TIDMINS

RNS Number : 7249A

Instem plc

27 September 2022

Instem plc

("Instem", the "Company" or the "Group")

Half Year Report

Instem plc (AIM: INS.L), a leading provider of IT solutions to the global life sciences market, announces its unaudited half year results for the six months ended 30 June 2022.

Financial Highlights

   --      Total Group revenues increased by 39 % to GBP 27.6m (H1 2021: GBP19.8m) 

-- Recurring revenue (annual support and SaaS) increased 62 % to GBP16.0m (H1 2021: GBP9.9m) with SaaS increasing 29% to GBP6.3m (H1 2021: GBP4.9m)

   --      Constant currency revenue growth was 34% 
   --      Annual Recurring Revenue ("ARR") of GBP32.0m at 1 July 2022 

-- Adjusted EBITDA* increased 8% to GBP4.5 m (H1 2021: GBP 4.2 m), representing 16.3% (H1 2021: 21.0%) of revenue

   --      Profit before tax of GBP 1.9m (H1 2021: GBP1.2m) 
   --      Adjusted profit before tax** of GBP 3.2 m (H1 2021: GBP3.2m, as restated) 
   --      Basic and diluted earnings per share of 5.7p (H1 2021: 4.8p) and 5.5p (H1 2021: 4.6p) 

-- Adjusted basic and diluted earnings per share** of 11.3p (H1 2021: 14.3p, as restated) and 10.8p (H1 2021: 13.6p, as restated)

   --      Net cash generated from operations of GBP1.8m (H1 2021 GBP4.1m) 
   --      Gross cash balance as at 30 June 2022 of GBP10.3m (H1 2021: GBP17.9m) 

*Earnings before interest, tax, depreciation, amortisation and non-recurring items (non recurring items are legal costs and increased settlement provision relating to an historical contract dispute plus acquisition costs, exceptional share based payment charge and US government loan forgiveness)

** After adjusting for the effect of foreign currency exchange and the unwinding of the finance liability included in finance income/(costs), non-recurring items and amortisation of intangibles on acquisitions

Operational Highlights

-- First reporting period with full contribution from The Edge Software Consultancy Ltd ("The Edge"), d-Wise Technologies, Inc ("d-Wise") and PDS Pathology Data Systems Ltd ("PDS") (the "Acquisitions"), with integration almost finalised

o Increasing recurring revenues and visibility

o Strengthening relationships with clients

o Increasing routes to market and cross selling opportunities

   --      Earn-outs met in full for d-Wise and The Edge (PDS has no earn out provision) 

-- New banking facility finalised with HSBC of up to GBP20m, GBP10m of which is committed and none currently utilised

Post-period end Highlights

   --      Won largest ever contract 

o $12m five-year agreement with global CRO, lead client for new Aspire software solution

o Significant future SaaS revenues with long-term client

o Further expands the Group's global coverage and end-to-end solutions

   --      Full and final settlement of historical contractual licence dispute 

o No impact on current operations; dispute arose in 2017

o Settled at EUR1.48m (GBP1.3m), offset by insurance contribution of EUR450k (GBP400k), net GBP0.9m

o Settlement provision increased by GBP0.65m during H1 2022 toGBP0.9m as a non-recurring charge

o Cash payment of GBP0.9m due in October 2022

Outlook

-- Our ability to increase revenue per client, add new clients as well as service larger contracts underpins management's growth expectations in the current period and beyond

-- The market backdrop remains favourable, and we continue to see high demand for our products and solutions

Phil Reason, CEO, commented: "The combination of continued underlying growth and the contribution of the Acquisitions meant that this was another strong period for the Company.

"Our ability to increase revenues per client, add new clients as well as to increase recurring revenues underpins management's growth expectations in the current period and beyond. The market backdrop remains favourable and we continue to see high demand for our products and solutions. While, as previously flagged, essential salary inflation created a lag in H1 operating profit growth, this will be less pronounced in H2 as the price rises we have implemented take effect. Slower than expected consulting and service revenue growth is expected to be offset by stronger growth in higher margin software business, resulting in full year profit performance in line with market expectations(1) .

The Acquisitions are now substantially integrated and we expect to see further benefit to the enlarged Group as we convert our order backlog. We will continue to focus on organic and acquisitive growth opportunities with a view to further leveraging our business model and strong industry standing."

1. The Board understands that consensus market expectation adjusted profit before tax is GBP7.8m

Analyst Presentation: 11:30 today

Management will be hosting a presentation via web conference today at 11:30. Analysts wishing to join should

register their interest by emailing  instem@walbrookpr.com   or by telephoning 020 7933 8780. 

Investor Presentation: 16:30 today

Management will be providing a presentation and hosting an Investor Q&A session on the results and future prospects today at 16:30, through the digital platform Investor Meet Company. Investors can sign up for free and add to attend the presentation via the following link https://www.investormeetcompany.com/instem-plc/register-investor . Questions can be submitted pre-event and at any time during the live presentation via the Investor Meet Company Platform.

For further information, please contact:

 
 Instem plc                           Via Walbrook PR 
 Phil Reason, CEO 
 Nigel Goldsmith, CFO 
 
 Singer Capital Markets (Nominated 
  Adviser & Joint Broker)             +44 (0) 20 7496 3000 
 Peter Steel 
  Alex Bond 
  Rachel Hayes 
 
 Stifel Nicolaus Europe Limited 
  (Joint Broker)                      +44 (0) 20 7710 7600 
 Richard Short 
  Ben Madison 
  Alex Price 
 
  Walbrook Financial PR               +44 (0) 20 7933 8780 
 Nick Rome                            instem@walbrookpr.com 
 Tom Cooper 
 Joseph Walker 
 

About Instem

Instem is a leading provider of IT solutions & services to the life sciences market delivering compelling solutions for Study Management and Data Collection; Regulatory Solutions for Submissions and Compliance; and Informatics-based Insight Generation.

Instem solutions are in use by over 700 customers worldwide, including all the largest 25 pharmaceutical companies, enabling clients to bring life enhancing products to market faster. Instem's portfolio of software solutions increases client productivity by automating study-related processes while offering the unique ability to generate new knowledge through the extraction and harmonisation of actionable scientific information.

Instem products and services address aspects of the entire drug development value chain, from discovery through to market launch. Management estimate that over 50% of all drugs on the market have been through some part of Instem's platform at some stage of their development.

   To learn more about Instem solutions and its mission, please visit    www.instem.com 

Chairman's Statement

This period has been of considerable strategic importance for the Company as we substantially completed the integration of the three recent Acquisitions. This is the first set of results to include their full contribution. The strong performance of the significantly enlarged Group emphasises the benefits of our acquisition strategy - with our increased scale and product range strengthening our growth ambitions whilst helping to reduce susceptibility to ongoing market fluctuations.

Having grown our reach, routes to market and ability to cross sell, our combined operations are increasingly setting us apart from our competitors.

Earn-Outs

I am delighted to confirm that the earn-out periods for d-wise and The Edge have now completed, with both earn-out targets met in full. PDS has no earn-out arrangement.

Financial Performance

While, as previously reported, there was minimal disruption to revenue in the challenging macro-economic environment, there were headwinds, mainly due to inflationary pressures, which led to essential increases in remuneration for staff across the Company. As stated earlier in the year, we successfully instigated a number of price increases to mitigate the impact of these additional costs.

We have seen a change in the revenue mix during the period with greater increases in higher margin recurring SaaS and annual support fees and lower growth in services. While service revenue is picking up again in the second half, we anticipate that software-related revenues will be the primary driver of growth in the full year.

Our performance during the period was largely in line with the Board's expectations, despite the above short-term issues, while importantly we established foundations for continued growth and margin improvement.

Performance in the Period for some of our key financial metrics is summarised below:

   --      Revenue increased 39% 
   --      SaaS Revenue increased 29% 
   --      Recurring Revenue increased 62% 
   --      Adjusted EBITDA increased 8% 

Looking Forwards

As I noted earlier, our acquisition strategy is expected to extend the reach of the Company, enabling us to take advantage of additional growth opportunities as they arise. In this regard, we are extremely encouraged by the recently announced post-period end, $12m contract win - our largest ever contract. In this we will be supporting a large contract research organisation ("CRO"), with over 2,000 users worldwide, in its clinical trial analysis as it adopts our new Aspire software solution. This is being supplied by Company's Clinical Trial Acceleration business unit, formed following the acquisition of d-Wise. We believe that over the next 3-5 years we can achieve compound annual organic growth of 10% and, with further acquisitions, have the potential to more than double our 2022 revenue (i.e. reaching total revenue of GBP120m+).

