DCTH

Filed pursuant to Rule 424(b)(5)

Registration No. 333-257428

Prospectus Supplement

(To Prospectus Supplement dated November 9, 2021)

Up to $17,000,000

Common Stock

This prospectus supplement amends and supplements the information in the prospectus supplement, dated November 9, 2021, filed with the Securities and Exchange Commission as a part of our registration statement on Form S-3 (File No. 333-257428) (the “Prior Prospectus”), relating to the offer and sale of up to $25,000,000 of shares of our common stock, $0.01 par value per share, pursuant to the Controlled Equity Offering^SM Sales Agreement dated as of August 18, 2020 (the “Sales Agreement”) we previously entered into with Cantor Fitzgerald & Co. (the “Agent”). This prospectus supplement should be read in conjunction with the Prior Prospectus, and is qualified by reference thereto, except to the extent that the information herein amends or supersedes the information contained in the Prior Prospectus. This prospectus supplement is not complete without, and may only be delivered or utilized in connection with, the Prior Prospectus and any future amendments or supplements thereto.

Through February 27, 2023, we have sold an aggregate of 515,000 shares of our common stock in accordance with the Sales Agreement under the Prior Prospectus for aggregate gross proceeds of approximately $4 million. We are filing this prospectus supplement to amend the Prior Prospectus because we are now subject to General Instruction I.B.6 of Form S-3, which limits the amounts that we may sell under the registration statement of which this prospectus supplement and the Prior Prospectus are a part. After giving effect to these limitations and the current public float of our common stock, and after giving effect to the terms of the Sales Agreement, we currently may offer and sell shares of our common stock having an aggregate offering price of up to $17,000,000 under the Sales Agreement, which amount is in addition to the shares of common stock that we have sold to date in accordance with the Sales Agreement under the Prior Prospectus. If our public float increases such that we may sell additional amounts under the Sales Agreement and the registration statement of which this prospectus supplement and the Prior Prospectus are a part, we will file another prospectus supplement prior to making additional sales.

Our common stock is listed on The Nasdaq Capital Market under the symbol “DCTH.” On February 24, 2023, the last report sale price of our common stock on The Nasdaq Capital Market was $4.91 per share.

The aggregate market value of our common stock held by non-affiliates as of February 27, 2023 pursuant to General Instruction I.B.6 of Form S-3 is $51,156,403 which was calculated based on 9,386,496 shares of our common stock outstanding held by non-affiliates and at a price of $5.45 per share, the closing price of our common stock on February 9, 2023. As of the date hereof, we have not offered or sold any securities pursuant to General Instruction I.B.6 of Form S-3 during the prior 12 calendar month period that ends on and includes the date hereof. As a result of the limitations of General Instruction I.B.6 of Form S-3, and in accordance with the terms of the Sales Agreement, we are registering the offer and sale of shares of our common stock having an aggregate offering price of up to $17,000,000 from time to time through the Agent.

Investing in our securities involves risks. See “Risk Factors” on page S-6 of the Prior Prospectus and in the documents incorporated by reference into the Prior Prospectus and in our most recent Annual Report on Form 10-K and in our most recent Quarterly Reports on Form 10-Q, and any amendments thereto, which are incorporated by reference into the Prior Prospectus, and under similar headings in the other documents that are filed after the date hereof and incorporated by reference into this prospectus supplement and the Prior Prospectus for a discussion of the factors you should carefully consider before deciding to purchase our common stock.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or passed upon the adequacy or accuracy of the Prior Prospectus, this prospectus supplement or the accompanying prospectus. Any representation to the contrary is a criminal offense.

The date of this prospectus supplement is February 27, 2023.