- Initial Statement of Beneficial Ownership (3)

FORM 3	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES	OMB APPROVAL OMB Number: 3235-0104 Expires: February 28, 2011 Estimated average burden hours per response... 0.5
	Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person ^*

Skyline Venture Partners V LP

2. Date of Event Requiring Statement (MM/DD/YYYY) 10/28/2008

3. Issuer Name and Ticker or Trading Symbol

MAKO Surgical Corp. [MAKO]

(Last) (First) (Middle)

525 UNIVERSITY AVE.

4. Relationship of Reporting Person(s) to Issuer (Check all applicable)

_____ Director ___ X ___ 10% Owner
_____ Officer (give title below) _____ Other (specify below)

(Street)

PALO ALTO, CA 94301

(City) (State) (Zip)

5. If Amendment, Date Original Filed (MM/DD/YYYY)

6. Individual or Joint/Group Filing (Check Applicable Line)

___ Form filed by One Reporting Person
_ X _ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Stock	2437249	I	By Skyline Venture Partners V, L.P. ⁽¹⁾

*Table II - Derivative Securities Beneficially Owned ( e.g.* , puts, calls, warrants, options, convertible securities)**
1. Title of Derivate Security (Instr. 4)	2. Date Exercisable and Expiration Date (MM/DD/YYYY)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
1. Title of Derivate Security (Instr. 4)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	4. Conversion or Exercise Price of Derivative Security		6. Nature of Indirect Beneficial Ownership (Instr. 5)
Warrant to Purchase Common Stock	10/28/2008	10/28/2015	Common Stock	487450	$7.44	I	By Skyline Venture Partners V, L.P. ⁽²⁾

Explanation of Responses:
( 1)	The shares are owned by Skyline Venture Partners V, L.P. ("SVP V"). Skyline Venture Management V, LLC ("SVM V") serves as the sole General Partner of SVP V, has sole voting and investment control over the respective shares owned by SVP V, and may be deemed to own beneficially the shares held by SVP V. SVM V however owns no securities of the Issuer directly. John G. Freund ("Freund") is the sole Managing Director of SVM V and has voting and dispositive power over the shares held by SVP V. Freund disclaims beneficial ownership of the shares reported herein, except to the extent of his respective pecuniary interest therein.
( 2)	The warrant is held by SVP V.

Reporting Owners
Reporting Owner Name / Address	Relationships
Reporting Owner Name / Address	Director	10% Owner	Officer	Other
Skyline Venture Partners V LP 525 UNIVERSITY AVE. PALO ALTO, CA 94301		X
Skyline Venture Management V, LLC 525 UNIVERSITY AVE. PALO ALTO, CA 94301		X
Freund John Gordon 525 UNIVERSITY AVE. PALO ALTO, CA 94301		X

Signatures
SKYLINE VENTURE PARTNERS V, L.P. By: SKYLINE VENTURE MANAGEMENT V, LLC Its: General Partner By: John G. Freund, Managing Director		2/27/2009
^** Signature of Reporting Person		Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
*	If the form is filed by more than one reporting person, see Instruction 5(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note:	File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.