Initial Statement of Beneficial Ownership (3)

FORM 3	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES	OMB APPROVAL OMB Number: 3235-0104 Estimated average burden hours per response... 0.5
	Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person ^*

Zohar Yishai

2. Date of Event Requiring Statement (MM/DD/YYYY) 1/13/2022

3. Issuer Name and Ticker or Trading Symbol

GELESIS HOLDINGS, INC. [GLS]

(Last) (First) (Middle)

GELESIS HOLDINGS, INC., 501 BOYLSTON STREET, SUITE 6102

4. Relationship of Reporting Person(s) to Issuer (Check all applicable)

__X__ Director _____ 10% Owner
___X___ Officer (give title below) _____ Other (specify below)
President & CEO /

(Street)

BOSTON, MA 02116

(City) (State) (Zip)

5. If Amendment, Date Original Filed(MM/DD/YYYY)

6. Individual or Joint/Group Filing(Check Applicable Line)

_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Stock	465121	D

*Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)*
1. Title of Derivate Security (Instr. 4)	2. Date Exercisable and Expiration Date (MM/DD/YYYY)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
1. Title of Derivate Security (Instr. 4)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	4. Conversion or Exercise Price of Derivative Security		6. Nature of Indirect Beneficial Ownership (Instr. 5)
Earnout Shares	⁽¹⁾⁽²⁾	1/13/2027	Common Stock	1180446	⁽¹⁾⁽²⁾	D
Stock Option (Right to Buy)	⁽³⁾	6/25/2022	Common Stock	335349	$0.57	D
Stock Option (Right to Buy)	⁽³⁾	8/29/2024	Common Stock	441070	$3.11	D
Stock Option (Right to Buy)	⁽³⁾	2/16/2025	Common Stock	4525	$4.05	D
Stock Option (Right to Buy)	⁽³⁾	9/7/2026	Common Stock	390595	$4.05	D
Stock Option (Right to Buy)	⁽³⁾	6/15/2027	Common Stock	77760	$4.05	D
Stock Option (Right to Buy)	⁽³⁾	7/17/2028	Common Stock	453605	$4.05	D
Stock Option (Right to Buy)	⁽⁴⁾	7/15/2030	Common Stock	1036884	$4.26	D
Restricted Stock Units	⁽⁵⁾	⁽⁵⁾	Common Stock	388804	⁽⁵⁾	D

Explanation of Responses:
(1)	On January 13, 2022, the reporting person received the right to acquire 1,180,446 shares of the Issuer's Common Stock (the "Earnout Shares"). The Earnout Shares shall vest and be released upon the satisfaction of certain share price vesting conditions (the "Earnout Conditions") as follows: (i) if, at any time prior to January 13, 2027 (the "Earnout Period") the volume-weighted average price ("VWAP") of the Issuer's Common Stock equals or exceeds $12.50 per share for any 20 trading days within a 30-trading day period, one third (1/3) of the Earnout Shares shall vest;
(2)	(ii) if, at any time during the Earnout Period, the VWAP of the Issuer's Common Stock equals or exceeds $15.00 per share for any 20 trading days within a 30-trading day period, one third (1/3) of the Earnout Shares shall vest; and (iii) if, at any time during the Earnout Period, the VWAP of the Issuer's Common Stock equals or exceeds $17.50 per share for any 20 trading days within a 30-trading day period, one third (1/3) of the Earnout Shares shall vest.
(3)	The shares underlying this option are fully vested and exercisable as of the date hereof.
(4)	One-third of the shares underlying this option vested and became exercisable on July 15, 2021, with the remainder vesting in eight substantially equal quarterly installments thereafter, subject to the reporting person's continued service on each such vesting date.
(5)	Each restricted stock unit ("RSU") represents the contingent right to receive one share of the Issuer's common stock. The RSUs vest in full on November 10, 2022, contingent upon the Issuer's filing of Form S-8 to register the shares underlying the RSUs.

Remarks:
Immediately after the closing of the transactions contemplated by that certain Business Combination Agreement dated as of July 19, 2021, as amended, by and among the Issuer (f/k/a Capstar Special Purpose Acquisition Corp.), CPSR Gelesis Merger Sub, Inc. and Gelesis, Inc., the reporting person became an officer and director of the Issuer. Exhibit 24 - Power of Attorney

Reporting Owners
Reporting Owner Name / Address	Relationships
Reporting Owner Name / Address	Director	10% Owner	Officer	Other
Zohar Yishai GELESIS HOLDINGS, INC. 501 BOYLSTON STREET, SUITE 6102 BOSTON, MA 02116	X		President & CEO