TIDMMDST 
 
 
Medicsight Plc 
06 March 2009 
 
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|                                  |                 Friday 6 March 2009 | 
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Medicsight PLC 
 
 
("Medicsight" or "the Company") 
 
 
Medicsight unveils new version of ColonCAD(TM) at ECR 2009 
Medicsight PLC (AIM:MDST), industry leader in the development of Computer-Aided 
Detection (CAD) and image analysis software which assists in the early detection 
and diagnosis of disease, is pleased to announce it has launched ColonCAD API 
4.0, the latest version of its computer-aided detection software, today at the 
European Congress of Radiology (ECR 2009) show in Vienna. The software is 
designed to assist radiologists in the detection of colorectal polyps in CT 
colonography image data. Version 4.0 includes a significant increase in the 
performance of the polyp detection algorithm, reducing the number of false 
positive CAD marks displayed for each patient case. 
Dr David Burling, Consultant Gastrointestinal Radiologist and VC Program 
Director at St. Mark's Hospital, London, UK commented today "We welcome this 
latest improvement to Medicsight's ColonCAD product.  CAD is now an integral 
part of our reading strategy in routine clinical practice. It improves 
interpretation accuracy and is complimentary to workflow". 
Internal testing on a dataset of 91 patient cases showed that the ColonCAD API 
4.0 maintains the same high levels of sensitivity to the previous version but 
displays a 50% reduction in false positives, with the CAD now returning a mean 
of 6.5 false positive marks per patient case *. ColonCAD API 4.0 demonstrates 
the following sensitivity: 
+---------------------------+------------------+ 
| Size of Polyp             | Sensitivity      | 
+---------------------------+------------------+ 
| 2mm-50mm                  | 85%              | 
+---------------------------+------------------+ 
| 6mm-9mm                   | 90%              | 
+---------------------------+------------------+ 
| 10mm+ (clinically         | 92%+             | 
| significant)              |                  | 
+---------------------------+------------------+ 
The patient data used in this testing remained independent from the development 
of the CAD and have been endoscopically validated and reviewed by a panel of 
expert radiologists to determine the ground truth against which the CAD 
performance was assessed. 
Allan Rowley, Chief Executive of Medicsight, commented "Previous research has 
shown Medicsight's ColonCAD significantly improves the performance of 
radiologists in the detection of polyps in CT colonography image data. The 
reduction in the numbers of false positives returned by our latest version of 
CAD is expected to further improve the performance of radiologists, by reducing 
the number of CAD marks which must be assessed when reviewing a patient 
dataset." 
ColonCAD API 4.0 has been CE Marked and will be available for sale in Europe 
through Medicsight's network of partners. 
More than 17,000 medical and industry professionals from over 95 countries will 
be attending this year's ECR which is taking place in the Austria Center, Vienna 
from 6-10 March. Visitors will be able to see demonstrations of the Medicsight 
ColonCAD software integrated into their partners' 3D advanced visualisation 
workstations at the company's exhibition booth no 506 in Expo E. 
 
 
* Data on file, Medicsight PLC 
- ENDS - 
 
 
For further information: 
 
 
+-------------------------------------------+----------------------------+ 
| Medicsight PLC                            | www.medicsight.com         | 
+-------------------------------------------+----------------------------+ 
| Allan Rowley                              | +44 (0)20 7605 7950        | 
+-------------------------------------------+----------------------------+ 
| Nomura Code                               |                            | 
+-------------------------------------------+----------------------------+ 
| Juliet Thompson                           | +44 (0) 20 7776 1204       | 
| Jonathan Senior                           | +44 (0) 20 7776 1219       | 
+-------------------------------------------+----------------------------+ 
Media enquiries: 
+-------------------------------------------+----------------------------+ 
| Abchurch                                  | +44 (0) 20 7398 7700       | 
+-------------------------------------------+----------------------------+ 
| Heather Salmond / Stephanie Cuthbert /    | +44 (0) 20 7398 7718       | 
| Simone Alves                              |                            | 
+-------------------------------------------+----------------------------+ 
| stephanie.cuthbert@abchurch-group.com     | www.abchurch-group.com     | 
+-------------------------------------------+----------------------------+ 
 
 
Notes to editors 
Medicsight PLC is a UK-headquartered, research driven, leading developer of 
computer-aided detection (CAD) and image analysis software for the 
medical imaging market. The CAD software automatically highlights suspicious 
areas on computerised tomography (CT) scans of the colon and lung, 
helping radiologists to identify, measure and analyse potential disease and 
early indicators of disease. Medicsight's CAD software has been validated using 
one of the world's largest and most population diverse databases of verified 
patient CT scan data. Medicsight's ColonCAD(TM) and LungCAD(TM) software 
products are seamlessly integrated with the advanced 3D visualisation 
workstations of several industry-leading imaging equipment partners. 
 
 
About Computer-Aided Detection 
With increasingly sophisticated radiological imaging hardware such as 
Multi-Detector CT scanners, radiologists are facing a growing challenge in the 
amount of detailed patient image data that they must review for each patient 
examination. Some CT scan examinations generate as many as 2000 images per 
patient. Review of this data by the radiologist is not only time-consuming but 
also prone to error due to reader fatigue. CAD software can help the reviewing 
radiologist by analysing the image data and automatically highlighting 
suspicious regions of interest for closer inspection. Without CAD software some 
potential abnormalities or areas of disease may be overlooked. This can 
be critical for diagnosis and the management of patient outcomes as early 
detection of disease greatly increases the probability of successful treatment 
and a positive therapeutic outcome. In addition to supporting individual 
radiologists CAD also has the potential to help standardise CT interpretation 
across both individuals and institutions thereby supporting population based 
screening programmes. 
 
 
 
 
About Medicsight's CAD software 
Medicsight's ColonCAD(TM) and LungCAD(TM) software use an advanced CAD algorithm 
to analyse CT scans of the colon and lung and automatically highlight suspicious 
areas that may be indicators of disease. CAD may highlight areas easily 
overlooked by the reviewing radiologist, such as small lesions or regions that 
are hidden from view behind folds in the colon or normal structures and 
surrounding tissue in the lung. 
 
 
Both CAD products seamlessly integrate with the advanced 3D visualisation 
platforms of industry-leading imaging equipment partners. The integrated systems 
provide sophisticated image viewing capabilities, including 3D reconstructed 
image data, with the added advantage of demonstrating automatic CAD findings to 
assist clinical end users in the detection and analysis of disease. This allows 
clinical end users to perform either a 'second read', where CAD findings are 
displayed to the user after completion of an initial review of the CT scan data, 
or a 'concurrent read' where CAD findings are displayed during the user's 
initial review of the original CT scan images. 
 
 
Since inception, Medicsight has developed close and lasting relationships with 
some of the world's foremost clinicians in product related areas. This provides 
the Company with a wealth of clinical expertise and dedicated clinical research 
to support ongoing product development. Medicsight also collaborates with a 
number of leading academic institutions and clinical research programmes 
worldwide to develop the Company's comprehensive database of population diverse 
verified patient CT scan data, thus allowing Medicsight's products to be 
validated to the highest possible standards. 
 
 
 
 
 
 
 
 
 
This information is provided by RNS 
            The company news service from the London Stock Exchange 
   END 
 
 NRAILFSEVIIEIIA 
 

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