TEKLA LIFE SCIENCES INVESTORS

 

Schedule of Investments

 

June 30, 2023 (Unaudited)

 

Convertible Preferreds (Restricted) (a)(b) - 7.4%  Shares   Value 
Biotechnology – 4.4%          
Arbor Biotechnologies, Series B, 8.00%   38,624   $640,000 
Arkuda Therapeutics, Inc. Series A, 6.00%   1,008,829    1,783,811 
Arkuda Therapeutics, Inc. Series B, 6.00%   447,566    791,386 
Flamingo Therapeutics, Inc. Series A3 (c)   107,120    714,194 
Hotspot Therapeutics, Inc. Series B, 6.00%   1,291,668    4,186,167 
Hotspot Therapeutics, Inc. Series C, 6.00%   284,119    920,801 
ImmuneID, Inc. Series A, 8.00%   480,000    309,024 
Invetx, Inc. Series A, 8.00%   3,229,167    2,163,865 
Invetx, Inc. Series B, 8.00%   1,387,853    930,000 
Parthenon Therapeutics, Inc. Series A   832,650    1,599,995 
Priothera Ltd. Series A, 6.00% (c)   152,534    1,664,452 
Quell Therapeutics, Series B (c)   731,121    1,520,001 
ReCode Therapeutics, Series B, 5.00%   138,630    1,279,998 
         18,503,694 
Health Care Equipment & Supplies – 0.3%          
IO Light Holdings, Inc. Series A2   421,634    1,200,814 
           
Pharmaceuticals – 2.7%          
Amolyt Pharma SAS Series C (c)   480,841    1,122,845 
Aristea Therapeutics, Inc. Series B, 8.00%   290,187    1,600,004 
Biotheryx, Inc. Series E, 8.00%   609,524    1,600,000 
Curasen Therapeutics, Inc. Series A   7,801,332    3,740,739 
Endeavor Biomedicines, Inc. Series B, 8.00%   296,855    1,399,998 
HiberCell, Inc. Series B   1,305,163    1,599,999 
         11,063,585 
Total Convertible Preferreds (Cost $33,917,539)        30,768,093 

 

Common Stocks - 83.5%  Shares   Value 
Biotechnology – 67.3%          
89bio, Inc. (b)   105,898    2,006,767 
Adicet Bio, Inc. (b)   40,329    97,999 
Affimed N.V. (b)(c)   208,624    124,799 
Akero Therapeutics, Inc. (b)   21,447    1,001,360 
Alkermes plc (b)   135,706    4,247,598 
Alnylam Pharmaceuticals, Inc. (b)   50,776    9,644,393 
Altimmune, Inc. (b)   75,000    264,750 
ALX Oncology Holdings, Inc. (b)   66,211    497,245 
Amgen, Inc.   125,819    27,934,334 
Apellis Pharmaceuticals, Inc. (b)   52,609    4,792,680 
ARCA biopharma, Inc. (b)   32,461    65,896 
Arcus Biosciences, Inc. (b)   32,839    666,960 
Arcutis Biotherapeutics, Inc. (b)(d)   62,005    590,908 
Ardelyx, Inc. (b)   257,406    872,606 
argenx SE ADR (b)   17,273    6,731,806 
Ascendis Pharma A/S ADR (b)   45,830    4,090,328 
Beam Therapeutics, Inc. (b)   15,817    505,037 

 

The accompanying notes are an integral part of this Schedule of Investments.

 

 

 

 