Our customers are continuing to experience increased demand for their services and, as a result, we continue to see strong demand for our solutions across the drug development lifecycle. We have a healthy and growing order book, increased scale of operations and increased levels of visibility resulting from our SaaS conversion program. We remain confident about the future performance of the business.

David Gare

Non-Executive Chairman

27 September 2022

Chief Executive's Report

Strategic Development

The Group has continued to pursue its mission to help our clients radically reduce the cost and time of life sciences research and development through data driven optimisation of traditional non-clinical and clinical study processes, ultimately replacing many of those studies with "in silico" alternatives such as predictive analytics, simulation and modelling. The strategy is based on leveraging trusted client and regulatory relationships and our intimate understanding of complex scientific data, established by providing a broad portfolio of market leading IT solutions that optimise today's life sciences R&D processes, from early discovery to late-stage clinical trials.

The increasing SaaS deployment of an expanded suite of solutions ensures that we are in a stronger position to help our clients aggregate and leverage a broader and deeper set of information while increasing recurring revenue and visibility.

Group growth was supported by a robust underlying life sciences research and development market as we experienced demand for our solutions across the entire drug development life cycle. We further embedded operations from the Acquisitions, positioning the enlarged Group to take advantage of the positive prevailing market conditions.

Our larger suite of solutions and broader market reach provides further cross-selling opportunities to increase revenues from existing and new clients. This is further enhanced by our capacity to service larger contracts and provide a one-stop shop for clients seeking to reduce and simplify their supplier network.

Having previously integrated areas such as Finance, People & Culture, Information Systems and Marketing from the Acquisitions, we have been able to complete the more comprehensive integration of larger teams, such as those in Software Development, Out-Sourced Services, SaaS Delivery and Customer Implementations / Support. This is already starting to generate economies of scale, the ability to standardise on best practice processes and opportunities to target highly skilled resources at the most compelling business opportunities.

A combined Governance, Risk and Compliance team is now in place, overseeing global implementation and compliance with standards such as ISO 9001 Quality Management, ISO 27001 Information Security Management, industry regulation such as Good Laboratory / Clinical Practice ("GLP" and "GCP") and the increasing importance of Environmental, Social and Governance ("ESG") practices, standards and regulation, which is increasingly important to all of our stakeholders.

Most recently, we have been able to liberate senior management bandwidth from the enlarged team to make three new US-based appointments:

-- VP Investor Relations, to support increased investor engagement following the appointment of Stifel as joint broker and an active programme intended to broaden institutional shareholding in North America and mainland Europe

-- VP Corporate Development, to support our ability to target a growing landscape of acquisition targets, many of which are based in North America

-- VP Strategic Partnerships, to ensure we maximise the benefits to Instem and a growing list of existing partners while ensuring we optimise our ability to evaluate, consummate and manage future additions. These relationships help differentiate Instem in the market and have previously led to acquisition opportunities.

Market Review

The market backdrop continues to be favourable for the Group given global population growth and life expectancy underpinning increased demand for successful innovation in life sciences. Increasing amounts of money are being invested in the biotech industry with the pharmaceuticals sector investing heavily in drug development, underpinning a strong pipeline for Instem.

In the pharmaceutical industry, which represents the largest proportion of Instem's revenue, we refer again to the Pharma R&D Annual Review, the 2022 version of which was released by Pharma Intelligence in March this year. This report shows that the industry grew strongly in 2021 with an 8.2% increase (2020: 4.8%) in the total number of drugs in the regulatory stages of global R&D, continuing a multi-year growth trend that shows no sign of abating. Most relevant to Instem are the increase in the number of drugs at the preclinical (or non-clinical) phase of drug development of 11.0% (2020: 6.0%) and clinical phases 1-3 where there was an 8.3% increase (2020: 3.6%), as these areas account for much of our business.

The Company works with most of the world's leading public and private CROs and tracks their business performance as this provides additional insight into the health of the underlying market and almost all of those companies have recently reported strong underlying growth and very limited impact of wider macro-economic headwinds.

Business Performance

Study Management

Most of our study management solutions address areas where technology adoption is mature and Instem enjoys significant market penetration. However, with global R&D study volume steadily increasing, existing clients have continued to expand numbers of users for most of our study management solutions, while adding further products from our solution portfolio. This is the area with the greatest opportunity to transition existing clients from on-premise to SaaS deployment. While this transition has slowed over the last two years, as clients concentrated on advancing Covid vaccines and therapies, we are now seeing clients refocussing on SaaS conversion projects.

This area generates a significant proportion of our recurring revenue, so client retention is critical and once again this has been exceptionally strong. Clients have generally been understanding of the inflationary pressures that are impacting Instem, particularly salary costs, in what remains a very competitive labour market, and have been accepting of material price increases as recurring contracts renew. As such, the Board remains confident that margins can be protected through this phase.

Regulatory Solutions

The majority of our clients and revenue in this area are associated with our software and out-sourced services to create, visualise and share information using Food & Drug Administration ("FDA") mandated format S (Standard for the Exchange of Non-clinical Data). The acquisition of PDS in September 2021, number two in the market behind Instem in S out-sourced services, has led to Instem taking substantial market share of new and repeat business, with good growth in new business bookings. However, revenue conversion (particularly in Q1 2022) was at a slower rate than in recent periods as client studies failed to deliver as many data sets ready for S conversion as they had anticipated. We are now seeing an improving flow of data for conversion and expect a stronger revenue performance in Q4 2022 and beyond.

Our out-sourced services productivity was also negatively impacted by a significant change in the commercial terms to use a widely adopted third-party product that helps check S packages for conformance against the standard. Along with many other organisations, Instem stopped using the third-party product and has performed the equivalent checks manually. In parallel we have been developing our own automated checking software, which will be implemented by our out-sourced services team in Q4 2022. This will be timely as we work through a growing order book for S conversions.

In Silico Solutions

Our Leadscope predictive analytics solutions which provide an in silico assessment of the potential safety liabilities associated with a specific chemical structure have continued to grow strongly in the period. New predictive assays, developed in collaboration with industry and regulatory partners, have been licensed and deployed, and work continues to add new in silico models, some of which will replace animal-based studies.

Our introduction of an out-sourced alternative to clients licensing our software is starting to build revenue momentum, and work is progressing well on a collaborative European Medicine Agency funded research project to investigate the mutagenicity of different classes of N-nitrosamines ("NAs"). Nitrosamines have become a focus of significant concern for the global pharmaceutical industry, and we are anticipating that a new NA-related in silico model will be created as we contribute to this important research project.

Our KnowledgeScan target safety assessment business, having slowed through the height of the Covid crisis, has picked up well in Q2 2022 and continues to grow strongly in Q3 as client scientists have returned to their laboratories and have once again outsourced this work.

Clinical Trial Acceleration

The highlight in this area is undoubtedly the post period end award of Instem's largest ever contract, a $12 million multi-year SaaS project for a large CRO. As detailed in the 2 September 2022 RNS, this project will create an early adopter and key reference client for our new Aspire(TM) statistical computing environment ("SCE"). Our Clinical Trial Acceleration team are global leaders in this market, providing many small to medium sized CROs and pharma companies with a productised SCE and the largest companies with custom SCE solutions. Aspire is expected to provide a transformational product-based alternative for the larger clients and to replace large, resource intensive consulting projects with a standardised SaaS solution.

With several large consulting projects completing in the period and other large opportunities taking longer through the sales cycle, growth in consulting revenue will be modest in 2022; a scenario that will diminish in frequency and impact as a consequence of the growing annuity revenue stream arising from Aspire.

Outlook

The combination of continued underlying growth and the contribution of the Acquisitions meant that this was another strong period for the Company.

Our ability to increase revenue per client, add new clients as well as service larger contracts underpins the Board's growth expectations in the current period and beyond. The market backdrop remains favourable, and we continue to see high demand for our products and solutions. While, as previously flagged, essential salary inflation created a lag in H1 operating profit growth, this will be less pronounced in H2 as the price rises we have implemented take effect. Slower than expected consulting and service revenue growth is expected to be offset by stronger growth in higher margin software business resulting in full year profit performance in line with market expectations(1) .

The Acquisitions are now substantially integrated, and we expect to see further benefit to the enlarged Group as we convert our order backlog. We will continue to focus on organic and acquisitive growth opportunities with a view to further leveraging our business model and strong industry standing.

