RNS Number:6615F
Cambridge Antibody Tech Group PLC
30 December 2002

                                  SCHEDULE 10

                   NOTIFICATION OF MAJOR INTERESTS IN SHARES


1)   Name of company
Cambridge Antibody Technology


2)   Name of shareholder having a major interest
FMR Corp and Fidelity International Ltd


3)   Please state whether notification indicates that it is in respect of
holding of the shareholder named in 2 above or in respect of a
non-beneficial interest or in the case of an individual holder if it is a
holding of that person's spouse or children under the age of 18

None Beneficial

4)   Name of the registered holder(s) and, if more than one holder, the
     number of shares held by each of them

Chase Nominees Limited (1,060,242), State Street Nominees Limited (130,570),
HSBC (1,012,375), Chase Manhattan Bank London (142,832), Chase Nominees Ltd
(307,299), Bankers Trust (277,628), MSS Nominees Ltd (36,600), Bank of New York
Europe (37,700), BT Globenet Nominees Ltd (7,000), Nortrust Nominees Ltd
(132,200), RBS Trust Bank (173,837), HSBC (4,310), Northern Trust (128,607), BT
Globenet Nominees Ltd (47,900), Morgan Stanley (51,739), Bankers Trust (14,700),
Bank of New York Europe (14,400), Citibank (6,100), Bank of New York - London
(50,500), JP Morgan (104,653), Chase Manhattan Bank London (8,600), State Street
Nominees Ltd (38,900), Bank of New York Brussels (79,477), State Street Bank &
Trust (14,300), Deutsche Bank (39,000)

5)   Number of shares/amount of stock acquired
Nil


6)   Percentage of issued class
Nil


7)   Number of shares/amount of stock disposed
359,850


8)   Percentage of issued class
0.99%


9)   Class of security
Ordinary 10p shares


10)  Date of transaction
Not disclosed


11)  Date company informed
30 December 2002


12)  Total holding following this notification
3,921,469



13)  Total percentage holding of issued class following this notification
10.79%


14)  Any additional information
None of the entities act as a group or in concert in respect to the interests
disclosed.


15)  Name of contact and telephone number for queries
Diane Mellett 01223 471471


16)  Name and signature of authorised company official responsible for
     making this notification


Diane Mellett, Company Secretary


     Date of notification 30 December 2002


                      This information is provided by RNS
            The company news service from the London Stock Exchange
END

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