Filed pursuant to Rule 424(b)(5)
Registration No. 333-270030
PROSPECTUS SUPPLEMENT
(To Prospectus dated February 27, 2023)
6,635,112 Shares of Common Stock
Pre-Funded Warrants to Purchase up to
3,088,888 Shares of Common Stock
We are offering 6,635,112 shares
of our common stock, par value $0.01 per share, and, in lieu of offering shares of our common stock to certain investors who so choose,
pre-funded warrants to purchase up to 3,088,888 shares of our common stock.
The purchase price of each pre-funded warrant will be equal the price per share at which shares of common stock are being sold to the
public in this offering, minus $0.01, which is the exercise price of each pre-funded warrant. This prospectus supplement also relates
to the offering of the shares of common stock issuable upon the exercise of such pre-funded warrants.
Our common stock is listed on the Nasdaq Global Market under the symbol
“XNCR.” The closing price of our common stock on the Nasdaq Global Market on September 10, 2024 was $19.13 per share. We do
not intend to list the pre-funded warrants on the Nasdaq Global Market or any other national securities exchange or nationally recognized
trading system.
Investing in our securities involves a high degree of risk. See
the section titled “Risk Factors” beginning on page S-6 of this prospectus supplement and under similar headings in the documents
incorporated by reference into this prospectus supplement and the accompanying base prospectus for a discussion of certain risks you
should consider before investing in our securities.
| |
Per Share | | |
Per Pre- Funded Warrant | | |
Total | |
Public offering price | |
$ | 18.00 | | |
$ | 17.99 | | |
$ | 175,001,111 | |
Underwriting discounts and commissions(1) | |
$ | 1.08 | | |
$ | 1.08 | | |
$ | 10,501,920 | |
Proceeds, before expenses, to us | |
$ | 16.92 | | |
$ | 16.91 | | |
$ | 164,499,191 | |
| (1) | See “Underwriting”
beginning on page S-19 for additional information regarding underwriter compensation. |
We have granted the underwriters an option for a period of 30 days
to purchase up to 1,458,600 additional
shares of our common stock from us at the public offering price set forth above, less underwriting discounts and commissions.
The underwriters expect to deliver the shares and pre-funded warrants
against payment on or about September 12,
2024.
Neither the Securities and Exchange Commission nor any state securities
commission has approved or disapproved of these securities or determined if this prospectus supplement or the accompanying base prospectus
is truthful or complete. Any representation to the contrary is a criminal offense.
Joint Bookrunning
Managers
Leerink Partners |
Raymond James |
RBC
Capital Markets
Co-Manager
Wedbush PacGrow
The date of this prospectus supplement is
September 10, 2024
TABLE OF CONTENTS
TABLE OF CONTENTS
ABOUT THIS PROSPECTUS SUPPLEMENT
This prospectus supplement and the accompanying
base prospectus are part of an “automatic shelf” registration statement on Form S-3 that we filed with the U.S. Securities
and Exchange Commission (SEC) as a “well-known seasoned issuer” as defined in Rule 405 under the Securities Act of 1933, as
amended (Securities Act) using a “shelf” registration process. This prospectus supplement describes the specific terms of
this offering. The accompanying base prospectus, including the documents incorporated by reference therein, provides general information
about us, some of which, such as the section therein titled “Plan of Distribution,” may not apply to this offering. Generally,
when we refer to this prospectus, we are referring to both this prospectus supplement and the accompanying base prospectus, combined.
We urge you to carefully read this prospectus
supplement, the accompanying base prospectus, the documents incorporated by reference herein and therein and the additional information
under the headings “Where You Can Find More Information” and “Information Incorporated by Reference” before buying
any of the securities being offered under this prospectus supplement. These documents contain information you should consider when making
your investment decision.
You should rely only on the information contained
or incorporated by reference in this prospectus supplement and the accompanying base prospectus. We have not, and the underwriters have
not, authorized anyone to provide you with different information. If anyone provides you with different or inconsistent information, you
should not rely on it. This prospectus supplement may add, update or change information contained in the accompanying base prospectus.
To the extent any information in this prospectus supplement is inconsistent with the accompanying base prospectus, you should rely on
the information in this prospectus supplement. The information in this prospectus supplement will be deemed to modify or supersede the
information in the accompanying base prospectus and the documents incorporated by reference therein, except for those documents incorporated
by reference therein which we file with the SEC after the date of this prospectus supplement.
You should not assume that the information contained
or incorporated by reference in this prospectus supplement and the accompanying base prospectus is accurate on any date subsequent to
the date set forth on the front cover of this prospectus supplement and the accompanying base prospectus or on any date subsequent to
the date of the document incorporated by reference, as applicable. Our business, financial condition, results of operations and prospects
may have changed since those dates.
We are offering to sell, and seeking offers to
buy, the securities described in this prospectus supplement only in jurisdictions where offers and sales are permitted. The distribution
of this prospectus supplement and the offering of the securities in certain jurisdictions may be restricted by law. Persons outside the
United States who come into possession of this prospectus supplement must inform themselves about, and observe any restrictions relating
to, the offering of the securities and the distribution of this prospectus supplement outside the United States. This prospectus supplement
does not constitute, and may not be used in connection with, an offer to sell, or a solicitation of an offer to buy, any securities offered
by this prospectus supplement by any person in any jurisdiction in which it is unlawful for such person to make such an offer or solicitation.
We further note that the representations, warranties
and covenants made by us in any agreement that is filed as an exhibit to any document that is incorporated by reference into this prospectus
supplement or the accompanying base prospectus were made solely for the benefit of the parties to such agreement, including, in some cases,
for the purpose of allocating risk among the parties to such agreements, and should not be deemed to be a representation, warranty or
covenant to you. Moreover, such representations, warranties or covenants were accurate only as of the date when made. Accordingly, such
representations, warranties and covenants should not be relied on as accurately representing the current state of our affairs.
In this prospectus supplement, unless otherwise
indicated or required by the context, the terms “Xencor,” “we,” “our,” “us” and the “Company”
refer to Xencor, Inc. and its consolidated subsidiary.
We use our trademarks and our logo in this prospectus
supplement, the accompanying prospectus and the documents incorporated by reference. This prospectus supplement, the accompanying prospectus
and the documents incorporated by reference also include trademarks, tradenames and service marks that are the property of other organizations.
Solely for convenience, trademarks and tradenames referred to in this prospectus supplement appear without the “®” and
“™” symbols, but those references are not intended to indicate, in any way, that we will not assert, to the fullest
extent under applicable law, our rights or that the applicable owner will not assert its rights, to these trademarks and tradenames.
PROSPECTUS SUPPLEMENT SUMMARY
This summary contains basic information about us and this offering.
This summary highlights selected information contained elsewhere in, or incorporated by reference into, this prospectus supplement. This
summary is not complete and may not contain all of the information that may be important to you and that you should consider before deciding
whether or not to invest in our securities. For a more complete understanding of Xencor and this offering, you should carefully read this
prospectus supplement, including the information incorporated by reference into this prospectus supplement, in its entirety. Investing
in our securities involves risks that are described in this prospectus supplement under the heading “Risk Factors,” under
the heading “Item 1A. Risk Factors” in our Annual Report on Form 10-K for the year ended December 31, 2023 and in our other
filings with the Securities and Exchange Commission (SEC).
Overview
We are a clinical-stage biopharmaceutical company
focused on discovering and developing engineered antibody therapeutics to treat patients with cancer and other serious diseases, who have
unmet medical needs. We are advancing a broad portfolio of clinical-stage XmAb drug candidates from our proprietary Fc technology platforms.
We also use our protein engineering capabilities to increase our understanding of protein structure and interactions and to design new
Fc technologies and XmAb development candidates with improved properties. In addition to engineering protein-target interactions, our
approach to protein design includes engineering Fc domains, the parts of antibodies that interact with multiple segments of the immune
system and control antibody structure. The Fc domain is constant and interchangeable among antibodies, and our engineered Fc domains can
be readily substituted for natural Fc domains.
Our protein engineering capabilities and Fc technologies
enable us and our partners to develop XmAb antibodies and other types of biotherapeutic drug candidates with improved properties and functionality,
which can provide innovative approaches to treating disease and potential clinical advantage over other treatment options. For example,
we developed an antibody scaffold to rapidly create novel multi-specific antibodies that bind two or more different targets simultaneously,
creating entirely new biological mechanisms. Other applications of our protein engineering technologies enhance antibody performance by
increasing immune inhibitory activity, improving cytotoxicity, extending circulating half-life and stabilizing novel protein structures.
Three marketed XmAb medicines have been developed with our protein engineering technologies.
Clinical-Stage XmAb Drug Candidates
Our modular XmAb
bispecific technology and protein engineering capabilities enable us to rapidly advance multiple drug candidates into clinical development. We
are currently enrolling Phase 1 or Phase 2 studies for four wholly-owned candidates to treat patients with many different types of serious
diseases:
| ● | XmAb819 (ENPP3 x CD3): XmAb819 is designed to engage the immune system, activating T cells for highly potent and targeted killing
of tumor cells expressing ENPP3, an antigen highly expressed on kidney cancers. Xencor’s XmAb 2+1 multivalent format used in XmAb819
enables greater selectivity of ENPP3-expressing tumor cells compared to normal cells, which express lower levels of ENPP3. We are currently
conducting a Phase 1 study to evaluate XmAb819 in patients with advanced clear cell RCC. |
| ● | XmAb808 (B7-H3 x CD28): XmAb808 is a tumor-selective, co-stimulatory CD28 bispecific antibody that binds to the broadly expressed
tumor antigen B7-H3 and is constructed with the XmAb 2+1 format. Co-stimulation is required for T cells to achieve full activation, and
targeted CD28 bispecific antibodies may provide conditional co-stimulation of T cells when the antibodies are bound to tumor cells. We
are conducting a Phase 1 study to evaluate XmAb808 in combination with pembrolizumab in patients with advanced solid tumors. |
| ● | XmAb541 (CLDN6 x CD3): XmAb541 is a bispecific T-cell engager that targets Claudin-6 (CLDN6), a tumor-associated antigen in
ovarian cancer and other solid tumors, and CD3. The XmAb 2+1 multivalent format used in XmAb541 enables greater selectivity for CLDN6
over similar Claudin family members, such as CLDN9, CLDN3 and CLDN4. We are currently conducting a Phase 1 study to evaluate XmAb541 in
patients with ovarian cancer and other CLDN6 expressing tumor types. The first patient was dosed in April 2024. Through 2025, we plan
to advance the ongoing Phase 1 dose-escalation study toward target dose levels. |
| ● | Vudalimab (PD-1 x CTLA-4): Vudalimab is a bispecific antibody that targets PD-1 and CTLA-4, two immune checkpoint receptors,
to selectively activate the tumor microenvironment, and it is being developed for patients with metastatic castration-resistant prostate
cancer (mCRPC) and patients with locally advanced or metastatic non-small cell lung cancer. Data from a Phase 1 study that enrolled heavily
pretreated patients with multiple solid tumor types indicated that vudalimab was generally well-tolerated with encouraging clinical activity. We
are conducting two Phase 2 studies of vudalimab in patients with mCRPC who have progressed beyond current standard of care options, as
a monotherapy or in combination with chemotherapy, and we anticipate a data readout from these studies in the first half of 2025. We
are also conducting a Phase 1b/2 study evaluating vudalimab in combination with chemotherapy as a first-line treatment in patients with
locally advanced or metastatic non-small cell lung cancer, and we plan to evaluate the safety of the combination in the first half of
2025. |
Recent Developments
Clinical Progress Updates in Early-Stage Oncology Programs
On September 9, 2024, we announced the following
updates to ongoing clinical studies:
| ● | XmAb819
(ENPP3 x CD3): Initial evidence of anti-tumor activity has been observed in recent dose-escalation cohorts in the ongoing
Phase 1 study, including RECIST responses, and the duration of treatment for several patients in earlier dose cohorts has extended beyond
one year. Cytokine release syndrome remains manageable, and the tolerability profile from recent dose cohorts, including no maximum tolerated
dose being reached, supports continued dose escalation toward target dose levels. We continue to anticipate reaching target dose levels
by year end and plan to provide a clinical update around initiation of the first dose expansion cohort during the first half of 2025. |
| | |
| ● | XmAb808 (B7-H3 x CD28): The majority of patients enrolled into the ongoing Phase
1 dose-escalation study are men with metastatic castration-resistant prostate cancer (mCRPC). In this group of patients, prostate specific
antigen (PSA) declines have been observed during the four-week monotherapy safety run-in period. Tolerability from recent dose cohorts
remains supportive of continued dose escalation in combination with pembrolizumab. We continue to anticipate reaching target dose levels
by year end and plan to provide a clinical update around initiation of dose expansion cohorts during the first half of 2025. |
XmAb Drug Candidates for
the Treatment of Patients with Autoimmune and Inflammatory Diseases and Planned Clinical Studies
On September
9, 2024, we announced new clinical development plans for plamotamab and announced new XmAb drug candidates to be evaluated for the treatment
of patients with autoimmune and inflammatory diseases. We believe that plamotamab and XmAb657 could address significant unmet needs for
patients with a wide-range of autoimmune diseases that could be responsive to targeted B-cell depletion, such as rheumatoid arthritis,
multiple sclerosis, advanced systemic lupus erythematosus, anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, idiopathic
inflammatory myopathy, myasthenia gravis, neuromyelitis optica spectrum disorder, pemphigus vulgaris, Sjogren’s syndrome, and systemic
sclerosis. We believe that XmAb942 and a drug candidate to potentially emerge from the XmAb TL1A x IL-23 program could address significant
unmet medical needs for patients with inflammatory bowel diseases (IBD), such as Crohn’s disease and ulcerative colitis, the two
most common forms of IBD.
| ● | Plamotamab (CD20 x CD3): We plan to initiate a Phase 1b/2a proof-of-concept study for plamotamab in multi-drug resistant rheumatoid
arthritis (MDR-RA) in the first half of 2025. The Phase 1b portion of the study will select a priming and step-up dose regimen based on
the regimen established in oncology, and will assess the initial safety, efficacy, and biomarkers of plamotamab in patients with MDR-RA.
The selected dose regimen will then be evaluated in the randomized Phase 2a portion, with efficacy determined at week 24. We previously
completed a Phase 1 clinical study of plamotamab in hematologic cancers, completing enrollment in late 2023. Results from the study showed
favorable tolerability and comparable preliminary efficacy data, when cross compared to results from studies of a competitor molecule
within the class, with similar patient baseline characteristics. Based on these clinical outcomes, significant B-cell depletion observed
in preclinical studies, and the emergent biology supportive of B-cell targeted T cell engagers for the treatment of patients with autoimmune
diseases, we plan to evaluate plamotamab in MDR-RA, in which patients progressed through two prior lines of therapy. |
| ● | XmAb657 (CD19 x CD3): We have leveraged our XmAb protein engineering platforms to create XmAb657, a potent, potentially long-acting
CD19 x CD3 bispecific antibody, utilizing the XmAb 2+1 bispecific antibody format and Xtend Fc technology. In non-human primate studies,
a single dose of XmAb657 deeply reduced B cells by over 99.98% in the peripheral compartment, bone marrow and lymph nodes, which was sustained
for at least 28 days. Half-life was estimated to be 15 days, which indicates a potential for durable B-cell depletion in clinical studies.
XmAb657 was well tolerated preclinically, with no clinical signs of cytokine release syndrome. We plan to initiate a first-in-human study
during the second half of 2025. |
| ● | XmAb942 (Xtend TL1A): XmAb924 is a monospecific anti-TL1A antibody, utilizing Xencor’s Xtend Fc domain and
proprietary Fc silencing technology, with potentially class-leading potency, and is under development for patients with IBD. The two
most common forms of IBD are Crohn’s disease and ulcerative colitis. Half-life preclinically was greater than 22 days,
potentially supporting an 8- to 12-week dosing regimen in humans. An abstract with preclinical characterization was accepted for
presentation at the United Europe Gastroenterology Week (UEGW) in Vienna, Austria on Tuesday, October 15. We anticipate dosing the
first subject in a first-in-human, single-ascending dose study of XmAb942 in the fourth quarter of 2024, with interim data during
the first half of 2025. |
| ● | XmAb TL1A x IL-23: An expertly engineered XmAb TL1A x IL-23p19 bispecific antibody could potentially provide dual targeting
of important inflammatory pathways for autoimmune and inflammatory disease, while avoiding the complexities of dosing and formulary access
for two separate TL1A and IL23 targeted drugs. We anticipate initiating first-in-human studies during 2026. |
Legal Proceeding
We are currently a party to an action initiated by
Merus N.V. (Merus) in the District of Delaware alleging that our manufacture, use, offer for sale, sale, and/or importation of common
light chain antibodies and heterodimeric antibodies infringes certain claims of three Merus patents. Merus filed its complaint against
us on August 5, 2024. Merus asserted claims of U.S. Patent Nos. 9,944,695, 9,358,286 and 11,926,859 (collectively, the Asserted Patents).
Merus seeks a judgment of patent infringement, an order enjoining us from infringing the Asserted Patents, a damages award (together with
interest), a declaration of willful infringement, and a finding that this case is exceptional. Our deadline to answer, move, or otherwise
respond to Merus’s complaint is October 10, 2024. We believe we have strong defenses to Merus’s claims, including defenses
of invalidity and/or non-infringement, but there is no guarantee that we will prevail.
Cash Runway
Based on our planned use of the net proceeds
from this offering and our existing cash, cash equivalents and marketable debt securities, as of the date of this prospectus
supplement, we estimate that such funds will be sufficient to enable us to fund our operating expenses and capital expenditure
requirements through 2027. We have based this estimate on assumptions that may prove to be wrong, and we could use our available
capital resources sooner, or for purposes that are different, than we currently expect. We will need to raise additional financing
to continue our products’ development for the foreseeable future, and expect to continue doing so until we becomes profitable.
Our ability to access capital when needed is not assured and, if capital is not available to us when, and in the amounts, needed, we
may be required to significantly curtail, delay or discontinue one or more of our research or development programs or the
commercialization of any product candidate, or be unable to expand our operations or otherwise capitalize on our business
opportunities, as desired, which could materially harm our business, financial condition and results of operations.
Corporate and Other Information
We were incorporated in California in August 1997
under the name Xencor. In September 2004, we reincorporated in the state of Delaware under the name Xencor, Inc. Our principal offices
are located at 465 North Halstead Street, Suite 200, Pasadena, CA 91107, and our telephone number is (626) 305-5900. Our website address
is www.xencor.com. Our website and the information contained on, or that can be accessed through, the website will not be deemed
to be incorporated by reference in and are not considered part of this Annual Report. Our Annual Reports on Form 10-K, Quarterly Reports
on Form 10-Q, Current Reports on Form 8-K and amendments to reports filed or furnished pursuant to Section 13(a) and 15(d) of the Securities
Exchange Act of 1934, as amended (Exchange Act), are available free of charge on the Investor Relations portion of our web site at www.xencor.com
as soon as reasonably practical after we electronically file such material with, or furnish it to, the SEC. The SEC maintains an internet
site at www.sec.gov that contains reports, proxy and information statements, and other information regarding issuers that file
electronically with the SEC.
THE OFFERING
Common stock offered by us |
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6,635,112 shares of common
stock. |
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Pre-funded warrants offered by us |
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We are also offering, in lieu of common stock
to certain investors who so choose, pre-funded warrants to purchase up to 3,088,888 shares of our common stock. The purchase price
of each pre-funded warrant is equal to the price per share at which shares of our common stock are being sold in this offering,
minus $0.01, which is the exercise price of each pre-funded warrant. Each Pre-Funded warrant will be exercisable from the date of
issuance and will expire on the date the warrant is exercised in full, subject to an ownership limitation. See the section titled
“Description of Pre-Funded Warrants” for additional detail. This prospectus supplement also relates to the offering of
the shares of common stock issuable upon exercise of the pre-funded warrants. |
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Option to purchase additional shares from us |
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We have granted the underwriters an option for
a period of 30 days from the day of this prospectus supplement to purchase up to an additional 1,458,600 shares of our common stock
from us at the public offering price, less underwriting discounts and commissions. The number of shares subject to the
underwriters’ option will equal 15% of the total number of shares of common stock we are offering plus the shares of our
common stock underlying the pre-funded warrants. |
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|
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Common stock to be outstanding immediately after this offering |
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68,401,166 shares
(or 69,859,766 shares
if the underwriters exercise their option to purchase additional shares in full), in each case assuming no exercise of any
pre-funded warrants. |
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Use of proceeds |
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We estimate the net proceeds from this
offering will be approximately $163.1 million, or approximately $187.8 million
if the underwriters exercise their option to purchase additional shares in full, after deducting underwriting discounts and
commissions and estimated offering expenses payable by us and excluding proceeds from any pre-funded warrant exercises. |
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We currently intend to use the net proceeds from this offering for general corporate purposes, which may include research and development, capital expenditures, working capital and general and administrative expenses. See the section titled “Use of Proceeds” for additional detail. |
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Risk factors |
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Investing in our securities involves a significant risks. See the section titled “Risk Factors” and other information included or incorporated by reference in this prospectus supplement for a discussion of factors you should carefully consider before investing in our securities. |
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Nasdaq Global Market symbol |
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“XNCR”. We do not intend to list the pre-funded warrants on the Nasdaq Global Market or any other national securities exchange or nationally recognized trading system. |
The above discussion is based on 61,766,054 shares of our common stock
outstanding as of June 30, 2024, and excludes:
| ● | 12,661,426 shares of our common stock issuable upon the exercise of stock options outstanding as of June 30, 2024 with a weighted-average
exercise price of $28.48 per share; |
| ● | 1,778,656 shares of our common stock reserved for future issuance upon vesting of outstanding restricted stock units as of June 30,
2024; |
| ● | 4,281,022 shares of our common stock reserved as of June 30, 2024 for future issuance under our 2023 Equity Incentive Plan; |
| ● | 987,344 shares of our common stock reserved as of June 30, 2024 for future issuance under our 2013 Employee Stock Purchase Plan; |
| ● | 130,298 shares of common stock issuable upon the exercise of stock options granted subsequent to June 30, 2024 with a weighted-average
exercise price of $18.54 per share; and |
| ● | 67,149 shares of our common stock reserved for future issuance upon vesting of outstanding restricted stock units granted subsequent
to June 30, 2024. |
Further, the number of shares of our common stock to be outstanding
after this offering does not take into account the shares of our common stock issuable upon the exercise of the pre-funded warrants.