Phil Reason

Chief Executive Officer

27 September 2022

1. The Board understands that consensus market expectation adjusted profit before tax is GBP7.8m.

Financial Review

Key Performance Indicators (KPIs)

The directors review monthly revenue and operating costs to ensure that sufficient cash resources are available for the working capital requirements of the Group.

The primary KPIs at 30 June 2022 were:

 
                                                    6 months to     6 months to                % Change   12 months to 
                                                   30 June 2022    30 June 2021    (H1 2021 to H1 2022)         31 Dec 
                                                         GBP000          GBP000                                   2021 
                                                                                                                GBP000 
 
 Total revenue                                           27,604          19,826                     39%         46,017 
 
 Recurring revenue                                       15,973           9,889                     62%         24,083 
 
 Recurring revenue as a percentage of total 
  revenue                                                   58%             50%                       -            52% 
 
 Annual recurring revenue                               32, 124             n/a                       -         28,741 
 
 Adjusted EBITDA                                          4,500           4,161                      8%          8,250 
 
 Adjusted EBITDA margin %                                 16.3%             21%                 -470bps          17.9% 
 
 Cash and cash equivalents                               10,280          17,850                    -42%         15,021 
 
 Operating profit after non-recurring items               1,568           1,921                    -18%          4,098 
 

In addition, certain non-financial KPIs are periodically reviewed and assessed, including customer and staff retention rates.

Instem's revenue model consists of perpetual licence income with annual support and maintenance contracts, professional fees, technology enabled outsourced services fees, SaaS subscriptions and consulting services fees.

Total revenues in the period increased by 39% to GBP27.6m (H1 2021: GBP19.8m) with constant currency revenue growth at 34%. Recurring revenue, derived from support & maintenance contracts and SaaS subscriptions, increased in the period by 62% to GBP16.0m (H1 2021: GBP9.9m). Recurring revenue as a percentage of total revenue was 58% (H1 2021: 50%). In absolute terms, recurring revenue increased over the prior year by GBP6.1m. Revenue from technology enabled outsourced services increased by 42% to GBP3.7m (H1 2021: GBP2.6m).

Operating expenses increased by 47% in the period reflecting the full year cost of the 2021 acquisitions, ongoing investment in operational teams and the increase in the rate of inflation, primarily in salaries.

Adjusted earnings before interest, tax, depreciation, amortisation, and non-recurring items (Adjusted EBITDA) increased by 4% to GBP4.5m (H1 2021: GBP4.2m). For this measure of earnings, the margin as a percentage of revenue decreased in the period to 16.3% from 21% in H1 2021, due to the impact of the lower than Instem average margins of d-Wise and PDS and abnormally high salary cost inflation across the Group from January 2022. The average number of employees (including non-executive directors) for the period was 485 globally, an increase of 49 since December 2021.

Non-recurring costs in the period were GBP0.8m (H1 2021: GBP1.6m), consisting of an GBP0.7m increase of the provision associated with an historical contract dispute (see Subsequent Events section below for more detail) and GBP0.1m for integration costs relating to the 2021 acquisitions of The Edge, d-Wise and PDS.

The reported profit before tax for the period was GBP1.9m (H1 2021: GBP1.2m). The calculation for the adjusted profit before tax was changed in 2022 to include two additional components; the effect of foreign currency exchange and the unwinding of the financial liability included in finance income/(costs). Those two components have been included to better reflect the normalised, ongoing operations of the Group. Adjusted profit before tax (i.e. after adjusting for the effect of foreign currency exchange and the unwind of the finance liability included in finance income/(costs), non-recurring items and amortisation of intangibles on acquisitions) was GBP3.2m (H1 2021: GBP3.2m, restated).

The Group operates internationally and is exposed to foreign currency risk on transactions denominated in a currency other than the functional currency and on the translation of the statement of financial position and statement of comprehensive income of foreign operations into sterling. The currency that gave rise to this risk in 2022 was primarily from realised US dollars transactions. In 2022, the revenue and Adjusted EBITDA growth on a constant currency basis, excluding the foreign exchange exposure was 34-% and 3% respectively. The foreign exchange gain recorded during H1 2022 was GBP0.94m (H1 2021: GBP0.26m loss), which is composed of unrealised gains/losses from translation of intercompany balances. The Group seeks to settle those intercompany balances whenever possible.

The Group continues to invest in its product portfolio. Development costs incurred in the period were GBP3.7m (H1 2021: GBP2.3m), of which GBP1.4m (H1 2021: GBP1.0m) was capitalised. The Group has a development process in place and is committed to ensure its own technology continues to evolve to meet client needs.

Basic and diluted earnings per share calculated on an adjusted basis were 11.3p and 10.8p respectively (H1 2021: 14.3p basic and 13.6p diluted, as restated). The reported basic and diluted earnings per share were 5.7p and 5.5p respectively (H1 2021: 4.8p basic and 4.6p diluted).

The Group cash generated from operations for the period was GBP1.8m (H1 2021: GBP4.1m), a reduction from prior year primarily due to more cash tied up in working capital. The deferred and contingent consideration payments of GBP4.5m which related to the 2021 acquisitions were part of the net cash used in financing activities. The net cash used in investing activities includes GBP1.4m (H1 2021: GBP1.0m) from the capitalisation of software development. As a result of the above the gross cash balance decreased from GBP15.0m at 31 December 2021 to GBP10.3m at 30 June 2022.

The remaining financial obligations associated with The Edge, d-Wise and PDS acquisitions for H2 2022 and 2023 are deferred and contingent consideration payments of GBP4.2m and GBP2.2m respectively in cash. The contingent consideration provision reflected management's estimate that the entities would achieve their profitability targets and that the full amount of contingent consideration would be paid. This was confirmed in the period.

Intangible assets increased from the 30 June 2021 to the 30 June 2022 interim results due to the PDS acquisition completed on 1 September 2021 and an element of deferred consideration GBP3.2m (US$ 4.3m) relating to the d-Wise acquisition, which was originally recognised in H1 2021 as employee remuneration through the Statement of Comprehensive Income. As part of the procedures performed at the 31 December 2021 year end the accounting treatment was reassessed and it was concluded that no substantive employment link existed. Appropriate adjustments were made to the results in the year ended 31 December 2021 to include the deferred consideration as part of the cost of business combination. Any employment remuneration expense recognised in the interim 2021 results was reversed in H2 2021. Additionally, in 2022 the Goodwill in d-wise has increased by GBP0.05m (US$0.06m) due to a change in the contingent consideration paid.

The deficit on the Group's legacy defined benefit pension scheme was GBP1.3m at 30 June 2022 (H1 2021: GBP2.7m) having improved from a deficit of GBP2.0m at 31 December 2021. Liabilities decreased from GBP16.0m at 31 December 2021 to GBP12.5m at 30 June 2022 and Plan Assets have decreased from GBP14.0m at 31 December 2021 to GBP11.2m at 30 June 2022. The scheme liabilities fell in value due to significantly higher discount rates, which reflect the rise in the yields on corporate bonds over the period and contributions paid by the Group during the period have caused the deficit to reduce.

These reductions in the scheme deficit were offset by investment returns that were materially lower than expected, as well as higher inflation assumptions over the period that led to a decrease in the value of the Scheme's assets.

Movements in share capital and the share premium, merger rand share based payment reserves reflect the exercise of share options during the period, the fair value of share options granted being charged to the Statement of Comprehensive Income and the issue of shares paid in lieu of cash as deferred consideration for d-Wise. The share capital of Instem at 30 June 2022 was 22,676,808 ordinary shares of 10p each (note 12).

In line with previous periods and given our policy of retaining cash within the business to capitalise on available growth opportunities, the Board has not recommended the payment of a dividend.

Principal risks and uncertainties

The principal risk and uncertainties that management have made for the six months ended 30 June 2022 remained unchanged with those reported in the annual statutory financial statement for the year ended 31 December 2021.

The current weak economic conditions, spiralling cost inflation, the Ukrainian conflict and the threat of a global recession, compounded by the UK's departure from the European Union ("EU"), may disrupt or negatively impact the Group's operations and associated revenues. The Group has no clients or operations located in either Ukraine or Russia. The Board is actively monitoring the developing situation and is mindful of the potential for escalation. The impact of Covid-19 remains a challenge, particularly in China where the zero-tolerance approach by the Chinese government and consequent widespread lockdowns has impacted the Group's ability to implement its solutions on site for some clients in a timely way. However, it is not apparent that this has caused any material revenue or client loss and the Group continues to work closely with its clients to service their needs.

