Wyeth's (WYE) second-quarter profit rose 13% on cost cutting while strong sales of its Prevnar pneumococcal vaccine nearly offset declines for its top-selling antidepressant Effexor.

Earnings topped analysts' expectations, and the drug maker became the latest in the industry this week to boost its 2009 profit outlook. It now expects $3.48 to $3.58 a share, excluding costs related to its pending acquisition by rival Pfizer Inc. (PFE) and work-force reductions, up from a prior of $3.33 to $3.53.

The drug maker is being acquired by rival Pfizer Inc. (PFE) in a $66 billion deal expected to close by year's end. Wyeth shareholders and European regulators both have backed the merger, which still requires U.S. antitrust approval. Acquiring Wyeth will give Pfizer access to fast-growing biotechnology drugs and vaccines as its blockbuster cholesterol drug Lipitor faces the loss of U.S. patent protections in 2011. The combined entity's work force is expected to be cut 15%.

Wyeth, which also makes Advil pain reliever and Centrum vitamins, reported earnings of $1.27 billion, or 94 cents a share, from $1.12 billion, or 83 cents a share, a year earlier. Excluding merger and restructuring costs, earnings rose to 98 cents from 91 cents.

Revenue fell 4.2% to $5.7 billion, but was up 2% excluding foreign currency fluctuations.

Analysts were expecting earnings, excluding items, of 85 cents a share on revenue of $5.59 billion.

Gross margin rose to 73.2% from 72.5% while overhead costs declined 13%.

Effexor logged a 25% decline sales decline while Prevnar, a vaccine against pneumococcal disease, rose 13%, or 24% excluding currency effects. Rheumatoid-arthritis drug Enbrel, which Wyeth co-markets with Amgen Inc. (AMGN), had a 7% sales jump for U.S. and Canada and 6% rise outside those countries. Wyeth distributes the drug internationally.

Wyeth shares closed at $46.86.

Tuesday, Pfizer posted a 19% profit drop, but earnings beat Wall Street estimates despite currency impacts and lower Lipitor sales. The world's largest drug maker by sales also boosted its 2009 profit view while projecting revenue at the high end of its forecast.

-By Mike Barris, Dow Jones Newswires; 212-416-2330; mike.barris@dowjones.com;