MicroIslet Expands Expertise in Product Development
November 30 2006 - 8:00AM
PR Newswire (US)
* Two Key Hires Are Added to Support Initiation of Human Trials SAN
DIEGO, Nov. 30 /PRNewswire-FirstCall/ -- MicroIslet, Inc.
(AMEX:MII), a biotechnology company engaged in the research,
development and commercialization of patented technologies in
transplantation therapy for people with insulin-dependent diabetes,
today announced the appointment of two scientific officers to
support the Company's goal of moving its islet transplantation
therapies into human trials and, ultimately, commercialization.
MicroIslet has appointed Mohammad A. El-Kalay, Ph.D. as Vice
President of Research and Development, replacing Ronnda L. Bartel,
Ph.D., and has added William Soo Hoo, Ph.D. to its scientific
roster as Director of Cell Biology. Dr. El-Kalay has over twenty
years of biotechnology management experience building and leading
Research and Product/Process Development teams. He has participated
in the development of cell-based therapies for tissue regeneration
applications including bone, cartilage and cardiac repair. Dr. Soo
Hoo brings to MicroIslet fifteen years of scientific research
experience in mid-size, large and start-up companies in oncology,
immunotherapy, cell and molecular immunology, highlighted by his
strengths in team management and taking research work into
development stages. Both Dr. El-Kalay and Dr. Soo Hoo join the
Company from Telos Pharmaceuticals, LLC, a San Diego-based company
that developed monoclonal antibodies that modulate T-cell activity.
Dr. El-Kalay was Director of Product Development at Applied Immune
Sciences where he led the team that designed and manufactured
various cell selection (T-cell and hematopoietic stem cell)
devices. Dr. El-Kalay was Director of Device Engineering, at
SyStemix, Inc., where he lead a multi-disciplinary team of
scientists and engineers and developed a novel immunoselection
device to isolate and purify rare populations of hematopoietic stem
cells. He also served at Osiris Therapeutics, Inc. where he and his
team applied the regenerative properties of bone marrow-derived
mesenchymal stem cells (MSCs) in clinical trials that evaluated
these cells in alveolar ridge augmentation. He was Vice President
of Process and Product Development, at Morphogen Pharmaceuticals
Inc., where he and his team demonstrated that allogeneic
muscle-derived pluripotent stem cells significantly improved
cardiac function in myocardial infarcted rat models. Most recently,
Dr. El-Kalay was Senior Vice President of Research and Development
at ValeocyTe Therapies developing activated T-cell products to
treat renal cell carcinoma. He served as Senior Vice President of
Development at Telos Pharmaceuticals until joining MicroIslet, and
led a program to generate various monoclonal antibodies. Dr.
El-Kalay holds a B.Sc. in Chemical Engineering with honors, and a
Masters Degree and Ph.D. in Biomedical Engineering from Strathclyde
University in Glasgow, Scotland. Dr. El-Kalay has served on the
scientific advisory boards of several stem cell companies, is
currently a Scientific Associate in the Molecular Biology
Department at The Scripps Research Institute, and serves as a
Member of the Institutional Animal Care and Use Committee of a San
Diego-based biotechnology company. He holds multiple patents on
methods for the processing of whole blood and cell separation for
therapeutic uses. Dr. Soo Hoo was most recently Director of
Research at Telos Pharmaceuticals until joining MicroIslet. He
managed team research activities, developmental programs, and
outside collaborative efforts in the areas of infectious disease
vaccine adjuvants for influenza and hepatitis B. Earlier he was a
Staff Scientist with Genoptix, Inc., where he conceived and built
and led a team to develop that company's first cellular diagnostic
applications in the areas of immunology, infectious diseases, and
cancer. In addition, he was Research Manager with Tragen
Pharmaceuticals, LLC (formerly Immunogenex), where he worked with a
team using recombinant adenoviral vectors for the immunotherapy of
chronic lymphocytic leukemia. Dr. Soo Hoo held progressively more
responsible positions with The Immune Response Corporation,
beginning as Postdoctoral Fellow in the Department of
Immunotherapeutics and then as Senior Research Scientist in the
Autoimmune Disease Department, where he developed recombinant
T-cell receptor proteins for a rodent model of multiple sclerosis.