The Group operates internationally and is exposed to foreign currency risks on transactions denominated in a currency other than the functional currency. The main currency giving rise to this risk is the US dollar. Whilst weak sterling against the US dollar is beneficial to revenue , our substantial US cost base provides a natural hedge so that a strengthening USD is only modestly beneficial to profit.

Finally, any significant inflationary increases would quickly impact the Group's cost base as experienced during the period with salary increases across the Group. The Group has taken steps to mitigate these increases with corresponding increases in sales prices wherever possible but there will be a time lag before the full impact of these increases is reflected in the Group's results.

The Group seeks to mitigate exposure to all forms of risk through a combination of regular performance review and a comprehensive insurance programme. Additionally, t he Group has a significant proportion of recurring revenue (circa 58% of total) from annual support & maintenance and SaaS contracts from a well-established global customer base. Consequently, the Group ensures that it maintains a diversified portfolio in terms of customers, revenue mix, geography and markets.

Subsequent events

No adjusting events have occurred between the 30 June 2022 reporting date and the date of approval of this Interim Report.

A full and final settlement has been negotiated and agreed with a former customer regarding an historical contractual licence dispute that arose in 2017. Instem has agreed to pay EUR1.48m (approx. GBP1.3m), of which its insurer has agreed to contribute EUR0.45m (approx. GBP0.4m) resulting in a net payment due of approx. EUR1.0m (GBP0.9m). This will be made in October 2022.

As previously announced, the Company had created a provision of GBP0.25m in respect of the dispute and this was increased in the period by GBP0.64m, resulting in a provision at 30 June 2022 of approx. GBP0.9m. The increase in the provision was treated as a non-recurring, exceptional charge in the half year ended 30 June 2022.

The issue involved does not affect the ongoing operations of the Group.

Alternative performance measures

This report contains certain financial alternative performance measures ("APMs") that are not defined or recognised under IFRS but are presented to provide readers with additional financial information that is evaluated by management and investors in assessing the performance of the Group. This additional information presented is not uniformly defined by all companies and may not be comparable with similarly titled measures and disclosures by other companies.

The table below provides the data for certain performance measures mentioned above:

 
                                                                       30 Jun 2022      30 Jun 2021      31 Dec 2021 
                                                                            GBP000         GBP000          GBP000 
 
 Annual support fees                                                         9,716               4,988        14,378 
 SaaS subscription and support fees                                          6,257               4,901         9,704 
 
 Recurring revenue                                                          15,973               9,889        24,082 
 
 Licence fees                                                                2,803               3,086         4,597 
 Professional services                                                       1,486               1,509         3,651 
 Technology enabled outsourced services                                      3,738               2,594         6,378 
 Consultancy services                                                        3,604               2,748         7,309 
 
 Total revenue                                                              27,604              19,826        46,017 
 
 Recurring revenue is the revenue that repeats annually under contractual arrangements. It 
  highlights how much of the Group's total revenue is secured and anticipated to repeat in future 
  periods, providing a measure of the financial strength of the business. 
                                                                       30 Jun 2022      30 Jun 2021      31 Dec 2021 
                                                                            GBP000         GBP000             GBP000 
 
 Annual Recurring Revenue                                                   32,124                   -        28,741 
 
   Annual recurring revenue is revenue that annually repeats under contractual arrangements and 
   consists of Software as a Service (SaaS) revenue together with annual support and maintenance 
   fees. 
 
 
 
 
                                                                     30 Jun 2022           30 Jun 2021   31 Dec 2021 
                                                                          GBP000                GBP000        GBP000 
 
 EBITDA (before non recurring items)                                       3,731                 3,344         7,769 
 Non recurring cost (see note 6)                                             769                 1,622         1,286 
 Non recurring income (see note 6)                                             -                 (805)         (805) 
 
 Adjusted EBITDA                                                           4,500                 4,161         8,250 
 
 Adjusted EBITDA is EBITDA plus non-recurring items (as set out in note 6). The same adjustments 
  are also made in determining the adjusted EBITDA margin. Items are only classified as non-recurring 
  or exceptional due to their nature or size and the Board considers that this metric provides 
  the best measure of assessing underlying trading performance. 
 
 
 
 
                   30 Jun 2022      30 Jun 2021                 30 Jun 2021      31 Dec 2021                 31 Dec 2021 
                                  (as restated)    (as originally reported)    (as restated)    (as originally reported) 
                                                                     GBP000                                       GBP000 
                        GBP000           GBP000                                       GBP000 
 
 Profit before 
  tax                    1,918            1,177                       1,177            2,984                       2,984 
 Amortisation 
  of 
  intangibles 
  arising on 
  acquisition              977              599                         599            1,563                       1,563 
 Non recurring 
  cost (see 
  note 6)                  769            1,622                       1,622            1,286                       1,286 
 Non recurring 
  income (see 
  note 6)                    -            (805)                       (805)            (805)                       (805) 
 Intercompany 
  foreign 
  exchange 
  (gain)/loss                -                -                         268                -                        (18) 
 Foreign 
  currency 
  exchange 
  (gain)/ loss           (944)              258                           -               44                           - 
 Unwinding 
  discount on 
  deferred 
  consideration            455              318                           -              867                           - 
 
 Adjusted 
  profit before 
  tax                    3,175            3,169                       2,861            5,939                       5,010 
 
 The calculation for the adjusted profit before tax was changed in H1 2022 compared with prior 
  periods by including two additional components, the effect of the foreign currency exchange 
  and the unwinding of the finance liability included in finance income/(costs). Those two components 
  have been included as adjustments as they do not affect the ongoing operations of the Group. 
 
 
  Adjusted profit before tax is after adjusting for the effect of foreign currency exchange 
  and the unwinding of the finance liability included in finance income/(costs), non-recurring 
  items and amortisation of intangibles on acquisitions. The same adjustments are also made 
  in determining adjusted earnings per share ("EPS"). The Board considers this adjusted measure 
  of operating profit provides the best metric of assessing underlying performance. 
 
 
                   30 Jun 2022      30 Jun 2021                 30 Jun 2021      31 Dec 2021                 31 Dec 2021 
                                  (as restated)    (as originally reported)    (as restated)    (as originally reported) 
                                                                     GBP000                                       GBP000 
                        GBP000           GBP000                                       GBP000 
 
 Weighted 
  average 
  number of 
  shares 
  (000's)               23,547           22,168                      22,168           22,719                      22,719 
 Adjusted 
  diluted 
  earnings per 
  share                  10.8p            13.6p                       12.2p            20.4p                       16.3p 
 
 
                   30 Jun 2022   30 Jun 2021   31 Dec 2021 
                        GBP000        GBP000        GBP000 
 
 Cash at bank           10,280        26,848        24,019 
 Bank overdraft              -       (8,998)       (8,998) 
 
 Cash balance           10,280        17,850        15,021 
 
 

Nigel Goldsmith

Chief Financial Officer

27 September 2022

Instem plc

CONSOLIDATED STATEMENT OF COMPREHENSIVE INCOME

For the six months ended 30 June 2022

 
                                                               Unaudited           Unaudited                   Audited 
                                                        Six months ended    Six months ended                      Year 
                                                                 30 June             30 June    ended 31 December 2021 
                                                                    2022                2021                    GBP000 
                                                                  GBP000              GBP000 
                                                 Note 
 
 REVENUE                                         4                27,604              19,826                    46,017 
 Employee benefits expense                                      (14,676)            (11,504)                  (26,918) 
 Other expenses                                                  (8,428)             (4,161)                  (10,491) 
 Net impairment loss on financial assets                               -                   -                     (358) 
 
 EARNINGS BEFORE INTEREST, TAXATION, 
  DEPRECIATION, AMORTISATION AND 
  NON-RECURRING COSTS (ADJUSTED 
  EBITDA)                                                          4,500               4,161                     8,250 
 
 Depreciation                                                      (168)               (123)                     (312) 
 Amortisation of intangibles arising on 
  acquisition                                                      (977)               (599)                   (1,563) 
 Amortisation of internally generated 
  intangibles                                                      (469)               (397)                     (851) 
 Amortisation of right of use assets                               (549)               (304)                     (945) 
 
 OPERATING PROFIT BEFORE NON-RECURRING COSTS                       2,337               2,738                     4,579 
 
 Non-recurring income                            6                     -                 805                       805 
 Non-recurring costs                             6                 (769)             (1,622)                   (1,286) 
                                                       -----------------  ------------------  ------------------------ 
 OPERATING PROFIT AFTER NON-RECURRING COSTS                        1,568               1,921                     4,098 
 