   SHARES   VALUE 
Biotechnology – continued          
BeiGene Ltd. ADR (b)   16,838   $3,002,215 
Bellicum Pharmaceuticals, Inc. (b)   6,000    2,220 
Bicycle Therapeutics plc ADR (b)   44,338    1,131,506 
BioCryst Pharmaceuticals, Inc. (b)   202,491    1,425,537 
Biogen, Inc. (b)   66,498    18,941,955 
BioMarin Pharmaceutical, Inc. (b)   73,705    6,388,749 
BioNTech SE ADR   37,462    4,043,274 
Black Diamond Therapeutics, Inc. (b)(d)   41,586    210,009 
Bridgebio Pharma, Inc. (b)   26,580    457,176 
Caribou Biosciences, Inc. (b)   181,487    771,320 
Cerevel Therapeutics Holdings, Inc. (b)   74,161    2,357,578 
Chinook Therapeutics, Inc. (b)   59,063    2,269,200 
Corbus Pharmaceuticals Holdings, Inc. (b)   5,143    40,321 
Crinetics Pharmaceuticals, Inc. (b)   78,529    1,415,093 
CRISPR Therapeutics AG (b)(c)   22,571    1,267,136 
Cytokinetics, Inc. (b)   86,944    2,836,113 
Denali Therapeutics, Inc. (b)   110,331    3,255,868 
Exelixis, Inc. (b)   192,199    3,672,923 
Fusion Pharmaceuticals, Inc. (b)(c)   6,511    30,471 
Fusion Pharmaceuticals, Inc. (Restricted) (a)(b)(c)   3,256    13,714 
G1 Therapeutics, Inc. (b)   223,377    556,209 
Galera Therapeutics, Inc. (b)   125,773    392,412 
Gilead Sciences, Inc.   441,671    34,039,584 
Harpoon Therapeutics, Inc. (b)   259,910    184,536 
HilleVax, Inc. (b)   27,000    464,130 
I-Mab ADR (b)   26,109    78,066 
Immunovant, Inc. (b)   150,400    2,853,088 
Intellia Therapeutics, Inc. (b)   50,605    2,063,672 
Intercept Pharmaceuticals, Inc. (b)   18,630    206,048 
Ionis Pharmaceuticals, Inc. (b)   31,341    1,285,921 
iTeos Therapeutics, Inc. (b)   45,735    605,531 
Karuna Therapeutics, Inc. (b)   19,434    4,214,263 
Madrigal Pharmaceuticals, Inc. (b)   12,110    2,797,410 
Mereo Biopharma Group plc ADR (b)(c)   487,283    643,214 
Moderna, Inc. (b)   107,787    13,096,120 
Natera, Inc. (b)   24,636    1,198,788 
Neurocrine Biosciences, Inc. (b)   38,692    3,648,656 
NexGel, Inc. (b)   1,273    3,195 
Nkarta, Inc. (b)   28,988    63,484 
Novavax, Inc. (b)(d)   26,612    197,727 
Praxis Precision Medicines, Inc. (b)   23,594    27,133 
Precision BioSciences, Inc. (b)   69,727    36,676 
Pyxis Oncology, Inc. (b)(d)   226,657    580,242 
Rallybio Corp. (b)   377,375    2,135,943 
Regeneron Pharmaceuticals, Inc. (b)   44,256    31,799,706 
Repare Therapeutics, Inc. (b)(c)   29,150    308,407 
Sarepta Therapeutics, Inc. (b)   58,187    6,663,575 
Scholar Rock Holding Corp. (b)   40,716    306,999 

 

The accompanying notes are an integral part of this Schedule of Investments.

 

 

 

 

   SHARES   VALUE 
Biotechnology – continued          
Seagen, Inc. (b)   39,220   $7,548,281 
Sutro Biopharma, Inc. (b)   28,965    134,687 
TScan Therapeutics, Inc. (b)   61,943    154,858 
uniQure N.V. (b)(c)   112,194    1,285,743 
United Therapeutics Corp. (b)   14,745    3,254,959 
Vaxcyte, Inc. (b)(c)   61,919    3,092,235 
Vertex Pharmaceuticals, Inc. (b)   95,726    33,686,937 
Xencor, Inc. (b)   16,800    419,496 
Xenon Pharmaceuticals, Inc. (b)(c)   67,506    2,598,981 
Zentalis Pharmaceuticals, Inc. (b)   40,156    1,132,801 
         281,427,557 
Health Care Equipment & Supplies  – 1.1%(b)          
Cercacor Laboratories, Inc. (Restricted) (a)   130,000    186,947 
Guardant Health, Inc.   44,542    1,594,604 
IDEXX Laboratories, Inc.   2,989    1,501,165 
Tactile Systems Technology, Inc.   58,472    1,457,707 
         4,740,423 
Health Care Providers & Services – 1.2%          
Charles River Laboratories International, Inc. (b)   14,134    2,971,674 
InnovaCare, Inc. Escrow Shares (Restricted) (a)   148,148    18,711 
Medpace Holdings, Inc. (b)   8,195    1,968,193 
         4,958,578 
Life Sciences Tools & Services – 4.4% (b)          
Adaptive Biotechnologies Corp.   206,072    1,382,743 
Codexis, Inc.   69,125    193,550 
Illumina, Inc.   88,297    16,554,805 
         18,131,098 
Pharmaceuticals – 9.5%          
Amylyx Pharmaceuticals, Inc. (b)   31,467    678,743 
AstraZeneca plc ADR (c)   238,720    17,085,190 
Edgewise Therapeutics, Inc. (b)   150,418    1,165,740 
Eli Lilly & Co.   9,361    4,390,122 
Endo International plc (b)   29,100    509 
Fulcrum Therapeutics, Inc. (b)   256,888    847,730 
Horizon Therapeutics plc (b)   21,912    2,253,649 
Intra-Cellular Therapies, Inc. (b)   52,352    3,314,929 
IQVIA Holdings, Inc. (b)   1,647    370,196 
Jazz Pharmaceuticals plc (b)   27,751    3,440,291 
Marinus Pharmaceuticals, Inc. (b)   125,041    1,357,945 
Mirati Therapeutics, Inc. (b)   22,852    825,643 
Oculis Holding AG (Restricted) (a)(c)   236,704    2,635,226 
Reata Pharmaceuticals, Inc. Class A (b)   11,300    1,152,148 
Spectrum Pharmaceuticals, Inc. (b)   34,880    33,485 
Tetraphase Pharmaceuticals, Inc. CVR (a)(b)   14,218    853 
Theseus Pharmaceuticals, Inc. (b)(d)   23,250    216,923 

