FORM 4 [ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      
1. Name and Address of Reporting Person * Greenberg Richard S 2. Issuer Name and Ticker or Trading Symbol NEXIEN BIOPHARMA, INC. [ NXEN ] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable)__X__ Director                    __X__ 10% Owner
__X__ Officer (give title below)    _____ Other (specify below)
Chief Executive Officer
(Last)         (First)         (Middle)
4340 E KENTUCKY AVE, SUITE 206
3. Date of Earliest Transaction (MM/DD/YYYY)
1/27/2022
(Street)
GLENDALE, CO 80246
(City)       (State)       (Zip)
4. If Amendment, Date Original Filed (MM/DD/YYYY)
 
6. Individual or Joint/Group Filing (Check Applicable Line) _X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock  1/27/2022    A    250000  A  (1) 4435192  D   

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Trans. Date 3A. Deemed Execution Date, if any 4. Trans. Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
6. Date Exercisable and Expiration Date 7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Class A Warrant  $0.0403                  11/24/2020  11/24/2025  common stock  1062953    1062953  D   
Class B Warrant  $0.0433                  11/24/2020  11/24/2025  common stock  1062953    1062953  D   
Class C Warrant  $0.0452                  11/24/2020  11/24/2025  common stock  1062953    1062953  D   
Convertible note  $0.0376                  11/24/2020  11/24/2023  common stock  1062953    40000  D   
Options to purchase common stock (right to buy)  $0.54                  7/25/2018  7/25/2025  common stock  150000    150000  D   
Options to purchase common stock (right to buy)  $0.655                  10/26/2018  10/26/2025  common stock  100000    100000  D   
Options to purchase common stock (right to buy)  $0.08                  8/19/2020  8/19/2027  common stock  2500000    2500000  D   

Explanation of Responses:
(1)  Issued in lieu of compensation for services.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director 10% Owner Officer Other
Greenberg Richard S
4340 E KENTUCKY AVE
SUITE 206
GLENDALE, CO 80246
X X Chief Executive Officer

Signatures
Richard S. Greenberg 1/31/2022
**Signature of Reporting Person Date
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