(DEL AM)

September 4, 2018

VIA EDGAR

Securities and Exchange Commission

Division of Corporate Finance

100 F. Street, N.E.

Washington, DC 20549

Re: Delaying Amendment for Obalon Therapeutics, Inc. – Registration Statement on Form S-3 (File No. 333-227160)

Ladies and Gentlemen:

Pursuant to Rule 473 of the Securities Act of 1933, as amended (the “Securities Act”), Obalon Therapeutics, Inc. (the “Registrant”) is hereby filing a delaying amendment with respect to its Registration Statement on Form S-3 (File No. 333-227160) filed by the Registrant on August 31, 2018 (the “Registration Statement”). The following delaying amendment, prescribed by Rule 473(a) of the Securities Act, is hereby incorporated into the cover page of the Registration Statement:

“The registrant hereby amends this registration statement on such date or dates as may be necessary to delay its effective date until the registrant shall file a further amendment which specifically states that this registration statement shall thereafter become effective in accordance with Section 8(a) of the Securities Act of 1933, as amended, or until the registration statement shall become effective on such date as the Commission, acting pursuant to said Section 8(a), may determine.”

If you have any questions or comments in connection with this delaying amendment, please contact Shayne B. Kennedy (714-540-1235) of Latham & Watkins LLP, counsel to the Registrant.

Sincerely,

/s/Andrew Rasdal

Andrew Rasdal

Chief Executive Officer