 Finance income                                  7                 1,030                  22                        30 
 Finance costs                                   8                 (680)               (766)                   (1,144) 
                                                       -----------------  ------------------  ------------------------ 
 PROFIT BEFORE TAXATION                                            1,918               1,177                     2,984 
 
 Taxation                                                          (631)               (154)                   (1,306) 
                                                       -----------------  ------------------  ------------------------ 
 PROFIT FOR THE PERIOD                                             1,287              -1,023                     1,678 
                                                       =================  ==================  ======================== 
 
 OTHER COMPREHENSIVE INCOME 
 Items that will not be reclassified to 
 profit and loss account 
 Actuarial gain on retirement benefit 
  obligations                                                        382                 785                     1,375 
 Deferred tax on actuarial gain & loss                              (96)               (149)                     (140) 
 Deferred tax on share options                                         -                   -                         - 
                                                       -----------------  ------------------  ------------------------ 
                                                                     286                 636                     1,235 
 Items that may be reclassified to profit 
 and loss account: 
 Exchange differences on translating foreign 
  operations                                                     (1,216)                  24                     (294) 
                                                       -----------------  ------------------  ------------------------ 
 OTHER COMPREHENSIVE (EXPENSE)/ INCOME FOR 
  THE PERIOD                                                       (930)                 660                       941 
 TOTAL COMPREHENSIVE INCOME FOR THE PERIOD                           354               1,683                     2,619 
                                                       =================  ==================  ======================== 
 
 PROFIT ATTRIBUTABLE TO OWNERS OF THE PARENT 
  COMPANY                                                          1,287               1,023                     1,678 
                                                       =================  ==================  ======================== 
 
   TOTAL COMPREHENSIVE INCOME ATTRIBUTABLE 
   TO OWNERS OF THE PARENT COMPANY                                   354               1,683                     2,619 
                                                       =================  ==================  ======================== 
 Earnings per share from continuing 
  operations 
  - Basic                                         5                 5.7p                4.8p                      7.8p 
 - Diluted                                       5                  5.5p                4.6p                      7.4p 
 

Instem plc

CONSOLIDATED STATEMENT OF FINANCIAL POSITION

 
 As at 30 June 2022                       Unaudited   Unaudited       Audited 
                                            30 June     30 June   31 December 
                                               2022        2021          2021 
                                   Note      GBP000      GBP000        GBP000 
 ASSETS 
 NON-CURRENT ASSETS 
 Intangible assets                           58,381      43,098        58,311 
 Property, plant and equipment                  552         637           592 
 Right of use assets                          1,542       2,110         2,077 
 Finance lease receivables                       69         105            85 
 TOTAL NON-CURRENT ASSETS                    60,544      45,950        61,065 
                                         ----------  ----------  ------------ 
 
 CURRENT ASSETS 
 Inventories                                     99          54            64 
 Trade and other receivables                 15,224      12,250        14,852 
 Finance lease receivables                       51          42            44 
 Tax receivable                                  15         648           130 
 Cash and cash equivalents          9        10,280      17,850        15,021 
                                         ----------  ----------  ------------ 
 TOTAL CURRENT ASSETS                        25,669      30,844        30,111 
                                         ----------  ----------  ------------ 
 TOTAL ASSETS                                86,213      76,794        91,176 
                                         ==========  ==========  ============ 
 
 LIABILITIES 
 CURRENT LIABILITIES 
 Trade and other payables                     4,905       4,055         5,723 
 Deferred income                             17,672      14,243        18,935 
 Provision for liabilities and 
  charges                           10          885           -             - 
 Financial liabilities              11        6,235       4,515         6,612 
 Lease liabilities                              935       1,079         1,077 
 TOTAL CURRENT LIABILITIES                   30,632      23,892        32,347 
                                         ----------  ----------  ------------ 
 
 NON-CURRENT LIABILITIES 
 Financial liabilities              11            -       3,244         4,728 
 Retirement benefit obligations               1,303       2,729         2,014 
 Provision for liabilities and 
  charges                           10           43         250           291 
 Lease liabilities                              858       1,312         1,248 
 Deferred tax liabilities                     2,977       2,855         3,247 
                                         ----------  ----------  ------------ 
 TOTAL NON-CURRENT LIABILITIES                5,181      10,390        11,528 
                                         ----------  ----------  ------------ 
 TOTAL LIABILITIES                           35,813      34,482        43,875 
                                         ==========  ==========  ============ 
 
 EQUITY 
 Share capital                                2,268       2,178         2,219 
 Share premium                               28,224      28,191        28,191 
 Merger reserve                              14,013       9,359        12,104 
 Share based payment reserve                  3,045       1,447         2,294 
 Translation reserve                        (1,418)          66         (202) 
 Retained earnings                            4,268       1,221         2,695 
                                         ----------  ----------  ------------ 
 TOTAL EQUITY ATTRIBUTABLE TO 
  OWNERS OF THE PARENT                       50,400      42,512        47,301 
                                         ----------  ----------  ------------ 
 TOTAL EQUITY AND LIABILITIES                86,213      76,794        91,176 
                                         ==========  ==========  ============ 
 

Instem plc

CONSOLIDATED STATEMENT OF CASH FLOWS

 
 For the six months ended 30 
 June 2022                                               Unaudited                  Unaudited                  Audited 
                                          Six months ended 30 June   Six months ended 30 June   Year ended 31 December 
                                   Note                       2022                       2021                     2021 
                                                            GBP000                     GBP000                   GBP000 
 CASH FLOWS FROM OPERATING 
 ACTIVITIES 
 Profit before taxation                                      1,918                      1,177                    2,984 
 Adjustments for: 
 Depreciation                                                  168                        123                      312 
 Amortisation of intangibles                                 1,446                        996                    2,414 
 Amortisation of right of use 
  assets                                                       549                        304                      945 
 Share based payment charge                                    751                        517                    1,061 
 Retirement benefit obligations                              (398)                      (380)                    (530) 
 Finance income                     7                      (1,030)                       (22)                     (30) 
 US government loans forgiven       6                            -                      (805)                    (805) 
 Finance costs                      8                          680                        766                    1,144 
 d-Wise acquisition cost            6                            -                        809                        - 
 Loss on disposal of fixed 
  assets                                                         -                          6                        3 
                                         -------------------------  -------------------------  ----------------------- 
 CASH FLOWS FROM OPERATIONS 
  BEFORE MOVEMENTS IN WORKING 
  CAPITAL                                                    4,084                      3,491                    7,498 
 Movements in working capital: 
 (Increase) in inventories                                    (35)                        (4)                     (14) 
 Decrease/ (Increase) in trade 
  and other receivables                                        140                      (151)                  (1,573) 
 (Decrease)/ Increase in trade, 
  other payables and deferred 
  income                                                   (2,995)                        746                    4,432 
 Increase in provisions                                        637                          -                        - 
                                         -------------------------  -------------------------  ----------------------- 
 NET CASH GENERATED FROM 
  OPERATIONS                                                 1,831                      4,082                   10,343 
 Finance income                                                 86                          3                        6 
 Finance costs                                               (116)                      (482)                    (276) 
 Income taxes                                                (936)                      (485)                    (873) 
                                         -------------------------  -------------------------  ----------------------- 
 NET CASH GENERATED FROM 
  OPERATING ACTIVITIES                                         865                      3,118                    9,200 
 CASH FLOWS FROM INVESTING 
 ACTIVITIES 
 Capitalisation of development 
  costs                                                    (1,465)                      (922)                  (2,238) 
 Purchase of property, plant and 
  equipment                                                  (122)                       (37)                    (144) 
 Purchase of subsidiary 
  undertaking (net of cash 
  acquired)                                                      -                   (10,567)                 (14,840) 
                                         -------------------------  -------------------------  ----------------------- 
 NET CASH USED IN INVESTING 
  ACTIVITIES                                               (1,587)                   (11,526)                 (17,222) 
 CASH FLOWS FROM FINANCING 
 ACTIVITIES 
 Proceeds from issue of share 
  capital                                                       35                         22                       22 
 Payment of deferred 
  consideration                                            (3,061)                          -                    (277) 
 Payment of contingent                                     (1,412)                          -                        - 
 consideration 
 Repayment of lease liabilities                              (587)                      (367)                    (963) 
 Receipts from sublease of asset                                16                         22                       40 
 Repayment of former PDS 
  shareholder loan                                               -                          -                  (2,387) 
                                         -------------------------  -------------------------  ----------------------- 
 NET CASH (USED)/GENERATED FROM 
  FINANCING ACTIVITIES                                     (5,009)                      (323)                  (3,565) 
 NET (DECREASE) /INCREASE IN 
  CASH AND CASH EQUIVALENTS                                (5,731)                    (8,731)                 (11,587) 
 Cash and cash equivalents at 
  start of period                                           15,021                     26,724                   26,724 
 Effect of exchange rate changes 
  on the balance of cash held in 
  foreign currencies                                           990                      (143)                    (116) 
                                         -------------------------  -------------------------  ----------------------- 
 CASH AND CASH EQUIVALENTS AT OF PERIOD                                             10,280                     17,850                   15,021 
                                         =========================  =========================  ======================= 
 

