United Therapeutics Corporation (Nasdaq: UTHR), a public
benefit corporation, today announced its financial results for the
quarter and year ended December 31, 2023. Full year 2023 revenues
rose to a record $2.33 billion, reflecting 20% growth over
2022.
“Congratulations to the dedicated Unitherians who worked
tirelessly to help us achieve our third straight quarter and second
straight year of record revenue,” said Martine Rothblatt,
Ph.D., Chairperson and Chief Executive Officer of United
Therapeutics. “This represents only the beginning of our growth,
driven by a strong foundation in our current commercial business
and upcoming enrollment milestones for our innovative pipeline. On
top of this, we have continued momentum for our revolutionary organ
manufacturing programs, with the first human clinical study of a
bioengineered organ, the miroliverELAP, cleared by the FDA, and the
recent opening of the world’s first designated pathogen-free
clinical supply facility to support our upcoming
xenotransplantation clinical program.”
“Our commercial business remains a solid foundation supporting
our innovative and revolutionary efforts to cure end stage organ
disease,” said Michael Benkowitz, President and Chief
Operating Officer of United Therapeutics. “To that end, in the
fourth quarter we saw record revenue for our Tyvaso business, and
we achieved solid growth in our U.S. Remodulin business, with
strong revenue growth and a record number of patients on therapy
despite the presence of generic competition since 2019.”
Fourth Quarter and Full Year 2023 Financial Results
Key financial highlights include (in millions, except per share
data):
Three Months Ended
December 31,
Year Ended December
31,
2023
2022
2023
2022
Total revenues
$
614.7
$
491.5
$
2,327.5
$
1,936.3
Net income
$
217.1
$
132.1
$
984.8
$
727.3
Net income, per basic share
$
4.62
$
2.88
$
21.04
$
15.98
Net income, per diluted share
$
4.36
$
2.67
$
19.81
$
15.00
Revenues
The table below presents the components of total revenues
(dollars in millions):
Three Months Ended
December 31,
Dollar Change
Percentage Change
Year Ended December
31,
Dollar Change
Percentage Change
2023
2022
2023
2022
Net product sales:
Tyvaso DPI®(1)
$
213.7
$
92.2
$
121.5
132%
$
731.1
$
158.3
$
572.8
362%
Nebulized Tyvaso®(1)
136.9
150.1
(13.2)
(9)%
502.6
714.7
(212.1)
(30)%
Total Tyvaso
350.6
242.3
108.3
45%
1,233.7
873.0
360.7
41%
Remodulin®(2)
115.1
122.5
(7.4)
(6)%
494.8
500.2
(5.4)
(1)%
Orenitram®
84.1
75.8
8.3
11%
359.4
325.1
34.3
11%
Unituxin®
54.2
36.7
17.5
48%
198.9
182.9
16.0
9%
Adcirca®
6.8
10.4
(3.6)
(35)%
28.9
41.3
(12.4)
(30)%
Other
3.9
3.8
0.1
3%
11.8
13.8
(2.0)
(14)%
Total revenues
$
614.7
$
491.5
$
123.2
25%
$
2,327.5
$
1,936.3
$
391.2
20%
(1)
Net product sales include both the drug
product and the respective inhalation device.
(2)
Net product sales include sales of
infusion devices including the Remunity® Pump.
Fourth Quarter 2023 Compared to Fourth Quarter 2022.
Total Tyvaso revenues grew by 45% to $350.6 million in the fourth
quarter of 2023, compared to $242.3 million in the fourth quarter
of 2022. This growth was primarily due to an increase in quantities
sold, driven by the commercial launch of Tyvaso DPI in June 2022
and continued growth in utilization by patients with pulmonary
hypertension associated with interstitial lung disease
(PH-ILD). The growth in Tyvaso DPI revenues resulted
primarily from an increase in quantities sold. The decrease in
nebulized Tyvaso revenues was primarily due to a decrease in U.S.
quantities sold following the commercial launch of Tyvaso DPI,
partially offset by an increase in international nebulized Tyvaso
revenues, primarily due to the commercial launch of nebulized
Tyvaso in Japan in December 2022, as shown in the table below. The
decrease in Remodulin revenues resulted from a decrease in
international Remodulin revenues, partially offset by an increase
in U.S. Remodulin revenues, as shown in the table below. The
increase in Orenitram revenues resulted from a price increase and
an increase in quantities sold. The increase in Unituxin revenues
resulted from an increase in quantities sold and a price
increase.
