By Sara Sjolin, MarketWatch

LONDON (MarketWatch) -- U.K. stocks moved mostly lower on Wednesday, after rate hikes in Turkey and South Africa failed to halt the slides in their currencies and calm fears about emerging markets. Miners moved mostly higher after upbeat production updates.

The FTSE 100 index lost 0.4% to end at 6,544.28, marking the lowest closing level since Dec. 18.

The benchmark had started in positive territory after the Turkish central bank late Tuesday aggressively increased interest rates to halt a recent slide in the currency and stem capital outflows. Markets across Europe, however, started moving lower as investors started to doubt if the move was enough to calm the currency volatility. On Wednesday, the South African Reserve Bank on also raised interest rates, as the bank sought to reduce turbulence caused by the withdrawal of U.S. monetary stimulus and fears of a growth slowdown in China.

Banks posted some of the biggest losses in London. HSBC Holdings PLC (HSBC) dropped 1.2%, Standard Chartered PLC lost 1% and Lloyds Banking Group PLC (LYG) gave up 0.9%.

Shares of J Sainsbury PLC lost 2.3% after the supermarket chain said Chief Executive Justin King has decided to step down and will be replaced by Mike Coupe.

On a more upbeat note, shares of Anglo American gained 5.7% after the miner said production rose across most commodities in the fourth quarter. Iron-ore output jumped 25%, while copper production rose 24% to a record 214,400 tons in the period.

Antofagasta picked up 6.1% after posting a rise in full-year copper production, which it attributed to strong performance across all its operations.

Other mining companies were also on the rise, with shares of Randgold Resources Ltd. up 3.2% and Rio Tinto PLC rising 1.1%. Metals prices were mixed.

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