Statement of Changes in Beneficial Ownership (4)

FORM 4 [ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES	OMB APPROVAL OMB Number: 3235-0287 Estimated average burden hours per response... 0.5
	Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person ^* KIRK RANDAL J	2. Issuer Name and Ticker or Trading Symbol PRECIGEN, INC. [ PGEN ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __X__ Director __X__ 10% Owner _____ Officer (give title below) _____ Other (specify below)
(Last) (First) (Middle) C/O THIRD SECURITY, LLC, 1881 GROVE AVENUE	3. Date of Earliest Transaction (MM/DD/YYYY) 3/25/2022
(Street) RADFORD, VA 24141 (City) (State) (Zip)	4. If Amendment, Date Original Filed (MM/DD/YYYY)	6. Individual or Joint/Group Filing (Check Applicable Line) _X _ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	3. Trans. Code (Instr. 8)		4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	Code	V	Amount	(A) or (D)	Price		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
Common Stock	3/25/2022		M		32425	A	$0 ⁽¹⁾	19037059	I	by R.J. Kirk DOT ⁽²⁾
Common Stock								1000000	I	by Parkview 2020 ⁽²⁾
Common Stock								479857	I	by JPK 2008 ⁽²⁾
Common Stock								3597953	I	by JPK 2009 ⁽²⁾
Common Stock								1612186	I	by JPK 2012 ⁽²⁾
Common Stock								447405	I	by Kellie L. Banks LTT ⁽²⁾
Common Stock								478894	I	by MGK 2008 ⁽²⁾
Common Stock								3838992	I	by MGK 2009 ⁽²⁾
Common Stock								1594863	I	by MGK 2011 ⁽²⁾
Common Stock								567535	I	by ZSK 2008 ⁽²⁾
Common Stock								342685	I	by ZSK 2009 ⁽²⁾
Common Stock								1144481	I	by Spouse
Common Stock								13520789	I	by Kapital Joe ⁽²⁾
Common Stock								1403	I	by Lotus ⁽²⁾
Common Stock								16406828	I	by Sunset 2020 ⁽²⁾
Common Stock								989243	I	by Sr. Staff 2015 ⁽³⁾
Common Stock								989252	I	by Staff 2015 ⁽³⁾
Common Stock								1839946	I	by Staff 2010 ⁽³⁾
Common Stock								1383858	I	by Staff 2009 ⁽³⁾
Common Stock								3223803	I	by Sr. Staff 2008 ⁽³⁾
Common Stock								691929	I	by Incentive 2009 ⁽³⁾
Common Stock								1384408	I	by Incentive 2010 ⁽³⁾
Common Stock								311287	I	by Staff 2001 ⁽³⁾
Common Stock								58800	I	by Sr. Staff ⁽³⁾
Common Stock								59133	I	by Staff 2006 ⁽³⁾
Common Stock								118266	I	by Sr. Staff 2006 ⁽³⁾
Common Stock								19711	I	by Incentive 2006 ⁽³⁾
Common Stock								4995000	I	by Sr. Staff 2007 ⁽⁴⁾
Common Stock								2497500	I	by Staff 2007 ⁽⁴⁾
Common Stock								832500	I	by Incentive 2007 ⁽⁴⁾

*Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)*
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	4. Trans. Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	8. Price of Derivative Security (Instr. 5)			11. Nature of Indirect Beneficial Ownership (Instr. 4)
Restricted Stock Units	⁽¹⁾	3/25/2022		M			32425	⁽¹⁾	⁽¹⁾	Common Stock	32425	$0	0	I	by R.J. Kirk DOT ⁽²⁾

Explanation of Responses:
(1)	Each restricted stock unit represents a contingent right to receive one (1) share of issuer common stock. The restricted stock units were granted on March 25, 2021 and vested in their entirety on the one-year anniversary of the date of grant.
(2)	Randal J. Kirk controls each of R.J. Kirk Declaration of Trust ("R.J. Kirk DOT"), Parkview 2020 Limited Partnership ("Parkview 2020"), JPK 2008 LLC ("JPK 2008"), JPK 2009 LLC ("JPK 2009"), JPK 2012 LLC ("JPK 2012"), Kellie L. Banks (2009) Long Term Trust ("Kellie L. Banks LTT"), MGK 2008 LLC ("MGK 2008"), MGK 2009 LLC ("MGK 2009"), MGK 2011 LLC ("MGK 2011"), ZSK 2008 LLC ("ZSK 2008"), ZSK 2009 LLC ("ZSK 2009"), Kapital Joe, LLC ("Kapital Joe"), Lotus Capital (2000) Company, Inc. ("Lotus"), and Sunset 2020 LLC ("Sunset 2020"). Shares held by these entities may be deemed to be beneficially owned (as defined under Rule 13d-3 promulgated under the Securities Exchange Act of 1934, as amended) by Mr. Kirk. Mr. Kirk disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein.
(3)	Randal J. Kirk controls each of Third Security Senior Staff 2015 LLC ("Sr. Staff 2015"), Third Security Staff 2015 LLC ("Staff 2015"), Third Security Staff 2010 LLC ("Staff 2010"), Third Security Staff 2009 LLC ("Staff 2009"), Third Security Senior Staff 2008 LLC ("Sr. Staff 2008"), Third Security Incentive 2009 LLC ("Incentive 2009"), Third Security Incentive 2010 LLC ("Incentive 2010"), Third Security Staff 2001 LLC ("Staff 2001"), Third Security Senior Staff LLC ("Sr. Staff"), Third Security Staff 2006 LLC ("Staff 2006"), Third Security Senior Staff 2006 LLC ("Sr. Staff 2006"), and Third Security Incentive 2006 LLC ("Incentive 2006"). Mr. Kirk disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein.
(4)	Randal J. Kirk controls each of Third Security Senior Staff 2007 LLC ("Sr. Staff 2007"), Third Security Staff 2007 LLC ("Staff 2007"), and Third Security Incentive 2007 LLC ("Incentive 2007"). Shares held by these entities may be deemed to be beneficially owned (as defined under Rule 13d-3 promulgated under the Securities Exchange Act of 1934, as amended) by Mr. Kirk. Mr. Kirk disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein.

Reporting Owners
Reporting Owner Name / Address	Relationships
Reporting Owner Name / Address	Director	10% Owner	Officer	Other
KIRK RANDAL J C/O THIRD SECURITY, LLC 1881 GROVE AVENUE RADFORD, VA 24141	X	X

Signatures
/s/ Randal J. Kirk		3/28/2022
^**Signature of Reporting Person		Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
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