In addition, the number of shares of our common stock to be outstanding
immediately after this offering excludes shares of common stock that we may sell pursuant to our sales agreement (Sales Agreement) with
Leerink Partners LLC, dated February 27, 2023. As of the date of this prospectus supplement, we may sell up to $200.0 million of shares
of our common stock remaining available for sale by us under the Sales Agreement after the expiration or waiver of the lock-up period
applicable to us and described under the section titled “Underwriting.”
Except as otherwise noted, all information in this prospectus supplement
assumes no exercise of the underwriters’ option to purchase additional shares of our common stock, no exercise of the pre-funded
warrants offered hereby, no exercise of the outstanding stock options and no vesting of the restricted stock units described above.
RISK FACTORS
Investing in our securities involves a high
degree of risk. Our Annual Report on Form 10-K for the year ended December 31, 2023, which is incorporated by reference into this prospectus
supplement, as well as our other filings with the SEC, include material risk factors relating to our business. Those risks and uncertainties
and the risks and uncertainties described below are not the only risks and uncertainties that we face. Additional risks and uncertainties
that are not presently known to us or that we currently deem immaterial or that are not specific to us, such as general economic conditions,
may also materially and adversely affect our business and operations. If any of those risks and uncertainties or the risks and uncertainties
described below actually occurs, our business, financial condition, results of operations or prospects could be harmed substantially.
In such a case, the trading price of our common stock could decline and you could lose all or part of your investment. You should carefully
consider the risks and uncertainties described below and those risks and uncertainties incorporated by reference into this prospectus
supplement, as well as the other information included in this prospectus supplement, before making an investment decision with respect
to our common stock. Please also carefully read the section below titled “Disclosure Regarding Forward-Looking Statements.”
Risks Related to This Offering
Purchasers of securities in this offering will experience immediate
and substantial dilution in the book value of their investment.
The public offering price per share of common stock
and pre-funded warrants in this offering is substantially higher than the net tangible book value per share of our common stock before
giving effect to this offering. Accordingly, if you purchase securities in this offering, you will incur immediate and substantial dilution
of approximately $7.67 per share, representing the difference between the public offering price per share of common stock and pre-funded warrant
(rounded for purposes of the pre-funded warrants) and our as adjusted net tangible book value as of June 30, 2024, assuming no exercise
of the pre-funded warrants and excluding any resulting accounting associated with the pre-funded warrants. In addition, if our outstanding
stock options are exercised, restricted stock units vest and settle or we raise additional capital, you could experience further dilution.
For a further description of the dilution that you will experience immediately after this offering, see the section titled “Dilution.”
Future sales of our common stock or securities convertible into
common stock, or the perception that such future sales may occur, may cause our stock price to decline.
Sales of a substantial number of shares of our
common stock or other securities convertible into, exercisable or exchangeable for our common stock, in the public market, or the perception
that these sales could occur, following this offering could cause the market price of our common stock to decline. A substantial majority
of the outstanding shares of our common stock are, and the securities sold in this offering upon issuance will be, freely tradable without
restriction or further registration under the Securities Act. We may sell large quantities of our common stock at any time pursuant to
one or more separate offerings in the future, including pursuant to the Sales Agreement. We cannot predict the effect that future sales
of common stock or other equity-related securities would have on the market price of our common stock.
We may issue additional equity or convertible debt securities
in the future, which may result in additional dilution to you.
In order to raise additional capital, we expect
to in the future offer additional shares of our common stock or other securities convertible into or exchangeable for our common stock.
We cannot assure you that we will be able to sell shares or other securities in any other offering at a price per share that is equal
to or greater than the price per share paid by investors in this offering, and investors purchasing shares or other securities in the
future could have rights superior to existing stockholders. The price per share at which we sell additional shares of our common stock
or other securities convertible into or exchangeable for our common stock, in future transactions, including any sales of shares of our
common stock pursuant to the Sales Agreement, may be higher or lower than the price per share in this offering.
Our management will have broad discretion to determine how to
use the net proceeds from this offering, and may use or invest them in ways with which investors may disagree or that may not enhance
our operating results or the price of our common stock.
Our management will have broad discretion over
the use of proceeds from this offering, and we could spend the proceeds from this offering in ways with which investors may not agree
or that do not yield a favorable return, if at all. If we do not invest or apply the net proceeds from this offering in ways that improve
our operating results, we may fail to achieve expected financial results, which could cause our stock price to decline and could harm
our business, financial condition, results of operations and prospects. See the section titled “Use of Proceeds” for additional
detail.
We do not expect to pay dividends for the foreseeable future.
As a result, you must rely on stock appreciation for any return on your investment.
We do not anticipate paying cash dividends on our
common stock for the foreseeable future. Any payment of cash dividends will also depend on our financial condition, results of operations,
capital requirements and other factors and will be at the discretion of our board of directors. Accordingly, you will have to rely on
future appreciation in the market value of our common stock, if any, to earn a return on your investment in our common stock. There is
no guarantee that our common stock will appreciate or even maintain the price at which investors have purchased it.
There is no public market for the pre-funded warrants
being offered in this offering.
There is no public trading
market for the pre-funded warrants being offered in this offering, and we do not expect a market to develop. In addition, we
do not intend to apply to list the pre-funded warrants on any securities exchange or nationally recognized trading system. Without
an active market, the liquidity of the pre-funded warrants will be limited.
Holders of pre-funded warrants
purchased in this offering will have no rights as holders of common stock until such holders exercise their pre-funded warrants
and acquire our common stock.
Until holders of pre-funded warrants
acquire shares of our common stock upon exercise of the pre-funded warrants, as applicable, holders of pre-funded warrants
will have no rights with respect to the shares of our common stock underlying such pre-funded warrants, as applicable. Upon
exercise of the pre-funded warrants, the holders will be entitled to exercise the rights of a holder of common stock only as
to matters for which the record date occurs after the exercise date.
The pre-funded warrants are speculative
in nature.
The pre-funded warrants
merely represent the right to acquire shares of common stock at a fixed price. Specifically, commencing on the date of issuance, holders
of the pre-funded warrants may exercise their right to acquire the common stock and pay an exercise price of $0.01 per share, subject
to certain adjustments. Moreover, following this offering, the market value of the pre-funded warrants is uncertain and there can be no
assurance that the market value of the pre-funded warrants will equal or exceed their public offering price.
Furthermore, each pre-funded
warrant will expire once exercised in full. In the event that our common stock price does not exceed the exercise price of the pre-funded
warrants during the period when the pre-funded warrants are exercisable, as applicable, such pre-funded warrants may not have any value.
Significant holders or beneficial holders
of our common stock may not be permitted to exercise pre-funded warrants that they hold.
A holder of a pre-funded warrant will
not be entitled to exercise any portion of any pre-funded warrant which, upon giving effect to such exercise, would
cause (i) the aggregate number of shares of our common stock beneficially owned by the holder (together with its affiliates) to exceed
9.99% of the number of shares of our common stock outstanding immediately after giving effect to the exercise, or (ii) the combined
voting power of our securities beneficially owned by the holder (together with its affiliates) to exceed 9.99% of the combined voting
power of all of our capital stock then outstanding immediately after giving effect to the exercise, as such percentage ownership
is determined in accordance with the terms of the pre-funded warrants, as applicable, unless such percentage is increased
upon at least 61 days’ prior notice, but not in excess of 19.99%. As a result, you may not be able to exercise your pre-funded warrants
for shares of our common stock at a time when it would be financially beneficial for you to do so. In such circumstances, you could seek
to sell your pre-funded warrants to realize value, but you may be unable to do so in the absence of an established
trading market for the pre-funded warrants.
Risks Related to our Intellectual Property
Our products could infringe patents
and other property rights of others, which may result in costly litigation and, if we are not successful, could cause us to pay substantial
damages or limit our ability to commercialize our products, which could have a material adverse effect on our business.
Our commercial success depends
upon our ability, and the ability of our collaborators, to develop, manufacture, market and sell our product candidates and use our proprietary
technologies without infringing the patents and other proprietary rights of third parties. There is considerable intellectual property
litigation in the biotechnology and pharmaceutical industries. For example, we are aware of issued patents owned by Merus N.V. (Merus)
that may relate to and claim components of our bispecific antibody product candidates and partnered bispecific product candidates, including
plamotamab, vudalimab and XmAb819, will putatively expire in 2033. In August 2024, Merus filed suit against us in the United States District
Court of the District of Delaware alleging that we have infringed three of its patents. We maintain that our development of these candidates
currently falls into the “safe harbor” of non-infringement under 35 U.S.C. §271(e)(1). This protection, however, would
not be available upon commercialization nor can we give assurances on how the Court would rule on this issue. We also believe we have
strong defenses to Merus’s claims, including defenses of invalidity and/or non-infringement for the Merus patents, but there is
no guarantee that we will prevail. If we are found to infringe the Merus patents, we may be ordered by a court to cease commercializing
the applicable product candidates, which could materially harm our business. In addition, we could be found liable for monetary damages,
including treble damages and attorneys’ fees if we are found to have willfully infringed the Merus patents.
In addition, as the biopharmaceutical
industry expands and more patents are issued, the risk increases that there may be patents issued to third parties that relate to our
products and technology of which we are not aware or that we must challenge to continue our operations as currently contemplated. Our
products may infringe or may be alleged to infringe these patents. Because some patent applications in the United States may be maintained
in secrecy until the patents are issued, because patent applications in the United States and many foreign jurisdictions are typically
not published until eighteen months after filing and because publications in the scientific literature often lag behind actual discoveries,
we cannot be certain that others have not filed patents that may cover our technologies, our product candidates or their use. Additionally,
pending patent applications which have been published can, subject to certain limitations, be later amended in a manner that could cover
our technologies, our products or the use of our products. We may become party to, or threatened with, future adversarial proceedings
or litigation regarding intellectual property rights with respect to our products and technology. Third parties may assert infringement
claims against us based on existing patents or patents that may be granted in the future.
In order to defend against
a claim of patent infringement, we would need to demonstrate that our products or methods either do not infringe the patent claims of
the relevant patent or that the patent claims are invalid, and we may not be able to do this. Proving invalidity is difficult. For example,
in the United States, proving invalidity requires a showing of clear and convincing evidence to overcome the presumption of validity enjoyed
by issued patents. This burden is a high one, and there is no assurance that a court would find these claims to be invalid or not infringed.
Even if we are successful in these proceedings, we may incur substantial costs and divert management’s time and attention in pursuing
these proceedings, which could have a material adverse effect on us.
Any such claims are likely
to be expensive to defend, and some of our competitors may be able to sustain the costs of complex patent litigation more effectively
than we can because they have substantially greater resources.
If we are found to infringe
a third party’s intellectual property rights, we could be required to obtain a license from such third party to continue developing
and marketing our products and technology. We may also elect to enter into such a license in order to settle litigation or in order to
resolve disputes prior to litigation. However, we may not be able to obtain any required license on commercially reasonable terms or at
all. Even if we were able to obtain a license, it could be non-exclusive, thereby giving our competitors access to the same technologies
licensed to us and could require us to make substantial royalty payments. We could also be forced, including by court order, to cease
commercializing the infringing technology or product. In addition, we could be found liable for monetary damages, including treble damages
and attorneys’ fees if we are found to have willfully infringed a patent. A finding of infringement could prevent us from commercializing
our product candidates or force us to cease some of our business operations, which could materially harm our business. Claims that we
have misappropriated the confidential information or trade secrets of third parties could have a similar negative impact on our business.
DISCLOSURE REGARDING FORWARD-LOOKING STATEMENTS
This prospectus supplement and the documents incorporated
by reference in this prospectus supplement contain “forward-looking statements” within the meaning of Section 27A of the Securities
Act and Section 21E of the Exchange Act, which statements involve substantial risks and uncertainties. These statements relate to future
events or to our future operating or financial performance and involve known and unknown risks, uncertainties and other factors that may
cause our actual results, performance or achievements to be materially different from any future results, performance or achievements
expressed or implied by the forward-looking statements. Forward-looking statements contained in this prospectus supplement and the documents
incorporated by reference in this prospectus supplement include, but are not limited to, statements about:
| ● | the
effects of inflation on our financial condition, results of operations, cash flows and performance; |
| ● | our
ability to execute on our plans to research, develop and commercialize our product candidates; |
| ● | the
timing or success of our ongoing and planned clinical trials; |
| ● | the
timing of and our ability to obtain and maintain regulatory approval for our product candidates; |
| ● | our
ability to identify additional products or product candidates with significant commercial
potential that are consistent with our business objectives; |
| ● | our
ability to receive research funding and achieve anticipated milestones under our collaborations; |
| ● | our
partners’ ability to advance drug candidates into, and successfully complete, clinical
trials; |
| ● | our
ability to attract collaborators with development, regulatory, and commercialization expertise; |
| ● | the
ability of our publicly announced preliminary clinical trial data to support continued clinical
development and regulatory approval for specific treatments; |
| ● | our
ability to protect our intellectual property position; |
| ● | the
rate and degree of market acceptance and clinical utility of our product candidates; |
| ● | costs
of compliance and our failure to comply with new and existing governmental regulations; |
| ● | the
capabilities and strategy of our suppliers and vendors including key manufacturers of our
clinical drug supplies; |
| ● | significant
competition in our industry; |
| ● | costs
of litigation and the failure to successfully defend lawsuits and other claims against us; |
| ● | the
potential loss or retirement of key members of management; |
| ● | our
failure to successfully execute our growth strategy including any delays in our planned future
growth; |
| ● | our
failure to maintain effective internal controls; and |
| ● | our
ability to accurately estimate expenses, future revenues, capital requirements and needs
for additional financing. |
In some cases, you
can identify forward-looking statements by terms such as “anticipates,” “believes,” “could,” “estimates,”
“expects,” “may,” “plans,” “potential,” “predicts,” “projects,”
“should,” “would,” “will” and similar expressions intended to identify forward-looking statements.
These statements reflect our current views with
respect to future events, are based on assumptions and are subject to risks and uncertainties. Given these risks and uncertainties, you
should not place undue reliance on these forward-looking statements. We discuss in greater detail, and incorporate by reference into this
prospectus supplement in their entirety, many of these risks and uncertainties under the section titled “Risk Factors” in
this prospectus supplement, in any free writing prospectus we may authorize for use in connection with this offering, and in our most
recent annual report on Form 10-K, as well as any amendments thereto reflected in subsequent filings with the SEC. Also, these forward-looking
statements represent our estimates and assumptions only as of the date of the document containing the applicable statement. Unless required
by law, we undertake no obligation to update or revise any forward-looking statements to reflect new information or future events or developments.
Thus, you should not assume that our silence over time means that actual events are bearing out as expressed or implied in such forward-looking
statements. You should read this prospectus supplement, together with the documents we have filed with the SEC that are incorporated by
reference and any free writing prospectus we have authorized for use in connection with this offering completely and with the understanding
that our actual future results may be materially different from what we expect. We qualify all of the forward-looking statements in the
foregoing documents by these cautionary statements.
MARKET AND INDUSTRY DATA
This prospectus supplement and the information
incorporated by reference herein contain statistical data, estimates, forecasts, projections and other information concerning our industry,
our business and the markets for certain diseases, including data regarding the estimated size of those markets and the incidence and
prevalence of certain medical conditions. Information that is based on statistical data, estimates, forecasts, projections, market research
or similar methodologies is inherently subject to uncertainties and actual events or circumstances may differ materially from events and
circumstances reflected in this information. Unless otherwise expressly stated, we obtained this industry, business, market and other
data from reports, research surveys, medical and general publications, government data, studies and similar data prepared by market research
firms and other third parties. These third parties may, in the future, alter the manner in which they conduct surveys and studies regarding
the markets in which we operate our business. The market and other estimates included in this prospectus supplement and the information
incorporated by reference herein, as they relate to projections, involve numerous assumptions, are subject to risks and uncertainties,
and are subject to change based on various factors, including those discussed in the section of this prospectus supplement titled “Risk
Factors” and in the other information contained or incorporated by reference in this prospectus supplement.
USE OF PROCEEDS
We estimate that the net proceeds from the
sale of the common stock and pre-funded warrants in this offering will be approximately
$163.1 million, or
approximately $187.8 million
if the underwriters exercise their option to purchase additional shares in full, after deducting underwriting discounts and
commissions and estimated offering expenses payable by us. We will receive nominal proceeds, if any, upon the exercise of the
pre-funded warrants.
We currently intend to use the net proceeds of
this offering for general corporate purposes, which may include research and development, capital expenditures, working capital and general
and administrative expenses. We also may use a portion of the net proceeds to acquire or invest in other businesses, products and technologies
that are complementary to our own, although we have no current plans, commitments or arrangements to do so.
The amounts and timing of our use of the net proceeds
from this offering will depend on a number of factors, such as the timing and progress of our research and development efforts, the timing
and progress of any partnering and commercialization efforts, technological advances and the competitive environment for our products.
As of the date of this prospectus supplement, we cannot specify with certainty all of the particular uses for the net proceeds to be received
upon the completion of this offering. Additionally, our management will have broad discretion in the timing and application of these proceeds.
Pending application of the net proceeds as described above, we intend to invest the proceeds of this offering in short-term and long-term,
investment grade, interest-bearing securities, money market funds, certificates of deposit and corporate debt securities.
DIVIDEND POLICY
We have never declared or paid cash dividends
on our common stock and do not anticipate paying cash dividends on our common stock in the foreseeable future. The payment of dividends
on our capital stock will depend on our earnings, financial condition and other business and economic factors affecting us at such time
as the board of directors may consider relevant. If we do not pay dividends, our common stock may be less valuable because a return on
your investment will only occur if the common stock price appreciates.
DILUTION
Purchasers of securities in this offering will
experience immediate dilution to the extent of the difference between the public offering price per share of common stock or pre-funded
warrant and the as adjusted net tangible book value per share of common stock immediately after this offering.
Our net tangible book value as of June 30, 2024
was approximately $543.8 million, or $8.80 per share of common stock. Net tangible book value per share is determined by dividing the
net of total tangible assets less total liabilities, by the aggregate number of shares of common stock outstanding as of June 30, 2024.
After giving effect to the sale by us of
6,635,112 shares of common stock at the public offering price of
$18.00 per
share of common stock and pre-funded warrants to
purchase 3,088,888 shares
of common stock at the public offering price of
$17.99 per
pre-funded warrant (which equals the public offering price per share of common stock less the $0.01 exercise price of each such
pre-funded warrant) (and excluding shares of common stock issued and any proceeds received upon the exercise of the pre-funded
warrants or any resulting accounting associated with the pre-funded warrants), and after deducting underwriting discounts and
commissions and estimated offering expenses, our as adjusted net tangible book value as of June 30, 2024 would have been
approximately
$706.8 million,
or $10.33 per
share of common stock. This represents an immediate increase in net tangible book value of
$1.53 per share
to our existing stockholders and an immediate dilution of
$7.67 per share
of common stock issued to the investors purchasing shares of our common stock and pre-funded warrants in this offering. The
following table illustrates this dilution on a per share basis:
Public offering price per share of common stock | |
| | | |
$ | 18.00 | |
Net tangible book value per share as of June 30, 2024 | |
$ | 8.80 | | |
| | |
Increase in net tangible book value per share attributable to investors participating in this offering | |
| 1.53 | | |
| | |
As adjusted net tangible book value per share as of June 30, 2024, after giving effect to this offering | |
| | | |
| 10.33 | |
Dilution per share to investors participating in this offering | |
| | | |
$ | 7.67 | |
If the underwriters exercise their option to
purchase additional shares of common stock in this offering in full at the public offering price of $18.00 per share of common stock
(and excluding shares of our common stock issued and any proceeds received upon exercise of the pre-funded warrants or any resulting
accounting associated with the pre-funded warrants), after deducting underwriting discounts and commissions and estimated offering
expenses payable by us, our as adjusted net tangible book value per share as of June 30, 2024 would be $10.47 per share, and
the immediate dilution in as adjusted net tangible book value to investors participating in this offering would be $7.53 per
share.