He was then promoted to Staff Scientist within the Cancer Vaccine
department, where he led a group in the development and evaluation
of cytokine-secreting tumor cell vaccines in preclinical and
clinical projects. Dr. Soo Hoo also worked on monoclonal antibody
development and molecular immunology preclinical projects at
Hybritech Incorporated for five years. Dr. Soo Hoo holds a B.A. in
Biochemistry and Cell Biology from the University of California,
San Diego, and a Ph.D. in Biochemistry from the University of
Illinois, Urbana-Champaign. Dr. Soo Hoo is a reviewer for Cancer
Letters and has authored numerous scientific papers, presentations,
grant applications and patents in areas of immunology,
immunotherapy, diagnostics, and adjuvant technology. Dr. Soo Hoo is
the inventor of a technology for the generation and evaluation of
membrane-bound GM-CSF cancer vaccines. "We are very pleased to add
Dr. El-Kalay and Dr. Soo Hoo to MicroIslet's scientific team,"
commented James R. Gavin III, M.D., Ph.D., President and Chief
Executive Officer of MicroIslet. "Both gentlemen will greatly
strengthen our resources in product development and validation
assay support for clinical trials." Dr. Gavin continued, "We will
miss the day-to-day contributions of Dr. Ronnda Bartel, who left
our company to assume the role of Vice President of Research and
Development with a stem cell based company. However, Dr. Bartel
will continue to provide her insights and guidance to us as a
consultant and as a member of our Scientific Advisory Board. We are
positioned to move forward with our pending clinical trials of our
microencapsulated allotransplantation candidate known as
MicroIslet-H(TM), in collaboration with The Scripps Research
Institute and the City of Hope." About MicroIslet MicroIslet is a
biotechnology company engaged in the research, development, and
commercialization of patented technologies in the field of
transplantation therapy for people with insulin-dependent diabetes.
MicroIslet's islet transplantation technology, including patented
technology exclusively licensed from Duke University, includes
methods for isolating, culturing, cryopreservation, and
immuno-protection (microencapsulation) of islet cells. MicroIslet
is working to develop and commercialize a first product, called
MicroIslet-H(TM), a microencapsulated human islet cell suspension
that will be used for transplantation in patients with
insulin-dependent diabetes. MicroIslet is also working to develop
and commercialize a second product, MicroIslet-P(TM), a
microencapsulated porcine islet cell suspension for transplantation
in patients with insulin-dependent diabetes, which if successful,
will address the inherently limited supply of human islets.
Additional information about MicroIslet can be found at
http://www.microislet.com/. Except for the historical information
contained herein, the matters set forth in this press release,
including the expectation of development of new therapeutic
products and the impact of MicroIslet's products on diabetes
patients, are forward-looking statements within the meaning of the
"safe harbor" provisions of the Private Securities Litigation
Reform Act of 1995. These forward-looking statements are subject to
risks and uncertainties that may cause actual results to differ
materially, including MicroIslet's ability to continue as a going
concern, the risks and uncertainties inherent in medical treatment
discovery, development and commercialization, the risks and
uncertainties associated with MicroIslet's early stage
allotransplantation and xenotransplantation technologies, the risks
and uncertainties of governmental approvals and regulation,
dependence on the Mayo Foundation for Medical Education and
Research as a sole source supplier of animal parts for pre-clinical
and clinical studies, MicroIslet's need to raise substantial
additional capital to proceed through human clinical trials and
bring any product to market, the risks that MicroIslet's
competitors will develop or market technologies or products that
are more effective or commercially attractive than MicroIslet's
products, and other risks detailed from time to time in
MicroIslet's most recent filings with the Securities and Exchange
Commission. These forward-looking statements speak only as of the
date hereof. MicroIslet disclaims any intent or obligation to
update these forward-looking statements. For more information,
please visit our Web site at http://www.microislet.com/. For
further information, contact: Kevin A. Hainley, MicroIslet Inc.
858-657-0287, Sean Collins, Senior Partner CCG Investor Relations
& Strategic Communications 310-231-8600 ext. 202 ISIN
US59507Q1067 DATASOURCE: MicroIslet, Inc. CONTACT: Kevin A. Hainley
of MicroIslet Inc., +1-858-657-0287, ; or Sean Collins, Senior
Partner, of CCG Investor Relations & Strategic Communications,
+1-310-231-8600, ext. 202, for MicroIslet, Inc. Web site:
http://www.microislet.com/
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