By Jessica Hodgson

LONDON--Royalty Pharma AG, the New York-based pharmaceutical investor bidding around $6.4 billion in cash for drugmaker Elan Corp. (ELN) Thursday said it was lowering the threshold for shareholder acceptance for its offer to 50% plus one share, from an earlier 90%.

Royalty's move is the latest twist in a months-long struggle over Dublin-based Elan after Royalty Pharma, which invests in royalty streams from drugs, made its initial approach in February.

Lowering the acceptance threshold for investors during bid situations is a tactic which tends to encourage more shorter-term shareholders such as hedge funds who are trading the stock based on takeover activity, often buying from the longer-term strategic holders who have the heft to block the approach.

"The Elan directors have failed to maintain an appropriate balance between supporting management's acquisition plan and their fiduciary responsibilities to Elan shareholders in respect of Royalty Pharma's offer," Pablo Legorreta, Chief Executive Officer of Royalty Pharma, said in a statement.

"We believe that the increased offer provides Elan Shareholders an attractive financial alternative that will allow them to realize value for their Elan stock in cash immediately."

Elan declined to comment Thursday, but had earlier "strongly advised" recommended its investors take no action in relation to the $12.50 per share offer.

Elan, which has its primary listing in the U.S., earlier this year sold its only revenue-producing drug. It's in the process of reshaping itself, buying and selling companies as it shifts away from a historical focus on neurological disorders and into areas such as orphan drugs and heart and respiratory medicine.

Royalty Pharma on Monday raised its multibillion-dollar takeover bid for Elan to $12.50 a share in cash, the same day Elan announced a string of transactions designed to rebuild its business and secure its independence.

Monday's revised offer values Elan at $6.4 billion, less than the $7.3 billion that the company would have been valued at under Royalty's earlier bid of $12 per share. The lower valuation, despite the raised per-share offer, reflects a reduced number of shares in issue as a result of a $1 billion share buyback which was taking place at the same time as Royalty's bid approach.

Days before Monday's raised approach, Elan announced a $1 billion deal with Theravance Inc. (THRX), giving it a share of the royalty stream from four respiratory drug programs. Last week it said, subject to shareholder approval, it would buy AOP Orphan, a closely-held Austrian company focused on rare diseases in a deal valued at EUR263.5 million and Newbridge Pharmaceuticals, a Dubai-based startup for $40 million and would spin off a drug in development for Alzheimer's disease into a new company with an undisclosed investor. It also outlined plns to buy back an additional $200 million in shares and issue $800 million of debt.

Elan has faced uncertainty over its future since it sold its half of blockbuster multiple sclerosis drug Tysabri in February to development partner Biogen Idec Inc. (BIIB) for $3.25 billion. Tysabri was Elan's only revenue-producing drug.

The company has retained a royalty stream from sales of Tysabri, but the deal raised questions about its strategic direction and future, prompting the approaches from Royalty, which Elan shareholders so far have rebuffed.

Royalty said Monday Elan "dramatically overpaid" in the Theravance deal.

Royalty, founded in 1996, owns royalty interests in products such as Gilead Sciences Inc.'s (GILD) HIV drugs Emtriva, Truvada and Atripla and Abbott Laboratories' (ABT) arthritis drug Humira.

Write to Jessica Hodgson at jessica.hodgson@dowjones.com

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