Instem plc

CONSOLIDATED STATEMENT OF CHANGES IN EQUITY

For the six months ended 30 June 2022

 
 
                                                                Share 
                                                                based 
                          Share        Share      Merger      payment    Translation    Retained      Total 
                        capital      premium     reserve      reserve        reserve    earnings     equity 
                         GBP000       GBP000      GBP000       GBP000         GBP000      GBP000     GBP000 
 
 Balance as at 1 
  January 2021 - 
  (Audited)               2,048       28,172       2,432          930             92       (438)     33,236 
 
 Profit for the 
  period                      -            -           -            -              -       1,023      1,023 
 Other 
  comprehensive 
  income                      -            -           -            -             24         636        660 
                    -----------  -----------  ----------  -----------  -------------  ----------  --------- 
 Total 
  comprehensive 
  income                      -            -           -            -             24       1,659      1,683 
 
 Shares issued              130           19       6,927            -              -           -      7,076 
 Share based 
  payment                     -            -           -          517              -           -        517 
                    -----------  -----------  ----------  -----------  -------------  ----------  --------- 
 Balance as at 30 
  June 2021 
  (Unaudited)             2,178       28,191       9,359        1,447            116       1,221     42,512 
 Profit for the 
  period                      -            -           -            -              -         655        655 
 Other 
  comprehensive 
  (expense)/income            -            -           -            -          (318)         599        281 
                    -----------  -----------  ----------  -----------  -------------  ----------  --------- 
 Total 
  comprehensive 
  expense                     -            -           -            -          (318)       1,254        936 
 
 Shares issued               41            -       2,745            -              -           -      2,786 
 Share based 
  payment                     -            -           -          544              -           -        544 
 Deferred tax on 
  share options               -            -           -          528              -           -        528 
 Nil cost option 
  charge                      -            -           -          (5)              -           -        (5) 
 Reserve transfer 
  on lapse of 
  share options               -            -           -         (25)              -          25          - 
 Reserve transfer 
  on exercise of 
  share options               -            -           -        (195)              -         195          - 
                    -----------  -----------  ----------  -----------  -------------  ----------  --------- 
 Balance as at 31 
  December 2021 
  (Audited)               2,219       28,191      12,104        2,294          (202)       2,695     47,301 
 
   Profit for the 
   period                     -            -           -            -              -       1,287      1,287 
 Other 
  comprehensive 
  income                                                                     (1,216)         286      (930) 
                    -----------  -----------  ----------  -----------  -------------  ----------  --------- 
 Total 
  comprehensive 
  income                      -            -           -            -        (1,216)       1,573        357 
 
 Shares issued               49           33       1,909            -              -           -      1,991 
 Share based 
  payment                     -            -           -          751              -           -        751 
                    -----------  -----------  ----------  -----------  -------------  ----------  --------- 
 Balance as at 30 
  June 2022 
  (Unaudited)             2,268       28,224      14,013        3,045        (1,418)       4,505     50,400 
                    ===========  ===========  ==========  ===========  =============  ==========  ========= 
 
 
 
 

NOTES TO THE FINANCIAL INFORMATION

For the six months ended 30 June 2022

   1.            General information 

The principal activity and nature of operations of the Group is the provision of world class IT solutions and services to the life sciences research and development market. Instem's solutions for data collection, management and analysis are used by customers worldwide to meet the needs of life science organisations for data-driven decision making leading to safer, more effective products. Instem plc is a public limited company, listed on AIM, incorporated in England and Wales under the Companies Act 2006 and domiciled in England. The registered office is Diamond Way, Stone Business Park, Stone, Staffordshire ST15 0SD, UK.

   2.            Basis of preparation and accounting policies 

Basis of preparation

The Group's half-yearly financial information, which is unaudited, consolidates the results of Instem plc and its subsidiary undertakings made up to 30 June 2022. The Group's accounting reference date is 31 December.

The consolidated financial information is presented in Pounds Sterling (GBP) which is also the functional currency of the parent.

The financial information contained in this half year financial report does not constitute statutory accounts as defined in section 434 of the Companies Act 2006. It does not therefore include all of the information and disclosures required in the annual financial statements.

The financial information presented for the six months ended 30 June 2022 and 30 June 2021 is unaudited.

Instem plc's consolidated statutory accounts for the year ended 31 December 2021, prepared under IFRS, have been delivered to the Registrar of Companies. The report of the auditors on these accounts was unqualified and did not contain a statement under Section 498 (2) or (3) of the Companies Act 2006.

Significant accounting policies

The accounting policies used in the preparation of the financial information for the six months ended 30 June 2022 are in accordance with the recognition and measurement criteria of international accounting standards and are consistent with those that will be adopted in the annual statutory financial statements for the year ending 31 December 2022.

While the financial information included has been prepared in accordance with the recognition and measurement criteria of International Financial Reporting Standards (IFRS), these financial statements do not contain sufficient information to comply with IFRS's.

Instem plc and its subsidiaries have not applied IAS 34, Interim Financial Reporting, which is not mandatory for UK AIM listed groups, in the preparation of this half-yearly financial report.

Significant judgement and estimates

The judgements and estimations that management have made for the six months ended 30 June 2022 are consistent with those reported in the annual statutory financial statements for the year ended 31 December 2021.

Going concern

The Directors continue to adopt the going concern basis of accounting in preparing these financial statements, which the Directors believe is appropriate given the Group's trading performance and financial liquidity. At 30 June 2022, the Group had cash balances of GBP10.3m together with a GBP10.0m committed banking facility.

The Group signed a new financing arrangement on 8 April 2022, which consists of a committed facility of GBP10.0m with HSBC UK Bank plc to support the Group's working capital needs and its acquisition strategy, which can be extended up to GBP20.0m if needed, subject to further bank approval. The financial covenants have been considered in the Group cash forecast to ensure compliance. During 2022, the Group settled the bank overdraft facility of GBP9.0m with NatWest Bank plc.

The Group has considered a downside scenario which is also linked to the company's risks when modelling the forecast results and cash flow. The downside scenario showed that there is sufficient liquidity headroom for at least 12 months from the date of approval of these financial statements.

In the period to 30 June 2022, we have not observed any material detriment to our overall existing business or in the level of new business opportunities that are being presented to us in the markets in which we operate, and we do not anticipate any during the next 12 months.

Cash and cash equivalents

Cash and cash equivalents for the purposes of the Statement of Cash Flows comprise the net of cash and overdraft balances that are shown in the Statement of Financial Position in Cash and Cash Equivalents.

   3.            Segmental Reporting 

The business is organised into four operating segments to better manage and report revenues; Study Management, Regulatory Solutions, In Silico Solutions and Clinical Trial Acceleration. During 2021 the fourth segment , Clinical Trial Acceleration (CTA), was established following the acquisition of d-Wise.

The Group's Chief Operating Decision Maker (CODM) is its Chief Executive who monitors the performance of these operating segments as well as deciding on the allocation of resources to them alongside the executive management team.

Historically the Group's finance systems have recorded costs centrally and have managed costs in this way. Over recent years the Group has expanded both organically and through acquisition, increasing the number of products and services offered.

During 2021 the financial system enabled more centrally recorded costs to be allocated to the individual segments and that process was further developed during 2022. The operations of the Group are managed centrally along with group-wide functions including sales, marketing, software development, information technology, customer support, human resources. The CTA and In Silico segments already bear the majority of their costs directly and as such report a lower direct contribution margin to central overheads than the other two segments. However, for the Study Management and Regulatory Solutions segments most of their operational costs are centrally managed. Consequently, these bear a higher proportion of allocated central costs resulting in a reduction in profit contribution compared with prior periods.