If holders of the pre-funded warrants
exercise the pre-funded warrants in full, our as adjusted net tangible book value per share of common stock as of June 30, 2024,
after giving effect to this offering (but not the exercise of the underwriters’ option to purchase additional shares), would
be $9.89 per share, and the dilution in as adjusted net tangible book value per share to investors participating in this
offering would be $8.11 per share.
The foregoing table and calculations (other than
historical net tangible book value) are based on 61,766,054 shares of common stock outstanding as of June 30, 2024, and exclude:
| ● | 12,661,426
shares of our common stock issuable upon the exercise of stock options outstanding as of
June 30, 2024 with a weighted-average exercise price of $28.48 per share; |
| ● | 1,778,656
shares of our common stock reserved for future issuance upon vesting of outstanding restricted
stock units as of June 30, 2024; |
| ● | 4,281,022
shares of our common stock reserved as of June 30, 2024 for future issuance under our 2023
Equity Incentive Plan; |
| ● | 987,344
shares of our common stock reserved as of June 30, 2024 for future issuance under our 2013
Employee Stock Purchase Plan; |
| ● | 130,298
shares of common stock issuable upon the exercise of stock options granted subsequent to
June 30, 2024 with a weighted-average exercise price of $18.54 per share; and |
| ● | 67,149
shares of our common stock reserved for future issuance upon vesting of outstanding restricted
stock units granted subsequent to June 30, 2024. |
In
addition, the number of shares of our common stock outstanding immediately after this offering excludes additional shares of common stock
that we may sell pursuant to our Sales Agreement. As of the date of this prospectus supplement, we may sell up to $200.0 million of shares
of our common stock remaining under the Sales Agreement after the expiration or waiver of the lock-up period applicable to us and described
under the section titled “Underwriting”.
To
the extent that outstanding stock options as of June 30, 2024 have been or may be exercised, outstanding restricted stock units
vest or other shares are issued, investors purchasing our common stock or pre-funded warrants in this offering may experience further
dilution. In addition, we may choose to raise additional capital due to market conditions or strategic considerations even if we believe
we have sufficient funds for our current or future operating plans. To the extent that additional capital is raised through the sale
of equity or convertible debt securities, the issuance of these securities could result in further dilution to our stockholders.
DESCRIPTION OF PRE-FUNDED WARRANTS
The following is a brief summary of certain terms
and conditions of the pre-funded warrants being offered in this offering. The following description is subject in all respects to the
provisions contained in the pre-funded warrants.
Form
The pre-funded warrants will be issued as individual
warrant agreements to each individual purchaser of pre-funded warrants. The form of pre-funded warrants will be filed as an exhibit to
a Current Report on Form 8-K that we expect to file with the SEC.
Term
The pre-funded warrants will expire on the date
the warrant is exercised in full.
Exercisability
The pre-funded warrants are exercisable at any
time after their original issuance. The pre-funded warrants will be exercisable, at the option of each holder, in whole or in part by
delivering to us a duly executed exercise notice and by payment in full of the exercise price in immediately available funds for the
number of shares of common stock purchased upon such exercise. As an alternative to payment of the exercise price in immediately available
funds, the holder may, in its sole discretion, elect to exercise the pre-funded warrants through a cashless exercise, in which case the
holder would receive upon such exercise the net number of shares of our common stock determined according to the formula set forth in
the pre-funded warrant. No fractional shares of our common stock will be issued in connection with the exercise of a pre-funded warrant.
In lieu of fractional shares, we will, at our election, either pay a cash adjustment in respect of any fractional share in an amount
equal to such fractional share multiplied by the exercise price or round down to the nearest whole share.
Exercise Limitations
Under the pre-funded warrants, we may not effect
the exercise of any pre-funded warrants, and a holder will not be entitled to exercise any portion of any pre-funded warrant that, upon
giving effect to such exercise, would cause: (i) the aggregate number of shares of our common stock beneficially owned by such holder
(together with its affiliates) to exceed 9.99% (or, at the election of the purchaser, 4.99%) of the number of issued and outstanding
shares of our common stock following such exercise; or (ii) the combined voting power of our securities beneficially owned by such holder
(together with its affiliates) to exceed 9.99% (or, at the election of the purchaser, 4.99%) of the combined voting power of all of our
securities outstanding following such exercise, as such percentage ownership is determined in accordance with the terms of the pre-funded
warrants. However, any holder of a pre-funded warrant may increase or decrease such percentage to any other percentage not in excess
of 9.99% upon at least 61 days’ prior notice from the holder to us.
Exercise Price
The exercise price of our common stock purchasable
upon the exercise of the pre-funded warrants is $0.01 per share. The exercise price of the pre-funded warrants and the number of shares
of our common stock issuable upon exercise of the pre-funded warrants is subject to appropriate adjustment in the event of certain stock
dividends and distributions, stock splits, stock combinations, reclassifications or similar events affecting our common stock, as well
as upon any distribution of assets, including cash, stock or other property, to our stockholders.
Transferability
Subject to the restrictions on transfer set forth
in the pre-funded warrants and applicable laws, the pre-funded warrants may be offered for sale, sold, transferred or assigned without
our consent.
Exchange Listing
There is no established trading market for the
pre-funded warrants, and we do not expect a market to develop. We do not intend to apply for the listing of the pre-funded warrants on
the Nasdaq Global Market or any other national securities exchange or any other nationally recognized trading system.
Fundamental Transactions
Upon the consummation of a fundamental transaction
(as described in the pre-funded warrants, and generally including any reorganization, recapitalization or reclassification of our common
stock, the sale, transfer or other disposition of all or substantially all of our properties or assets, our consolidation or merger with
or into another person, the acquisition of more than 50% of our voting power of our capital stock, or any person or group becoming the
beneficial owner of more than 50% of the voting power of our outstanding capital stock), the holders of the pre-funded warrants will
be entitled to receive, upon exercise of the pre-funded warrants, the kind and amount of securities, cash or other property that such
holders would have received had they exercised the pre-funded warrants immediately prior to such fundamental transaction, without regard
to any limitations on exercise contained in the pre-funded warrants.
No Rights as a Stockholder
Except by virtue of such holder’s ownership
of shares of our common stock, the holder of a pre-funded warrant does not have the rights or privileges of a holder of our common stock,
including any voting rights or the right to receive dividends, until such holder exercises the pre-funded warrant.
Material
U.S. Federal Income Tax Considerations for U.S. AND Non-U.S. Holders
The following is a summary of the material U.S.
federal income tax consequences of the acquisition, ownership and disposition of our common stock and pre-funded warrants, but does not
purport to be a complete analysis of all the potential tax considerations relating thereto. Throughout this summary, all references to
our common stock are meant to include our pre-funded warrants. This summary is based upon the provisions of the Internal Revenue Code
of 1986, as amended, or the Code, Treasury Regulations promulgated thereunder, administrative rulings and judicial decisions, all as of
the date hereof. These authorities may be changed or subject to differing interpretations, possibly with retroactive effect, with the
resulting U.S. federal income tax consequences being different from those set forth below. We have not sought and will not seek any ruling
from the Internal Revenue Service, or the IRS, with respect to the statements made and the conclusions reached in the following summary,
and there can be no assurance that the IRS or a court will agree with such statements and conclusions.
This summary also does not address the tax considerations
arising under the laws of any U.S. state or local or any non-U.S. jurisdiction, estate or gift tax, the 3.8% Medicare tax on net investment
income or any alternative minimum tax consequences. In addition, this discussion does not address tax considerations applicable to a holder’s
particular circumstances or to a holder that may be subject to special tax rules, including, without limitation:
| ● | banks,
insurance companies or other financial institutions; |
| ● | tax-exempt
or government organizations; |
| ● | brokers
or dealers in securities or currencies; |
| ● | traders
in securities that elect to use a mark-to-market method of accounting for their securities
holdings; |
| ● | persons
that own, or are deemed to own, more than 5.0% of our capital stock; |
| ● | certain
U.S. expatriates, citizens or former long-term residents of the United States; |
| ● | persons
who hold our common stock as a position in a hedging transaction, “straddle,”
“conversion transaction,” synthetic security, other integrated investment, or
other risk reduction transaction; |
| ● | persons
who do not hold our common stock as a capital asset within the meaning of Section 1221 of
the Code (generally, for investment purposes); |
| ● | persons
deemed to sell our common stock under the constructive sale provisions of the Code; |
| ● | partnerships,
or other entities or arrangements treated as partnerships for U.S. federal income tax purposes,
or investors in any such entities or arrangements; |
| ● | persons
for whom our stock constitutes “qualified small business stock” within the meaning
of Section 1202 of the Code; |
| ● | integral
parts or controlled entities of foreign sovereigns; |
| ● | passive
foreign investment companies and corporations that accumulate earnings to avoid U.S. federal
income tax; or |
| ● | persons
that acquire our common stock as compensation for services. |
In addition, if a partnership, including any entity
or arrangement classified as a partnership for U.S. federal income tax purposes, holds our common stock, the tax treatment of a partner
generally will depend on the status of the partner, the activities of the partnership, and certain determinations made at the partner
level. Accordingly, partnerships that hold our common stock, and partners in such partnerships, should consult their tax advisors regarding
the U.S. federal income tax consequences to them of the purchase, ownership, and disposition of our common stock.
You are urged to consult your tax advisor with
respect to the application of the U.S. federal income tax laws to your particular situation, as well as any tax consequences of the purchase,
ownership and disposition of our common stock arising under the U.S. federal estate or gift tax rules or under the laws of any U.S. state
or local or any non-U.S. or other taxing jurisdiction or under any applicable tax treaty.
Definition of a U.S. Holder
For purposes of this summary, a “U.S. Holder”
is any beneficial owner of our common stock that is a “U.S. person,” and is not a partnership, or an entity treated as a partnership
or disregarded from its owner, each for U.S. federal income tax purposes. A U.S. person is any person that, for U.S. federal income tax
purposes, is or is treated as any of the following:
| ● | an
individual who is a citizen or resident of the United States; |
| ● | a
corporation created or organized under the laws of the United States, any state thereof,
or the District of Columbia; |
| ● | an
estate, the income of which is subject to U.S. federal income tax regardless of its source;
or |
| ● | a
trust that (1) is subject to the primary supervision of a U.S. court and the control of one
or more U.S. persons (within the meaning of Section 7701(a)(30) of the Code), or (2) has
a valid election in effect to be treated as a U.S. person for U.S. federal income tax purposes. |
For purposes of this summary, a “Non-U.S.
Holder” is any beneficial owner of our common stock that is not a U.S. Holder or a partnership, or other entity treated as a partnership
or disregarded from its owner, each for U.S. federal income tax purposes.
Treatment of Pre-Funded Warrants
Although it is not entirely free from doubt,
we generally believe a pre-funded warrant should be treated as common stock for U.S. federal income tax purposes and a U.S. Holder
or Non-U.S. Holder of pre-funded warrants should generally be taxed in the same manner as a holder of our common stock, as described
below. Accordingly, no gain or loss should be recognized (other than with respect to cash paid in lieu of a fractional share) upon
the exercise of a pre-funded warrant, and, upon exercise, the holding period of a pre-funded warrant should carry over to the common
stock received. Similarly, the tax basis of the pre-funded warrant should carry over to the common stock received upon exercise,
increased by the exercise price of $0.01 per share. However, our characterization of a pre-funded warrant is not binding on the IRS,
and the IRS may treat our pre-funded warrants as warrants to acquire our common stock. If so, the amount and character of your gain
with respect to an investment in our pre-funded warrants could change. Accordingly, each holder should consult his, her or its own
tax advisor regarding the risks associated with the acquisition of pre-funded warrants pursuant to this offering (including
potential alternative characterizations). The balance of this discussion generally assumes that our characterization described above
is respected for U.S. federal income tax purposes.
Tax Consequences to U.S. Holders
Distributions on Common Stock
As discussed above under “Dividend Policy,”
we do not currently expect to make distributions on our common stock. In the event that we do make distributions of cash or other property,
distributions paid on common stock, other than certain pro rata distributions of common stock, will be treated as a dividend to the extent
paid out of our current or accumulated earnings and profits, if any, and will be includible in income by the U.S. Holder and taxable as
ordinary income when received. If a distribution exceeds our current and accumulated earnings and profits, the excess will be first treated
as a tax-free return of the U.S. Holder’s investment, up to the U.S. Holder’s tax basis in the common stock. Any remaining
excess will be treated as a capital gain. Subject to applicable limitations, dividends paid to certain non-corporate U.S. Holders may
be eligible for taxation as “qualified dividend income” and therefore may be taxable at rates applicable to long-term capital
gains. U.S. Holders should consult their tax advisers regarding the availability of the reduced tax rate on dividends in their particular
circumstances. Dividends received by a corporate U.S. Holder will be eligible for the dividends-received deduction if the U.S. Holder
meets certain holding period and other applicable requirements.
Constructive Distributions on Our Pre-Funded Warrants
Under Section 305 of the Code, an adjustment
to the exercise price or number of shares of common stock that will be issued on the exercise of our pre-funded warrants may be
treated as a constructive distribution to a U.S. Holder of pre-funded warrants if, and to the extent that, such adjustment has the
effect of increasing such U.S. Holder’s proportionate interest in our “earnings and profits” or assets, depending
on the circumstances of such adjustment (for example, if such adjustment is to compensate for a distribution of cash or other
property to holders of our common stock). Adjustments made pursuant to a bona fide reasonable adjustment formula that has the effect
of preventing dilution of the interest of the holder of the pre-funded warrants should generally not result in a constructive
distribution. Any constructive distributions generally would be subject to the tax treatment described under “—Distributions on Common Stock” above.
Sale or Other Disposition of Common Stock
For U.S. federal income tax purposes, gain or
loss realized on the sale or other disposition of common stock will be capital gain or loss, and will be long-term capital gain or loss
if the U.S. Holder held the common stock for more than one year. The amount of the gain or loss will equal the difference between the
amount realized on the disposition and the U.S. Holder’s tax basis in the common stock disposed of. Long-term capital gains recognized
by non-corporate U.S. Holders will be subject to reduced tax rates. The deductibility of capital losses is subject to limitations.
Tax Consequences to Non-U.S. Holders
Distribution
As discussed in the section entitled “Dividend
Policy,” we do not anticipate paying any dividends on our common stock in the foreseeable future. If we make distributions on our
common stock, those payments will constitute dividends for U.S. federal income tax purposes to the extent we have current or accumulated
earnings and profits, as determined under U.S. federal income tax principles. To the extent those distributions exceed both our current
and our accumulated earnings and profits, they will constitute a return of capital and will first reduce a Non-U.S. Holder’s basis
in our common stock, as applicable, but not below zero. Any excess will be treated as capital gain and will be treated as described below
under the “—Gain on Sale or Other Disposition of Common Stock” section. Any such distributions would be subject to the
discussions below regarding back up withholding and the Foreign Account Tax Compliance Act, or FATCA.
Subject to the discussion below on effectively
connected income, any dividend paid to a Non-U.S. Holder generally will be subject to U.S. withholding tax either at a rate of 30% of
the gross amount of the dividend or such lower rate as may be specified by an applicable income tax treaty between the U.S. and such holder’s
country of residence. To receive a reduced treaty rate, a Non-U.S. Holder must provide us or our agent with an IRS Form W-8BEN or W-8
BEN-E (generally including a U.S. taxpayer identification number), or another appropriate version of IRS Form W-8 (or a successor form),
which must be updated periodically, and which, in each case, must certify qualification for the reduced treaty rate. Non-U.S. Holders
should consult their tax advisors regarding their entitlement to benefits under any applicable income tax treaty.
Dividends paid to a Non-U.S. Holder that are effectively
connected with the Non-U.S. Holder’s conduct of a trade or business within the United States and that are not eligible for relief
from U.S. (net basis) income tax under an applicable income tax treaty, generally are exempt from the (gross basis) withholding tax described
above. To obtain this exemption from withholding tax, the Non-U.S. Holder must provide the applicable withholding agent with an IRS Form
W-8ECI or successor form or other applicable IRS Form W-8 certifying that the dividends are effectively connected with the Non-U.S. Holder’s
conduct of a trade or business within the United States. Such effectively connected dividends, if not eligible for relief under a tax
treaty, would not be subject to a withholding tax, but would be taxed at the same rates applicable to U.S. persons, net of certain
deductions and credits and if, in addition, the Non-U.S. Holder is a corporation, may also be subject to a branch profits tax at a rate
of 30% (or such lower rate as may be specified by an applicable income tax treaty)
If you are eligible for a reduced rate of withholding
tax pursuant to a tax treaty, you may be able to obtain a refund of any excess amounts withheld if you timely file an appropriate claim
for refund with the IRS.
As described under “Tax Consequences to
U.S. Holders —Constructive Distributions on Our Pre-Funded Warrants” above, an adjustment to the pre-funded warrants
could result in a constructive distribution to a Non-U.S. Holder, which would be treated as described above in this section. Any
resulting withholding tax attributable to deemed dividends would be collected from other amounts payable or distributable to the
Non-U.S. Holder. Non-U.S. Holders should consult their tax advisors regarding the proper treatment of any adjustments to the
pre-funded warrants.
Gain on Sale or Other Disposition
of Common Stock
Subject to the discussion below regarding backup
withholding and FATCA, a Non-U.S. Holder generally will not be required to pay U.S. federal income tax on any gain realized upon the sale
or other disposition of our common stock unless:
| ● | the
gain is effectively connected with the Non-U.S. Holder’s conduct of a trade or business within the United States and not eligible
for relief under an applicable income tax treaty, in which case the Non-U.S. Holder will be required to pay tax on the net gain derived
from the sale under regular U.S. federal income tax rates applicable to U.S. persons, and for a Non-U.S. Holder that is a corporation,
such Non-U.S. Holder may be subject to the branch profits tax at a 30% rate (or such lower rate as may be specified by an applicable
income tax treaty) on such effectively connected gain, as adjusted for certain items; |
| ● | the
Non-U.S. Holder is an individual who is present in the United States for a period or periods
aggregating 183 days or more during the calendar year in which the sale or disposition occurs
and certain other conditions are met, in which case the Non-U.S. Holder will be required
to pay a flat 30% tax on the gain derived from the sale, which tax may be offset by U.S.
source capital losses (even though the Non-U.S. Holder is not considered a resident of the
United States) (subject to applicable income tax or other treaties); or |
| ● | we
are a “U.S. real property holding corporation” for U.S. federal income tax purposes, or a USRPHC, at any time within the
shorter of the five-year period preceding the disposition or the Non-U.S. Holder’s holding period for our common stock. We believe
we are not currently and do not anticipate becoming a USRPHC. However, because the determination of whether we are a USRPHC depends on
the fair market value of our United States real property interests relative to the fair market value of our other business assets, there
can be no assurance that we will not become a USRPHC in the future. Even if we become a USRPHC, however, gain arising from the sale or
other taxable disposition by a Non-U.S. Holder of our common stock will not be subject to United States federal income tax if (a) shares
of our common stock are “regularly traded,” as defined by applicable Treasury Regulations, on an established securities market,
such as the Nasdaq Global Market, and (b) the Non-U.S. Holder owns or owned, actually and constructively, 5% or less of the shares of
our common stock throughout the five-year period ending on the date of the sale or exchange. If the foregoing exception does not apply,
such Non-U.S. Holder’s proceeds received on the disposition of shares will generally be subject to withholding at a rate of 15%
and such Non-U.S. Holder will generally be taxed on any gain in the same manner as gain that is effectively connected with the conduct
of a U.S. trade or business, except that the branch profits tax generally will not apply. Non-U.S. Holders of pre-funded warrants should
consult their tax advisors regarding the application of these rules with respect to the pre-funded warrants (which are not expected to
be “regularly traded” on an established securities market). |
Information Reporting and Backup Withholding
Information returns may be filed with the IRS
in connection with distributions on common stock, and the proceeds of a sale or other disposition of common stock. A non-exempt U.S.
Holder may be subject to U.S. backup withholding on these payments if it fails to provide its taxpayer identification number to the withholding
agent and comply with certification procedures or otherwise establish an exemption from backup withholding.
A Non-U.S. Holder may be subject to U.S. information
reporting and backup withholding on these payments unless the Non-U.S. Holder complies with certification procedures to establish that
it is not a U.S. person (within the meaning of the Code). The certification requirements generally will be satisfied if the Non-U.S. Holder
provides the applicable withholding agent with a statement on the applicable IRS Form (or a suitable substitute or successor form), together
with all appropriate attachments, signed under penalties of perjury, stating, among other things, that such Non-U.S. Holder is not a U.S.
person. Applicable Treasury Regulations provide alternative methods for satisfying this requirement. In addition, the amount of distributions
on common stock paid to a Non-U.S. Holder, and the amount of any U.S. federal tax withheld therefrom, must be reported annually to the
IRS and the holder. This information may be made available by the IRS under the provisions of an applicable tax treaty or agreement to
the tax authorities of the country in which the Non-U.S. Holder resides.