Full Year 2023 Compared to Full Year 2022. Total Tyvaso
revenues grew by 41% to $1,233.7 million in 2023, compared to
$873.0 million in 2022. This growth was primarily due to an
increase in quantities sold, driven by the commercial launch of
Tyvaso DPI in June 2022 and continued growth in utilization by
patients with PH-ILD. The growth in Tyvaso DPI revenues resulted
primarily from an increase in quantities sold. The decrease in
nebulized Tyvaso revenues was driven by a decrease in U.S.
nebulized Tyvaso revenues, primarily due to a decrease in
quantities sold following the commercial launch of Tyvaso DPI,
partially offset by an increase in international nebulized Tyvaso
revenues, primarily due to the commercial launch of nebulized
Tyvaso in Japan in December 2022, as shown in the table below. The
decrease in Remodulin revenues resulted from a decrease in
international Remodulin revenues, partially offset by an increase
in U.S. Remodulin revenues, as shown in the table below. The
increase in Orenitram revenues resulted from a price increase and
an increase in quantities sold. The increase in Unituxin revenues
resulted primarily from a price increase.
The table below presents the breakdown of total revenues between
the United States and rest-of-world (ROW) (in millions):
Three Months Ended December
31,
Year Ended December
31,
2023
2022
2023
2022
U.S.
ROW
Total
U.S.
ROW
Total
U.S.
ROW
Total
U.S.
ROW
Total
Net product sales:
Tyvaso DPI(1)
$
213.7
$
—
$
213.7
$
92.2
$
—
$
92.2
$
731.1
$
—
$
731.1
$
158.3
$
—
$
158.3
Nebulized Tyvaso(1)
123.7
13.2
136.9
148.4
1.7
150.1
477.1
25.5
502.6
708.6
6.1
714.7
Total Tyvaso
337.4
13.2
350.6
240.6
1.7
242.3
1,208.2
25.5
1,233.7
866.9
6.1
873.0
Remodulin(2)
106.3
8.8
115.1
97.7
24.8
122.5
414.6
80.2
494.8
407.5
92.7
500.2
Orenitram
84.1
—
84.1
75.8
—
75.8
359.4
—
359.4
325.1
—
325.1
Unituxin
48.7
5.5
54.2
36.4
0.3
36.7
181.3
17.6
198.9
170.5
12.4
182.9
Adcirca
6.8
—
6.8
10.4
—
10.4
28.9
—
28.9
41.3
—
41.3
Other
2.6
1.3
3.9
2.8
1.0
3.8
9.8
2.0
11.8
2.8
11.0
13.8
Total revenues
$
585.9
$
28.8
$
614.7
$
463.7
$
27.8
$
491.5
$
2,202.2
$
125.3
$
2,327.5
$
1,814.1
$
122.2
$
1,936.3
(1)
Net product sales include both the drug
product and the respective inhalation device.
(2)
Net product sales include sales of
infusion devices including the Remunity Pump.
Expenses
Cost of sales. The table below summarizes cost of sales
by major category (dollars in millions):
Three Months Ended
December 31,
Dollar Change
Percentage Change
Year Ended December
31,
Dollar Change
Percentage Change
2023
2022
2023
2022
Category:
Cost of sales
$
70.1
$
55.9
$
14.2
25%
$
255.1
$
146.7
$
108.4
74%
Share-based compensation
expense(1)
0.9
2.9
(2.0)
(69)%
2.4
4.9
(2.5)
(51)%
Total cost of sales
$
71.0
$
58.8
$
12.2
21%
$
257.5
$
151.6
$
105.9
70%
(1)
See Share-based compensation below.
Cost of sales, excluding share-based compensation. The increase
in cost of sales for the quarter ended December 31, 2023, as
compared to the same period in 2022, was primarily due to an
increase in Tyvaso DPI royalty expense and product costs following
its commercial launch in June 2022.