 

The accompanying notes are an integral part of this Schedule of Investments.

 

 

 

 

   Shares   Value 
Pharmaceuticals – continued          
VYNE Therapeutics, Inc. (b)(d)   2,255   $9,155 
         39,778,477 
Total Common Stocks (Cost $313,540,382)        349,036,133 
Exchange Traded Fund(b)(d) - 1.8%          
SPDR S&P Biotech ETF   90,677    7,544,326 
Total Exchange Traded Fund (Cost $6,888,393)        7,544,326 

 

Short-Term Investments – 6.5%  PRINCIPAL
AMOUNT
     
MUFG Bank Ltd. Commercial Paper, 5.00%, due 07/06/23  $8,000,000    7,994,445 
Repurchase Agreement, Fixed Income Clearing Corp., repurchase value $10,461,325, 1.52%, dated 06/30/23, due 07/03/23 (collateralized by U.S. Treasury Note 1.500%, due 01/31/27, market value $10,669,262)  10,460,000    10,460,000 

 

   SHARES     
State Street Institutional U.S. Government Money Market Fund, Institutional Class, 5.03% (e)   8,965,139    8,965,139 
TOTAL SHORT-TERM INVESTMENTS (Cost $27,419,584)        27,419,584 
TOTAL INVESTMENTS BEFORE MILESTONE INTERESTS - 99.2% (Cost $381,765,898)        414,768,136 

 

MILESTONE INTERESTS (Restricted)(a)(b) - 2.4%        
   INTERESTS     
Biotechnology – 0.0%          
Amphivena Milestone Interest   1    0 
Rainier Therapeutics Milestone Interest   1    0 
Therachon Milestone Interest   1    0 
           
Pharmaceuticals – 2.4%          
Afferent Milestone Interest   1    113,219 
Ethismos Research Milestone Interest   1    0 
Impact Biomedicines Milestone Interest   1    1,209,320 
Neurovance Milestone Interest   1    8,629,194 
         9,951,733 
Total Milestone Interests (Cost $4,723,320)        9,951,733 
Total Investments - 101.6% (Cost $386,489,218)        424,719,869 
Other Liabilities In Excess Of Assets - (1.6)%        (6,743,945)
Net Assets - 100%       $417,975,924 

 

The percentage shown for each investment category in the Schedule of Investments is based on net assets.

 

(a) Security fair valued using significant unobservable inputs. See Investment Valuation and Fair Value Measurements.
(b) Non-income producing security.
(c) Foreign security.
(d) All or a portion of this security is on loan as of June 30, 2023.
(e) This security represents the investment of cash collateral received for securities lending and is a registered investment company advised by State Street Global Advisors. The rate shown is the annualized seven-day yield as of  June 30, 2023.

 

ADR American Depository Receipt
CVR Contingent Value Right

 

The accompanying notes are an integral part of this Schedule of Investments.

