FORM 4
[X] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      
1. Name and Address of Reporting Person * Baker Christine D. 2. Issuer Name and Ticker or Trading Symbol TYME TECHNOLOGIES, INC. [ TYME ] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable)__X__ Director                    _____ 10% Owner
_____ Officer (give title below)    _____ Other (specify below)
(Last)          (First)          (Middle)
C/O TYME TECHNOLOGIES, INC., 1 PLUCKEMIN WAY - SUITE 103
3. Date of Earliest Transaction (MM/DD/YYYY)
9/16/2022
(Street)
BEDMINISTER, NJ 07921
(City)        (State)        (Zip)
4. If Amendment, Date Original Filed (MM/DD/YYYY)
 
6. Individual or Joint/Group Filing (Check Applicable Line) _X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Trans. Date 3A. Deemed Execution Date, if any 4. Trans. Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
6. Date Exercisable and Expiration Date 7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Director Stock Option - Option to buy  $0.35  9/16/2022    D        14666    (1) 3/22/2032  Common Stock  14666   (1) 0  D   
Director Stock Option - Option to buy  $0.35  9/16/2022    D        36888    (2) 3/22/2032  Common Stock  36888   (2) 0  D   
Director Stock Option - Option to buy  $0.31  9/16/2022    D        88000    (3) 8/23/2032  Common Stock  36888   (3) 0  D   

Explanation of Responses:
(1)  This award consisted of options to purchase 176,000 shares of Tyme common stock, 14,666 of which had vested as of the date of the merger between the issuer and Syros Pharmaceuticals, Inc ("Syros"). The vested portion was assumed by Syros in the merger and replaced with an option to purchase 642 shares of Syros common stock for $7.99 per share, after giving effect to a 1-for-10 reverse stock split by Syros (the "Reverse Split"). The remaining unvested portion of the option award was cancelled upon the reporting person's resignation from the board in connection with the merger, pursuant to the terms of the award.
(2)  This option was fully vested and assumed by Syros in the merger and replaced with an option to purchase 1,616 shares of Syros common stock for $7.99 per share, after giving effect to the Reverse Split.
(3)  This option was fully vested and assumed by Syros in the merger and replaced with an option to purchase 3,856 shares of Syros common stock for $7.07 per share, after giving effect to the Reverse Split.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director 10% Owner Officer Other
Baker Christine D.
C/O TYME TECHNOLOGIES, INC.
1 PLUCKEMIN WAY - SUITE 103
BEDMINISTER, NJ 07921
X



Signatures
By: /s/ Richard Cunningham as attorney-in-fact for Christine D. Baker 9/16/2022
**Signature of Reporting Person Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.
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