The increase in cost of sales for the year ended December 31,
2023, as compared to the same period in 2022, was primarily due to
an increase in Tyvaso DPI royalty expense and product costs,
following its commercial launch in June 2022, and an increase in
Remunity product sales.
Research and development expense. The table below
summarizes the nature of research and development expense by major
expense category (dollars in millions):
Three Months Ended
December 31,
Dollar Change
Percentage Change
Year Ended December
31,
Dollar Change
Percentage Change
2023
2022
2023
2022
Category:
External research and development(1)
$
50.4
$
46.7
$
3.7
8%
$
192.0
$
168.8
$
23.2
14%
Internal research and development(2)
43.2
35.4
7.8
22%
146.6
131.4
15.2
12%
Share-based compensation expense(3)
5.7
11.0
(5.3)
(48)%
15.6
23.8
(8.2
)
(34)%
Impairments(4)
—
—
—
—%
—
—
—
—%
Other(5)
52.1
0.8
51.3
NM(6)
53.8
(1.1)
54.9
NM(6)
Total research and development expense
$
151.4
$
93.9
$
57.5
61%
$
408.0
$
322.9
$
85.1
26%
(1)
External research and development
primarily includes fees paid to third parties (such as clinical
trial sites, contract research organizations, and contract
laboratories) for preclinical and clinical studies and payments to
third-party contract manufacturers before FDA approval of the
relevant product.
(2)
Internal research and development
primarily includes salary-related expenses for research and
development functions, internal costs to manufacture product
candidates before FDA approval, and internal facilities-related
expenses, including depreciation, related to research and
development activities.
(3)
See Share-based compensation below.
(4)
Impairments primarily includes impairment
charges to write down the carrying value of in-process research and
development (IPR&D) and of certain property, plant, and
equipment as a result of research and development activities. There
were no impairment charges during the years ended December 31, 2023
and December 31, 2022.
(5)
Other primarily includes upfront fees and
milestone payments to third parties under license agreements
related to development-stage products, adjustments to the fair
value of our contingent consideration obligations, and costs to
acquire certain IPR&D assets. During the quarter and year ended
December 31, 2023, we recorded $46.0 million in IPR&D expense
in connection with the acquisition of IVIVA Medical, Inc.
(IVIVA).
(6)
Calculation is not meaningful.
Research and development, excluding share-based compensation.
The increase in research and development expense for the quarter
ended December 31, 2023, as compared to the same period in 2022,
was due to an increase in IPR&D expense in connection with the
acquisition of IVIVA and increased expenditures related to the
TETON 1 and TETON 2 clinical studies of nebulized Tyvaso in
patients with idiopathic pulmonary fibrosis (IPF).
The increase in research and development expense for the year
ended December 31, 2023, as compared to the same period in 2022,
was due to: (1) an increase in IPR&D expense in connection with
the acquisition of IVIVA; (2) increased expenditures related to the
TETON 1 and TETON 2 clinical studies of nebulized Tyvaso in
patients with IPF; and (3) increased expenditures related to organ
manufacturing projects.
Selling, general, and administrative expense. The table
below summarizes selling, general, and administrative expense by
major category (dollars in millions):
Three Months Ended
December 31,
Dollar Change
Percentage Change
Year Ended December
31,
Dollar Change
Percentage Change
2023
2022
2023
2022
Category:
General and administrative
$
98.1
$
89.3
$
8.8
10%
$
374.2
$
333.2
$
41.0
12%
Sales and marketing
24.1
23.0
1.1
5%
81.8
70.8
11.0
16%
Share-based compensation expense(1)
10.0
50.9
(40.9)
(80)%
21.1
78.1
(57.0)
(73)%
Total selling, general, and administrative
expense
$
132.2
$
163.2
$
(31.0)
(19)%
$
477.1
$
482.1
$
(5.0)
(1)%
(1)
See Share-based compensation below.
General and administrative, excluding share-based compensation.
The increase in general and administrative expense for the year
ended December 31, 2023, as compared to the same period in 2022,
was primarily due to increases in: (1) office expenses; (2)
personnel expense due to growth in headcount; and (3) sponsorships
and grants.