 

 

 

 

Investment Valuation

 

Shares of publicly traded companies listed on national securities exchanges or trading in the over-the-counter market are typically valued at the last sale price, as of the close of trading, generally 4 p.m., Eastern Time. The Board of Trustees of the Fund (the Trustees) has established and approved fair valuation policies and procedures with respect to securities for which quoted prices may not be available or which do not reflect fair value. Convertible, corporate and government bonds are valued using a third-party pricing service. Convertible bonds are valued using this pricing service only on days when there is no sale reported. Restricted securities of companies that are publicly traded are typically valued based on the closing market quote on the valuation date adjusted for the impact of the restriction as determined in good faith by Tekla Capital Management LLC (the Adviser) also using fair valuation policies and procedures approved by the Trustees described below. Non-exchange traded warrants of publicly traded companies are generally valued using the Black-Scholes model, which incorporates both observable and unobservable inputs. Short-term investments with a maturity of 60 days or less are generally valued at amortized cost, which approximates fair value.

 

Convertible preferred shares, warrants or convertible note interests in private companies, milestone interests, and other restricted securities, as well as shares of publicly traded companies for which market quotations are not readily available, such as stocks for which trading has been halted or for which there are no current day sales, or which do not reflect fair value, are typically valued in good faith, based upon the recommendations made by the Adviser pursuant to fair valuation policies and procedures approved by the Trustees.

 

The Adviser has a Valuation Sub-Committee comprised of senior management which reports to the Valuation Committee of the Board at least quarterly. Each fair value determination is based on a consideration of relevant factors, including both observable and unobservable inputs. Observable and unobservable inputs may include (i) the existence of any contractual restrictions on the disposition of securities; (ii) information obtained from the company, which may include an analysis of the company’s financial statements, products, intended markets or technologies; (iii) the price of the same or similar security negotiated at arm’s length in an issuer’s completed subsequent round of financing; (iv) the price and extent of public trading in similar securities of the issuer or of comparable companies; or (v) a probability and time value adjusted analysis of contractual terms. Where available and appropriate, multiple valuation methodologies are applied to confirm fair value. Significant unobservable inputs identified by the Adviser are often used in the fair value determination. A significant change in any of these inputs may result in a significant change in the fair value measurement. Due to the uncertainty inherent in the valuation process, such estimates of fair value may differ significantly from the values that would have been used had a ready market for the investments existed, and differences could be material. Additionally, changes in the market environment and other events that may occur over the life of the investments may cause the gains or losses ultimately realized on these investments to be different from the valuations used at the date of this schedule of investments.

 

Federal Income Tax Cost

 

At June 30, 2023, the cost of securities for Federal income tax purposes was $386,489,218. The net unrealized gain on securities held by the Fund was $38,230,651, including gross unrealized gain of $117,726,507 and gross unrealized loss of $79,495,856.

 

Securities Lending

 

The Fund may lend its securities to approved borrowers to earn additional income. The Fund receives cash collateral from the borrower and the initial collateral received by the Fund is required to have a value of at least 102% of the current value of the loaned securities traded on U.S. exchanges, and a value of at least 105% for all other securities. The Fund will invest its cash collateral in State Street Institutional U.S. Government Money Market Fund (SAHXX), which is registered with the Securities and Exchange Commission (SEC) as an investment company. SAHXX invests substantially all of its assets in the State Street U.S. Government Money Market Portfolio. The Fund will receive the benefit of any gains and bear any losses generated by SAHXX with respect to the cash collateral.

 

 

 

 

The Fund has the right to recall loaned securities on demand. If a borrower fails to return loaned securities when due, then the lending agent is responsible and indemnifies the Fund for the lent securities. The lending agent uses the collateral received from the borrower to purchase replacement securities of the same issue, type, class and series of the loaned securities. If the value of the collateral is less than the purchase cost of replacement securities, the lending agent is responsible for satisfying the shortfall but only to the extent that the shortfall is not due to any decrease in the value of SAHXX.

 

Although the risk of loss on securities lent is mitigated by receiving collateral from the borrower and through lending agent indemnification, the Fund could experience a delay in recovering securities or could experience a lower than expected return if the borrower fails to return the securities on a timely basis. The Fund receives compensation for lending its securities by retaining a portion of the return on the investment of the collateral and compensation from fees earned from borrowers of the securities. Securities lending income received by the Fund is net of fees retained by the securities lending agent. Net income received from SAHXX is a component of securities lending income as recorded by the Fund.

 

As of June 30, 2023, the Fund loaned securities valued at $8,872,702 and received $8,965,139 of cash collateral.