Payment of the proceeds of the sale or other disposition
of common stock to or through a non-U.S. office of a U.S. broker or of a non-U.S. broker with certain specified U.S. connections generally
will be subject to information reporting requirements, but not backup withholding, unless the Non-U.S. Holder certifies under penalties
of perjury that it is not a U.S. person or an exemption otherwise applies. Payments of the proceeds of a sale or other disposition of
common stock to or through a U.S. office of a broker generally will be subject to information reporting and backup withholding, unless
the Non-U.S. Holder certifies under penalties of perjury that it is not a U.S. person or otherwise establishes an exemption.
Backup withholding is not an additional tax.
The amount of any backup withholding from a payment generally will be allowed as a credit against the holder’s U.S. federal income
tax liability and may entitle the holder to a refund, provided that the required information is timely furnished to the IRS.
Foreign Account
The Code generally imposes a U.S. federal withholding
tax of 30% on dividends and, subject to the discussion below regarding proposed regulations issued by the U.S. Treasury Department, the
gross proceeds of a disposition of securities paid to a “foreign financial institution” (as specifically defined for this
purpose), unless such institution enters into an agreement with the U.S. government to, among other things, withhold on certain payments
and to collect and provide to the U.S. tax authorities substantial information regarding U.S. account holders of such institution (which
includes certain equity and debt holders of such institution, as well as certain account holders that are foreign entities with U.S. owners)
or otherwise qualifies for an exemption from these rules. A U.S. federal withholding tax of 30% also applies to dividends and, subject
to the discussion below regarding proposed regulations issued by the U.S. Treasury Department, will apply to the gross proceeds of a disposition
of securities paid to a non-financial foreign entity (as defined in the Code), unless such entity either provides the withholding agent
with a certification that it does not have any substantial direct or indirect “United States owners” (as defined in the Code)
or provides information regarding each substantial United States owners of the entity, or otherwise qualifies for an exemption from these
rules.
Under certain circumstances, a Non-U.S. Holder
might be eligible for refunds or credits of such taxes. An intergovernmental agreement between the United States and an applicable foreign
country may modify the requirements described in the paragraph above.
The U.S. Treasury Department released proposed
regulations which, if finalized in their present form, would eliminate the federal withholding tax of 30% applicable to the gross proceeds
of a sale or other disposition of our common stock. In its preamble to such proposed regulations, the U.S. Treasury Department stated
that taxpayers may generally rely on the proposed regulations until final regulations are issued. Prospective investors should consult
their own tax advisors regarding the possible impact of these rules on their investment in our common stock, and the possible impact of
these rules and the proposed regulations on the entities through which they hold our common stock, including, without limitation, the
process and deadlines for meeting the applicable requirements to prevent the imposition of this 30% withholding tax.
EACH PROSPECTIVE INVESTOR SHOULD CONSULT ITS
TAX ADVISOR REGARDING THE PARTICULAR U.S. FEDERAL, STATE AND LOCAL AND NON-U.S. TAX CONSEQUENCES OF PURCHASING, HOLDING AND
DISPOSING OF OUR SECURITIES, INCLUDING THE CONSEQUENCES OF ANY PROPOSED OR OTHER CHANGE IN APPLICABLE LAWS.
UNDERWRITING
Leerink Partners LLC, Raymond James & Associates,
Inc. and RBC Capital Markets, LLC are acting as representatives of each of the underwriters named below and as joint bookrunning managers
for this offering. Subject to the terms and conditions set forth in the underwriting agreement among us and the underwriters, we have
agreed to sell to the underwriters, and each of the underwriters has agreed, severally and not jointly, to purchase from us, the number
of shares of common stock and pre-funded warrants set forth opposite its name below.
Underwriter | |
Number of Shares | | |
Number of Pre-Funded Warrants | |
Leerink Partners LLC | |
| 3,284,381 | | |
| 1,528,999 | |
Raymond James & Associates, Inc. | |
| 1,658,778 | | |
| 772,222 | |
RBC Capital Markets, LLC | |
| 895,740 | | |
| 417,000 | |
Wedbush Securities Inc. | |
| 796,213 | | |
| 370,667 | |
Total | |
| 6,635,112 | | |
| 3,088,888 | |
Subject to the terms and conditions set forth
in the underwriting agreement, the underwriters have agreed, severally and not jointly, to purchase all of the shares and pre-funded warrants
sold under the underwriting agreement if any of the shares or pre-funded warrants are purchased. If an underwriter defaults, the underwriting
agreement provides that the purchase commitments of the non-defaulting underwriters may be increased or the underwriting agreement may
be terminated.
We have agreed to indemnify the underwriters against
certain liabilities, including liabilities under the Securities Act, or to contribute to payments the underwriters may be required to
make in respect of those liabilities.
BMO Capital Markets Corp. is acting as a capital
markets advisor to us in connection with this offering, and will receive a fee for acting in such capacity. BMO Capital Markets Corp.
will not engage in, nor is affiliated with any FINRA member that is engaging in, the solicitation or distribution of the offering.
The underwriters are offering the shares and pre-funded
warrants, subject to prior sale, when, as and if issued to and accepted by them, subject to approval of legal matters by their counsel,
including the validity of the shares and pre-funded warrants, and subject to other conditions contained in the underwriting agreement,
such as the receipt by the underwriters of officers’ certificates and legal opinions. The underwriters reserve the right to withdraw,
cancel or modify offers to the public and to reject orders in whole or in part.
Discounts and Commissions
The representatives have advised us that the underwriters
propose initially to offer the shares and pre-funded warrants to the public at the public offering price set forth on the cover page of
this prospectus supplement and to dealers at that price less a concession not in excess of $0.648 per
share and $0.648 per pre-funded warrant. After the initial offering
of the shares and pre-funded warrants, the public offering price, concession or any other term of this offering may be changed by the
representatives.
The following table shows the public offering
price, underwriting discounts and commissions and proceeds, before expenses, to us. The information assumes either no exercise or full
exercise by the underwriters of their option to purchase additional shares of our common stock.
| |
| | |
Per Pre- | | |
Total | |
| |
Per Share | | |
Funded Warrant | | |
Without Option | | |
With Option | |
Public offering price | |
$ | 18.00 | | |
$ | 17.99 | | |
$ | 175,001,111.12 | | |
$ | 201,255,911 | |
Underwriting discounts and commissions | |
$ | 1.08 | | |
$ | 1.08 | | |
$ | 10,501,920.00 | | |
$ | 12,077,208 | |
Proceeds, before expenses, to us | |
$ | 16.92 | | |
$ | 16.91 | | |
$ | 164,499,191.12 | | |
$ | 189,178,703 | |
We estimate expenses payable by us in connection
with this offering, other than the underwriting discounts and commissions referred to above, will be approximately $1.4 million.
We have also agreed to reimburse the underwriters for certain of their expenses in an amount up to $25,000. The underwriters have also
agreed to reimburse us for certain expenses.
Option to Purchase Additional Shares
We have granted an option to the
underwriters, exercisable for 30 days after the date of this prospectus supplement, to purchase up
to 1,458,600 additional shares at the
public offering price, less underwriting discounts and commissions. If the underwriters exercise this option, each underwriter will
be obligated, subject to the conditions contained in the underwriting agreement, to purchase a number of additional shares
proportionate to that underwriter’s initial amount reflected in the above table.
No Sales of Similar Securities
We and our executive officers and directors have
agreed not to sell or transfer any common stock or securities convertible into or exchangeable or exercisable for common stock, for 60
days after the date of this prospectus supplement without first obtaining the written consent of Leerink Partners LLC and Raymond James
& Associates, Inc. on behalf of the underwriters. Specifically, we and these other persons have agreed, with certain limited exceptions,
not to directly or indirectly:
| ● | offer,
pledge, sell or contract to sell any common stock; |
| ● | sell
any option or contract to purchase any common stock; |
| ● | purchase
any option or contract to sell any common stock; |
| ● | grant
any option, right or warrant for the sale of any common stock; |
| ● | otherwise
dispose of or transfer any common stock; |
| ● | request
or demand that we file a registration statement related to the common stock; or |
| ● | enter
into any swap or other agreement or any transaction that transfers, in whole or in part,
the economic consequence of ownership of any common stock, whether any such swap, agreement
or transaction is to be settled by delivery of shares or other securities, in cash or otherwise. |
The lock-up provisions apply to common stock
and to securities convertible into or exchangeable or exercisable for common stock. They also apply to common stock owned now or acquired
later by the person executing the lock-up agreement or for which the person executing the lock-up agreement later acquires the power
of disposition. The lock-up restrictions will not apply to issuance of common stock upon the exercise of the pre-funded warrant during
the 60-day period.
Nasdaq Global Market Listing
Our common stock is listed on the Nasdaq Global
Market under the symbol “XNCR.” There is no established public trading market for the pre-funded warrants, and we do not expect
a market to develop. We do not intend to list the pre-funded warrants on the Nasdaq Global Market or any other national securities exchange
or nationally recognized trading system.
Price Stabilization, Short Positions and Penalty Bids
Until the distribution of the shares is completed,
SEC rules may limit underwriters and selling group members from bidding for and purchasing our common stock. However, the representatives
may engage in transactions that stabilize the price of the common stock, such as bids or purchases to peg, fix or maintain that price.
In connection with this offering, the underwriters
may purchase and sell our common stock in the open market. These transactions may include short sales, purchases on the open market to
cover positions created by short sales and stabilizing transactions. Short sales involve the sale by the underwriters of a greater number
of shares than they are required to purchase in this offering. “Covered” short sales are sales made in an amount not greater
than the underwriters’ option to purchase additional shares described above. The underwriters may close out any covered short position
by either exercising their option to purchase additional shares or purchasing shares in the open market. In determining the source of
shares to close out the covered short position, the underwriters will consider, among other things, the price of shares available for
purchase in the open market as compared to the price at which they may purchase shares through the option to purchase additional shares
granted to them under the underwriting agreement described above. “Naked” short sales are sales in excess of such option.
The underwriters must close out any naked short position by purchasing shares in the open market. A naked short position is more likely
to be created if the underwriters are concerned that there may be downward pressure on the price of our common stock in the open market
after pricing that could adversely affect investors who purchase in this offering. Stabilizing transactions consist of various bids for
or purchases of shares of common stock made by the underwriters in the open market prior to the closing of this offering.
The underwriters may also impose a penalty bid.
This occurs when a particular underwriter repays to the underwriters a portion of the underwriting discount received by it because the
representatives have repurchased shares sold by or for the account of such underwriter in stabilizing or short covering transactions.
Similar to other purchase transactions, the underwriters’
purchases to cover the syndicate short sales may have the effect of raising or maintaining the market price of our common stock or preventing
or retarding a decline in the market price of our common stock. As a result, the price of our common stock may be higher than the price
that might otherwise exist in the open market. The underwriters may conduct these transactions on the Nasdaq Global Market, in the over-the-counter
market or otherwise.
Neither we nor any of the underwriters make any
representation or prediction as to the direction or magnitude of any effect that the transactions described above may have on the price
of our common stock. In addition, neither we nor any of the underwriters make any representation that the representatives will engage
in these transactions or that these transactions, once commenced, will not be discontinued without notice.
Electronic Distribution
In connection with this offering, certain of the
underwriters or securities dealers may distribute prospectuses by electronic means, such as e-mail.
Other Relationships
The underwriters and certain of their affiliates
are full service financial institutions engaged in various activities, which may include securities trading, commercial and investment
banking, financial advisory, investment management, investment research, principal investment, hedging, financing and brokerage activities.
Some of the underwriters and certain of their affiliates may in the future engage in investment banking and other commercial dealings
in the ordinary course of business with us and our affiliates, for which they may in the future receive customary fees, commissions and
expenses.
Leerink Partners LLC is the agent under the Sales
Agreement, pursuant to which we may offer and sell up to $200.0 million of shares of our common stock remaining available for sale by
us under the Sales Agreement after the expiration or waiver of the lock-up period applicable to us and described above.
In addition, in the ordinary course of their business
activities, the underwriters and their affiliates may make or hold a broad array of investments and actively trade debt and equity securities
(or related derivative securities) and financial instruments (including bank loans) for their own account and for the accounts of their
customers. Such investments and securities activities may involve securities and/or instruments of ours or our affiliates. The underwriters
and their affiliates may also make investment recommendations and/or publish or express independent research views in respect of such
securities or financial instruments and may hold, or recommend to clients that they acquire, long and/or short positions in such securities
and instruments.
Selling Restrictions
Notice to Prospective Investors in the European Economic Area
In relation to each Member State of the European
Economic Area (each, a “Relevant State”), no securities have been offered or will be offered pursuant to the offering to the
public in that Relevant State prior to the publication of a prospectus in relation to the securities which has been approved by the competent
authority in that Relevant State or, where appropriate, approved in another Relevant State and notified to the competent authority in
that Relevant State, all in accordance with the Prospectus Regulation, except that securities may be offered to the public in that Relevant
State at any time:
| A. | to any legal entity which is a qualified investor as defined
under Article 2 of the Prospectus Regulation; |
| B. | to fewer than 150 natural or legal persons (other than qualified investors as defined under Article 2 of the Prospectus Regulation),
subject to obtaining the prior consent of the representatives for any such offer; or |
| C. | in any other circumstances falling within Article 1(4) of the Prospectus Regulation, |
provided that no such offer of securities shall require us or
any of the representatives to publish a prospectus pursuant to Article 3 of the Prospectus Regulation or supplement a prospectus pursuant
to Article 23 of the Prospectus Regulation.
For the purposes of this provision, the expression
an “offer to the public” in relation to any securities in any Relevant State means the communication in any form and by any
means of sufficient information on the terms of the offer and any securities to be offered so as to enable an investor to decide to purchase
or subscribe for any securities, and the expression “Prospectus Regulation” means Regulation (EU) 2017/1129, as amended.
Notice to Prospective Investors in the United Kingdom
No securities have been offered or will be offered
pursuant to the offering to the public in the United Kingdom prior to the publication of a prospectus in relation to the securities which
has been approved by the Financial Conduct Authority, except that the securities may be offered to the public in the United Kingdom at
any time:
| A. | to any legal entity which is a qualified investor as defined under Article 2 of the UK Prospectus Regulation; |
| B. | to fewer than 150 natural or legal persons (other than qualified investors as defined under Article 2 of the UK Prospectus Regulation),
subject to obtaining the prior consent of the representatives for any such offer; or |
| C. | in any other circumstances falling within Section 86 of the Financial Services and Markets Act 2000 (FMSA), |
provided that no such offer of the securities shall require
us or any representative to publish a prospectus pursuant to Section 85 of the FSMA or supplement a prospectus pursuant to Article
23 of the UK Prospectus Regulation. For the purposes of this provision, the expression an “offer to the public” in relation
to the securities in the United Kingdom means the communication in any form and by any means of sufficient information on the terms of
the offer and any securities to be offered so as to enable an investor to decide to purchase or subscribe for any securities and the expression
“UK Prospectus Regulation” means Regulation (EU) 2017/1129 as it forms part of domestic law by virtue of the European Union
(Withdrawal) Act 2018.
Notice to Prospective Investors in Canada
The securities may be sold only to purchasers
purchasing, or deemed to be purchasing, as principal that are accredited investors, as defined in National Instrument 45-106 Prospectus
Exemptions or subsection 73.3(1) of the Securities Act (Ontario), and are permitted clients, as defined in National Instrument 31-103 Registration
Requirements, Exemptions and Ongoing Registrant Obligations. Any resale of the securities must be made in accordance with an exemption
from, or in a transaction not subject to, the prospectus requirements of applicable securities laws.
Securities legislation in certain provinces or
territories of Canada may provide a purchaser with remedies for rescission or damages if this prospectus supplement (including any amendment
thereto) contains a misrepresentation, provided that the remedies for rescission or damages are exercised by the purchaser within the
time limit prescribed by the securities legislation of the purchaser’s province or territory. The purchaser should refer to any
applicable provisions of the securities legislation of the purchaser’s province or territory for particulars of these rights or
consult with a legal advisor.
Pursuant to section 3A.3 of National Instrument 33-105 Underwriting
Conflicts (NI 33-105), the underwriters are not required to comply with the disclosure requirements of NI 33-105 regarding
underwriter conflicts of interest in connection with this offering.
Notice to Prospective Investors in Israel
In the State of Israel this prospectus supplement
shall not be regarded as an offer to the public to purchase securities under the Israeli Securities Law, 5728—1968, which requires
a prospectus to be published and authorized by the Israel Securities Authority, if it complies with certain provisions of Section 15 of
the Israeli Securities Law, 5728–1968, including, inter alia, if: (i) the offer is made, distributed or directed to not more than
35 investors, subject to certain conditions, or the Addressed Investors; or (ii) the offer is made, distributed or directed to certain
qualified investors defined in the First Addendum of the Israeli Securities Law, 5728—1968, subject to certain conditions, or the
“Qualified Investors”. The Qualified Investors shall not be taken into account in the count of the Addressed Investors and
may be offered to purchase securities in addition to the 35 Addressed Investors. We have not and will not take any action that would require
it to publish a prospectus in accordance with and subject to the Israeli Securities Law, 5728—1968. We have not and will not distribute
this prospectus supplement or make, distribute or direct an offer to subscribe for our securities to any person within the State of Israel,
other than to Qualified Investors and up to 35 Addressed Investors.
Qualified Investors may have to submit written
evidence that they meet the definitions set out in of the First Addendum to the Israeli Securities Law, 5728—1968. In particular,
we may request, as a condition to be offered securities, that Qualified Investors will each represent, warrant and certify to us and/or
to anyone acting on our behalf: (i) that it is an investor falling within one of the categories listed in the First Addendum to the Israeli
Securities Law, 5728—1968; (ii) which of the categories listed in the First Addendum to the Israeli Securities Law, 5728—1968
regarding Qualified Investors is applicable to it; (iii) that it will abide by all provisions set forth in the Israeli Securities Law,
5728—1968 and the regulations promulgated thereunder in connection with the offer to be issued securities; (iv) that the securities
that it will be issued are, subject to exemptions available under the Israeli Securities Law, 5728—1968: (a) for its own account;
(b) for investment purposes only; and (c) not issued with a view to resale within the State of Israel, other than in accordance with the
provisions of the Israeli Securities Law, 5728—1968; and (v) that it is willing to provide further evidence of its Qualified Investor
status. Addressed Investors may have to submit written evidence in respect of their identity and may have to sign and submit a declaration
containing, inter alia, the Addressed Investor’s name, address and passport number or Israeli identification number.
LEGAL MATTERS
The validity of the securities offered by this
prospectus supplement will be passed upon for us by Paul Hastings LLP, San Diego, California. Certain legal matters in connection with
this offering will be passed upon for the underwriters by Latham & Watkins LLP, San Diego, California.
EXPERTS
The consolidated financial statements of Xencor, Inc. as of December 31, 2023 and 2022 and for each of the years in the three-year period
ended December 31, 2023 and the effectiveness of internal control over financial reporting as of December 31, 2023 incorporated in this
prospectus supplement by reference from the Xencor, Inc. Annual Report on Form 10-K for the year ended December 31, 2023 have been audited
by RSM US LLP, an independent registered public accounting firm, as stated in their reports thereon, incorporated herein by reference,
and have been incorporated and included in this prospectus supplement and Registration Statement in reliance upon such reports and upon
the authority of such firm as experts in accounting and auditing.
WHERE YOU CAN FIND MORE INFORMATION
We file annual, quarterly and current reports,
proxy statements and other information with the SEC. The SEC maintains an Internet website at www.sec.gov that contains
reports, proxy and information statements, and other information regarding issuers that file electronically with the SEC, including Xencor.
You may also access our reports and proxy statements free of charge at our Internet website, www.xencor.com. The information
contained in, or that can be accessed through, our website is not part of this prospectus supplement and the accompanying base prospectus.
This prospectus supplement and the accompanying base prospectus included in this filing is part of a registration statement filed by us
with the SEC. The full registration statement can be obtained from the SEC, as indicated above, or from us.
This prospectus supplement is part of a registration
statement on Form S-3 we filed with the SEC relating to the securities to be offered. This prospectus supplement does not contain all
of the information we have included in the registration statement and the accompanying exhibits and schedules in accordance with the rules
and regulations of the SEC, and we refer you to the omitted information. The statements this prospectus supplement makes pertaining to
the content of any contract, agreement or other document that is an exhibit to the registration statement necessarily are summaries of
their material provisions and do not describe all exceptions and qualifications contained in those contracts, agreements or documents.
You should read those contracts, agreements or documents for information that may be important to you. The registration statement, exhibits
and schedules are available at the SEC’s Internet website.
You should rely only on information in this prospectus
supplement or incorporated by reference herein. We have not authorized any person to provide you with different information. We are not
making an offer of these securities in any state where the offer is not permitted. You should not assume that the information in this
prospectus supplement is accurate as of any date other than the date of the front page of this prospectus supplement, regardless of the
time of delivery of this prospectus supplement or any sale of the securities offered by this prospectus supplement.
INFORMATION INCORPORATED BY REFERENCE
The SEC allows us to “incorporate by reference”
information into this prospectus supplements, which means that we can disclose important information to you by referring you to another
document filed separately with the SEC. The documents incorporated by reference into this prospectus supplement contain important information
that you should read about us.