Sales and marketing, excluding share-based compensation. The
increase in sales and marketing expense for the year ended December
31, 2023, as compared to the same period in 2022, was primarily due
to increases in: (1) personnel expense due to growth in headcount;
and (2) consulting expenses.
Share-based compensation. The table below summarizes
share-based compensation expense by major category (dollars in
millions):
Three Months Ended
December 31,
Dollar Change
Percentage Change
Year Ended December
31,
Dollar Change
Percentage Change
2023
2022
2023
2022
Category:
Stock options
$
2.9
$
5.8
$
(2.9)
(50)%
$
15.4
$
22.6
$
(7.2)
(32)%
Restricted stock units
14.1
12.1
2.0
17%
52.4
35.7
16.7
47%
Share tracking awards plan
(STAP)
(0.9)
46.5
(47.4)
(102)%
(30.7
)
46.7
(77.4)
(166)%
Employee stock purchase plan
0.5
0.4
0.1
25%
2.0
1.8
0.2
11%
Total share-based compensation expense
$
16.6
$
64.8
$
(48.2)
(74)%
$
39.1
$
106.8
$
(67.7)
(63)%
The decrease in share-based compensation expense for the quarter
ended December 31, 2023, as compared to the same period in 2022,
was primarily due to an increase in STAP benefit driven by a three
percent decrease in our stock price during the quarter ended
December 31, 2023, as compared to a 33 percent increase in our
stock price for the same period in 2022. The decrease in
share-based compensation expense for the year ended December 31,
2023, as compared to the same period in 2022, was primarily due to:
(1) an increase in STAP benefit driven by a 21 percent decrease in
our stock price during 2023, as compared to a 29 percent increase
in our stock price during 2022; and (2) a decrease in stock option
expense due to fewer awards remaining outstanding in 2023, as
compared to the same period in 2022, partially offset by an
increase in restricted stock unit expense.
Other expense, net. The change in other expense, net for
the year ended December 31, 2023, as compared to the same period in
2022, was primarily due to net unrealized and realized gains and
losses on equity securities.
Income tax expense. Income tax expense was $289.5 million
for the year ended December 31, 2023, compared to $223.3 million
for the same period in 2022. Our effective income tax rate was
approximately 23 percent for the years ended December 31, 2023 and
2022.
Inducement Restricted Stock Units
On February 19, 2024, we granted a total of 11,250 restricted
stock units under our 2019 Inducement Stock Incentive Plan to six
newly hired employees. All of these restricted stock units will
vest in full on February 19, 2027, the third anniversary of the
grant date, assuming continued employment on such date, and subject
to the standard terms and conditions we filed with the SEC as
Exhibit 10.2 to our Current Report on Form 8-K on March 1, 2019. We
are providing this information in accordance with Nasdaq Listing
Rule 5635(c)(4).
Webcast
We will host a webcast to discuss our fourth quarter and full
year 2023 financial results on Wednesday, February 21, 2024, at
9:00 a.m. Eastern Time. The webcast can be accessed live via our
website at
https://ir.unither.com/events-and-presentations/default.aspx. A
replay of the webcast will also be available at the same location
on our website.
United Therapeutics: Enabling Inspiration
At United Therapeutics, our vision and mission are one. We use
our enthusiasm, creativity, and persistence to innovate for the
unmet medical needs of our patients and to benefit our other
stakeholders. We are bold and unconventional. We have fun, we do
good. We are the first publicly-traded biotech or pharmaceutical
company to take the form of a public benefit corporation
(PBC). Our public benefit purpose is to provide a brighter
future for patients through (a) the development of novel
pharmaceutical therapies; and (b) technologies that expand the
availability of transplantable organs.
You can learn more about what it means to be a PBC here:
unither.com/pbc.
Forward-Looking Statements
Statements included in this press release that are not
historical in nature are “forward-looking statements” within the
meaning of the Private Securities Litigation Reform Act of 1995.