The expectation in future periods is to be able to allocate a higher proportion of centrally held operational costs to the individual segments as internal reporting systems evolve, thereby enabling the Board to use the segmental cost information for meaningful decision making. A higher proportion of central costs were allocated to the operating segments during H1 2022 (79% of total costs) compared with H1 2021 (40%).

The analysis provided below reflects costs directly attributable to the respective segments in H1 2022 and 2021, which are primarily third-party costs of sale and costs of allocated employees. The remaining indirect operational costs are accounted for centrally and are not allocated to specific segments.

 
 Unaudited six months        Study Management   Regulatory     In Silico        Clinical 
  ended                                          Solutions     Solutions           Trial      Total 
  30 June 2022                                                              Acceleration 
                                       GBP000       GBP000        GBP000          GBP000     GBP000 
 
 Total revenue                         11,908        5,594         1,651           8,451     27,604 
 Direct attributable 
  costs                               (6,072)      (4,262)         (907)         (6,900)   (18,141) 
                            -----------------  -----------  ------------  --------------  --------- 
 Contribution to indirect 
  overheads                             5,836        1,332           744           1,551      9,463 
 
 Contribution to indirect 
  overheads %                             49%          24%           45%             18%        34% 
 
 Central unallocated 
  indirect costs                                                                            (4,963) 
 
   Adjusted EBITDA                                                                            4,500 
 
 
 
 Unaudited six months        Study Management   Regulatory    In Silico              Clinical 
  ended                                          Solutions    Solutions    Trial Acceleration     Total 
  30 June 2021 
                                       GBP000       GBP000       GBP000                GBP000    GBP000 
 
 Total revenue                          9,798        4,686        1,487                 3,855    19,826 
 Direct attributable 
  costs                               (2,024)      (1,113)        (771)               (2,477)   (6,385) 
                            -----------------  -----------  -----------  --------------------  -------- 
 Contribution to indirect 
  overheads                             7,774        3,573          716                 1,378    13,441 
 
 Contribution to indirect 
  overheads %                             79%          76%          48%                   36%       68% 
 
 Central unallocated 
  indirect costs                                                                                (9,280) 
                                                                                                 ______ 
   Adjusted EBITDA                                                                                4,161 
 
 
 
 Audited year ended          Study Management   Regulatory    In Silico        Clinical 
  31 December 2021                               Solutions    Solutions          Trials      Total 
                                                                           Acceleration 
                                       GBP000       GBP000       GBP000          GBP000     GBP000 
 
 Total revenue                         20,259       10,010        3,042          12,706     46,017 
 Direct attributable 
  costs                              (10,388)      (6,016)      (1,681)        (11,308)   (29,393) 
                            -----------------  -----------  -----------  --------------  --------- 
 Contribution to indirect 
  overheads                             9,871        3,994        1,361           1,398     16,624 
 
 Contribution to indirect 
  overheads %                             49%          40%          45%             11%        36% 
 
 Central unallocated 
  indirect costs                                                                           (8,374) 
                                                                                            ______ 
   Adjusted EBITDA                                                                           8,250 
 
   4.          Key performance measures 
 
 
                                                            Unaudited            Unaudited              Audited 
                                                     Six months ended     Six months ended           Year ended 
                                                         30 June 2022         30 June 2021     31 December 2021 
                                                               GBP000               GBP000               GBP000 
 a) Recurring revenue 
 
         Annual support fees                                    9,716                4,988               14,378 
         SaaS subscriptions and support fees                    6,257                4,901                9,704 
                                                  -------------------  -------------------  ------------------- 
         Recurring revenue                                     15,973                9,889               24,082 
 
         Licence fees                                           2,803                3,086                4,597 
         Professional services                                  1,486                1,509                3,651 
         Technology enabled outsourced services                 3,738                2,594                6,378 
         Consulting services                                    3,604                2,748                7,309 
                                                  -------------------  -------------------  ------------------- 
         Total revenue                                         27,604               19,826               46,017 
 
 
  b) Adjusted EBITDA 
   c) 
   d) 
 
         EBITDA                                                 3,731                3,344                7,769 
         Non-recurring items (see note 6)                         769                  817                  481 
                                                  -------------------  -------------------  ------------------- 
         Adjusted EBITDA                                        4,500                4,161                8,250 
 

Adjusted profit after tax and bank balance performance measures are detailed in notes 5 and 9.

   5.            Earnings per share 

Basic earnings per share are calculated by dividing the profit attributable to ordinary shareholders by the weighted average number of ordinary shares in issue during the year. Diluted earnings per share is calculated by adjusting the weighted number of ordinary shares outstanding to assume conversion of all dilutive potential shares arising from the share option scheme.

The deferred and contingently issuable shares in relation to the d-Wise acquisition, which could potentially dilute basic EPS in the future, were not included in the calculation of diluted EPS as they are antidilutive for the half year and the year ended in 2021.

The dilutive impact of the share options is calculated by determining the number of shares that could have been acquired at fair value (determined as the average market share price of the Company's shares) minus the issue price. The number of ordinary shares that could have been acquired at their average market price during the period is ignored. However, the shares that would generate no proceeds and would not have any effect on profit or loss attributable to ordinary shares outstanding are included.

   a)     Basic earnings per share 
 
                                 Unaudited     Unaudited        Audited 
                                Six months    Six months     Year ended 
                                     ended         ended    31 December 
                                   30 June       30 June           2021 
                                      2022          2021 
 Profit after tax (GBP000)           1,287         1,023          1,678 
                              ------------  ------------  ------------- 
 
 Weighted average number of 
  shares (000's)                    22,464        21,145         21,591 
                              ------------  ------------  ------------- 
 
 Basic earnings per share             5.7p          4.8p           7.8p 
                              ============  ============  ============= 
 
   b)                    Diluted earnings per share 
 
                                       Unaudited     Unaudited 
                                      Six months    Six months        Audited 
                                           ended         ended     Year ended 
                                         30 June       30 June    31 December 
                                            2022          2021           2021 
 Profit after tax (GBP000)                 1,287         1,023          1,678 
                                    ------------  ------------  ------------- 
 
 Weighted average number of 
  shares (000's)                          22,464        21,145         21,591 
 Potentially dilutive shares 
  (000's)                                  1,083         1,023          1,128 
 Adjusted weighted average number 
  of shares (000's)                       23,547        22,168         22,719 
                                    ------------  ------------  ------------- 
 
 Diluted earnings per share                 5.5p          4.6p           7.4p 
                                    ============  ============  ============= 
 
   c)     Adjusted earnings per share 

Adjusted earnings per share is calculated after adjusting for the effect of foreign currency exchange and the unwinding of the finance liability included in finance income/(costs), non-recurring items and amortisation of intangibles on acquisitions.

The adjusted profit after tax has been amended in 2022 to ensure that the foreign exchange movements and exceptional business expenses do not impact and distort the earnings per share calculation.

Diluted adjusted earnings per share is calculated by adjusting the weighted number of ordinary shares outstanding to assume conversion of all dilutive potential shares arising from the share option scheme. The dilutive impact of the share options is calculated by determining the number of shares that could have been acquired at fair value (determined as the average market share price of the Company's shares) based on the monetary value of the subscription rights attached to the outstanding share options.

 
 
                     Unaudited      Unaudited           Audited 
   Unaudited        Six months     Six months        Year ended        Audited 
         Six             ended          ended       31 December     Year ended 
      months           30 June        30 June              2021    31 December 
       ended              2021           2021     (as restated)           2021 
     30 June     (as restated)     (initially                       (initially 
        2022                        reported)                        reported) 
 
 
 Profit after tax (GBP000)         1,287    1,023    1,023    1,678    1,678 
 
 Non-recurring costs                 769    1,622    1,622    1,286    1,286 
 Non- recurring income                 -    (805)    (805)    (805)    (805) 
 Amortisation of acquired 
  intangibles (GBP000)               977      599      599    1,563    1,563 
 Foreign exchange loss/(gain) 
  on revaluation of intergroup 
  balances (GBP000)                    -        -      268        -     (18) 
 Foreign currency exchange 
  (gain)/loss                      (944)      258        -       44        - 
 Finance cost on deferred 
  and contingent consideration 
  (GBP000)                           455      318        -      867        - 
 Adjusted profit after 
  tax (GBP000)                     2,544    3,169    2,707    5,939    3,704 
                                 -------  -------  -------  -------  ------- 
 
