By Sara Sjolin, MarketWatch

LONDON (MarketWatch) -- Most U.K. stocks were mired in the red on Thursday, ahead of the latest rate decision from the Bank of England.

The FTSE 100 index dropped 0.4% to 6,514.72, partly erasing a 1.3% gain from Wednesday.

Shares of AstraZenaca PLC posted one of the biggest losses, down 1.7%, after the drug maker reported a sharp decline in third-quarter profit.

RSA Insurance Group PLC lost 2.3% after the company posted a decline in net written premiums.

Miners were also falling as iron-ore prices sank to a near 5 1/2 year low. Shares of Rio Tinto PLC (RIO) dropped 0.9%, Anglo American PLC fell 1.1% and Antofagasta PLC lost 0.6%.

Corporates aside, the main event in London on Thursday was the rate announcement from the Bank of England due at noon London time, or 7 a.m. Eastern. Economists widely expect the bank to keep interest rates at a record low of 0.5% and make no changes to its 375 billion pound ($599 billion) asset-purchase program.

At 12:45 p.m. London time, the European Central Bank's rate decision is due, where no change is also the consensus. Read: ECB discord could 'neuter' Draghi's power

In U.K. data news, the Office for National Statistics said production rose 1.5% in September, year-over-year, a tad lower than consensus forecasts, according to FactSet.

You're invited: A free evening event focusing on investing opportunities in Europe

Will you be in London on Dec. 3? Then you're invited to our MarketWatch Investing Insights event, "The worse Europe gets, the more you should invest"

Governments are in trouble, reform efforts have stalled, unemployment is climbing... the news from the eurozone is bleak. And investors are fleeing. But that's a mistake: The worse the economic data from Europe get, the more you should be buying. Why? Because actions by the ECB will boost asset prices and the stock market in particular. And, big exporters can grow sales. Lower costs and steady sales translate into higher profits and dividends. Join us for an evening of cocktails and conversation to explore these opportunities.

Our panel will be led by MarketWatch Columnist Matthew Lynn, a renowned financial journalist based in London and the author of "Bust: Greece, the Euro and the Sovereign Debt Crisis." He'll be joined by Mark Hulbert, MarketWatch columnist and editor of the Hulbert Financial Digest. This event is free, but RSVPs are required. It will be held Wednesday evening, Dec. 3, in London. For more information or to RSVP, send an email to marketwatchevent@wsj.com

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