Forward-looking statements include, among others, statements
related to our future growth expectations from both our current
commercial operations and our pipeline; our organ manufacturing
programs, including our efforts to cure end-stage organ disease and
the anticipated clinical trials of miroliverELAP and our
xenotransplantation program; and our goals of innovating for the
unmet medical needs of our patients and to benefit our other
stakeholders, furthering our public benefit purpose of developing
novel pharmaceutical therapies and technologies that expand the
availability of transplantable organs. These forward-looking
statements are subject to certain risks and uncertainties, such as
those described in our periodic reports filed with the Securities
and Exchange Commission, that could cause actual results to differ
materially from anticipated results. Consequently, such
forward-looking statements are qualified by the cautionary
statements, cautionary language and risk factors set forth in our
periodic reports and documents filed with the Securities and
Exchange Commission, including our most recent Annual Report on
Form 10-K, Quarterly Reports on Form 10-Q, and Current Reports on
Form 8-K. We claim the protection of the safe harbor contained in
the Private Securities Litigation Reform Act of 1995 for
forward-looking statements. We are providing this information as of
February 21, 2024, and assume no obligation to update or revise the
information contained in this press release whether as a result of
new information, future events, or any other reason.
MIROLIVERELAP, ORENITRAM, REMODULIN, REMUNITY, TYVASO, TYVASO
DPI, and UNITUXIN are registered trademarks of United Therapeutics
Corporation and/or its subsidiaries.
ADCIRCA is a registered trademark of Eli Lilly and Company.
UNITED THERAPEUTICS
CORPORATION
CONSOLIDATED STATEMENTS OF
OPERATIONS
(In millions, except per share
data)
Three Months Ended
December 31,
Year Ended December
31,
2023
2022
2023
2022
(Unaudited)
Total revenues
$
614.7
$
491.5
$
2,327.5
$
1,936.3
Operating expenses:
Cost of sales
71.0
58.8
257.5
151.6
Research and development
151.4
93.9
408.0
322.9
Selling, general, and administrative
132.2
163.2
477.1
482.1
Total operating expenses
354.6
315.9
1,142.6
956.6
Operating income
260.1
175.6
1,184.9
979.7
Interest income
51.0
20.8
162.7
45.2
Interest expense
(15.1
)
(12.3
)
(59.3
)
(32.4
)
Other expense, net
(0.6
)
(5.3
)
(14.0
)
(40.2
)
Impairment of investment in privately-held
company
—
—
—
(1.7
)
Total other income (expense), net
35.3
3.2
89.4
(29.1
)
Income before income taxes
295.4
178.8
1,274.3
950.6
Income tax expense
(78.3
)
(46.7
)
(289.5
)
(223.3
)
Net income
$
217.1
$
132.1
$
984.8
$
727.3
Net income per common share:
Basic
$
4.62
$
2.88
$
21.04
$
15.98
Diluted
$
4.36
$
2.67
$
19.81
$
15.00
Weighted average number of common shares
outstanding:
Basic
47.0
45.8
46.8
45.5
Diluted
49.8
49.4
49.7
48.5
SELECTED CONSOLIDATED BALANCE
SHEET DATA
(In millions)
December 31,
2023
2022
Cash, cash equivalents, and marketable
investments
$
4,903.9
$
4,154.9
Total assets
7,167.0
6,044.5
Total liabilities
1,182.2
1,247.8
Total stockholders' equity
5,984.8
4,796.7
The table below presents the breakdown of select historical
total revenues between the United States and ROW (in millions):
Three Months Ended
March 31, 2023
June 30, 2023
September 30, 2023
December 31, 2023
U.S.
ROW
Total
U.S.
ROW
Total
U.S.
ROW
Total
U.S.
