BFRA Biofrontera AG

Item 1.  Security and Issuer

This statement on Schedule 13D (the “Schedule 13D”) relates to the ordinary shares, nominal value €1.00 per share (the “Ordinary Shares”), of Biofrontera AG (the “Issuer”). The principal executive offices of the Issuer are located at Hemmelrather Weg 201D-51377 Leverkusen Germany.

Item 2.  Identity and Background

(d) – (e) During the past five years, none of the Reporting Persons has been, and to their respective knowledge, none of the Scheduled Persons (as defined below) has been (i) convicted in any criminal proceeding (excluding traffic violations or similar misdemeanors) or (ii) party to a civil proceeding of a judicial or administrative body of competent jurisdiction and as a result of such proceeding was or is subject to a judgment, decree or final order enjoining future violations of, or prohibiting or mandating activities subject to, federal or state securities laws or finding any violation with respect to such laws.

(f) ABC, DB, VVB, and DU are each organized under the laws of Germany. Mr. Zours is a citizen of Germany.

The name, present business address, present principal occupation, and place of citizenship of the member(s) of the Board of Management of each Reporting Person is set forth on Schedule 1 (collectively, the “Scheduled Persons,” and each a “Scheduled Person”), and are incorporated herein by reference.

Item 3.  Source and Amount of Funds or Other Consideration

The source of funds for the purchases of the Shares reported on herein was cash on hand and the general working capital of the respective purchasers, which may, at any given time, include margin loans made by brokerage firms or banks in the ordinary course of business.

As of May 31, 2018, ABC had invested $3,630.13 (including brokerage commissions) in the Ordinary Shares of the Issuer, DB had invested $14,010,275.27 (including brokerage commissions) in the Ordinary Shares of the Issuer and $354,276.16 in the ADSs of the Issuer, and DU had invested $15,598,254.48 (excluding brokerage commissions) in the Ordinary Shares of the Issuer.

Item 4.  Purpose of Transaction

The Reporting Persons intend to acquire further voting rights, if possible at reasonable prices.

Mr. Zours and DU wish to change the composition of the Management Board and Supervisory Board of the Issuer. Mr. Zours and DU are seeking to dismiss Thomas Schaffer, currently Chief Financial Officer of the Issuer, as a member of the Management Board. In addition, Mr. Zours and DU are also in favor of changing the positions among the remaining members of the Management Board to the effect that the current Chairman of the Management Board, Prof. Dr. Hermann Lübbert, will be appointed as a member of the Management Board with responsibility for research, development and approvals and will no longer be the Chairman of the Management Board. It is intended that the Supervisory Board appoints a new Chairman of the Management Board. Furthermore, it is the intention of Mr. Zours and DU to appoint a new Chairman of the Supervisory Board and to amend the composition of the Supervisory Board as follows: (a) resignation of Dr. Granzer from the chairmanship of the Supervisory Board, (b) resignation of Mr. Baumann from the Supervisory Board, (c) resignation of Mr. Borer from the Supervisory Board, and (d) replacement of Mr. Reeth by a shareholder from the free float.

Item 5.  Interest in Securities of the Issuer

(a) Of the 7,079,467 shares reported in this Schedule 13D as the aggregate amount beneficially owned by each Reporting Person (representing 15.9% of the Issuer’s Ordinary Shares), 1,000 shares are held by ABC (representing 0.0% of the Issuer’s Ordinary Shares), 4,125,639 shares and 26,097 ADSs (each representing two shares) are held by DB (collectively representing 9.4% of the Issuer’s Ordinary Shares), and 2,900,634 shares are held by DU (representing 6.5% of the Issuer’s Ordinary Shares). DB owns a majority interest in ABC. VVB owns a majority interest in DB. DU owns a majority interest in VVB. Wilhelm Konrad Thomas Zours, an individual, owns a majority interest in DU and is the sole member of the board of management of VVB and DU. Each of DB, VVB, DU, and Wilhelm Konrad Thomas Zours may be deemed to have beneficial ownership with respect to the shares held by ABC and disclaims beneficial ownership of such shares, except to the extent of their respective pecuniary interest therein. Each of VVB, DU, and Wilhelm Konrad Thomas Zours may be deemed to have beneficial ownership with respect to all shares held by DB and disclaim beneficial ownership of such shares, except to the extent of their respective pecuniary interests therein. Wilhelm Konrad Thomas Zours may be deemed to have beneficial ownership with respect to all shares held by DU and disclaims beneficial ownership of such shares, except to the extent of his pecuniary interest therein.

All percentages set forth in this Schedule 13D are based upon 44,506,980 Ordinary Shares outstanding as of May 30, 2018.

(c)      During the past 60 days, the Reporting Persons have conducted transactions in the shares as reflected on Schedule 2.

(d) – (e) Not applicable.

Item 6. Contracts, Arrangements, Understandings or Relationships with Respect to Securities of the Issuer

Not Applicable.

Item 7. Material to Be Filed as Exhibits

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Dated:  June 4, 2018

Schedule 1

Members of Management of the Reporting Persons

The sole member of the Board of Management of ABC is Rolf Birkert. The members of the Board of Management of DB are Rolf Birkert and Jens Jüttner. The sole member of the Board of Management of each of VVB and DU is Wilhelm Konrad Thomas Zours.

The following table sets forth the name, present occupation or employment and citizenship of each such person.

Schedule 2