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As filed with the Securities and
Exchange Commission on November 8, 2023
Registration No. 333-
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UNITED
STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM
S-8
REGISTRATION
STATEMENT UNDER THE SECURITIES ACT OF 1933
BIOCRYST
PHARMACEUTICALS, INC.
(Exact Name of Registrant as Specified in its
Charter)
| Delaware |
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62-1413174 |
| (State of Incorporation) |
|
(I.R.S. Employer Identification No.) |
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4505 Emperor Blvd., Suite 200
Durham, North Carolina |
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27703 |
| (Address of Principal Executive Offices) |
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(Zip Code) |
Inducement Equity Incentive Plan
(as Amended and Restated as of October 26, 2023)
(Full Title of the Plan)
Jon P. Stonehouse
President and Chief Executive Officer
BioCryst Pharmaceuticals, Inc.
4505 Emperor Blvd., Suite 200
Durham, North Carolina 27703
(Name and Address of Agent for Service)
(919)
859-1302
(Telephone Number, Including Area Code, of Agent
for Service)
Copies to:
Brian Lane, Esq.
Robyn Zolman, Esq.
Gibson, Dunn and Crutcher LLP
1050 Connecticut Ave. N.W.
Washington, DC 20036
(202)
955-8500
Indicate by check mark
whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an
emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller
reporting company” and “emerging growth company” in Rule 12b-2 of the Exchange Act.
| Large accelerated filer ☒ |
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Accelerated filer ☐ |
| Non-accelerated filer ☐ |
|
Smaller reporting company ☐ |
| |
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Emerging growth company ☐ |
If an emerging growth company, indicate by check mark if the registrant
has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant
to Section 7(a)(2)(B) of the Securities Act. ☐
EXPLANATORY NOTE
This Registration Statement on Form S-8 (this “Registration
Statement”) is filed by BioCryst Pharmaceuticals, Inc. (the “Registrant”) to register 1,700,000 shares of the Registrant’s
common stock, par value $0.01 per share (“Common Stock”), to be offered and sold under the Registrant’s Inducement Equity
Incentive Plan (as amended and restated as of October 26, 2023), as approved by the Registrant’s Board of Directors in October 2023
(the “Inducement Plan”). The shares of Common Stock previously reserved for issuance under the Inducement Plan were registered
on the Registrant’s Registration Statements on Form S-8 previously filed with the Securities and Exchange Commission on April 29, 2019 (File No. 333-231108), June 10, 2020 (File No. 333-239078), August 12, 2020 (File No. 333-245024), September 30, 2021 (File No. 333-259919),
and August 31, 2022 (File No. 333-267193) (collectively, the “Prior Registration Statements”). The information contained in
the Prior Registration Statements, together with all exhibits filed therewith or incorporated therein by reference, is hereby incorporated
by reference pursuant to General Instruction E to Form S-8, except as amended hereby. The shares of Common Stock registered hereunder
are in addition to the shares of Common Stock registered on the Prior Registration Statements.
PART
II
INFORMATION
REQUIRED IN THE REGISTRATION STATEMENT
Item 8. Exhibits.
The following exhibits are submitted herewith or
incorporated by reference herein.
SIGNATURES
Pursuant to the requirements of the Securities
Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for
filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized,
in the City of Durham, State of North Carolina, on the 8th day of November, 2023.
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BIOCRYST PHARMACEUTICALS, INC. |
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By: |
/s/ Jon P. Stonehouse |
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Jon P. Stonehouse |
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President & Chief Executive Officer |
POWER
OF ATTORNEY
Each of the undersigned officers and directors
of BIOCRYST PHARMACEUTICALS, INC. hereby constitutes and appoints Jon P. Stonehouse, Anthony J. Doyle, and Alane P. Barnes, and each of
them, as the undersigned’s true and lawful attorneys-in-fact and agents, with full power of substitution and resubstitution, for
the undersigned and in the undersigned’s name, place and stead, in any and all capacities, to sign any and all amendments (including
post-effective amendments) to this Registration Statement, and to file the same, with all exhibits thereto, and all documents in connection
therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents full power and authority to do
and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully to all intents and purposes
as the undersigned might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or any of
them, or any of their substitutes, may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities
Act, this Registration Statement has been signed by the following persons in the capacities indicated on November 8, 2023.
| Signature |
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Title |
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| /s/ Jon P. Stonehouse |
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President, Chief Executive Officer and Director |
| Jon P. Stonehouse |
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(Principal Executive Officer) |
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| /s/ Anthony J. Doyle |
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Chief Financial Officer |
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Anthony J. Doyle
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(Principal Financial Officer and Interim Principal Accounting Officer) |
| /s/ George B. Abercrombie |
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Director |
| George B. Abercrombie |
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| /s/ Stephen J. Aselage |
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Director |
| Stephen J. Aselage |
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| /s/ Steven K. Galson, M.D. |
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Director |
| Steven K. Galson, M.D. |
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| /s/ Theresa M. Heggie |
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Director |
| Theresa M. Heggie |
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| /s/ Nancy J. Hutson, Ph.D. |
|
Director |
| Nancy J. Hutson, Ph.D. |
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| /s/ Kenneth B. Lee, Jr. |
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Director |
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Kenneth B. Lee, Jr.
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| /s/ Alan G. Levin |
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Director |
| Alan G. Levin |
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| /s/ Amy E. McKee, M.D. |
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Director |
| Amy E. McKee, M.D. |
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| /s/ Vincent J. Milano |
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Director |
| Vincent J. Milano |
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| /s/ Machelle Sanders |
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Director |
| Machelle Sanders |
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Exhibit 5.1
November 8, 2023
BioCryst Pharmaceuticals, Inc.
