Form 3 - Initial statement of beneficial ownership of securities

                                POWER OF ATTORNEY

        With respect to holdings of and transactions in securities issued by
Mereo BioPharma Group plc (the "Company"), the undersigned hereby constitutes
and appoints the individuals named on Schedule A attached hereto and as may
be amended from time to time, or any of them signing singly, with full power
of substitution and resubstitution, to act as the undersigned's true and
lawful attorney-in-fact to:

        1.      prepare, execute in the undersigned's name and on the
                undersigned's behalf, and submit to the United States
                Securities and Exchange Commission (the "SEC") a Form ID,
                including amendments thereto, and any other documents
                necessary or appropriate to obtain and/or regenerate codes
                and passwords enabling the undersigned to make electronic
                filings with the SEC of reports required by Section 16(a) of
                the Securities Exchange Act of 1934, as amended, or any rule
                or regulation of the SEC;

        2.      execute for and on behalf of the undersigned, Forms 3, 4, and
                5 in accordance with Section 16 of the Securities Exchange
                Act of 1934, as amended, and the rules thereunder;

        3.      do and perform any and all acts for and on behalf of the
                undersigned which may be necessary or desirable to complete
                and execute any such Form 3, 4, or 5, complete and execute
                any amendment or amendments thereto, and timely file such
                form with the SEC and any stock exchange or similar
                authority; and

        4.      take any other action of any type whatsoever in connection
                with the foregoing which, in the opinion of such attorney-in-
                fact, may be of benefit to, in the best interest of, or
                legally required by, the undersigned, it being understood
                that the documents executed by such attorney-in-fact on
                behalf of the undersigned pursuant to this Power of Attorney
                shall be in such form and shall contain such terms and
                conditions as such attorney-in-fact may approve in such
                attorney-in-fact's discretion.

        The undersigned hereby grants to each such attorney-in-fact full
power and authority to do and perform any and every act and thing whatsoever
requisite, necessary, or proper to be done in the exercise of any of the
rights and powers herein granted, as fully to all intents and purposes as the
undersigned might or could do if personally present, with full power of
substitution and resubstitution or revocation, hereby ratifying and
confirming all that such attorney-in-fact, or such attorneys-in-fact
substitute or substitutes, shall lawfully do or cause to be done by virtue of
this Power of Attorney and the rights and powers herein granted.

        The undersigned acknowledges that the foregoing attorneys-in-fact, in
serving in such capacity at the request of the undersigned, are not assuming,
nor is the Company assuming, any of the undersigned's responsibilities to
comply with Section 16 of the Securities Exchange Act of 1934, as amended.

        This Power of Attorney shall remain in full force and effect until
the undersigned is no longer required to file Forms 3, 4, and 5 with respect
to the undersigned's holdings of and transactions in securities issued by
Mereo BioPharma Group plc, unless earlier revoked by the undersigned in a
signed writing delivered to the foregoing attorneys-in-fact.

        IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney
to be executed as of this 2nd day of January, 2024.

Signature:  /s/ Daniel Shames
            -------------------------------

Print Name: Daniel Shames
            -------------------------------


                                Schedule A

        Individuals Appointed as Attorney-in-Fact with Full Power of
Substitution and Resubstitution

Charles Sermon
Christine Fox
Mereo BioPharma (NASDAQ:MREO)
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From Apr 2024 to May 2024