By Sara Sjolin, MarketWatch

LONDON (MarketWatch) -- European stock markets kicked off the weak in a downbeat fashion on Monday, as mining firms slumped on the back of tighter property-mortgage rules in China, while spending cuts in the U.S. kicked in.

The Stoxx Europe 600 index closed slightly lower at 288.89, adding to a 0.3% loss from Friday.

Mining companies posted some of the biggest drops in the index, while drug makers rose after a sector upgrade. Heavyweight HSBC Holdings PLC (HBC) posted its biggest loss since last summer after releasing earnings and France Télécom rallied after a broker upgrade.

The pan-European index managed to stay in positive territory for the year as aggressive monetary easing from central banks and broader hopes for a global economic recovery soothed investor skepticism. Worries about political instability in the euro zone, however, re-entered the spotlight last week after inconclusive election results in Italy. See: 10 reasons why the euro crisis may be incurable.

"We've had some good news and some bad news. The bad news is obviously Italy, where it has proved to be pretty difficult to form a government in the short term. Normally the backstop [for economic volatility] is the ECB, but if there's no government there's nobody to ask for help in case it's needed," said Koen de Leus, strategist at KBC Securities.

But the volatility should prove to be short lived, he added, as increased liquidity from central banks continue to provide an upside for the market.

"If Italy succeeds in making a coalition and the U.S. figures out how to deal with the sequester, then the risk rally can go on for a couple of months more," he said. "But at the moment investors get more and more optimistic about the future, so if everybody has bought already, who's going to be the marginal buyer? I think there's too much optimism at the moment."

The FTSE MIB index slumped 0.9% to 15,542.17 amid unconfirmed rumors the country's credit rating would be cut after the market close.

China tightening

Among notable movers in Europe, mining firms posted some of the biggest losses, after the Chinese government late Friday announced fresh measures to cool the real estate market, including higher down-payments and mortgage rates on second homes in cities with steep price gains. China is a major user of natural resources, and any indicators of a slowdown in the economy and the construction sector tend to weigh on mining firms. See: Property stocks sink China but boost Japan.

Additionally, China's official nonmanufacturing Purchasing Managers' Index fell to 54.5 in February from 56.2 in January, according to a statement released on Sunday.

"The bottom in China has been reached and economic growth is accelerating. Of course the PMI data are a little more weak than expected, but I think most of that is caused by the Lunar New Year, so we will have to wait for the PMIs next month to see if it's a trend. Other emerging markets have started to pick up and the world-wide economic environment is much more favorable than last year," said de Leus from KBC Securities.

Shares of Rio Tinto PLC (RIO) lost 3.7% and BHP Billiton PLC (BHP) fell 2.1%.

Shares of Anglo American PLC shaved off 2.7%, as Nomura cut the miner to reduce from neutral.

The losses for mining firms weighed on the U.K.'s FTSE 100 index which erased 0.5% to 6,345.63. See: HSBC weighs on U.K. stocks after results

U.S. sequester

In the U.S., stocks were mostly lower, amid worries that politicians are making no progress toward reversing billions of dollars in automatic spending cuts, referred to as the sequester, which started to take effect on Friday. Republican congressional leaders on Sunday rejected calls by Democrats to reduce the deficit through a mix of spending cuts and tax increases, insisting on spending cuts alone. See: U.S. stocks drop as China measures hit industrials.

Back in Europe, banks were among notable decliners, with shares of HSBC off 2.5%. The heavyweight bank said profit attributable to ordinary shareholders of the parent company fell 17% in 2012 to $13.5 billion. See: HSBC lifts dividend but continues to miss targets.

In Germany, Deutsche Bank AG lost 1.3%, while Commerzbank AG eased 0.5%.

The DAX 30 index closed 0.2% lower at 7,691.68.

And in France, shares of ArcelorMittal eased 3.6% to 10.84 euros ($14.10), after Goldman Sachs cut the steelmaker's target price to EUR11.10 from EUR11.50.

Headed the other direction, shares of France Télécom climbed 5.7%, after Morgan Stanley lifted the firm to overweight from underweight, citing a low valuation, reasonable estimates and better cost control.

The CAC 40 index rose 0.3% to 3,709.76.

Shares of drug maker Sanofi SA (SNY) added 0.7%, helped higher as Goldman Sachs lifted the European health care sector to overweight. See: Goldman Sachs ups Europe health care, tech

Other drug makers were also higher outside the major indexes, with shares of Novo Nordisk AS (NVO) picking up 2.5% and Novartis AG 0.4% higher.

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