 

Fair Value Measurements

 

The Fund uses a three-tier hierarchy to prioritize the assumptions, referred to as inputs, used in valuation techniques to measure fair value. The three-tier hierarchy of inputs is summarized in the three broad levels. Level 1 includes quoted prices in active markets for identical investments. Level 2 includes prices determined using other significant observable inputs (including quoted prices for similar investments, interest rates, credit risk, etc.). The independent pricing vendor may value bank loans and debt securities at an evaluated bid price by employing methodologies that utilize actual market transactions, broker-supplied valuations, and/or other methodologies designed to identify the market value for such securities and such securities are considered Level 2 in the fair value hierarchy. Level 3 includes prices determined using significant unobservable inputs (including the Fund’s own assumptions in determining the fair value of investments). These inputs or methodology used for valuing securities are not necessarily an indication of the risk associated with investing in those securities.

 

For the period ended June 30, 2023, there were no transfers between levels.

 

The following is a summary of the levels used as of June 30, 2023 to value the Fund's investments.

 

Assets at Value  Level 1   Level 2   Level 3   Total 
Convertible Preferreds                    
Biotechnology  $-   $-   $18,503,694   $18,503,694 
Health Care Equipment & Supplies   -    -    1,200,814    1,200,814 
Pharmaceuticals   -    -    11,063,585    11,063,585 
Common Stocks                    
Biotechnology   281,413,843    13,714    -    281,427,557 
Health Care Equipment & Supplies   4,553,476    -    186,947    4,740,423 
Health Care Providers & Services   4,939,867    -    18,711    4,958,578 
Life Sciences Tools & Services   18,131,098    -    -    18,131,098 
Pharmaceuticals   37,142,398    2,636,079    -    39,778,477 
Exchange Traded Fund   7,544,326    -    -    7,544,326 
Short-term Investments     8,965,139    18,454,445    -    27,419,584 
Milestone Interests                    
Biotechnology   -    -    0*   0*
Pharmaceuticals   -    -    9,951,733    9,951,733 
Other Assets   -    -    189    189 
Total   362,690,147    21,104,238    40,925,673    424,720,058 

 

* Represents security valued at zero.

 

 

 

 

The following is a reconciliation of Level 3 assets for which significant unobservable inputs were used to determine fair value.

 

Investment in securities  Balance as of
September
30, 2022
   Net realized
gain (loss) and
change in
unrealized
appreciation
(depreciation)
   Cost of
purchases
and
conversions
   Proceeds
from
sales and
conversions
   Net
transfers
into
(out of)
Level 3
   Balance as
of June 30,
2023
 
Convertible Preferred                              
Biotechnology  $19,442,876   $(649,173)  $1,041,096   $(1,331,105)  $-   $18,503,694 
Health Care Equipment & Supplies   1,423,015    (222,954)   753    -    -    1,200,814 
Pharmaceuticals   11,406,061    (1,604,872)   1,262,396    -    -    11,063,585 
Convertible Notes                              
Biotechnology   0*   -    -    -    -    - 
Common Stocks                              
Health Care Equipment & Supplies   502,845    (315,898)   -    -    -    186,947 
Health Care Providers & Services   37,689    13,485    -    (32,463)   -    18,711 
Milestone Interests                              
Biotechnology   657,235    (657,235)   -    -    -    0*
Health Care Equipment & Supplies   727    (641)   -    (86)   -    - 
Pharmaceuticals   5,028,292    4,923,441    -    -    -    9,951,733 
Other Assets   189    -    -    -    -    189 
Total  $38,498,929   $1,486,153   $2,304,245   $(1,363,654)  $-   $40,925,673 
                               
Net change in unrealized appreciation (depreciation) from investments still held as of June 30, 2023     $1,748,298 

 

* Represents security valued at zero.

 

The following is a quantitative disclosure about significant unobservable inputs used in the determination of the fair value of Level 3 assets.

 

    Fair Value at
June 30, 2023
  Valuation
Technique
  Unobservable
Input
  Range
(Weighted Average)
Common Stocks   $ 186,947   Market approach   Discount for lack of marketability
Revenue allocation
  50.00% (50.00%)
    18,711   Probability adjusted
value
  Probability of events
Timing of events
  50.00%-100.00% (50.00%)
0.75-2.50 (0.75) years
Convertible Preferreds   30,768,093   Transaction Price   (a)   N/A
Milestone Interests   9,951,733   Probability adjusted
value
  Probability of events
Timing of events
  0.00%-100.00% (43.90%)
0.00-14.75 (1.98) years
Other Assets   189   Probability adjusted
value
  Probability of events
Timing of events
  95.00%(95.00%)
5.5 (5.5) years
    $ 40,925,673              

 

(a)The valuation technique used as a basis to approximate fair value of these investments is based transaction price or subsequent financing rounds.