The following documents are incorporated by reference
into this prospectus supplement:
|
(a) |
Our Annual Report on Form
10-K for the fiscal year ended December 31, 2023, filed with the SEC on February 29, 2024; |
|
|
|
|
(b) |
The information specifically incorporated by reference into our Annual Report on Form 10-K for the
fiscal year ended December 31, 2023 from our Definitive Proxy Statement on Schedule 14A, filed with the SEC on April 24, 2024; |
|
|
|
|
(c) |
Our Quarterly Report on Form 10-Q for the quarter ended March 31, 2024, filed with the SEC on May
9, 2024; |
|
|
|
|
(d) |
Our Quarterly Report on Form 10-Q for the quarter ended June 30, 2024, filed with the SEC on August
5, 2024; |
|
|
|
|
(e) |
Our Current Reports on Form
8-K filed with the SEC on (i) November 7, 2023, (ii) April
9, 2024, (iii) June 13, 2024,
(iv) June 14, 2024 and (v) September 9, 2024 (other than the Item 7.01 and Exhibit 99.1); |
|
|
|
|
(f) |
the description of our common stock contained in our Registration Statement on Form 8-A (File
No. 001-36182), filed under Section 12(b) of the Exchange Act on November 7, 2013, including any subsequent amendment or report
filed for the purpose of amending such description, including the description of common stock contained in Exhibit 4.3 of our Annual
Report on Form 10-K for the fiscal year ended December 31, 2019, filed with the SEC on February 25, 2020. |
We also incorporate by reference any future filings
(other than current reports furnished under Item 2.02 or Item 7.01 of Form 8-K and exhibits filed on such form that are related to such
items unless such Form 8-K expressly provides to the contrary) made with the SEC pursuant to Sections 13(a), 13(c), 14 or 15(d) of the
Exchange Act, including those made after the date of the initial filing of the registration statement of which this prospectus supplement
is a part, until we file a post-effective amendment that indicates the termination of the offering of the securities made by this prospectus
supplement and will become a part of this prospectus supplement from the respective dates that such documents are filed with the SEC.
Any statement contained herein or in a document incorporated, or deemed to be incorporated, by reference herein shall be deemed to be
modified or superseded to the extent that a statement contained herein or in any other subsequently filed document that also is, or is
deemed to be, incorporated by reference herein modifies or supersedes such statement. Any such statement so modified or superseded shall
not be deemed, except as so modified or superseded, to constitute a part of this prospectus supplement.
Documents incorporated by reference are available
from us, without charge. You may obtain documents incorporated by reference in this prospectus supplement by requesting them in writing
or by telephone at the following address:
Xencor, Inc.
465 North Halstead Street, Suite 200
Pasadena, California 91107
Telephone Number: (626) 305-5900
PROSPECTUS
Xencor, Inc.
Common Stock
Preferred Stock
Debt Securities
Warrants
Rights
Units
From time to time, we may offer and sell any combination
of the securities described in this prospectus, either individually or in combination with other securities, in one or more offerings.
We may also offer common stock or preferred stock upon conversion of debt securities, common stock upon conversion of preferred stock,
or common stock, preferred stock or debt securities upon the exercise of warrants, rights or units. In addition, certain selling security
holders to be identified in supplements to this prospectus may offer and sell these securities from time to time.
This prospectus provides a general description of
the securities we may offer. Each time we sell securities pursuant to this prospectus, we will provide the specific terms of these offerings
and securities in one or more supplements to this prospectus. We may also authorize one or more free writing prospectuses to be provided
to you in connection with these offerings. The prospectus supplement and any related free writing prospectus may also add, update or change
information contained in this prospectus. You should carefully read this prospectus, the applicable prospectus supplement and any related
free writing prospectus, as well as any documents incorporated by reference herein or therein before you invest in any of the securities
being offered.
Our common stock is listed on The Nasdaq Global
Market under the trading symbol “XNCR.” On February 24, 2023, the last reported sale price of our common stock was $34.18
per share. The applicable prospectus supplement will contain information, where applicable, as to other listings, if any, on The Nasdaq
Global Market or other securities exchange of the securities covered by the applicable prospectus supplement.
Investing in our securities involves a high
degree of risk. You should review carefully the risks and uncertainties described under the heading “Risk Factors” on page
3 of this prospectus and contained in the applicable prospectus supplement and in any free writing prospectuses we have authorized for
use in connection with a specific offering, and under similar headings in the documents that are incorporated by reference into this prospectus.
This prospectus may not be used to consummate a
sale of securities unless accompanied by a prospectus supplement.
The securities may be offered and sold from time
to time directly to investors by us or by any selling security holder, through agents designated by us or to or through underwriters,
brokers or dealers, on a continuous or delayed basis. If applicable, we will provide specific information about any selling security holders
in one or more supplements to this prospectus. For additional information on the methods of sale, you should refer to the section entitled
“Plan of Distribution” in this prospectus. If any agents, underwriters, brokers or dealers are involved in the sale of any
securities with respect to which this prospectus is being delivered, the names of such agents, underwriters, brokers or dealers and any
applicable fees, commissions, discounts and over allotment options will be set forth in a prospectus supplement or a related free writing
prospectus. The price to the public of such securities and the net proceeds we expect to receive from such sale will also be set forth
in a prospectus supplement or a related free writing prospectus.
Neither the Securities and Exchange Commission
nor any state securities commission has approved or disapproved of these securities or determined if this prospectus is truthful or complete.
Any representation to the contrary is a criminal offense.
The date of this prospectus is February 27,
2023.
TABLE OF CONTENTS
ABOUT THIS PROSPECTUS
This prospectus is part of an automatic shelf registration
statement on Form S-3 that we filed with the Securities and Exchange Commission (the “SEC”), as a “well-known seasoned
issuer” as defined in Rule 405 under the Securities Act of 1933, as amended (the “Securities Act”), utilizing a
“shelf” registration process. Under this shelf registration process, we may offer and sell shares of our common stock, shares
of our preferred stock, various series of debt securities and warrants or rights to purchase any of such securities, either individually
or in combination with other securities described in this prospectus or in units, in one or more offerings. There is no limit on the aggregate
amount of the securities that we may offer pursuant to the registration statement of which this prospectus is a part. In addition, selling
security holders to be named in a prospectus supplement may sell certain of our securities from time to time. This prospectus provides
you with a general description of the securities we may offer.
Each time we or any selling security holder offer
securities under this prospectus, we or the selling security holder will provide a prospectus supplement that will contain more specific
information about the terms of that offering. We may also authorize one or more free writing prospectuses to be provided to you that may
contain material information relating to these offerings. The prospectus supplement and any related free writing prospectus that we may
authorize to be provided to you may also add, update or change any of the information contained in this prospectus or in any documents
that we have incorporated by reference into this prospectus. To the extent that any statement that we make in a prospectus supplement
is inconsistent with statements made in this prospectus, the statement made in this prospectus will be deemed modified or superseded by
those made in the prospectus supplement. We urge you to read carefully this prospectus, any applicable prospectus supplement and any related
free writing prospectuses we have authorized for use in connection with a specific offering, together with the information incorporated
herein by reference as described under the heading “Where You Can Find More Information” and “Incorporation of Certain
Information by Reference,” before buying any of the securities being offered.
This prospectus may not be used to consummate
a sale of securities unless it is accompanied by a prospectus supplement.
You should rely only on the information that we
have provided or incorporated by reference in this prospectus, any applicable prospectus supplement and any related free writing prospectus
that we may authorize to be provided to you. We have not authorized anyone to provide you with any information or to make any representations
other than those contained in this prospectus, any applicable prospectus supplement or any related free writing prospectuses prepared
by or on behalf of us or to which we have referred you. We take no responsibility for, and can provide no assurance as to the reliability
of, any other information that others may give you. This prospectus is an offer to sell only the securities offered hereby, but only under
circumstances and in jurisdictions where it is lawful to do so.
You should not assume that the information appearing
in this prospectus, any applicable prospectus supplement or any related free writing prospectus is accurate on any date subsequent to
the date set forth on the front of the document or that any information we have incorporated by reference herein or therein is correct
on any date subsequent to the date of the document incorporated by reference, regardless of the time of delivery of this prospectus, the
applicable prospectus supplement or any related free writing prospectus, or any sale of a security. Our business, financial condition,
results of operations and prospects may have changed since those dates.
This prospectus contains summaries of certain provisions
contained in some of the documents described herein, but reference is made to the actual documents for complete information. All of the
summaries are qualified in their entirety by the actual documents. Copies of some of the documents referred to herein have been filed,
will be filed or will be incorporated by reference as exhibits to the registration statement of which this prospectus is a part, and you
may obtain copies of those documents as described below under the section entitled “Where You Can Find More Information.”
Unless the context requires otherwise, references
in this prospectus to “Xencor,” “we,” “us” and “our” refer to Xencor, Inc.
PROSPECTUS SUMMARY
This summary highlights selected information
contained elsewhere in this prospectus or incorporated by reference in this prospectus, and does not contain all of the information that
you need to consider in making your investment decision. You should carefully read the entire prospectus, the applicable prospectus supplement
and any related free writing prospectus, including the risks of investing in our securities discussed under the heading “Risk Factors”
contained in the applicable prospectus supplement and any related free writing prospectus, and under similar headings in the other documents
that are incorporated by reference into this prospectus. You should also carefully read the information incorporated by reference into
this prospectus, including our financial statements, and the exhibits to the registration statement of which this prospectus is a part.
Xencor, Inc.
We are a clinical-stage biopharmaceutical company
focused on discovering and developing engineered monoclonal antibody and cytokine therapeutics to treat patients with cancer and autoimmune
diseases who have unmet medical needs. We use our protein engineering capabilities to increase our understanding of protein structures
and interactions and to design new technologies and XmAb® drug candidates with improved properties. We advance these candidates into
clinical-stage development, where we are conducting Phase 1 and Phase 2 studies for a broad portfolio of programs, to determine which
programs we advance into later stages of development and potentially commercialization, which programs we partner to access complementary
resources to optimize development, or which programs we terminate.
Our approach to protein design includes engineering
Fc domains, the parts of antibodies that interact with multiple segments of the immune system and controls antibody structural architecture.
The Fc domain is constant and interchangeable among antibodies, and our engineered XmAb Fc domains can be readily substituted for natural
Fc domains.
Our protein engineering capabilities and Fc technologies
enable us and our partners to develop XmAb antibodies and biotherapeutic drug candidates with improved properties and functionality, which
can provide innovative approaches to treating disease and potential clinical advantage over other treatment options. For example, we have
developed an antibody scaffold to rapidly create novel multi-specific antibodies that bind two or more different targets simultaneously,
creating entirely new biological mechanisms. Other applications of our protein engineering technologies enhance antibody performance by
increasing immune inhibitory activity, improving cytotoxicity, extending circulating half-life and stabilizing novel protein structures,
such as engineered cytokines. Three marketed XmAb medicines have been developed with our protein engineering technologies and are generating
royalties for us.
Our Corporate Information
We were incorporated in California in August 1997
under the name Xencor. In September 2004, we reincorporated in the State of Delaware under the name Xencor, Inc. Our principal executive
offices are located at 111 West Lemon Avenue, Monrovia, CA 91016, and our telephone number is (626) 305-5900. Our website address is www.xencor.com.
Information found on, or accessible through, our website is not a part of, and is not incorporated into, this prospectus, and you should
not consider it part of this prospectus or part of any prospectus supplement. Our website address is included in this prospectus as an
inactive textual reference only.
Description of Securities
We may offer shares of our common stock and preferred
stock, various series of debt securities and warrants or rights to purchase any of such securities, either individually or in combination
with other securities or in units, from time to time under this prospectus, together with the applicable prospectus supplement and
any related free writing prospectus, at prices and on terms to be determined by market conditions at the time of any offering. This prospectus
provides you with a general description of the securities we may offer. Each time we offer a type or series of securities under this prospectus,
we will provide a prospectus supplement that will describe the specific amounts, prices and other important terms of the securities, including,
to the extent applicable:
| ● | designation or classification; |
| ● | aggregate principal amount or aggregate offering price; |
| ● | maturity date, if applicable; |
| ● | original issue discount, if any; |
| ● | rates and times of payment of interest or dividends, if any; |
| ● | redemption, conversion, exercise, exchange or sinking fund terms, if any; |
| ● | restrictive covenants, if any; |
| ● | voting or other rights, if any; |
| ● | conversion or exchange prices or rates, if any, and, if applicable, any provisions for changes to or adjustments in the conversion
or exchange prices or rates and in the securities or other property receivable upon conversion or exchange; and |
| ● | material or special U.S. federal income tax considerations, if any. |
The applicable prospectus supplement and any related
free writing prospectus that we may authorize to be provided to you may also add, update or change any of the information contained in
this prospectus or in the documents we have incorporated by reference.
The securities may be offered directly to investors
by us or by any selling security holder from time to time, through agents designated by us or to or through agents, underwriters, brokers
or dealers. We will provide specific information about any selling security holders in one or more supplements to this prospectus. We,
and our agents, underwriters, brokers or dealers, reserve the right to accept or reject all or part of any proposed purchase of securities.
If we do offer securities to or through agents, underwriters, brokers or dealers, we will include in the applicable prospectus supplement:
| ● | the names of those agents, underwriters, brokers or dealers; |
| ● | applicable fees, discounts and commissions to be paid to them; |
| ● | details regarding over-allotment or other options to purchase additional securities, if any; and |
| ● | the net proceeds to us, if any. |
Use of Proceeds
Except as described in any applicable prospectus
supplement or in any free writing prospectuses we have authorized for use in connection with a specific offering, we intend to use the
net proceeds from the sale of the securities under this prospectus for general corporate purposes, which may include funding research
and development, capital expenditures, working capital and general and administrative expenses. See “Use of Proceeds” on page
5 of this prospectus.
Nasdaq Global Market Listing
Our common stock is listed on The Nasdaq Global
Market under the symbol “XNCR.”
RISK FACTORS
Investing in our securities involves a high degree
of risk. Before deciding whether to invest in our securities, you should consider carefully the risks and uncertainties described under
the heading “Risk Factors” contained in the applicable prospectus supplement and any related free writing prospectus, and
described under the section entitled “Risk Factors” contained in our most recent Annual Report on Form 10-K, as well as any
amendments thereto and other filings we make with the SEC from time to time, which are incorporated by reference into this prospectus
in their entirety, together with other information in this prospectus, the documents incorporated by reference and any free writing prospectus
that we may authorize for use in connection with a specific offering. The risks described in these documents are not the only ones we
face, but those that we consider to be material. There may be other unknown or unpredictable economic, business, competitive, regulatory
or other factors that could have material adverse effects on our future results. Past financial performance may not be a reliable indicator
of future performance, and historical trends should not be used to anticipate results or trends in future periods. If any of these risks
actually occur, our business, financial condition, results of operations, cash flow and future growth prospects could be seriously harmed.
This could cause the market price of our securities to decline, resulting in a loss of all or part of your investment. Please also carefully
read the section below entitled “Forward-Looking Statements.”
FORWARD-LOOKING STATEMENTS
This prospectus and any accompanying prospectus
supplement, as well as the documents incorporated by reference in this prospectus or any accompanying prospectus supplement, contain “forward-looking
statements” within the meaning of Section 27A of the Securities Act of 1933, as amended, or the Securities Act, and Section 21E
of the Securities Exchange Act of 1934, as amended (the “Exchange Act”). These statements relate to future events or to our
future operating or financial performance and involve known and unknown risks, uncertainties and other factors that may cause our actual
results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied
by the forward-looking statements. Forward-looking statements may include, but are not limited to, statements about:
| ● | the effects of the ongoing COVID-19 pandemic on our financial condition, results of operations, cash flows and performance; |
| ● | our ability to execute on our plans to research, develop and commercialize our product candidates; |
| ● | the success of our ongoing and planned clinical trials; |
| ● | the timing of and our ability to obtain and maintain regulatory approval for our product candidates; |
| ● | our ability to identify additional products or product candidates with significant commercial potential that are consistent with our
business objectives; |
| ● | our ability to receive research funding and achieve anticipated milestones under our collaborations; |
| ● | our partners’ ability to advance drug candidates into, and successfully complete, clinical trials; |
| ● | our ability to attract collaborators with development, regulatory, and commercialization expertise; |
| ● | our ability to protect our intellectual property position; |
| ● | the rate and degree of market acceptance and clinical utility of our products; |
| ● | costs of compliance and our failure to comply with new and existing governmental regulations; |
| ● | the capabilities and strategy of our suppliers and vendors including key manufacturers of our clinical drug supplies; |
| ● | significant competition in our industry; |
| ● | the potential loss or retirement of key members of management; |
| ● | our failure to successfully execute our growth strategy including any delays in our planned future growth; |
| ● | our failure to maintain effective internal controls; and |
our ability to accurately estimate expenses, future revenues, capital
requirements and needs for additional financing.
In some cases, you can identify forward-looking
statements by terms such as “anticipates,” “believes,” “could,” “estimates,” “expects,”
“may,” “plans,” “potential,” “predicts,” “projects,” “should,”
“would,” “will” and similar expressions intended to identify forward-looking statements.
These statements reflect our current views with
respect to future events, are based on assumptions and are subject to risks and uncertainties. Given these risks and uncertainties, you
should not place undue reliance on these forward-looking statements. We discuss in greater detail, and incorporate by reference into this
prospectus in their entirety, many of these risks and uncertainties under the heading “Risk Factors” contained in the applicable
prospectus supplement, in any free writing prospectus we may authorize for use in connection with a specific offering, and in our most
recent annual report on Form 10-K, as well as any amendments thereto reflected in subsequent filings with the SEC. Also, these forward-looking
statements represent our estimates and assumptions only as of the date of the document containing the applicable statement. Unless required
by law, we undertake no obligation to update or revise any forward-looking statements to reflect new information or future events or developments.
Thus, you should not assume that our silence over time means that actual events are bearing out as expressed or implied in such forward-looking
statements. You should read this prospectus, the applicable prospectus supplement, together with the documents we have filed with the
SEC that are incorporated by reference and any free writing prospectus we have authorized for use in connection with a specific offering
completely and with the understanding that our actual future results may be materially different from what we expect. We qualify all of
the forward-looking statements in the foregoing documents by these cautionary statements.
USE OF PROCEEDS
Except as described in any applicable prospectus
supplement or in any free writing prospectuses we have authorized for use in connection with a specific offering, we currently intend
to use the net proceeds from the sale of the securities under this prospectus for general corporate purposes, which may include research
and development, capital expenditures, working capital and general and administrative expenses. We may also use a portion of the net proceeds
to acquire or invest in businesses, products and technologies that are complementary to our own, although we have no current plans, commitments
or agreements to do so. Accordingly, we will retain broad discretion over the use of such proceeds. We will set forth in the applicable
prospectus supplement or free writing prospectus our intended use for the net proceeds received from the sale of any securities sold pursuant
to such prospectus supplement or free writing prospectus. Unless otherwise specified in the applicable prospectus supplement or free writing
prospectus, we will not receive any proceeds from the sale of securities by selling security holders.
DESCRIPTION OF CAPITAL STOCK
As of the date of this prospectus, our amended and
restated certificate of incorporation authorizes us to issue 200,000,000 shares of common stock, par value $0.01 per share, and 10,000,000
shares of preferred stock, par value $0.01 per share. As of December 31, 2022, 59,997,713 shares of common stock were outstanding and
no shares of preferred stock were outstanding.
The following summary describes the material terms
of our capital stock. The descriptions of capital stock are qualified by reference to our amended and restated certificate of incorporation
and our second amended and restated bylaws, which are incorporated by reference as exhibits into the registration statement of which this
prospectus is a part, and by reference to the applicable provisions of the Delaware General Corporation Law (the “DGCL”).
Common Stock
Voting. Our common stock is entitled to one
vote for each share held of record on all matters submitted to a vote of the stockholders, including the election of directors, and does
not have cumulative voting rights. Accordingly, the holders of a majority of the shares of our common stock entitled to vote in any election
of directors can elect all of the directors standing for election.
Dividends. Subject to preferences that may
be applicable to any then-outstanding preferred stock, the holders of common stock are entitled to receive dividends, if any, as may be
declared from time to time by our board of directors out of legally available funds.
Liquidation. In the event of our liquidation,
dissolution or winding-up, holders of our common stock will be entitled to share ratably in the net assets legally available for distribution
to stockholders after the payment of all of our debts and other liabilities, subject to the satisfaction of any liquidation preference
granted to the holders of any outstanding shares of preferred stock.
Rights and Preferences. Holders of our common
stock have no preemptive, conversion or subscription rights, and there are no redemption or sinking fund provisions applicable to our
common stock. The rights, preferences and privileges of the holders of our common stock are subject to, and may be adversely affected
by, the rights of the holders of shares of any series of our preferred stock that we may designate and issue in the future.
Fully Paid and Nonassessable. All of our
outstanding shares of common stock are fully paid and nonassessable.
