciting new drug candidate
has a tremendous commercial potential if it meets its target profile of preventing tumour growth as well as metastasis while being
non-toxic. This has enhanced further the value of our product pipeline."

    For further information please contact: 
 ImmuPharma PLC: 
 Dimitri Dimitriou, Chief Executive Officer              +44 20 7152 4080
 Dr Robert Zimmer, President & Chief Scientific Officer  + 33 389 32 76 50
 Richard Warr, Chairman                                  +44 20 7152 4080

 Buchanan Communications                                 + 44 20 7466 5000
 Lisa Baderoon
 Rebecca Skye Dietrich

 Panmure Gordon & Co
 Andrew Burnett                                          +44 151 243 0963


    For further company information, visit www.immupharma.com

    About Nucants

    Nucants are pseudo-peptides which selectively bind to the nucleolin expressed at the surface of the cells. Located essentially,
antagonist peptides in the nucleus of normal cells where it is protected, nucleolin is much more abundant (often 30 times more) at the
surface of the cells which are proliferating as well as the surface of active endothelial cells where it can be a target for antagonist
peptides.  

    Cell surface expressed nucleolin is also a receptor for many growth factors and plays a key role in angiogenesis. Numerous papers have
been published demonstrating the role of nucleolin in stabilization of mRNAs (among them Bcl2 mRNA targeted by Taxol derivatives and gastrin
mRNA involved in pancreatic cancer) in the nucleus. This stabilization is required for protein synthesis and therefore cell proliferation.
Blocking nucleolin destabilizes mRNAs and prevents proliferation. Nucants and IPP-204106 in particular have therefore both anti-angiogenic
and anti-proliferative properties. Anti-angiogenesis alone has been a target in the pharmaceutical industry for cancer, so has inhibition of
proliferation. ImmuPharma's Nucant programme targets both approaches and this dual mechanism makes it particularly effective.



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