 

 

 

 

Private Companies and Other Restricted Securities

 

The Fund may invest in private companies and other restricted securities if these securities would currently comprise 40% or less of net assets. The value of these securities represented 10% of the Fund’s net assets at June 30, 2023.

 

At June 30, 2023, the Fund had a commitment of $954,696 relating to additional investments in three private companies.

 

The following table details the acquisition date, cost, carrying value per unit, and value of the Fund’s private companies and other restricted securities at June 30, 2023. The Fund on its own does not have the right to demand that such securities be registered.

 

Security (#)  Acquisition
Date
  Cost   Carrying Value
per Unit
   Value 
Afferent Milestone Interest  07/27/16  $161,871   $113,219.00   $113,219 
Amolyt Pharma SAS Series C Cvt. Pfd  01/25/23   1,125,854    2.34    1,122,845 
Amphivena Milestone Interest  10/18/22   0    0.00    0 
Arbor Biotechnologies, Series B Cvt. Pfd  10/29/21   643,318    16.57    640,000 
Aristea Therapeutics, Inc. Series B Cvt. Pfd  07/27/21   1,600,004    5.51    1,600,004 
Arkuda Therapeutics, Inc.                  
Series A Cvt. Pfd  05/16/19, 04/02/20, 07/15/21   2,403,867    1.77    1,783,811 
Series B Cvt. Pfd  01/24/22, 01/23/23   792,030    1.77    791,386 
Biotheryx, Inc. Series E Cvt. Pfd  05/19/21   3,206,621    2.62    1,600,000 
Cercacor Laboratories, Inc. Common  03/31/98  0    1.44    186,947 
Curasen Therapeutics, Inc. Series A Cvt. Pfd  09/18/18, 01/07/20, 10/21/21, 11/01/22   3,742,602    0.48    3,740,739 
Endeavor Biomedicines, Inc. Series B Cvt. Pfd  01/21/22   1,401,736    4.72    1,399,998 
Ethismos Research Milestone Interest  10/31/17   0    0.00    0 
Flamingo Therapeutics, Inc. Series A3 Cvt. Pfd  04/21/20,10/28/20  2,469,343    6.67    714,194 
Fusion Pharmaceuticals, Inc. Common  09/20/22   0    4.21    13,714 
HiberCell, Inc. Series B Cvt. Pfd  05/05/21   1,603,268    1.23    1,599,999 
Hotspot Therapeutics, Inc.                  
Series B Cvt. Pfd  04/22/20, 06/17/21   3,107,213    3.24    4,186,167 
Series C Cvt. Pfd  11/15/21   922,387    3.24    920,801 
ImmuneID, Inc. Series A Cvt. Pfd  04/28/21   962,127    0.64    309,024 
Impact Biomedicines Milestone Interest  7/20/10   0    1,209,320.00    1,209,320 
InnovaCare, Inc. Escrow Shares Common  12/21/12  16,696    0.13    18,711 
Invetx, Inc.                  
Series A Cvt. Pfd  08/06/20   1,551,319    0.67    2,163,865 
Series B Cvt. Pfd  03/28/22   930,567    0.67    930,000 
IO Light Holdings, Inc. Series A2 Cvt. Pfd  04/30/20, 05/17/21, 09/15/21  1,395,511    2.85    1,200,814 
Neurovance Milestone Interest  03/20/17   3,417,500    8,629,194.00    8,629,194 
Oculis Holding AG Common  03/06/23   1,990,345    11.13    2,635,226 
Parthenon Therapeutics, Inc. Series A Cvt. Pfd  08/12/21, 05/24/23   1,603,295    1.92    1,599,995 
Priothera Ltd. Series A Cvt. Pfd  10/07/20, 10/19/21   1,779,800    10.91    1,664,452 
Quell Therapeutics, Series B Cvt. Pfd  11/29/21, 03/23/22   1,391,039    2.08    1,520,001 
Rainier Therapeutics Milestone Interest  09/28/21   126,278    0.00    0 
ReCode Therapeutics, Series B Cvt. Pfd  10/12/21, 02/16/22   1,285,639    9.23    1,279,998 
Therachon Milestone Interest  07/01/19   1,017,671    0.00    0 
      $40,647,901        $43,574,424 

 

(#) See Schedule of Investments and corresponding footnotes for more information on each issuer.
Interest received as part of a corporate action for a previously owned security.

 

 


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