 Weighted average number 
  of shares (000's)               22,464   21,145   21,145   21,591   21,591 
 Potentially dilutive 
  shares (000's)                   1,083    1,023    1,023    1,128    1,128 
                                 -------  -------  -------  -------  ------- 
 Adjusted weighted average 
  number of shares (000's)        23,547   22,168   22,168   22,719   22,719 
                                 -------  -------  -------  -------  ------- 
 
 Adjusted basic earnings 
  per share                        11.3p    14.3p    12.8p    21.5p    17.2p 
                                 =======  =======  =======  =======  ======= 
 Adjusted diluted earnings 
  per share                        10.8p    13.6p    12.2p    20.4p    16.3p 
                                 =======  =======  =======  =======  ======= 
 
   6.               Non-recurring items 
 
                                        Unaudited     Unaudited 
                                       Six months    Six months        Audited 
                                            ended         ended     Year ended 
                                          30 June       30 June    31 December 
                                             2022          2021           2020 
   Non-recurring cost 
                                           GBP000        GBP000         GBP000 
 
 Legal cost relating to historical 
  contract dispute                            698            62             95 
 Share based payment                            -           170            175 
 Acquisition costs                             71         1,390          1,019 
                                              769         1,622          1,286 
                                     ------------  ------------  ------------- 
 
 
                                    Unaudited     Unaudited 
                                   Six months    Six months        Audited 
                                        ended         ended     Year ended 
                                      30 June       30 June    31 December 
                                         2022          2021           2020 
   Non-recurring income 
                                       GBP000        GBP000         GBP000 
 
 US government loans forgiven               -         (805)          (805) 
                                            -         (805)          (805) 
 --------------------------------------------  ------------  ------------- 
 

Non-recurring costs include a cost provision relating to an historical contractual licence dispute, which does not affect the ongoing operations of the Group. The provision was increased by GBP0.64m in the period to 30 June 2022.

Non-recurring costs also include acquisition costs relating to the 2021 acquisitions of The Edge, d-Wise and PDS.

The non-recurring income of GBP0.8m ($1.1m) included in 2021 relates to US federal government COVID-19 support loans which were forgiven during 2021 and there are no remaining unfulfilled conditions or contingencies related to this income

   7.               Finance income 
 
                                   Unaudited     Unaudited 
                                  Six months    Six months        Audited 
                                       ended         ended     Year ended 
                                     30 June       30 June    31 December 
                                        2022          2021           2021 
                                      GBP000        GBP000         GBP000 
 
 Foreign exchange gains                  945             -              - 
 Right of use interest income              2             3              6 
 Other interest                           83            19             24 
                                ------------  ------------  ------------- 
                                       1,030            22             30 
                                ============  ============  ============= 
 
   8.            Finance costs 
 
                                     Unaudited     Unaudited 
                                    Six months    Six months        Audited 
                                         ended         ended     Year ended 
                                       30 June       30 June    31 December 
                                          2022          2021           2021 
                                        GBP000        GBP000         GBP000 
 
 Bank loans and overdrafts                 116            43             85 
 Unwinding discount on deferred 
  consideration                            455           318            867 
 Net charge on pension scheme               69            26             51 
 Right of use asset interest 
  cost                                      40           121             97 
 Foreign exchange losses                     -           258             44 
                                  ------------  ------------  ------------- 
                                           680           766          1,144 
                                  ============  ============  ============= 
 
   9.               Cash and cash equivalents 
 
 
                     Unaudited     Unaudited        Audited 
                       30 June       30 June    31 December 
                          2022          2021           2021 
                        GBP000        GBP000         GBP000 
 
 Cash at bank           10,280        26,848         24,019 
 Bank overdraft              -       (8,998)        (8,998) 
 Bank balance           10,280        17,850         15,021 
                  ============  ============  ============= 
 

The Group signed a new financing arrangement with HSBC UK Bank plc in April 2022, which consists of a committed facility of GBP10.0m for general corporate purposes, which can be extended up to GBP20.0m if needed, subject to further bank approval. The financial covenants have been considered in the forecast to ensure compliance. During 2022, the Group settled its bank overdraft of GBP9.0m with former bankers NatWest Bank plc.

   10.             Provision for liabilities and charges 
 
 
                                        Unaudited   Unaudited        Audited 
                                          30 June     30 June    31 December 
   Current liability                         2022        2021           2021 
                                           GBP000      GBP000         GBP000 
 
 Historical legal dispute provision           885           -              - 
 
 At end of period Current liability           885           -              - 
                                     ============  ==========  ============= 
 
 
 
                                         Unaudited   Unaudited        Audited 
                                           30 June     30 June    31 December 
                                              2022        2021           2021 
   Non-current liability                    GBP000      GBP000         GBP000 
 
 Historical legal dispute provision              -         250            250 
 PDS warranty provision                         43           -             41 
 At end of period Non current 
  liability                                     43         250            291 
                                      ============  ==========  ============= 
 

At the period end the Group held a provision of GBP0.9m (2021: GBP0.25m) in respect of an historical contract dispute against a maximum exposure of approximately GBP3.8m. The maximum exposure included an additional claim for consequential loss. Since the period end a settlement has been agreed with the plaintiff (see note 13).

   11.             Financial liabilities 

An analysis of financial liabilities as presented in the statement of financial position is as follows:

 
 
                                         Unaudited   Unaudited        Audited 
                                           30 June     30 June    31 December 
   Current liability                          2022        2021           2021 
                                            GBP000      GBP000         GBP000 
 
 Deferred consideration                      4,271       2,435          4,276 
 Contingent consideration                    1,964       2,080          2,336 
 
 At end of period Current liability          6,235       4,515          6,612 
                                      ============  ==========  ============= 
 
 
 
                                    Unaudited   Unaudited        Audited 
                                      30 June     30 June    31 December 
   Non-current liability                 2022        2021           2021 
                                       GBP000      GBP000         GBP000 
 
 Deferred consideration                     -       1,780          3,060 
 Contingent consideration                   -       1,464          1,668 
 
 At end of period Non current 
  liability                                 -       3,244          4,728 
                                =============  ==========  ============= 
 

The contingent consideration is in respect of The Edge and d-Wise. The conditions to pay both sums have been met in full.

The deferred consideration above is in respect of the acquisitions of d-Wise and PDS.

   12.             Share Capital 

The share capital of Instem plc consists of fully paid ordinary shares with a nominal value of 10p per share.

 
                                                       30 June      30 June   31 December 
                                                          2022         2021          2021 
                                                        No. of       No. of        No. of 
                                                        shares       shares        shares 
 Shares issued: 
 Beginning of the period                            22,189,856   20,481,909    20,481,909 
            Issued on exercise of employee share 
             options                                   190,000       38,667        88,667 
            Share issue on acquisition of The 
             Edge                                            -      391,920       391,920 
            Share issue on acquisition of d-Wise       296,952      868,203       868,203 
            Share issue on acquisition of PDS                -            -       359,157 
 Total shares issued and fully paid 
  at end of period                                  22,676,808   21,780,699    22,189,856 
                                                   ===========  ===========  ============ 
 
 

Share premium

Proceeds received in addition to the nominal value of the shares issued during the year have been included in share premium, less fees, commissions and disbursements. Costs of new shares charged to equity amounted to GBPnil.

Share premium has also been recorded in respect of the issue of share capital related to employee share-based payment.

Merger reserve

The merger reserve represents

-- the difference between the consideration payable at the date of acquisition, net of merger relief, and the share capital and share premium of Instem Life Science Systems Limited and

-- the difference between the nominal value and share issue price of shares issued as consideration in the purchase of Leadscope Inc, The Edge Software Consultancy Ltd, d-Wise Technologies, Inc and PDS Pathology Data Systems

   13.             Subsequent Events 

No adjusting events have occurred between the 30 June 2022 reporting date and the date of approval of this Interim Report.

A full and final settlement has been negotiated and agreed with a former customer regarding an historical contractual licence dispute that arose in 2017. Instem has agreed to pay EUR1.48m (approx. GBP1.3m), of which its insurer has agreed to contribute EUR0.45m (approx. GBP0.4m) resulting in a net payment due of approx. EUR1.0m (GBP0.9m). This will be made in October 2022.

As previously announced, the Company had created a provision of GBP0.25m in respect of the dispute and this was increased in the period by GBP0.64m, resulting in a provision at 30 June 2022 of approx. GBP0.9m. The increase in the provision was treated as a non-recurring, exceptional charge in the half year ended 30 June 2022.

The issue involved does not affect the ongoing operations of the Group.

   14.             Availability of this Interim Announcement 

Copies of the 2022 Interim Report for Instem plc will be available from the Group's website at www.instem.com.

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