Marshall Edwards, Inc. to Present at the 26th Annual JPMorgan Healthcare Conference
January 09 2008 - 10:25AM
Marketwired
WASHINGTON, DC will present at the 26th Annual JPMorgan
Healthcare Conference in San Francisco on Thursday, January 10,
2008 at 12.30pm.
Marshall Edwards, Inc. is developing a drug called phenoxodiol
as a therapy for late-stage, chemoresistant ovarian cancer and for
prostate and cervical cancers. It is a novel-acting drug that
inhibits key pro-survival signaling pathways operating via
sphingosine-1-phosphate and Akt. Inhibition of these pathways leads
to prevention of phosphorylation of key anti-apoptotic proteins
such as XIAP. Loss of activity of these proteins induces cell death
by apoptosis and restores the sensitivity of chemoresistant tumor
cells to other chemotherapy drugs. The putative molecular target
for phenoxodiol is a cancer-specific protein, accounting for the
highly selective nature of the drug.
This helps explain the findings that phenoxodiol has been shown
not to adversely affect normal cells in animal and laboratory
testing.
Phenoxodiol has received Fast Track status from the FDA to
facilitate development as a therapy for recurrent ovarian and
prostate cancers. Phenoxodiol is an investigational drug and, as
such, is not commercially available. Under U.S. law, a new drug
cannot be marketed until it has been investigated in clinical
trials and approved by FDA as being safe and effective for the
intended use.
Phase III Multinational Trial for Ovarian Cancer Patients
Underway
Phenoxodiol in combination with carboplatin is currently being
studied in a multinational Phase III clinical trial called the
OVATURE (OVArian TUmor REsponse) Trial, following positive findings
of previous trials conducted in Australia and at Yale-New Haven
Hospital. The OVATURE trial is taking place at up to 60 clinical
sites in the United States, Europe, and Australia. Preliminary
results from the trial are expected within 18 months. For more
information on the trial, visit www.OVATUREtrial.com.
About Marshall Edwards, Inc.
Marshall Edwards, Inc. has licensed rights from Novogen Limited
(NASDAQ: NVGN) to bring three oncology drugs -- phenoxodiol, NV-196
and NV-143 -- to market globally. Marshall Edwards, Inc. is
majority owned by Novogen, an Australian biotechnology company that
is specializing in the development of therapeutics based on
regulation of the sphingomyelin pathway. Novogen, based in Sydney,
Australia, is developing a range of therapeutics across the fields
of oncology, cardiovascular disease and inflammatory diseases. More
information on phenoxodiol and on the Novogen group of companies
can be found at www.marshalledwardsinc.com and www.novogen.com.
Under U.S. law, a new drug cannot be marketed until it has been
investigated in clinical trials and approved by the FDA as being
safe and effective for the intended use. Statements included in
this press release that are not historical in nature are
"forward-looking statements" within the meaning of the "safe
harbor" provisions of the Private Securities Litigation Reform Act
of 1995. You should be aware that our actual results could differ
materially from those contained in the forward-looking statements,
which are based on management's current expectations and are
subject to a number of risks and uncertainties, including, but not
limited to, our failure to successfully commercialize our product
candidates; costs and delays in the development and/or FDA
approval, or the failure to obtain such approval, of our product
candidates; uncertainties in clinical trial results; our inability
to maintain or enter into, and the risks resulting from our
dependence upon, collaboration or contractual arrangements
necessary for the development, manufacture, commercialization,
marketing, sales and distribution of any products; competitive
factors; our inability to protect our patents or proprietary rights
and obtain necessary rights to third arty patents and intellectual
property to operate our business; our inability to operate our
business without infringing the patents and proprietary rights of
others; general economic conditions; the failure of any products to
gain market acceptance; our inability to obtain any additional
required financing; technological changes; government regulation;
changes in industry practice; and one-time events. We do not intend
to update any of these factors or to publicly announce the results
of any revisions to these forward-looking statements.
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Contact: David Sheon Email Contact 202-518-6321
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