4505 Emperor Blvd., Suite 200
Durham, North Carolina 27703
| Re: | BioCryst Pharmaceuticals, Inc.
Registration Statement on Form S-8 |
Ladies and Gentlemen:
We have examined the Registration Statement on Form S-8 (the “Registration
Statement”) of BioCryst Pharmaceuticals, Inc., a Delaware corporation (the “Company”), filed with the Securities and
Exchange Commission (the “Commission”) pursuant to the Securities Act of 1933, as amended (the “Securities Act”),
in connection with the offering by the Company of up to 1,700,000 shares of the Company’s common stock, par value $0.01 per share
(“Common Stock”), issuable pursuant to the Company’s Inducement Equity Incentive Plan (as amended and restated October
26, 2023, the “Plan,” and such shares, the “Shares”).
In arriving at the opinion expressed below, we have examined originals,
or copies certified or otherwise identified to our satisfaction as being true and complete copies of the originals, of specimen Common
Stock certificates and such other documents, corporate records, certificates of officers of the Company and of public officials and other
instruments as we have deemed necessary or advisable to enable us to render this opinion. In our examination, we have assumed without
independent investigation the genuineness of all signatures, the legal capacity and competency of all natural persons, the authenticity
of all documents submitted to us as originals and the conformity to original documents of all documents submitted to us as copies. As
to any facts material to this opinion, we have relied to the extent we deemed appropriate and without independent investigation upon statements
and representations of officers and other representatives of the Company and others. We have also assumed without independent investigation
that there are no agreements or understandings between or among the Company and any participants in the Plan that would expand, modify,
or otherwise affect the terms of the Plan or the respective rights or obligations of the participants thereunder.
Based on the foregoing and in reliance thereon, and subject to the
assumptions, exceptions, qualifications and limitations set forth herein, we are of the opinion that the Shares, when issued against payment
therefor in accordance with the terms set forth in the Plan, will be validly issued, fully paid and non-assessable.
Abu Dhabi –
Beijing – Brussels – Century City
– Dallas – Denver –
Dubai – Frankfurt – Hong Kong
– Houston – London –
Los Angeles
Munich – New York – Orange County
– Palo Alto – Paris –
San Francisco – Singapore – Washington,
D.C.
BioCryst Pharmaceuticals, Inc.
November 8, 2023
Page 2
The opinion expressed above is subject to the following exceptions,
qualifications, limitations and assumptions:
A.
We render no opinion herein as to matters involving the laws of any jurisdiction other than the Delaware General Corporation Law
(“DGCL”). This opinion is limited to the effect of the current state of the DGCL and the facts as they currently exist. We
assume no obligation to revise or supplement this opinion in the event of future changes in such laws or the interpretation thereof or
such facts. We express no opinion regarding any state securities laws or regulations.
We consent to the filing of this opinion as an exhibit to the Registration
Statement. In giving this consent, we do not thereby admit that we are within the category of persons whose consent is required under
Section 7 of the Securities Act or the Rules and Regulations of the Commission.
Very truly yours,
/s/ Gibson, Dunn & Crutcher LLP
Exhibit
23.1
Consent
of Independent Registered Public Accounting Firm
We consent to the incorporation
by reference in the Registration Statement (Form S-8) pertaining to the Inducement Equity Incentive Plan (as Amended and Restated as of
October 26, 2023) of BioCryst Pharmaceuticals, Inc. of our reports dated February 27, 2023, with respect to the consolidated financial
statements of BioCryst Pharmaceuticals, Inc. and the effectiveness of internal control over financial reporting of BioCryst Pharmaceuticals,
Inc. included in its Annual Report (Form 10-K) for the year ended December 31, 2022, filed with the Securities and Exchange Commission.
Raleigh, North Carolina
November 8, 2023
Exhibit 107
Calculation of Filing Fee Table
Form S-8
(Form Type)
BIOCRYST
PHARMACEUTICALS, INC.
(Exact Name of Registrant
as Specified in its Charter)
Table
1: Newly Registered Securities
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Security
Type |
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Fee
Calculation Rule |
Amount
Registered (1) |
Proposed
Maximum Offering Price Per Share (2) |
Maximum Aggregate
Offering Price (2)
|
Fee
Rate |
Amount
of Registration
Fee |
|
| Equity |
Common
Stock, $0.01 par value |
Other
(2) |
1,700,000 (3) |
$5.57 |
$9,469,000.00 |
$0.0001476 |
$1,397.62 |
|
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Total Offering
Amounts |
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$9,469,000.00 |
|
$1,397.62 |
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Total Fee Offsets |
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— |
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Net
Fee Due |
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$1,397.62 |
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(1) Pursuant to Rule 416(a) under the Securities Act of 1933, as amended
(the “Securities Act”), this Registration Statement shall also cover any additional shares of Common Stock which become issuable
by reason of any stock dividend, stock split, recapitalization or other similar transaction effected without the receipt of consideration
which results in an increase in the number of the Registrant’s outstanding shares of Common Stock.
(2) Estimated solely for the purpose of calculating the amount of the
registration fee pursuant to Rules 457(c) and 457(h) under the Securities Act, based on the average of the high and low prices of the
Registrant’s Common Stock on November 2, 2023, as reported on The Nasdaq Global Select Market.
(3) Increase in authorized number of shares under the Inducement Equity
Incentive Plan (as amended and restated as of October 26, 2023), as approved by the Registrant’s Board of Directors in October 2023.
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