ROW
Total
Net product sales:
Tyvaso DPI(1)
$
118.7
$
—
$
118.7
$
193.6
$
—
$
193.6
$
205.1
$
—
$
205.1
$
213.7
$
—
$
213.7
Nebulized Tyvaso(1)
115.7
4.0
119.7
119.6
5.7
125.3
118.1
2.6
120.7
123.7
13.2
136.9
Total Tyvaso
234.4
4.0
238.4
313.2
5.7
318.9
323.2
2.6
325.8
337.4
13.2
350.6
Remodulin(2)
93.2
28.2
121.4
103.5
23.7
127.2
111.6
19.5
131.1
106.3
8.8
115.1
Orenitram
88.2
—
88.2
95.1
—
95.1
92.0
—
92.0
84.1
—
84.1
Unituxin
44.3
4.8
49.1
39.5
4.8
44.3
48.8
2.5
51.3
48.7
5.5
54.2
Adcirca
7.3
—
7.3
7.5
—
7.5
7.3
—
7.3
6.8
—
6.8
Other
2.3
0.2
2.5
3.2
0.3
3.5
1.7
0.2
1.9
2.6
1.3
3.9
Total revenues
$
469.7
$
37.2
$
506.9
$
562.0
$
34.5
$
596.5
$
584.6
$
24.8
$
609.4
$
585.9
$
28.8
$
614.7
Three Months Ended
March 31, 2022
June 30, 2022
September 30, 2022
December 31, 2022
U.S.
ROW
Total
U.S.
ROW
Total
U.S.
ROW
Total
U.S.
ROW
Total
Net product sales:
Tyvaso DPI(1)
$
—
$
—
$
—
$
3.0
$
—
$
3.0
$
63.1
$
—
$
63.1
$
92.2
$
—
$
92.2
Nebulized Tyvaso(1)
170.1
1.9
172.0
196.2
1.8
198.0
193.9
0.7
194.6
148.4
1.7
150.1
Total Tyvaso
170.1
1.9
172.0
199.2
1.8
201.0
257.0
0.7
257.7
240.6
1.7
242.3
Remodulin(2)
99.1
32.6
131.7
108.5
23.5
132.0
102.2
11.8
114.0
97.7
24.8
122.5
Orenitram
82.8
—
82.8
79.0
—
79.0
87.5
—
87.5
75.8
—
75.8
Unituxin
48.0
7.6
55.6
43.3
1.2
44.5
42.8
3.3
46.1
36.4
0.3
36.7
Adcirca
9.8
—
9.8
10.4
—
10.4
10.7
—
10.7
10.4
—
10.4
Other
—
10.0
10.0
—
—
—
—
—
—
2.8
1.0
3.8
Total revenues
$
409.8
$
52.1
$
461.9
$
440.4
$
26.5
$
466.9
$
500.2
$
15.8
$
516.0
$
463.7
$
27.8
$
491.5
Three Months Ended
March 31, 2021
June 30, 2021
September 30, 2021
December 31, 2021
U.S.
ROW
Total
U.S.
ROW
Total
U.S.
ROW
Total
U.S.
ROW
Total
Net product sales:
Tyvaso DPI(1)
$
—
$
—
$
—
$
—
$
—
$
—
$
—
$
—
$
—
$
—
$
—
$
—
Nebulized Tyvaso(1)
122.4
0.6
123.0
152.6
1.2
153.8
160.7
3.5
164.2
165.0
1.5
166.5
Total Tyvaso
122.4
0.6
123.0
152.6
1.2
153.8
160.7
3.5
164.2
165.0
1.5
166.5
Remodulin(2)
107.1
23.1
130.2
111.0
28.8
139.8
106.8
18.6
125.4
98.5
19.8
118.3
Orenitram
72.4
—
72.4
76.2
—
76.2
85.2
—
85.2
72.3
—
72.3
Unituxin
42.8
1.1
43.9
48.3
4.8
53.1
44.8
10.5
55.3
42.2
7.8
50.0
Adcirca
9.6
—
9.6
23.6
—
23.6
14.6
—
14.6
8.1
—
8.1
Other
—
—
—
—
—
—
—
—
—
—
—
—
Total revenues
$
354.3
$
24.8
$
379.1
$
411.7
$
34.8
$
446.5
$
412.1
$
32.6
$
444.7
$
386.1
$
29.1
$
415.2
(1)
Net product sales include both the drug product and the
respective inhalation device.
(2)
Net product sales include sales of infusion devices including
the Remunity Pump.
Category: Earnings
View source
version on businesswire.com: https://www.businesswire.com/news/home/20240221477756/en/
Dewey Steadman at (202) 919-4097
https://ir.unither.com/contact-ir
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