Preferred Stock
Under our amended and restated certificate of incorporation,
our board of directors has the authority, without further action by stockholders, to designate up to 10,000,000 shares of preferred stock
in one or more series and to fix or alter, from time to time, the designations, powers and rights of each series of preferred stock and
the qualifications, limitations or restrictions of any series of preferred stock, including dividend rights, dividend rate, conversion
rights, voting rights, rights and terms of redemption (including sinking fund provisions), redemption price or prices, and the liquidation
preference of any wholly unissued series of preferred stock, any or all of which may be greater than the rights of the common stock, and
to establish the number of shares constituting any such series. To date, none of the 10,000,000 authorized shares of preferred stock have
been designated by our board of directors.
Our board of directors will fix the rights, preferences,
privileges, qualifications and restrictions of the preferred stock of each series that we sell under this prospectus and any applicable
prospectus supplements in the certificate of designation relating to each such series. We will incorporate by reference as an exhibit
to the registration statement of which this prospectus is a part or as an exhibit to one or more Current Reports on Form 8-K, the form
of any certificate of designation that describes the terms of the series of preferred stock we are offering before the issuance of the
related series of preferred stock. This description will include:
| ● | the title and stated value; |
| ● | the number of shares we are offering; |
| ● | the liquidation preference per share, if any; |
| ● | the purchase price per share; |
| ● | the dividend rate per share, dividend period, payment date or dates and method of calculation for dividends, as applicable; |
| ● | whether dividends, if any, will be cumulative or non-cumulative and, if cumulative, the date from which dividends will accumulate; |
| ● | our right, if any, to defer payment of dividends and the maximum length of any such deferral period; |
| ● | the procedures for any auction and remarketing, if any; |
| ● | the provisions for a sinking fund, if any; |
| ● | the provisions for redemption or repurchase, if applicable, and any restrictions on our ability to exercise those redemption or repurchase
rights; |
| ● | any listing of the preferred stock on any securities exchange or market; |
| ● | whether the preferred stock will be convertible into our common stock or other securities of ours, including warrants, and, if applicable,
the conversion price, or how it will be calculated, and under what circumstances and the mechanism by which it may be adjusted, and the
conversion period; |
| ● | whether the preferred stock will be exchangeable into debt securities or other securities of ours, and, if applicable, the exchange
price, or how it will be calculated, and under what circumstances it may be adjusted, and the exchange period; |
| ● | preemptive rights, if any; |
| ● | restrictions on transfer, sale or other assignment, if any; |
| ● | whether interests in the preferred stock will be represented by depositary shares; |
| ● | a discussion of any material or special U.S. federal income tax considerations applicable to the preferred stock; |
| ● | the relative ranking and preferences of the preferred stock as to dividend rights and rights if we liquidate, dissolve or wind up
our affairs; |
| ● | any limitations on issuances of any class or series of preferred stock ranking senior to or on parity with the series of preferred
stock being issued as to dividend rights and rights if we liquidate, dissolve or wind up our affairs; and |
| ● | Any other specific terms, rights, preferences, privileges, qualifications or limitations of, or restrictions on the preferred stock. |
If we issue and sell shares of preferred stock pursuant
to this prospectus, together with any applicable prospectus supplement or free writing prospectus, the shares will be fully paid and nonassessable
and will not have, or be subject to, any preemptive or similar rights.
The laws of the State of Delaware, the state of
our incorporation, provide that the holders of preferred stock will have the right to vote separately as a class on any proposal involving
fundamental changes in the rights of holders of such preferred stock. This right is in addition to any voting rights that may be provided
for in the applicable certificate of designation.
The issuance of preferred stock could adversely
affect the voting power, conversion or other rights of holders of common stock and reduce the likelihood that common stockholders will
receive dividend payments and payments upon liquidation. Preferred stock could be issued quickly with terms designed to delay, deter or
prevent a change in control of our company or make removal of management more difficult. Additionally, the issuance of preferred stock
may have the effect of decreasing the market price of our common stock.
Delaware Anti-Takeover Law and Provisions of Our Amended and Restated
Certificate of Incorporation and Second Amended and Restated Bylaws
Our amended and restated certificate of incorporation
and our second amended and restated bylaws contain certain provisions that could have the effect of delaying, deterring or preventing
another party from acquiring control of us, and therefore could adversely affect the market price of our common stock. These provisions
and certain provisions of the DGCL which are summarized below, may also discourage coercive takeover practices and inadequate takeover
bids, and are designed, in part, to encourage persons seeking to acquire control of us to negotiate first with our board of directors.
We believe that the benefits of increased protection of our potential ability to negotiate more favorable terms with an unfriendly or
unsolicited acquirer outweigh the disadvantages of potentially discouraging a proposal to acquire us.
Delaware Anti-Takeover Law
We are subject to Section 203 of the DGLC (“Section
203”). Section 203 generally prohibits a public Delaware corporation from engaging in a “business combination” with
an “interested stockholder” for a period of three years following the time that such stockholder became an interested stockholder,
unless:
| ● | prior to such time the board of directors of the corporation approved either the business combination or the transaction which resulted
in the stockholder becoming an interested stockholder; |
| ● | upon consummation of the transaction which resulted in the stockholder becoming an interested stockholder, the interested stockholder
owned at least 85% of the voting stock of the corporation outstanding at the time the transaction commenced, excluding for purposes of
determining the voting stock outstanding (but not the outstanding voting stock owned by the interested stockholder) those shares owned
(i) by persons who are directors and also officers and (ii) employee stock plans in which employee participants do not have the right
to determine confidentially whether shares held subject to the plan will be tendered in a tender or exchange offer; or |
| ● | at or subsequent to such time the business combination is approved by the board of directors and authorized at an annual or special
meeting of stockholders, and not by written consent, by the affirmative vote of at least 662/3% of the outstanding voting stock which
is not owned by the interested stockholder. |
Section 203 defines a business combination to include:
| ● | any merger or consolidation involving the corporation and the interested stockholder; |
| ● | any sale, transfer, pledge or other disposition involving the interested stockholder of 10% or more of the assets of the corporation; |
| ● | subject to exceptions, any transaction that results in the issuance or transfer by the corporation of any stock of the corporation
to the interested stockholder; |
| ● | subject to exceptions, any transaction involving the corporation that has the effect of increasing the proportionate share of the
stock of any class or series of the corporation beneficially owned by the interested stockholder; and |
| ● | the receipt by the interested stockholder of the benefit of any loans, advances, guarantees, pledges or other financial benefits provided
by or through the corporation. |
In general, Section 203 defines an interested stockholder
as any entity or person beneficially owning 15% or more of the outstanding voting stock of the corporation and any entity or person affiliated
with or controlling or controlled by the entity or person.
Amended and Restated Certificate of Incorporation and Second
Amended and Restated Bylaws
Among other things, our amended and restated certificate
of incorporation and second amended and restated bylaws:
| ● | permit our Board of Directors to issue up to 10,000,000 shares of preferred stock, with any rights, preferences and privileges as
they may designate (including the right to approve an acquisition or other change in our control); |
| ● | provide that the authorized number of directors may be changed only by resolution by a majority of the total number of authorized
directors; |
| ● | provide that all vacancies, including newly created directorships, may, except as otherwise required by law, be filled by the affirmative
vote of a majority of directors then in office, even if less than a quorum; |
| ● | require that any action to be taken by our stockholders must be effected at a duly called annual or special meeting of stockholders
and not be taken by written consent; |
| ● | provide that stockholders seeking to present proposals before a meeting of stockholders or to nominate candidates for election as
directors at a meeting of stockholders must provide notice in writing in a timely manner, and also specify requirements as to the form
and content of a stockholder’s notice; |
| ● | do not provide for cumulative voting rights (therefore allowing the holders of a majority of the shares of common stock entitled to
vote in any election of directors to elect all of the directors standing for election, if they should so choose); |
| ● | provide that special meetings of our stockholders may be called only by the chairman of our Board of Director, our Chief Executive
Officer or by our Board of Directors pursuant to a resolution adopted by a majority of the total number of authorized directors; and |
| ● | establish advance notice procedures with respect to stockholder proposals and the nomination of candidates for election as directors,
other than nominations made by or at the direction of the Board of Directors, as well as procedures and other requirements addressing
the universal proxy rules adopted by the SEC. |
The provisions of the DGCL and the provisions of
our amended and restated certificate of incorporation and second amended and restated bylaws could have the effect of discouraging others
from attempting hostile takeovers and, as a consequence, they might also inhibit temporary fluctuations in the market price of our common
stock that often result from actual or rumored hostile takeover attempts. These provisions might also have the effect of preventing changes
in our management. It is possible that these provisions could make it more difficult to accomplish transactions that stockholders might
otherwise deem to be in their best interests.
Transfer Agent and Registrar
The transfer agent and registrar for our common stock is Computershare
Trust Company, N.A. The transfer agent and registrar’s address is 250 Royall Street, Canton, MA, 02021. The transfer agent for any
series of preferred stock that we may offer under this prospectus will be named and described in the prospectus supplement for that series.
Listing on The Nasdaq Global Market
Our common stock is listed on The Nasdaq Global Market under the symbol
“XNCR”.
DESCRIPTION OF DEBT SECURITIES
The following description, together with the additional
information we include in any applicable prospectus supplements or free writing prospectuses, summarizes the material terms and provisions
of the debt securities that we may offer under this prospectus. We may issue debt securities from time to time, in one or more series,
as either senior or subordinated debt or as senior or subordinated convertible debt. While the terms we have summarized below will apply
generally to any debt securities that we may offer under this prospectus, we will describe the particular terms of any debt securities
that we may offer in more detail in the applicable prospectus supplement or free writing prospectus. The terms of any debt securities
offered under a prospectus supplement may differ from the terms described below. Unless the context requires otherwise, whenever we refer
to an “indenture,” we also are referring to any supplemental indentures that specify the terms of a particular series of debt
securities.
We will issue the debt securities under an indenture
that we will enter into with the trustee named in the indenture. The indenture will be qualified under the Trust Indenture Act of 1939,
as amended (the “Trust Indenture Act”). We have filed forms of senior and subordinated indentures as exhibits to the registration
statement, of which this prospectus is a part, and supplemental indentures and forms of debt securities containing the terms of the debt
securities being offered will be filed as exhibits to the registration statement of which this prospectus is a part or will be incorporated
by reference from reports that we file with the SEC.
The following summaries of material provisions of
the senior debt securities, the subordinated debt securities and the related indentures are subject to, and qualified in their entirety
by reference to, all of the provisions of the indenture applicable to a particular series of debt securities. We urge you to read the
applicable prospectus supplements and any related free writing prospectuses related to the debt securities that we may offer under this
prospectus, as well as the complete indentures that contain the terms of the debt securities. Except as we may otherwise indicate, the
terms of the senior indenture and the subordinated indenture are identical.
General
The terms of each series of debt securities will
be established by or pursuant to a resolution of our board of directors and set forth or determined in the manner provided in an officers’
certificate or by a supplemental indenture. Debt securities may be issued in separate series without limitation as to aggregate principal
amount. We may specify a maximum aggregate principal amount for the debt securities of any series. We will describe in the applicable
prospectus supplement the terms of the series of debt securities being offered, including:
| ● | the title of the series of debt securities; |
| ● | the principal amount being offered, and if a series, the total amount authorized and the total amount outstanding; |
| ● | any limit upon the aggregate principal amount that may be issued; |
| ● | the maturity date or dates; |
| ● | the form of the debt securities of the series; |
| ● | the applicability of any guarantees; |
| ● | whether or not the debt securities will be secured or unsecured, and the terms of any secured debt; |
| ● | whether the debt securities rank as senior debt, senior subordinated debt, subordinated debt or any combination thereof, and the terms
of any subordination; |
| ● | if the price (expressed as a percentage of the aggregate principal amount thereof) at which such debt securities will be issued is
a price other than the principal amount thereof, the portion of the principal amount thereof payable upon declaration of acceleration
of the maturity thereof, or if applicable, the portion of the principal amount of such debt securities that is convertible into another
security or the method by which any such portion shall be determined; |
| ● | the interest rate or rates, which may be fixed or variable, or the method for determining the rate and the date interest will begin
to accrue, the dates interest will be payable and the regular record dates for interest payment dates or the method for determining such
dates; |
| ● | our right, if any, to defer payment of interest and the maximum length of any such deferral period; |
| ● | if applicable, the date or dates after which, or the period or periods during which, and the price or prices at which, we may, at
our option, redeem the series of debt securities pursuant to any optional or provisional redemption provisions and the terms of those
redemption provisions; |
| ● | the date or dates, if any, on which, and the price or prices at which we are obligated, pursuant to any mandatory sinking fund or
analogous fund provisions or otherwise, to redeem, or at the holder’s option to purchase, the series of debt securities and the currency
or currency unit in which the debt securities are payable; |
| ● | the denominations in which we will issue the series of debt securities, if other than denominations of $1,000 and any integral multiple
thereof; |
| ● | any and all terms, if applicable, relating to any auction or remarketing of the debt securities of that series and any security for
our obligations with respect to such debt securities and any other terms which may be advisable in connection with the marketing of debt
securities of that series; |
| ● | whether the debt securities of the series shall be issued in whole or in part in the form of a global security or securities; the
terms and conditions, if any, upon which such global security or securities may be exchanged in whole or in part for other individual
securities; and the depositary for such global security or securities; |
| ● | if applicable, the provisions relating to conversion or exchange of any debt securities of the series and the terms and conditions
upon which such debt securities will be so convertible or exchangeable, including the conversion or exchange price, as applicable, or
how it will be calculated and may be adjusted, any mandatory or optional (at our option or the holders’ option) conversion or exchange
features, the applicable conversion or exchange period and the manner of settlement for any conversion or exchange; |
| ● | if other than the full principal amount thereof, the portion of the principal amount of debt securities of the series which shall
be payable upon declaration of acceleration of the maturity thereof; |
| ● | additions to or changes in the covenants applicable to the particular debt securities being issued, including, among others, the consolidation,
merger or sale covenant; |
| ● | additions to or changes in the events of default with respect to the securities and any change in the right of the trustee or the
holders to declare the principal, premium, if any, and interest, if any, with respect to such securities to be due and payable; |
| ● | additions to or changes in or deletions of the provisions relating to covenant defeasance and legal defeasance; |
| ● | additions to or changes in the provisions relating to satisfaction and discharge of the indenture; |
| ● | additions to or changes in the provisions relating to the modification of the indenture both with and without the consent of holders
of debt securities issued under the indenture; |
| ● | the currency of payment of debt securities if other than U.S. dollars and the manner of determining the equivalent amount in U.S.
dollars; |
| ● | whether interest will be payable in cash or additional debt securities at our or the holders’ option and the terms and conditions
upon which the election may be made; |
| ● | whether the debt securities are to be offered at a price such that they will be deemed to be offered at an “original issue discount”
as defined in paragraph (a) of Section 1273 of the Internal Revenue Code of 1986, as amended; |
| ● | the terms and conditions, if any, upon which we will pay amounts in addition to the stated interest, premium, if any and principal
amounts of the debt securities of the series to any holder that is not a “United States person” for federal tax purposes; |
| ● | any restrictions on transfer, sale or assignment of the debt securities of the series; and |
| ● | any other specific terms, preferences, rights or limitations of, or restrictions on, the debt securities, any other additions or changes
in the provisions of the indenture, and any terms that may be required by us or advisable under applicable laws or regulations. |
Conversion or Exchange Rights
We will set forth in the applicable prospectus supplement
the terms on which a series of debt securities may be convertible into or exchangeable for our common stock, our preferred stock or other
securities. We will include provisions as to settlement upon conversion or exchange and whether conversion or exchange is mandatory, at
the option of the holder or at our option. We may include provisions pursuant to which the number of shares of our common stock, our preferred
stock or other securities that the holders of the series of debt securities receive would be subject to adjustment.
Consolidation, Merger or Sale
Unless we provide otherwise in the prospectus supplement
applicable to a particular series of debt securities, the indenture will not contain any covenant that restricts our ability to merge
or consolidate, or sell, convey, transfer or otherwise dispose of all or substantially all of our assets. However, any successor to or
acquiror of such assets must assume all of our obligations under the indenture or the debt securities, as appropriate. If the debt securities
are convertible into or exchangeable for our other securities or securities of other entities, the person with whom we consolidate or
merge or to whom we sell all of our property must make provisions for the conversion of the debt securities into securities that the holders
of the debt securities would have received if they had converted the debt securities before the consolidation, merger or sale.
Events of Default under the Indenture
Unless we provide otherwise in the prospectus supplement
applicable to a particular series of debt securities, the following are events of default under the indenture with respect to any series
of debt securities that we may issue:
| ● | if we fail to pay interest when due and payable and our failure continues for 90 days and the time for payment has not been extended; |
| ● | if we fail to pay the principal, premium or sinking fund payment, if any, when due and payable and the time for payment has not been
extended; |
| ● | if we fail to observe or perform any other covenant or agreement contained in the debt securities or the indenture, other than a covenant
specifically relating to another series of debt securities, and our failure continues for 90 days after we receive written notice
of such failure from the trustee or we and the trustee receive notice from the holders of at least 25% in aggregate principal amount of
the outstanding debt securities of the applicable series; and |
| ● | if specified events of bankruptcy, insolvency or reorganization occur. |
We will describe in each applicable
prospectus supplement any additional events of default relating to the relevant series of debt securities. If an event of default
with respect to debt securities of any series occurs and is continuing, other than an event of default specified in the last bullet
point above, the trustee or the holders of at least 25% in aggregate principal amount of the outstanding debt securities of that
series, by notice to us in writing, and to the trustee if notice is given by such holders, may declare the unpaid
principal, premium, if any, and accrued interest, if any, due and payable immediately. If an event of default arises due to the occurrence
of certain specified bankruptcy, insolvency or reorganization events, the unpaid principal, premium, if any, and accrued interest, if
any, of each issue of debt securities then outstanding shall be due and payable without any notice or other action on the part of the
trustee or any holder.
The holders of a majority in principal amount of
the outstanding debt securities of an affected series may waive any default or event of default with respect to the series and its consequences,
except defaults or events of default regarding payment of principal, premium, if any, or interest, unless we have cured the default or
event of default in accordance with the indenture. Any waiver shall cure the default or event of default.
Subject to the terms of the applicable indenture,
if an event of default under an indenture shall occur and be continuing, the trustee will be required in the exercise of its powers to
use the same degree of care that a prudent person would use in the conduct of its own affairs; provided, however, that the trustee will
be under no obligation to exercise any of its rights or powers under such indenture at the request or direction of any of the holders
of the applicable series of debt securities, unless such holders have offered the trustee reasonable indemnity or security satisfactory
to it against any loss, liability or expense. The holders of a majority in principal amount of the outstanding debt securities of any
series will have the right to direct the time, method and place of conducting any proceeding for any remedy available to the trustee,
or exercising any trust or power conferred on the trustee, with respect to the debt securities of that series, provided that:
| ● | the direction so given by the holder is not in conflict with any law or the applicable indenture; and |
| ● | subject to its duties under the Trust Indenture Act, the trustee need not take any action that might involve it in personal liability
or might be unduly prejudicial to the holders not involved in the proceeding. |
A holder of the debt securities of any series will
have the right to institute a proceeding under the indenture or to appoint a receiver or trustee, or to seek other remedies only if:
| ● | the holder has given written notice to the trustee of a continuing event of default with respect to that series; |
| ● | the holders of at least 25% in aggregate principal amount of the outstanding debt securities of that series have made a written request
and such holders have offered reasonable indemnity to the trustee or security satisfactory to it against any loss, liability or expense
to be incurred in compliance with instituting the proceeding as trustee; and |
| ● | the trustee does not institute the proceeding, and does not receive from the holders of a majority in aggregate principal amount of
the outstanding debt securities of that series other conflicting directions within 60 days after the notice, request and offer. |
These limitations do not apply to a suit instituted
by a holder of debt securities if we default in the payment of the principal, premium, if any, or interest on, the debt securities.
We will periodically file statements with the trustee
regarding our compliance with specified covenants in the indenture.
If a default occurs and is continuing under the
applicable indenture and is actually known to a responsible officer of the trustee, the trustee must mail to each holder notice of the
default within 45 days after it occurs, unless such default has been cured. Except in the case of a default in the payment of principal
or premium of, or interest on, any debt security or certain other defaults specified in an indenture, the trustee shall be protected in
withholding such notice if and so long as the board of directors, the executive committee or a trust committee of directors, or responsible
officers of the trustee, in good faith determine that withholding notice is in the best interests of holders of the relevant series of
debt securities.
Modification of Indenture; Waiver
Subject to the terms of the indenture for any series
of debt securities that we may issue, we and the trustee may change an indenture without the consent of any holders with respect to the
following specific matters:
| ● | to fix any ambiguity, defect or inconsistency in the indenture; |
| ● | to comply with the provisions described above under “— Consolidation, Merger or Sale;” |
| ● | to provide for uncertificated debt securities in addition to or in place of certificated debt securities and to make all appropriate
changes for such purpose; |
| ● | to add to our covenants, restrictions, conditions or provisions such new covenants, restrictions, conditions or provisions for the
benefit of the holders of all or any series of debt securities, and to make the occurrence, or the occurrence and the continuance, of
a default in any such additional covenants, restrictions, conditions or provisions an event of default or to surrender any right or power
conferred to us in the indenture; |
| ● | to add to, delete from or revise the conditions, limitations and restrictions on the authorized amount, terms or purposes of issue,
authentication and delivery of debt securities, as set forth in such indenture; |
| ● | to provide for the issuance of, and establish the form and terms and conditions of, the debt securities of any series as provided
above under “— General,” to establish the form of any certifications required to be furnished pursuant to the terms
of the indenture or any series of debt securities, or to add to the rights of the holders of any series of debt securities; |
| ● | to evidence and provide for the acceptance of appointment under any indenture by a successor trustee; |
| ● | to comply with any requirements of the SEC in connection with the qualification of any indenture under the Trust Indenture Act; or |
| ● | to change anything that does not materially adversely affect the interests of any holder of debt securities of any series in any material
respect; provided that any amendment made solely to conform the provisions of the indenture to the corresponding description of the debt
securities contained in the applicable prospectus or prospectus supplement shall be deemed not to adversely affect the interests of the
holders of such debt securities; provided further, that in connection with any such amendment we will provide the trustee with an officers’
certificate certifying that such amendment will not adversely affect the rights or interests of the holders of such debt securities. |
In addition, under the indenture, the rights of
holders of a series of debt securities may be changed by us and the trustee with the written consent of the holders of at least a majority
in aggregate principal amount of the outstanding debt securities of each series that is affected. However, unless we provide otherwise
in the prospectus supplement applicable to a particular series of debt securities, we and the trustee may make the following changes only
with the consent of each holder of any outstanding debt securities affected:
| ● | extending the fixed maturity of any debt securities of any series; |
| ● | reducing the principal amount, reducing the rate of or extending the time of payment of interest, or reducing any premium payable
upon the redemption of any series of any debt securities; |
| ● | reducing the percentage of debt securities, the holders of which are required to consent to any amendment, supplement, modification
or waiver; |
| ● | changing any of our obligations to pay additional amounts; |
| ● | reducing the amount of principal of an original issue discount security or any other note payable upon acceleration of the maturity
thereof; |
| ● | changing the currency in which any note or any premium or interest is payable; |
| ● | impairing the right to enforce any payment on or with respect to any note; |
| ● | adversely changing the right to convert or exchange, including decreasing the conversion rate or increasing the conversion price of,
such note, if applicable; |
| ● | in the case of the subordinated indenture, modifying the subordination provisions in a manner adverse to the holders of the subordinated
debt securities; |
| ● | if the debt securities are secured, changing the terms and conditions pursuant to which the debt securities are secured in a manner
adverse to the holders of the secured debt securities; |
| ● | reducing the requirements contained in the applicable indenture for quorum or voting; |
| ● | changing any of our obligations to maintain an office or agency in the places and for the purposes required by the indenture; or |
| ● | modifying any of the above provisions set forth in this paragraph. |
Discharge
Each indenture provides that, subject to the terms
of the indenture and any limitation otherwise provided in the prospectus supplement applicable to a particular series of debt securities,
we may elect to be discharged from our obligations with respect to one or more series of debt securities, except for specified obligations,
including obligations to:
| ● | register the transfer or exchange of debt securities of the series; |
| ● | replace stolen, lost or mutilated debt securities of the series; |
| ● | pay principal of and premium and interest on any debt securities of the series; |
| ● | maintain paying agencies; |
| ● | hold monies for payment in trust; |
| ● | recover excess money held by the trustee; |
| ● | compensate and indemnify the trustee; and |
| ● | appoint any successor trustee. |
In order to exercise our rights to be discharged,
we must deposit with the trustee money or government obligations sufficient to pay all the principal of, any premium, if any, and interest
on, the debt securities of the series on the dates payments are due.
Form, Exchange and Transfer
We will issue the debt securities of each series
only in fully registered form without coupons and, unless we provide otherwise in the applicable prospectus supplement, in denominations
of $1,000 and any integral multiple thereof. The indentures provide that we may issue debt securities of a series in temporary or permanent
global form and as book-entry securities that will be deposited with, or on behalf of, The Depository Trust Company (“DTC”)
or another depositary named by us and identified in the applicable prospectus supplement with respect to that series. To the extent the
debt securities of a series are issued in global form and as book entry, a description of terms relating to any book-entry securities
will be set forth in the applicable prospectus supplement.
At the option of the holder, subject to the terms
of the applicable indenture and the limitations applicable to global securities described in the applicable prospectus supplement, the
holder of the debt securities of any series can exchange the debt securities for other debt securities of the same series, in any authorized
denomination and of like tenor and aggregate principal amount.
Subject to the terms of the applicable indenture
and the limitations applicable to global securities set forth in the applicable prospectus supplement, holders of the debt securities
may present the debt securities for exchange or for registration of transfer, duly endorsed or with the form of transfer endorsed thereon
duly executed if so required by us or the security registrar, at the office of the security registrar or at the office of any transfer
agent designated by us for this purpose. Unless otherwise provided in the debt securities that the holder presents for transfer or exchange,
we will impose no service charge for any registration of transfer or exchange, but we may require payment of any taxes or other governmental
charges.
We will name in the applicable prospectus supplement
the security registrar, and any transfer agent in addition to the security registrar, that we initially designate for any debt securities.
We may at any time designate additional transfer agents or rescind the designation of any transfer agent or approve a change in the office
through which any transfer agent acts, except that we will be required to maintain a transfer agent in each place of payment for the debt
securities of each series.
If we elect to redeem the debt securities of any
series, we will not be required to:
| ● | issue, register the transfer of, or exchange any debt securities of that series during a period beginning at the opening of business
15 days before the day of mailing of a notice of redemption of any debt securities that may be selected for redemption and ending
at the close of business on the day of the mailing; or |
| ● | register the transfer of or exchange any debt securities so selected for redemption, in whole or in part, except the unredeemed portion
of any debt securities we are redeeming in part. |
Information Concerning the Trustee
The trustee, other than during the occurrence and
continuance of an event of default under an indenture, undertakes to perform only those duties as are specifically set forth in the applicable
indenture. Upon an event of default under an indenture, the trustee must use the same degree of care as a prudent person would exercise
or use in the conduct of his or her own affairs. Subject to this provision, the trustee is under no obligation to exercise any of the
powers given it by the indenture at the request of any holder of debt securities unless it is offered reasonable security and indemnity
against the costs, expenses and liabilities that it might incur.
Payment and Paying Agents
Unless we otherwise indicate in the applicable prospectus
supplement, we will make payment of the interest on any debt securities on any interest payment date to the person in whose name the debt
securities, or one or more predecessor securities, are registered at the close of business on the regular record date for the interest
payment.
We will pay principal of and any premium and interest
on the debt securities of a particular series at the office of the paying agents designated by us, except that unless we otherwise indicate
in the applicable prospectus supplement, we will make interest payments by check that we will mail to the holder or by wire transfer to
certain holders. Unless we otherwise indicate in the applicable prospectus supplement, we will designate the corporate trust office of
the trustee as our sole paying agent for payments with respect to debt securities of each series. We will name in the applicable prospectus
supplement any other paying agents that we initially designate for the debt securities of a particular series. We will maintain a paying
agent in each place of payment for the debt securities of a particular series.
All money we pay to a paying agent or the trustee
for the payment of the principal of or any premium or interest on any debt securities that remains unclaimed at the end of two years
after such principal, premium or interest has become due and payable will be repaid to us, and the holder of the debt security thereafter
may look only to us for payment thereof.
Governing Law
The indenture and the debt securities will be governed
by and construed in accordance with the internal laws of the State of New York, except to the extent that the Trust Indenture Act is applicable.
Ranking Debt Securities
The subordinated debt securities will be unsecured
and will be subordinate and junior in priority of payment to certain of our other indebtedness to the extent described in a prospectus
supplement. The subordinated indenture does not limit the amount of subordinated debt securities that we may issue. It also does not limit
us from issuing any other secured or unsecured debt.
The senior debt securities will be unsecured and
will rank equally in right of payment to all our other senior unsecured debt. The senior indenture does not limit the amount of senior
debt securities that we may issue. It also does not limit us from issuing any other secured or unsecured debt.
DESCRIPTION OF WARRANTS
The following description, together with the additional
information we may include in any applicable prospectus supplement and free writing prospectus, summarizes the material terms and provisions
of the warrants that we may offer under this prospectus, which may consist of warrants to purchase common stock, preferred stock or debt
securities and may be issued in one or more series. Warrants may be offered independently or in combination with common stock, preferred
stock or debt securities offered by any prospectus supplement, and may be attached to or separate from those securities. While the terms
we have summarized below will apply generally to any warrants that we may offer under this prospectus, we will describe the particular
terms of any series of warrants that we may offer in more detail in the applicable prospectus supplement and any applicable free writing
prospectus. The following description of warrants will apply to the warrants offered by this prospectus unless we provide otherwise in
the applicable prospectus supplement. The applicable prospectus supplement for a particular series of warrants may specify different or
additional terms.
We will issue the warrants under a warrant agreement
that we will enter into with a warrant agent to be selected by us. The warrant agent will act solely as an agent of ours in connection
with the warrants and will not act as an agent for the holders or beneficial owners of the warrants. We will file as exhibits to the registration
statement of which this prospectus is a part, or will incorporate by reference from reports that we file with the SEC, the form of warrant
and/or the warrant agreement and warrant certificate, as applicable, that contain the terms of the particular series of warrants we are
offering, and any supplemental agreements, before the issuance of such warrants. The following summaries of material terms and provisions
of the warrants and the warrant agreements are subject to, and qualified in their entirety by reference to, all of the provisions of the
form of warrant and/or the warrant agreement and warrant certificate, as applicable, and any supplemental agreements applicable to a particular
series of warrants that we may offer under this prospectus. We urge you to read the applicable prospectus supplement and any applicable
free writing prospectus related to the particular series of warrants that we may offer under this prospectus, as well as any related free
writing prospectus, and the complete form of warrant and/or the warrant agreement and warrant certificate, as applicable, and any supplemental
agreements that contain the terms of the warrants.
General
We will describe in the applicable prospectus supplement
the terms of the series of warrants being offered, including:
| ● | the offering price and aggregate number of warrants offered; |
| ● | the currency for which the warrants may be purchased; |
| ● | if applicable, the designation and terms of the securities with which the warrants are issued and the number of warrants issued with
each such security or each principal amount of such security; |
| ● | if applicable, the date on and after which the warrants and the related securities will be separately transferable; |
| ● | in the case of warrants to purchase debt securities, the principal amount of debt securities purchasable upon exercise of one warrant
and the price at, and currency in which, this principal amount of debt securities may be purchased upon such exercise; |
| ● | in the case of warrants to purchase common stock or preferred stock, the number of shares of common stock or preferred stock, as the
case may be, purchasable upon the exercise of one warrant and the price at which these shares may be purchased upon such exercise; |
| ● | the effect of any merger, consolidation, sale or other disposition of our business on the warrant agreements and the warrants; |
| ● | the terms of any rights to redeem or call the warrants; |
| ● | any provisions for changes to or adjustments in the exercise price or number of securities issuable upon exercise of the warrants; |
| ● | the dates on which the right to exercise the warrants will commence and expire; |
| ● | the manner in which the warrant agreements and warrants may be modified; |
| ● | a discussion of material or special U.S. federal income tax considerations, if any, of holding or exercising the warrants; |
| ● | the terms of the securities issuable upon exercise of the warrants; and |
| ● | any other specific terms, preferences, rights or limitations of or restrictions on the warrants. |
Before exercising their warrants, holders of warrants
will not have any of the rights of holders of the securities purchasable upon such exercise, including:
| ● | in the case of warrants to purchase debt securities, the right to receive payments of principal of, or premium, if any, or interest
on, the debt securities purchasable upon exercise or to enforce covenants in the applicable indenture; or |
| ● | in the case of warrants to purchase common stock or preferred stock, the right to receive dividends, if any, or payments upon our
liquidation, dissolution or winding up or to exercise voting rights, if any. |
Exercise of Warrants
Each warrant will entitle the holder to purchase
the securities that we specify in the applicable prospectus supplement at the exercise price that we describe in the applicable prospectus
supplement. The warrants may be exercised as set forth in the prospectus supplement relating to the warrants offered. Unless we otherwise
specify in the applicable prospectus supplement, warrants may be exercised at any time up to the close of business on the expiration date
set forth in the prospectus supplement relating to the warrants offered thereby. After the close of business on the expiration date, unexercised
warrants will become void.
Holders of the warrants may exercise the warrants
by delivering the warrant certificate representing the warrants to be exercised together with specified information, and paying the required
amount to the warrant agent in immediately available funds, as provided in the applicable prospectus supplement. We will set forth on
the reverse side of the warrant certificate and in the applicable prospectus supplement the information that the holder of the warrant
will be required to deliver to the warrant agent.
Upon receipt of payment and the warrant or warrant
certificate, as applicable, properly completed and duly executed at the corporate trust office of the warrant agent, if any, or any other
office, including ours, indicated in the prospectus supplement, we will, as soon as practicable, issue and deliver the securities purchasable
upon such exercise. If less than all of the warrants (or the warrants represented by such warrant certificate) are exercised, a new warrant
or a new warrant certificate, as applicable, will be issued for the remaining warrants.
Governing Law
Unless we provide otherwise in the applicable prospectus
supplement, the warrants and any warrant agreements will be governed by and construed in accordance with the internal laws of the State
of New York.
Enforceability of Rights by Holders of Warrants
Each warrant agent, if any, will act solely
as our agent under the applicable warrant agreement and will not assume any obligation or relationship of agency or trust with any
holder of any warrant. A single bank or trust company may act as warrant agent for more than one issue of warrants. A warrant agent
will have no duty or responsibility in case of any default by us under the applicable warrant agreement or warrant, including any
duty or responsibility to initiate any proceedings at law or otherwise, or to make any demand upon us. Any holder of a warrant may,
without the consent of the related warrant agent or the holder of any other warrant, enforce by appropriate legal action its right
to exercise, and receive the securities purchasable upon exercise of, its warrants.
DESCRIPTION OF RIGHTS
General
We may issue rights to purchase common stock, preferred
stock or the other securities described in this prospectus. This prospectus and any accompanying prospectus supplement will contain the
material terms and conditions for each right. The accompanying prospectus supplement may add, update or change the terms and conditions
of the rights as described in this prospectus.
We will describe in the applicable prospectus supplement
the terms and conditions of the issue of rights being offered, the rights agreement relating to the rights and the rights certificates
representing the rights, including, as applicable:
| ● | the title of the rights; |
| ● | the date of determining the stockholders entitled to the rights distribution; |
| ● | the title, aggregate number of shares of common stock, preferred stock or other securities purchasable upon exercise of the rights; |
| ● | the currencies in which the rights are being offered; |
| ● | the aggregate number of rights issued; |
| ● | the date, if any, on and after which the rights will be separately transferable; |
| ● | the date on which the right to exercise the rights will commence and the date on which the right will expire; and |
| ● | any other terms of the rights, including terms, procedures and limitations relating to the distribution, exchange and exercise of
the rights. |
Exercise of Rights
Each right will entitle the holder of rights to
purchase for cash the principal amount of shares of common stock, preferred stock or other securities at the exercise price provided in
the applicable prospectus supplement. Rights may be exercised at any time up to the close of business on the expiration date for the rights
provided in the applicable prospectus supplement. After the close of business on the expiration date, all unexercised rights will be void.
Holders may exercise rights as described in the
applicable prospectus supplement. Upon receipt of payment and the rights certificate properly completed and duly executed at the corporate
trust office of the rights agent or any other office indicated in the prospectus supplement, we will, as soon as practicable, forward
the shares of common stock or preferred stock purchasable upon exercise of the rights. If less than all of the rights issued in any rights
offering are exercised, we may offer any unsubscribed securities directly to persons other than stockholders, to or through agents, underwriters,
brokers or dealers or through a combination of such methods, including pursuant to standby underwriting arrangements, as described in
the applicable prospectus supplement.
DESCRIPTION OF UNITS
The following description, together with the additional
information we may include in any applicable prospectus supplements and free writing prospectuses, summarizes the material terms and provisions
of the units that we may offer under this prospectus. While the terms we have summarized below will apply generally to any units
that we may offer under this prospectus, we will describe the particular terms of any series of units in more detail in the applicable
prospectus supplement. The terms of any units offered under a prospectus supplement may differ from the terms described below. However,
no prospectus supplement will fundamentally change the terms that are set forth in this prospectus or offer a security that is not registered
and described in this prospectus at the time of its effectiveness.
We will file as exhibits to the registration statement
of which this prospectus is a part, or will incorporate by reference from a report that we file with the SEC, the form of unit agreement
that describes the terms of the series of units we are offering, and any supplemental agreements, before the issuance of the related
series of units. The following summaries of material terms and provisions of the units are subject to, and qualified in their
entirety by reference to, all the provisions of the unit agreement and any supplemental agreements applicable to a particular series of units.
We urge you to read the applicable prospectus supplements related to the particular series of units that we sell under this prospectus,
as well as the complete unit agreement and any supplemental agreements that contain the terms of the units.
General
We may issue units comprised of one or more
debt securities, shares of common stock, shares of preferred stock, warrants or rights in any combination. Each unit will be issued so
that the holder of the unit is also the holder of each security included in the unit. Thus, the holder of a unit will have the rights
and obligations of a holder of each included security. The unit agreement under which a unit is issued may provide that the securities
included in the unit may not be held or transferred separately, at any time or at any time before a specified date.
We will describe in the applicable prospectus supplement
the terms of the series of units, including:
| ● | the designation and terms of the units and of the securities comprising the units, including whether and under what circumstances
those securities may be held or transferred separately; |
| ● | any provisions of the governing unit agreement that differ from those described below; and |
| ● | any provisions for the issuance, payment, settlement, transfer or exchange of the units or of the securities comprising the units. |
The provisions described in this section, as well
as those described under “Description of Capital Stock,” “Description of Debt Securities,” “Description
of Warrants” and “Description of Rights” will apply to each unit and to any common stock, preferred stock, debt security,
warrant or right included in each unit, respectively.
Issuance in Series
We may issue units in such amounts and in numerous
distinct series as we determine.
Enforceability of Rights by Holders of Units
Each unit agent will act solely as our agent
under the applicable unit agreement and will not assume any obligation or relationship of agency or trust with any holder of any unit.
A single bank or trust company may act as unit agent for more than one series of units. A unit agent will have no duty or responsibility
in case of any default by us under the applicable unit agreement or unit, including any duty or responsibility to initiate any proceedings
at law or otherwise, or to make any demand upon us. Any holder of a unit may, without the consent of the related unit agent or the holder
of any other unit, enforce by appropriate legal action its rights as holder under any security included in the unit.
We, the unit agents and any of their agents may
treat the registered holder of any unit certificate as an absolute owner of the units evidenced by that certificate for any purpose
and as the person entitled to exercise the rights attaching to the units so requested, despite any notice to the contrary. See “Legal
Ownership of Securities.”
LEGAL OWNERSHIP OF SECURITIES
We may issue securities in registered form or in
the form of one or more global securities. We describe global securities in greater detail below. We refer to those persons who have securities
registered in their own names on the books that we or any applicable trustee, depositary, warrant agent or other agent maintain for this
purpose as the “holders” of those securities. These persons are the legal holders of the securities. We refer to those persons
who, indirectly through others, own beneficial interests in securities that are not registered in their own names, as “indirect
holders” of those securities. As we discuss below, indirect holders are not legal holders, and investors in securities issued in
book-entry form or in street name will be indirect holders.
Book-Entry Holders
We may issue securities in book-entry form only,
as we will specify in the applicable prospectus supplement. This means securities may be represented by one or more global securities
registered in the name of a financial institution that holds them as depositary on behalf of other financial institutions that participate
in the depositary’s book-entry system. These participating institutions, which are referred to as participants, in turn, hold beneficial
interests in the securities on behalf of themselves or their customers.
Only the person in whose name a security is registered
is recognized as the holder of that security. Securities issued in global form will be registered in the name of the depositary or its
participants. Consequently, for securities issued in global form, we will recognize only the depositary as the holder of the securities,
and we will make all payments on the securities to the depositary. The depositary passes along the payments it receives to its participants,
which in turn pass the payments along to their customers who are the beneficial owners. The depositary and its participants do so under
agreements they have made with one another or with their customers; they are not obligated to do so under the terms of the securities.
As a result, investors in a book entry security
will not own securities directly. Instead, they will own beneficial interests in a global security, through a bank, broker or other financial
institution that participates in the depositary’s book-entry system or holds an interest through a participant. As long as the securities
are issued in global form, investors will be indirect holders, and not legal holders, of the securities.
Street Name Holders
We may terminate a global security or issue securities
that are not issued in global form. In these cases, investors may choose to hold their securities in their own names or in “street
name.” Securities held by an investor in street name would be registered in the name of a bank, broker or other financial institution
that the investor chooses, and the investor would hold only a beneficial interest in those securities through an account he or she maintains
at that institution.
For securities held in street name, we or any
applicable trustee or depositary will recognize only the intermediary banks, brokers and other financial institutions in whose names the
securities are registered as the holders of those securities, and we or any such trustee or depositary will make all payments on those
securities to them. These institutions pass along the payments they receive to their customers who are the beneficial owners, but only
because they agree to do so in their customer agreements or because they are legally required to do so. Investors who hold securities
in street name will be indirect holders, not legal holders, of those securities.
Legal Holders
Our obligations, as well as the obligations of any
applicable trustee, agent or third party employed by us or a trustee or any agents, run only to the legal holders of the securities. We
do not have obligations to investors who hold beneficial interests in global securities, in street name or by any other indirect means.
This will be the case whether an investor chooses to be an indirect holder of a security or has no choice because we are issuing the securities
only in global form.
For example, once we make a payment or give a notice
to the holder, we have no further responsibility for the payment or notice even if that holder is required, under agreements with its
participants or customers or by law, to pass it along to the indirect holders but does not do so. Similarly, we may want to obtain the
approval of the holders to amend an indenture, to relieve us of the consequences of a default or of our obligation to comply with a particular
provision of an indenture, or for other purposes. In such an event, we would seek approval only from the legal holders, and not the indirect
holders, of the securities. Whether and how the legal holders contact the indirect holders is up to the legal holders.
When we refer to “you” in this prospectus,
we mean those who invest in the securities being offered by this prospectus, whether they are the holders or only indirect holders of
those securities. When we refer to “your securities” in this prospectus, we mean the securities in which you will hold a direct
or indirect interest.
Special Considerations for Indirect Holders
If you hold securities through a bank, broker or
other financial institution, either in book-entry form because the securities are represented by one or more global securities or in street
name, you should check with your own institution to find out:
| ● | the performance of third-party service providers; |
| ● | how it handles securities payments and notices; |
| ● | whether it imposes fees or charges; |
| ● | how it would handle a request for the holders’ consent, if ever required; |
| ● | whether and how you can instruct it to send you securities registered in your own name so you can be a legal holder, if that is permitted
in the future; |
| ● | how it would exercise rights under the securities if there were a default or other event triggering the need for holders to act to
protect their interests; and |
| ● | if the securities are in book-entry form, how the depositary’s rules and procedures will affect these matters. |
Global Securities
A global security is a security that represents
one or any other number of individual securities held by a depositary. Generally, all securities represented by the same global securities
will have the same terms.
Each security issued in book-entry form will be
represented by a global security that we issue to, deposit with and register in the name of a financial institution or its nominee that
we select. The financial institution that we select for this purpose is called the depositary. Unless we specify otherwise in the applicable
prospectus supplement, DTC will be the depositary for all securities issued in book-entry form.
A global security may not be transferred to or registered
in the name of anyone other than the depositary, its nominee or a successor depositary, unless special termination situations arise. We
describe those situations below under “— Special Situations When a Global Security Will Be Terminated.” As a result
of these arrangements, the depositary, or its nominee, will be the sole registered owner and legal holder of all securities represented
by a global security, and investors will be permitted to own only beneficial interests in a global security. Beneficial interests must
be held by means of an account with a broker, bank or other financial institution that in turn has an account with the depositary or with
another institution that does. Thus, an investor whose security is represented by a global security will not be a legal holder of the
security, but only an indirect holder of a beneficial interest in the global security.
If the prospectus supplement for a particular security
indicates that the security will be issued as a global security, then the security will be represented by a global security at all times
unless and until the global security is terminated. If termination occurs, we may issue the securities through another book-entry clearing
system or decide that the securities may no longer be held through any book-entry clearing system.
Special Considerations for Global Securities
The rights of an indirect holder relating to a global
security will be governed by the account rules of the investor’s financial institution and of the depositary, as well as general
laws relating to securities transfers. We do not recognize an indirect holder as a holder of securities and instead deal only with the
depositary that holds the global security.
If securities are issued only in the form of a global
security, an investor should be aware of the following:
| ● | an investor cannot cause the securities to be registered in his or her name, and cannot obtain non-global certificates for his or
her interest in the securities, except in the special situations we describe below; |
| ● | an investor will be an indirect holder and must look to his or her own bank or broker for payments on the securities and protection
of his or her legal rights relating to the securities, as we describe above; |
| ● | an investor may not be able to sell interests in the securities to some insurance companies and to other institutions that are required
by law to own their securities in non-book-entry form; |
| ● | an investor may not be able to pledge his or her interest in a global security in circumstances where certificates representing the
securities must be delivered to the lender or other beneficiary of the pledge in order for the pledge to be effective; |
| ● | the depositary’s policies, which may change from time to time, will govern payments, transfers, exchanges and other matters
relating to an investor’s interest in a global security. We and any applicable trustee have no responsibility for any aspect of
the depositary’s actions or for its records of ownership interests in a global security. We and the trustee also do not supervise
the depositary in any way; |
| ● | the depositary may, and we understand that DTC will, require that those who purchase and sell interests in a global security within
its book-entry system use immediately available funds, and your broker or bank may require you to do so as well; and |
| ● | financial institutions that participate in the depositary’s book-entry system, and through which an investor holds its interest
in a global security, may also have their own policies affecting payments, notices and other matters relating to the securities. There
may be more than one financial intermediary in the chain of ownership for an investor. We do not monitor and are not responsible for the
actions of any of those intermediaries. |
Special Situations When a Global Security Will Be Terminated
In a few special situations described below, a global
security will terminate and interests in it will be exchanged for physical certificates representing those interests. After that exchange,
the choice of whether to hold securities directly or in street name will be up to the investor. Investors must consult their own banks
or brokers to find out how to have their interests in securities transferred to their own names, so that they will be direct holders.
We have described the rights of holders and street name investors above.
Unless we provide otherwise in the applicable
prospectus supplement, a global security will terminate when the following special situations occur:
| ● | if the depositary notifies us that it is unwilling, unable or no longer qualified to continue as depositary for that global security
and we do not appoint another institution to act as depositary within 90 days; |
| ● | if we notify any applicable trustee that we wish to terminate that global security; or |
| ● | if an event of default has occurred with regard to securities represented by that global security and has not been cured or waived. |
The applicable prospectus supplement may also list
additional situations for terminating a global security that would apply only to the particular series of securities covered by the applicable
prospectus supplement. When a global security is terminated, only the depositary, and not we, the trustee, the agent or other third party,
as applicable, is responsible for deciding the names of the institutions in whose names the securities represented by the global security
will be registered and, therefore, who will be the direct holders of those securities.
SELLING SECURITY HOLDERS
If the registration statement of which this prospectus
forms a part is used by selling security holders for the resale of any securities registered thereunder pursuant to a registration rights
agreement to be entered into by us with such selling security holders or otherwise, information about such selling security holders, their
beneficial ownership of our securities and their relationship with us will be set forth in a prospectus supplement, any free writing prospectus
or in filings we make with the SEC under the Exchange Act that are incorporated by reference into the registration statement.
PLAN OF DISTRIBUTION
We may sell the securities from time to time pursuant
to underwritten public offerings, “at-the-market” offerings, negotiated transactions, block trades or a combination of these
methods. We may sell the securities to or through one or more underwriters or dealers (acting as principal or agent), through agents,
or directly to one or more purchasers. We may distribute securities from time to time in one or more transactions:
| ● | at a fixed price or prices, which may be changed; |
| ● | at market prices prevailing at the time of sale; |
| ● | at prices related to such prevailing market prices; or |
Each time we offer and sell securities, we will
provide a prospectus supplement or supplements (and any related free writing prospectus that we may authorize to be provided to you) that
will describe the terms of the offering of the securities, including, to the extent applicable:
| ● | the name or names of any agents or underwriters, brokers or dealers and the amount of shares underwritten or purchased by each of
them; |
| ● | the purchase price of the securities or other consideration therefor and the proceeds we will receive from the sale; |
| ● | any over-allotment or other options under which underwriters may purchase additional securities from us; |
| ● | any agency fees or underwriting discounts and other items constituting agents’ or underwriters’ compensation; |
| ● | any initial public offering price; |
| ● | any discounts or concessions allowed or reallowed or paid to brokers or dealers; and |
| ● | any securities exchanges or markets on which such securities may be listed. |
Only underwriters named in the prospectus supplement
will be underwriters of the securities offered by the prospectus supplement. Dealers and agents participating in the distribution of the
securities may be deemed to be underwriters, and compensation received by them on resale of the securities may be deemed to be underwriting
discounts. If such dealers or agents were deemed to be underwriters, they may be subject to statutory liabilities under the Securities
Act.
We may designate agents who agree to use their reasonable
efforts to solicit purchases of our securities for the period of their appointment or to sell our securities on a continuing basis. We
will name any agent involved in the offering and sale of securities and we will describe any commissions we will pay to the agent in the
prospectus supplement.
If underwriters are used in the sale of securities,
the underwriters will acquire the securities for their own account and may resell the securities from time to time in one or more transactions,
including negotiated transactions, at a fixed public offering price, at varying prices determined at the time of sale, at prices related
to prevailing market prices or at negotiated prices. The obligations of the underwriters to purchase the securities will be subject to
the conditions set forth in the applicable underwriting agreement. We may offer the securities to the public through underwriting syndicates
represented by managing underwriters or by underwriters without a syndicate. Subject to certain conditions, the underwriters will be obligated
to purchase all of the securities offered by the prospectus supplement, other than securities covered by any over-allotment or other option.
If a dealer is used in the sale of securities, we or an underwriter will sell the securities to the dealer, as principal. The dealer may
then resell the securities to the public at varying prices to be determined by the dealer at the time of resale. To the extent required,
we will set forth in the prospectus supplement the name of the dealer and the terms of the transaction.
We may change from time to time any initial public
offering price and any discounts or concessions the underwriters allow or reallow or pay to brokers or dealers. We may use underwriters,
dealers or agents with whom we have a material relationship. We will describe in the prospectus supplement, naming the underwriter, dealer
or agent, the nature of any such relationship.
We may sell securities directly to one or more purchasers
without using underwriters or agents. Underwriters, brokers, dealers and agents that participate in the distribution of the securities
may be underwriters as defined in the Securities Act, and any discounts or commissions they receive from us and any profit on their resale
of the securities may be treated as underwriting discounts and commissions under the Securities Act. We will identify in the applicable
prospectus supplement any underwriters, brokers, dealers or agents and will describe their compensation. We may have agreements with the
underwriters, brokers, dealers and agents to indemnify them against specified civil liabilities, including liabilities under the Securities
Act, or to contribution with respect to payments which they may be required to make with respect to these liabilities. Agents, underwriters,
brokers and dealers, and their affiliates, may engage in transactions with, or perform services for, us in the ordinary course of business.
We, and/or the selling security holders, if applicable,
may authorize underwriters, brokers, dealers or agents to solicit offers by certain purchasers to purchase the securities from us at the
public offering price set forth in the prospectus supplement pursuant to delayed delivery contracts providing for payment and delivery
on a specified date in the future. The contracts will be subject only to those conditions set forth in the prospectus supplement, and
the prospectus supplement will set forth any commissions we pay for solicitation of these contracts.
Unless otherwise specified in the applicable prospectus
supplement, each class or series of securities we may offer will be a new issue of securities with no established trading market, other
than our common stock, which is listed on The Nasdaq Global Market. We may elect to list any other class or series of securities on any
exchange or market, but we are not obligated to do so. It is possible that one or more underwriters may make a market in these securities,
but the underwriters will not be obligated to do so and may discontinue any market making at any time without notice. We cannot guarantee
the liquidity of the trading markets for any securities.
Any underwriter may engage in overallotment, stabilizing
transactions, short covering transactions and penalty bids in accordance with Regulation M under the Exchange Act. Overallotment
involves sales in excess of the offering size, which create a short position. Stabilizing transactions permit bids to purchase the underlying
security so long as the stabilizing bids do not exceed a specified maximum price. Syndicate-covering or other short covering transactions
involve purchases of the securities, either through exercise of the over-allotment option or in the open market after the distribution
is completed to cover short positions. Penalty bids permit the underwriters to reclaim a selling concession from a dealer when the securities
originally sold by the dealer are purchased in a stabilizing or covering transaction to cover short positions. Those activities may cause
the price of the securities to be higher than it would otherwise be. If commenced, the underwriters may discontinue any of these activities
at any time.
Any underwriters who are qualified market makers
on The Nasdaq Global Market may engage in passive market making transactions in the securities on The Nasdaq Global Market in accordance
with Rule 103 of Regulation M under the Exchange Act, during the business day prior to the pricing of the offering, before the
commencement of offers or sales of the securities. Passive market makers must comply with applicable volume and price limitations and
must be identified as passive market makers. In general, a passive market maker must display its bid at a price not in excess of the highest
independent bid for such security. If all independent bids are lowered below the passive market maker’s bid, however, the passive
market maker’s bid must then be lowered when certain purchase limits are exceeded. Passive market making may stabilize the market
price of the securities at a level above that which might otherwise prevail in the open market and, if commenced, may be discontinued
at any time.
LEGAL MATTERS
Paul Hastings LLP, San Diego, California will pass
for us upon the validity of the securities being offered by this prospectus.
EXPERTS
The financial statements of Xencor, Inc. as of December
31, 2022 and 2021 and for each of the years in the three-year period ended December 31, 2022 and the effectiveness of internal control
over financial reporting as of December 31, 2022 incorporated in this prospectus and registration statement by reference from Xencor,
Inc.’s Annual Report on Form 10-K for the year ended December 31, 2022 have been audited by RSM US LLP, an independent registered
public accounting firm, as stated in their reports thereon incorporated herein by reference, and have been incorporated in this prospectus
and registration statement in reliance upon such reports and upon the authority of such firm as experts in accounting and auditing.
WHERE YOU CAN FIND MORE INFORMATION
We file annual, quarterly and current reports, proxy
statements and other information with the SEC. The SEC maintains an Internet website at http://www.sec.gov that contains
reports, proxy and information statements, and other information regarding issuers that file electronically with the SEC, including Xencor.
You may also access our reports and proxy statements free of charge at our Internet website, http://www.xencor.com. The information
contained in, or that can be accessed through, our website is not part of this prospectus. The prospectus included in this filing is part
of a registration statement filed by us with the SEC. The full registration statement can be obtained from the SEC, as indicated above,
or from us.
This prospectus is part of a registration statement
on Form S-3 we filed with the SEC relating to the securities to be offered. This prospectus does not contain all of the information we
have included in the registration statement and the accompanying exhibits and schedules in accordance with the rules and regulations of
the SEC, and we refer you to the omitted information. The statements this prospectus makes pertaining to the content of any contract,
agreement or other document that is an exhibit to the registration statement necessarily are summaries of their material provisions and
do not describe all exceptions and qualifications contained in those contracts, agreements or documents. You should read those contracts,
agreements or documents for information that may be important to you. The registration statement, exhibits and schedules are available
at the SEC’s Internet website.
You should rely only on information in this prospectus
or incorporated by reference herein. We have not authorized any person to provide you with different information. We are not making an
offer of these securities in any state where the offer is not permitted. You should not assume that the information in this prospectus
is accurate as of any date other than the date of the front page of this prospectus, regardless of the time of delivery of this prospectus
or any sale of the securities offered by this prospectus.
INCORPORATION OF CERTAIN INFORMATION BY REFERENCE
The SEC allows us to “incorporate by reference”
information from other documents that we file with it, which means that we can disclose important information to you by referring you
to those documents. The information incorporated by reference is considered to be part of this prospectus. We incorporate by reference
into this prospectus and the registration statement of which this prospectus is a part the information or documents listed below that
we have filed with the SEC (Commission File No. 001-36182):
| ● | our Annual Report on Form 10-K for the year ended December 31, 2022, filed with the SEC on February 27, 2023;
and |
| ● | the description of our common stock contained in our Registration Statement on Form 8-A (File No. 001-36182), filed under
Section 12(b) of the Exchange Act on November 7, 2013, including any subsequent amendment or report filed for the purpose of amending
such description. |
Any information in any of the foregoing
documents will automatically be deemed to be modified or superseded to the extent that information in this prospectus or in a later
filed document that is incorporated or deemed to be incorporated herein by reference modifies or replaces such information. Any
statement so modified or superseded will not be deemed, except as so modified or superseded, to constitute a part of this
prospectus.
We also incorporate by reference any future filings
(other than current reports furnished under Item 2.02 or Item 7.01 of Form 8-K and exhibits filed on such form that are related
to such items unless such Form 8-K expressly provides to the contrary) made with the SEC pursuant to Sections 13(a), 13(c), 14 or
15(d) of the Exchange Act until we file a post-effective amendment that indicates the termination of the offering of the securities covered
by this prospectus and will become a part of this prospectus from the date that such documents are filed with the SEC. Information in
such future filings updates and supplements the information provided in this prospectus. Any statements in any such future filings will
automatically be deemed to modify and supersede any information in any document we previously filed with the SEC that is incorporated
or deemed to be incorporated herein by reference to the extent that statements in the later filed document modify or replace such earlier
statements.
We will furnish without charge to each person, including
any beneficial owner, to whom a prospectus is delivered, upon written or oral request, a copy of any or all of the documents incorporated
by reference, including exhibits to these documents. Any such request may be made by writing us at Xencor, Inc., 111 West Lemon Avenue,
Monrovia, California 91016 Attn: Corporate Secretary or telephoning us at (626) 305-5900.
6,635,112 Shares of Common Stock
Pre-Funded Warrants to Purchase up to
3,088,888 Shares of Common Stock
PROSPECTUS SUPPLEMENT
Leerink Partners
Raymond James
RBC Capital Markets
Wedbush PacGrow
September 10, 2024
S-3
424B5
EX-FILING FEES
333-270030
0001326732
Xencor Inc
The prospectus is not a final prospectus for the related offering.
0001326732
2024-09-12
2024-09-12
0001326732
1
2024-09-12
2024-09-12
iso4217:USD
xbrli:pure
xbrli:shares
Calculation of Filing Fee Tables
|
S-3
|
Xencor Inc
|
Table 1: Newly Registered and Carry Forward Securities
|
|
|
Security Type
|
Security Class Title
|
Fee Calculation or Carry Forward Rule
|
Amount Registered
|
Proposed Maximum Offering Price Per Unit
|
Maximum Aggregate Offering Price
|
Fee Rate
|
Amount of Registration Fee
|
Carry Forward Form Type
|
Carry Forward File Number
|
Carry Forward Initial Effective Date
|
Filing Fee Previously Paid in Connection with Unsold Securities to be Carried Forward
|
Newly Registered Securities
|
Fees to be Paid
|
1
|
Equity
|
Common Stock, par value $0.01 per share
|
457(r)
|
11,182,600
|
$
18.00
|
$
201,286,800.00
|
0.0001476
|
$
29,709.94
|
|
|
|
|
Fees Previously Paid
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Carry Forward Securities
|
Carry Forward Securities
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Total Offering Amounts:
|
|
$
201,286,800.00
|
|
$
29,709.94
|
|
|
|
|
|
|
|
Total Fees Previously Paid:
|
|
|
|
$
0.00
|
|
|
|
|
|
|
|
Total Fee Offsets:
|
|
|
|
$
0.00
|
|
|
|
|
|
|
|
Net Fee Due:
|
|
|
|
$
29,709.94
|
|
|
|
|
1
|
The registration fee is calculated in accordance with Rule 457(r) of the Securities Act of 1933, as amended. This "Calculation of Filing Fee" table shall be deemed to update the "Calculation of Filing Fee" table filed as Exhibit 107 to the Registrant's Registration Statement on Form S-3 (File No. 333-270030) in accordance with Rules 456(b) and 457(r) under the Securities Act of 1933, as amended. Includes 1,458,600 shares of common stock that the underwriters have an option to purchase and 3,088,888 shares of common stock that are issuable upon the exercise of pre-funded warrants with a warrants sales price of $17.99 per pre-funded warrant and the exercise price of $0.01 per share issuable pursuant to the pre-funded warrants. Pursuant to Securities and Exchange Commission staff interpretation, the entire fee is allocated to the common stock underlying the pre-funded warrants.
|
|
|
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v3.24.2.u1
Offerings - Offering: 1
|
Sep. 12, 2024
USD ($)
shares
|
Offering: |
|
Fee Previously Paid |
false
|
Rule 457(r) |
true
|
Security Type |
Equity
|
Security Class Title |
Common Stock, par value $0.01 per share
|
Amount Registered | shares |
11,182,600
|
Proposed Maximum Offering Price per Unit |
18.00
|
Maximum Aggregate Offering Price |
$ 201,286,800.00
|
Fee Rate |
0.01476%
|
Amount of Registration Fee |
$ 29,709.94
|
Offering Note |
The registration fee is calculated in accordance with Rule 457(r) of the Securities Act of 1933, as amended. This "Calculation of Filing Fee" table shall be deemed to update the "Calculation of Filing Fee" table filed as Exhibit 107 to the Registrant's Registration Statement on Form S-3 (File No. 333-270030) in accordance with Rules 456(b) and 457(r) under the Securities Act of 1933, as amended. Includes 1,458,600 shares of common stock that the underwriters have an option to purchase and 3,088,888 shares of common stock that are issuable upon the exercise of pre-funded warrants with a warrants sales price of $17.99 per pre-funded warrant and the exercise price of $0.01 per share issuable pursuant to the pre-funded warrants. Pursuant to Securities and Exchange Commission staff interpretation, the entire fee is allocated to the common stock underlying the pre-funded warrants.
|
X |
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